Anil B Mukherjee

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Allergic asthma: influence of genetic and environmental factors
    Anil B Mukherjee
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 286:32883-9. 2011
  2. pmc Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions
    Asim K Mandal
    Bldg 10, Rm 9S241, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Exp Med 199:1317-30. 2004
  3. pmc Evaluation of neurodegeneration in a mouse model of infantile batten disease by magnetic resonance imaging and magnetic resonance spectroscopy
    Jeeva Munasinghe
    In Vivo NMR Center HNQ2 3, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Neurodegener Dis 9:159-69. 2012
  4. ncbi request reprint Uteroglobin: physiological role in normal glomerular function uncovered by targeted disruption of the uteroglobin gene in mice
    A B Mukherjee
    Section on Developmental Genetics, Heritable Disorders Branch, The National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Am J Kidney Dis 32:1106-20. 1998
  5. ncbi request reprint Uteroglobin: a novel cytokine?
    A B Mukherjee
    Section on Developmental Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Cell Mol Life Sci 55:771-87. 1999
  6. ncbi request reprint Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily
    Anil B Mukherjee
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institute of Health, Building 10, Bethesda, Maryland 20892 1830, USA
    Endocr Rev 28:707-25. 2007
  7. ncbi request reprint Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:32897-904. 2005
  8. ncbi request reprint Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Developement, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 16:837-47. 2007
  9. ncbi request reprint Uteroglobin suppresses SCCA gene expression associated with allergic asthma
    Rabindranath Ray
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:9761-4. 2005
  10. pmc RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis
    Arjun Saha
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, United States
    FEBS Lett 582:3823-31. 2008

Collaborators

Detail Information

Publications33

  1. pmc Allergic asthma: influence of genetic and environmental factors
    Anil B Mukherjee
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 286:32883-9. 2011
    ....
  2. pmc Uteroglobin represses allergen-induced inflammatory response by blocking PGD2 receptor-mediated functions
    Asim K Mandal
    Bldg 10, Rm 9S241, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Exp Med 199:1317-30. 2004
    ..We propose that UG is an essential component of a novel innate homeostatic mechanism in the mammalian airways to repress allergen-induced inflammatory responses...
  3. pmc Evaluation of neurodegeneration in a mouse model of infantile batten disease by magnetic resonance imaging and magnetic resonance spectroscopy
    Jeeva Munasinghe
    In Vivo NMR Center HNQ2 3, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Neurodegener Dis 9:159-69. 2012
    ..These methods may be useful in studies to understand the progression of neuropathology in animal models of neurodegenerative diseases as they allow repeated evaluations of the same animal in which experimental therapies are tested...
  4. ncbi request reprint Uteroglobin: physiological role in normal glomerular function uncovered by targeted disruption of the uteroglobin gene in mice
    A B Mukherjee
    Section on Developmental Genetics, Heritable Disorders Branch, The National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Am J Kidney Dis 32:1106-20. 1998
    ..Nevertheless, the UG gene-knockout mice provide a valuable animal model for investigation of human glomerulopathies in general and familial Fn-deposit glomerulopathy in particular...
  5. ncbi request reprint Uteroglobin: a novel cytokine?
    A B Mukherjee
    Section on Developmental Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Cell Mol Life Sci 55:771-87. 1999
    ..Molecular characterization of the UG receptor and signal transduction via this receptor pathway may show that this protein belongs to a novel cytokine/chemokine family...
  6. ncbi request reprint Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily
    Anil B Mukherjee
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institute of Health, Building 10, Bethesda, Maryland 20892 1830, USA
    Endocr Rev 28:707-25. 2007
    ..Recent studies on UG-binding proteins (receptors) provide further insight into the multifunctional nature of this protein. Based on its antiinflammatory and antiallergic properties, UG is a potential drug target...
  7. ncbi request reprint Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:32897-904. 2005
    ..We propose that uteroglobin plays important roles in maintaining homeostasis in organs that are vulnerable to inadvertent stimulation of FP-mediated inflammatory response...
  8. ncbi request reprint Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Developement, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 16:837-47. 2007
    ..We propose that increased cPLA(2)-catalyzed LPC production in the brain is at least one of the mechanisms that mediate phagocyte infiltration contributing to INCL neuropathology...
  9. ncbi request reprint Uteroglobin suppresses SCCA gene expression associated with allergic asthma
    Rabindranath Ray
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:9761-4. 2005
    ....
  10. pmc RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis
    Arjun Saha
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, United States
    FEBS Lett 582:3823-31. 2008
    ..We propose that RAGE signaling contributes to neuroinflammation in INCL...
  11. pmc Lack of an endogenous anti-inflammatory protein in mice enhances colonization of B16F10 melanoma cells in the lungs
    Arjun Saha
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 285:10822-31. 2010
    ..Taken together, our results suggest that a lack of an anti-inflammatory protein leads to increased pulmonary colonization of melanoma cells and identify RAGE as a potential anti-metastatic drug target...
  12. ncbi request reprint Interaction of uteroglobin with lipocalin-1 receptor suppresses cancer cell motility and invasion
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, NIH, Bethesda, MD 20892 1830, USA
    Gene 369:66-71. 2006
    ..Taken together, these results suggest that Lip-1R is at least one of the UG-binding proteins through which UG exerts anti-motility and anti-invasive effects...
  13. pmc Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43
    Eryan Kong
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892 1830, USA
    J Biol Chem 288:9112-25. 2013
    ....
  14. pmc The blood-brain barrier is disrupted in a mouse model of infantile neuronal ceroid lipofuscinosis: amelioration by resveratrol
    Arjun Saha
    Section on Developmental Genetics, Program on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 21:2233-44. 2012
    ..Our findings uncover a mechanism by which T(H)17 lymphocytes mediate BBB disruption and suggest that small molecules such as RSV that suppress T(H)17 differentiation are therapeutic targets for neurodegenerative disorders such as INCL...
  15. pmc Omega-3 and omega-6 fatty acids suppress ER- and oxidative stress in cultured neurons and neuronal progenitor cells from mice lacking PPT1
    Sung Jo Kim
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892 1830, United States
    Neurosci Lett 479:292-6. 2010
    ..Our results suggest that PUFA supplementation may have neuroprotective effects in INCL...
  16. ncbi request reprint Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in INCL
    Zhongjian Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 15:337-46. 2006
    ..Our results, for the first time, link PPT1 deficiency with the activation of UPR, apoptosis and neurodegeneration in INCL and identify potential targets for therapeutic intervention in this uniformly fatal disease...
  17. pmc Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice
    Sung Jo Kim
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland 20892 1830, USA
    J Clin Invest 118:3075-86. 2008
    ..This abnormality may contribute to INCL neuropathology...
  18. pmc Uteroglobin suppresses allergen-induced TH2 differentiation by down-regulating the expression of serum amyloid A and SOCS-3 genes
    Rabindranath Ray
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Building 10, Rm 9D42, 10, Center Drive, Bethesda, MD 20892 1830, USA
    FEBS Lett 580:6022-6. 2006
    ..We propose that UG suppresses allergen-mediated activation of T(H)2 response by down-regulating the expression of genes that are critical for T(H)2 differentiation...
  19. ncbi request reprint Palmitoyl-protein thioesterase-1 deficiency leads to the activation of caspase-9 and contributes to rapid neurodegeneration in INCL
    Sung Jo Kim
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Hum Mol Genet 15:1580-6. 2006
    ....
  20. pmc Disruption of adaptive energy metabolism and elevated ribosomal p-S6K1 levels contribute to INCL pathogenesis: partial rescue by resveratrol
    Hui Wei
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 20:1111-21. 2011
    ....
  21. ncbi request reprint Mice lacking uteroglobin are highly susceptible to developing pulmonary fibrosis
    Yi Ching Lee
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Building 10, Rm 9D42, 10, Center Drive, Bethesda, MD 20892 1830, USA
    FEBS Lett 580:4515-20. 2006
    ..Our results define a critical role of UG in preventing the development of PF and provide the proof of principle that recombinant UG may have therapeutic potential...
  22. ncbi request reprint ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones
    Hui Wei
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Hum Mol Genet 17:469-77. 2008
    ....
  23. pmc Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL
    Chinmoy Sarkar
    1 Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA 2
    Nat Neurosci 16:1608-17. 2013
    ..Our findings provide a proof of concept that thioesterase-mimetic and antioxidant small molecules such as NtBuHA are potential drug targets for thioesterase deficiency diseases such as INCL. ..
  24. ncbi request reprint Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL
    Sung Jo Kim
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1826-34. 2006
    ..Our results provide insight into at least one of the molecular mechanisms of apoptosis in INCL and may allow the identification of potential targets for therapeutic intervention...
  25. pmc Uteroglobin interacts with the heparin-binding site of fibronectin and prevents fibronectin-IgA complex formation found in IgA-nephropathy
    Bhabadeb Chowdhury
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, NIH, Bethesda, MD 20892 1830, USA
    FEBS Lett 582:611-5. 2008
    ..We report here that UG interacts with the heparin-binding site of Fn and propose that small molecules competing for interaction with this site may reduce the level of circulating Fn-IgA complexes in IgAN...
  26. ncbi request reprint IFN-gamma stimulates the expression of a novel secretoglobin that regulates chemotactic cell migration and invasion
    Moonsuk S Choi
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:4245-52. 2004
    ..Taken together, these results raise the possibility that this novel SCGB has immunological functions...
  27. ncbi request reprint Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:6271-3. 2005
    ..We propose that while pro- and anti-inflammatory PGs counteract each other to maintain homeostasis, selective COX-2 inhibitors may disrupt this balance, thereby resulting in reported adverse effects...
  28. ncbi request reprint Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity
    Bhabadeb Chowdhury
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, Bethesda, MD 20892 1830, USA
    Biochem Biophys Res Commun 295:877-83. 2002
    ....
  29. ncbi request reprint Neutral ceramidase gene: role in regulating ceramide-induced apoptosis
    Moonsuk S Choi
    Section on Developmental Genetics, Heritable Disorders Branch, The National Institute of Child Health and Human Development, The National Institutes of Health, Room 9S241, Building 10, Bethesda, MD 20892 1830, USA
    Gene 315:113-22. 2003
    ..We propose that N-CDase is an essential component of an innate detoxifying mechanism to prevent ceramide-induced apoptosis...
  30. pmc Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from INCL patients
    Chinmoy Sarkar
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    Mol Genet Metab 104:338-45. 2011
    ..The clinical relevance of these effects may be tested in animal models of INCL carrying nonsense mutations in the PPT1 gene...
  31. ncbi request reprint Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke
    Yongping Yang
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Rockville, Maryland 20850, USA
    J Biol Chem 279:29336-40. 2004
    ..We propose that CC10 has a protective role against NNK-induced lung tumorigenesis mediated via down-regulation of the above-mentioned predisposing events...
  32. pmc Children with infantile neuronal ceroid lipofuscinosis have an increased risk of hypothermia and bradycardia during anesthesia
    Ning Miao
    Department of Anesthesia and Surgical Services, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1512, USA
    Anesth Analg 109:372-8. 2009
    ..The infantile NCL (INCL) subtype is rare (1 in >100,000 births), the most devastating of childhood subtypes, and is caused by mutations in the gene CLN1, which encodes palmitoyl-protein thioesterase-1...
  33. ncbi request reprint Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line
    Chiu Ya Wang
    Department of Biological Science and Technology, National Chiao Tung University, 75 Po Ai Street, Hsinchu 30050, Taiwan, ROC
    Biochem Pharmacol 64:177-84. 2002
    ..This finding implies that staurosporine-mediated COX-2 gene expression is specific and independent of protein kinase C activity...