Geoffrey A Mueller

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins
    Benjamin G Bobay
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 27695, USA
    FEBS Lett 579:5669-74. 2005
  2. doi request reprint Characterization of an anti-Bla g 1 scFv: Epitope mapping and cross-reactivity
    Geoffrey A Mueller
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA Electronic address
    Mol Immunol 59:200-7. 2014
  3. doi request reprint The molecular basis of peanut allergy
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, MD MR 01, Research Triangle Park, NC, 27709, USA
    Curr Allergy Asthma Rep 14:429. 2014
  4. pmc The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC Electronic address
    J Allergy Clin Immunol 132:1420-6. 2013
  5. pmc Structural studies of the PARP-1 BRCT domain
    Paul A Loeffler
    Department of Chemistry, Sam Houston State University, Huntsville, Texas 77340, USA
    BMC Struct Biol 11:37. 2011
  6. doi request reprint Analytical solution to the coupled evolution of multidimensional NMR data
    Geoffrey A Mueller
    National Institute of Environment Health Sciences, 111 T W Alexander Drive, MD MR 01, Research Triangle Park, NC 27709, USA
    J Biomol NMR 44:13-23. 2009
  7. pmc Solution structure of the Drosha double-stranded RNA-binding domain
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Silence 1:2. 2010
  8. pmc The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    J Allergy Clin Immunol 125:909-917.e4. 2010
  9. pmc Der p 5 crystal structure provides insight into the group 5 dust mite allergens
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:25394-401. 2010
  10. pmc Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity
    G A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Allergy 66:878-85. 2011

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins
    Benjamin G Bobay
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 27695, USA
    FEBS Lett 579:5669-74. 2005
    ..This strongly suggests that MraZ also binds DNA and allows for a consensus model of DNA recognition by the members of this novel protein superfamily...
  2. doi request reprint Characterization of an anti-Bla g 1 scFv: Epitope mapping and cross-reactivity
    Geoffrey A Mueller
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA Electronic address
    Mol Immunol 59:200-7. 2014
    ..This scFv could be best utilized as a capture antibody in an IgE detection ELISA, or to differentiate Bla g 1 from Per a 1 in environmental exposure assays. ..
  3. doi request reprint The molecular basis of peanut allergy
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, MD MR 01, Research Triangle Park, NC, 27709, USA
    Curr Allergy Asthma Rep 14:429. 2014
    ..The molecular features of peanut allergens continue to inform predictions and provide new research directions in the study of allergic disease. ..
  4. pmc The novel structure of the cockroach allergen Bla g 1 has implications for allergenicity and exposure assessment
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC Electronic address
    J Allergy Clin Immunol 132:1420-6. 2013
    ..Sensitization to cockroach allergens is a major risk factor for asthma. The cockroach allergen Bla g 1 has multiple repeats of approximately 100 amino acids, but the fold of the protein and its biological function are unknown...
  5. pmc Structural studies of the PARP-1 BRCT domain
    Paul A Loeffler
    Department of Chemistry, Sam Houston State University, Huntsville, Texas 77340, USA
    BMC Struct Biol 11:37. 2011
    ..The co-localization of XRCC1, as well as bound DNA repair factors, to sites of DNA damage is important for cell survival and genomic integrity...
  6. doi request reprint Analytical solution to the coupled evolution of multidimensional NMR data
    Geoffrey A Mueller
    National Institute of Environment Health Sciences, 111 T W Alexander Drive, MD MR 01, Research Triangle Park, NC 27709, USA
    J Biomol NMR 44:13-23. 2009
    ..This algorithm is shown to be robust in that erroneous solutions give rise to large artifacts...
  7. pmc Solution structure of the Drosha double-stranded RNA-binding domain
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Silence 1:2. 2010
    ..To gain insight into the function of this domain, we determined the nuclear magnetic resonance (NMR) solution structure...
  8. pmc The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    J Allergy Clin Immunol 125:909-917.e4. 2010
    ..Allergen function might contribute to allergenicity, as shown for the protease activity of group 1 mite allergens and the interaction with the innate immune system by group 2 mite allergens...
  9. pmc Der p 5 crystal structure provides insight into the group 5 dust mite allergens
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:25394-401. 2010
    ..Many allergens are known to bind hydrophobic ligands, which are thought to stimulate the innate immune system and have adjuvant-like effects on IgE-mediated inflammatory responses...
  10. pmc Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity
    G A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Allergy 66:878-85. 2011
    ..Peanut allergy affects 1% of the population and causes the most fatal food-related anaphylactic reactions. The protein Ara h 2 is the most potent peanut allergen recognized by 80-90% of peanut allergic patients...
  11. pmc A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda
    Geoffrey A Mueller
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, MD MR 01, Research Triangle Park, NC 27709, USA
    DNA Repair (Amst) 7:1340-51. 2008
    ..In conclusion, both the structure of the Pol lambda BRCT domain and its mode of interaction with the other components of the NHEJ complex significantly differ from the two previously studied homologs, Pol mu and TdT...
  12. pmc Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining
    Eugene F Derose
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 46:12100-10. 2007
    ..Further, the similarity between the interaction regions of the BRCT domains of pol mu and TdT support the conclusion that they participate in NHEJ as alternate polymerases...
  13. pmc Nuclear magnetic resonance solution structure of the Escherichia coli DNA polymerase III theta subunit
    Geoffrey A Mueller
    Laboratory of Structural Biology, MR 01, National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA
    J Bacteriol 187:7081-9. 2005
    ..The new theta structure is expected to provide additional insight into its physiological role and its effect on the epsilon proofreading subunit...
  14. pmc NMR analysis of [methyl-13C]methionine UvrB from Bacillus caldotenax reveals UvrB-domain 4 heterodimer formation in solution
    Matthew J DellaVecchia
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    J Mol Biol 373:282-95. 2007
    ..In summary, UvrB homodimerization is disfavored, while domain 4 homodimerization and UvrB-domain 4 heterodimerization are allowed...
  15. ncbi request reprint Solution structure of the lyase domain of human DNA polymerase lambda
    Eugene F Derose
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Box 12233, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 42:9564-74. 2003
    ..g., K60 in pol beta and K307 in pol lambda. Additionally, on the basis of the structural alignment obtained, several previously proposed mechanistic hypotheses can be evaluated...
  16. pmc Metal-induced DNA translocation leads to DNA polymerase conformational activation
    Thomas W Kirby
    Laboratory of Structural Biology, NIEHS, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:2974-83. 2012
    ..These findings provide new insight into the relationships between conformational activation, enzyme activity and polymerase fidelity...
  17. pmc Dependence of amino acid side chain 13C shifts on dihedral angle: application to conformational analysis
    Robert E London
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, MD MR 01, Research Triangle Park, North Carolina 27709, USA
    J Am Chem Soc 130:11097-105. 2008
    ....
  18. doi request reprint Homodimerization of the p51 subunit of HIV-1 reverse transcriptase
    Xunhai Zheng
    Laboratory of Structural Biology, MR 01, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 49:2821-33. 2010
    ..A reduced level of dimer formation then results from the reduced ratio of the p51E(L289K) to p51C(L289K) monomers...
  19. ncbi request reprint Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta
    Bidisha Bose-Basu
    Laboratory of Structural Biology, NIEHS, NIH, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 43:8911-22. 2004
    ..Thus, the NMR data indicate that the nucleotide-DNA interaction appears to be essential for conformational activation...
  20. pmc Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode
    Yanshun Liu
    Laboratory of Neurobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 287:43030-41. 2012
    ..We propose a two-step mechanism for CaM-dependent Orai1 inactivation initiated by binding of the C-lobe of CaM to the CMBD of one Orai1 followed by the binding of the N-lobe of CaM to the CMBD of a neighboring Orai1...
  21. pmc A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction
    Andrea F Moon
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Protein Sci 19:901-13. 2010
    ..This crystallization technique represents a valuable rescue strategy for protein structure solution when conventional methods fail...
  22. pmc Solution characterization of [methyl-(13)C]methionine HIV-1 reverse transcriptase by NMR spectroscopy
    Xunhai Zheng
    Laboratory of Molecular Biophysics, MR 01, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Antiviral Res 84:205-14. 2009
    ..Conformational features that might explain the multiple peaks are discussed...
  23. pmc NMR assignment of polymerase beta labeled with 2H, 13C, and 15N in complex with substrate DNA
    Geoffrey A Mueller
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 23455, USA
    Biomol NMR Assign 1:33-5. 2007
    ..We present here the first assignments of the full-length protein (335 residues, 39 kDa) in the presence of a double gap--double hairpin DNA (22 nucleotides, 7 kDa)...
  24. ncbi request reprint Backbone dynamics of the RNase H domain of HIV-1 reverse transcriptase
    Geoffrey A Mueller
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 43:9332-42. 2004
    ....
  25. ncbi request reprint NMR assignment of protein side chains using residue-correlated labeling and NOE spectra
    Geoffrey A Mueller
    National Institute of Environmental Health Sciences, Laboratory of Structural Biology, 111 Alexander Drive, PO Box 12233 MD MR 01, Research Triangle Park, NC 27709, USA
    J Magn Reson 165:237-47. 2003
    ..5 ns, and at 5 degrees C, corresponding to a rotational correlation time of 22 ns...
  26. pmc Protein-mediated antagonism between HIV reverse transcriptase ligands nevirapine and MgATP
    Xunhai Zheng
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Biophys J 104:2695-705. 2013
    ..Protein-mediated interactions appear to explain most of the affinity variation of NVP for RT. ..
  27. pmc Metal and ligand binding to the HIV-RNase H active site are remotely monitored by Ile556
    Xunhai Zheng
    Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 40:10543-53. 2012
    ..Ordering of helix E results specifically from the interaction with the lower affinity binding to the A divalent ion site...
  28. ncbi request reprint Solution structure of the RNase H domain of the HIV-1 reverse transcriptase in the presence of magnesium
    Koteppa Pari
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, P O Box 12233, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 42:639-50. 2003
    ..The poor Mg(2+) binding and conformational flexibility of residues located near the active site indicate that substrate binding is a precondition for metal ion binding and for selecting the active site conformation of the RNase H domain...
  29. ncbi request reprint Phage like it HOT: solution structure of the bacteriophage P1-encoded HOT protein, a homolog of the theta subunit of E. coli DNA polymerase III
    Eugene F Derose
    Laboratory of Structural Biology, NIEHS, Box 12233, Research Triangle Park, NC 27709, USA
    Structure 12:2221-31. 2004
    ..As judged by CD measurements, the melting temperature of HOT was 62 degrees C, compared to 56 degrees C for theta, consistent with other data suggesting greater thermal stability of the HOT protein...
  30. ncbi request reprint NvAssign: protein NMR spectral assignment with NMRView
    Nigel I Kirby
    Laboratory of Structural Biology, MR 01, National Institute of Environmental Health Sciences, National Institutes of Health, Box 12233, Research Triangle Park, NC 27709, USA
    Bioinformatics 20:1201-3. 2004
    ..What is lacking is a flexible interface to help a spectroscopist easily move from clustering (step 2) to assignment algorithms (step 3) and back to verification of the algorithm output with spectral analysis (step 4)...
  31. ncbi request reprint The nuclease A inhibitor represents a new variation of the rare PR-1 fold
    Thomas W Kirby
    National Institute of Environmental Health Sciences, P O Box 12233, MD MR 01, Research Triangle Park, NC 27709, USA
    J Mol Biol 320:771-82. 2002
    ..This hypothesis is supported by data that show that when NuiA is bound to NucA significant changes in chemical shift occur in the extended loop between helices III and IV...
  32. ncbi request reprint NMR studies of the interaction of a type II dihydrofolate reductase with pyridine nucleotides reveal unexpected phosphatase and reductase activity
    Wayne H Pitcher
    Laboratory of Structural Biology, MR 01, National Institute of Environmental Health Sciences, National Institutes of Health, Box 12233, Research Triangle Park, North Carolina 27709, USA
    Biochemistry 42:11150-60. 2003
    ..Analysis of DHFR backbone dynamics revealed little change upon binding of NADP(+). These additional catalytic activities and dynamic behavior are in marked contrast to those of type I DHFR...
  33. doi request reprint (1)H, (13)C, and (15)N NMR assignments for the Bacillus subtilis yndB START domain
    Kelly A Mercier
    Department of Chemistry, University of Nebraska Lincoln, Lincoln, NE 68588 0304, USA
    Biomol NMR Assign 3:191-4. 2009
    ..Here we report the near complete (1)H, (15)N and (13)C backbone and side chain NMR resonance assignments for the Bacillus subtilis START domain protein yndB...
  34. pmc Genomic, RNAseq, and molecular modeling evidence suggests that the major allergen domain in insects evolved from a homodimeric origin
    Thomas A Randall
    Integrative Bioinformatics, National Institute of Environmental Health Sciences, Research Triangle Park, NC
    Genome Biol Evol 5:2344-58. 2013
    ..An extensive search for this domain outside of Insecta confirms that the MAs are restricted to insects...
  35. pmc NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins
    Benjamin G Bobay
    Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, 27695, USA
    J Biol Chem 281:21399-409. 2006
    ..The results of accompanying in vitro DNA-binding studies serve to highlight binding differences between the two proteins...
  36. ncbi request reprint The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation
    Kirk C Prutzman
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
    Structure 12:881-91. 2004
    ..We have also identified a mutant that dimerizes approximately 8 fold more than WT FAT domain and exhibits increased phosphorylation of tyrosine 926 both in vitro and in vivo...
  37. ncbi request reprint The N-terminal domain of the Drosophila histone mRNA binding protein, SLBP, is intrinsically disordered with nascent helical structure
    Roopa Thapar
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 43:9390-400. 2004
    ..The implications of this unfolded state for the function of dSLBP in regulating histone metabolism are discussed...