Kathrin Muegge

Summary

Affiliation: National Cancer Institute
Country: USA

Publications

  1. pmc The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase
    M S Schlissel
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Exp Med 191:1045-50. 2000
  2. ncbi request reprint Lsh, a guardian of heterochromatin at repeat elements
    Kathrin Muegge
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21701, USA
    Biochem Cell Biol 83:548-54. 2005
  3. pmc Lsh participates in DNA methylation and silencing of stem cell genes
    Sichuan Xi
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21701, USA
    Stem Cells 27:2691-702. 2009
  4. pmc Lsh, an epigenetic guardian of repetitive elements
    Jiaqiang Huang
    Laboratory of Molecular Immunoregulation, SAIC Basic Research Program, National Cancer Institute, Frederick, MD 21701, USA
    Nucleic Acids Res 32:5019-28. 2004
  5. pmc Lsh controls Hox gene silencing during development
    Sichuan Xi
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 104:14366-71. 2007
  6. pmc Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation
    Yongguang Tao
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS ONE 5:e9163. 2010
  7. pmc DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development
    Tao Fan
    Laboratory of Cancer Prevention, SAIC FCRDC, Basic Research Program, National Cancer Institute, Frederick, Maryland, USA
    Epigenetics 3:134-42. 2008
  8. pmc Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences
    Yongguang Tao
    Basic Science Program, Laboratory of Cancer Prevention, Advanced Biomedical Computing Center, and Data Management Services, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 108:5626-31. 2011
  9. pmc Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS
    Yongguang Tao
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21701, USA
    Nucleic Acids Res 39:9508-20. 2011
  10. ncbi request reprint Lsh controls silencing of the imprinted Cdkn1c gene
    Tao Fan
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Development 132:635-44. 2005

Collaborators

Detail Information

Publications24

  1. pmc The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase
    M S Schlissel
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
    J Exp Med 191:1045-50. 2000
    ..We found a reduction in chromatin accessibility for Rag-mediated cleavage in IL-7R-/- thymocytes compared with wild-type. Thus, IL-7 controls recombination at the TCR-gamma locus by regulating locus accessibility...
  2. ncbi request reprint Lsh, a guardian of heterochromatin at repeat elements
    Kathrin Muegge
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21701, USA
    Biochem Cell Biol 83:548-54. 2005
    ..Thus, Lsh is a major epigenetic regulator crucial for normal heterochromatin structure and function...
  3. pmc Lsh participates in DNA methylation and silencing of stem cell genes
    Sichuan Xi
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21701, USA
    Stem Cells 27:2691-702. 2009
    ..Our results indicate that Lsh is involved in the control of stem cell genes and suggest that Lsh is an important epigenetic modulator during early stem cell differentiation...
  4. pmc Lsh, an epigenetic guardian of repetitive elements
    Jiaqiang Huang
    Laboratory of Molecular Immunoregulation, SAIC Basic Research Program, National Cancer Institute, Frederick, MD 21701, USA
    Nucleic Acids Res 32:5019-28. 2004
    ..These data suggest that the repetitive sites are direct targets of Lsh action and that Lsh plays an important role as 'epigenetic guardian' of the genome to protect against deregulation of parasitic retroviral elements...
  5. pmc Lsh controls Hox gene silencing during development
    Sichuan Xi
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Proc Natl Acad Sci U S A 104:14366-71. 2007
    ..Moreover, Lsh can associate with PRC1 components and influence PRC-mediated histone modifications. Thus Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of PRC targets...
  6. pmc Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation
    Yongguang Tao
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS ONE 5:e9163. 2010
    ..Taken together, the data suggests that DNA methylation can be compatible with Pol II binding at selected genes and Pol II stalling can act as alternate mechanism to explain transcriptional silencing associated with DNA methylation...
  7. pmc DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development
    Tao Fan
    Laboratory of Cancer Prevention, SAIC FCRDC, Basic Research Program, National Cancer Institute, Frederick, Maryland, USA
    Epigenetics 3:134-42. 2008
    ..Thus DNA hypomethylation caused by Lsh depletion is linked to transcriptional upregulation of retroviral elements and oncogenes such as PU.1 which in turn may promote the development of erythroleukemia in mice...
  8. pmc Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences
    Yongguang Tao
    Basic Science Program, Laboratory of Cancer Prevention, Advanced Biomedical Computing Center, and Data Management Services, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 108:5626-31. 2011
    ..Our data indicate that Lsh is an epigenetic modulator that is critical for normal distribution of cytosine methylation throughout the murine genome...
  9. pmc Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS
    Yongguang Tao
    Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21701, USA
    Nucleic Acids Res 39:9508-20. 2011
    ..Thus release of Pol II stalling can act as a mechanism for gene reactivation at specific target genes after DNA demethylating treatment in cancer cells...
  10. ncbi request reprint Lsh controls silencing of the imprinted Cdkn1c gene
    Tao Fan
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Development 132:635-44. 2005
    ..Furthermore, it suggests that Lsh is not required for maintenance of imprinting marks in general, but is only crucial for imprinting at distinct genomic sites...
  11. pmc CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity
    Weishi Yu
    Mouse Cancer and Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702
    Proc Natl Acad Sci U S A 111:5890-5. 2014
    ..Our results suggest a functional link of H3K4me1 enrichment at CG hypomethylated sites, enhancer formation, and cellular plasticity. ..
  12. pmc Lsh is involved in de novo methylation of DNA
    Heming Zhu
    Laboratory of Cancer Prevention, SAIC FCRDC, Basic Research Program, National Cancer Institute, Frederick, MD 21701 1201, USA
    EMBO J 25:335-45. 2006
    ..Finally, we demonstrate that Lsh associates with Dnmt3a or Dnmt3b but not with Dnmt1 in embryonic cells. These results suggest that the epigenetic regulator, Lsh, is directly involved in the control of de novo methylation of DNA...
  13. pmc Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin
    Qingsheng Yan
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702, USA
    Mol Cell Biol 23:8416-28. 2003
    ..These results are consistent with a model in which Lsh is recruited by intact heterochromatin structure and then assists in maintaining heterochromatin organization by establishing CpG methylation patterns...
  14. pmc Lsh, a modulator of CpG methylation, is crucial for normal histone methylation
    Qingsheng Yan
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    EMBO J 22:5154-62. 2003
    ..Thus, Lsh is crucial for the formation of normal heterochromatin, implying a functional role for Lsh in the regulation of transcription and mitosis...
  15. doi request reprint The ghosts in the machine: DNA methylation and the mystery of differentiation
    Victorino Briones
    Laboratory of Cancer Prevention, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21701, USA
    Biochim Biophys Acta 1819:757-62. 2012
    ..This article is part of a Special Issue entitled: Chromatin in time and space...
  16. doi request reprint The see-saw of differentiation: tipping the chromatin balance
    Kathrin Muegge
    Laboratory of Cancer Prevention, SAIC FCRDC, National Cancer Institute, Frederick, MD 21701, USA
    Mol Interv 8:15-8, 2. 2008
    ..This switch in chromatin states may be key to our understanding of developmental and tissue specific regulation of gene expression and may be therapeutically useful in regenerative medicine...
  17. doi request reprint DNA methylation in early development
    Theresa M Geiman
    Laboratory of Cancer Prevention, National Cancer Institute Frederick, SAIC Frederick, MD 21702, USA
    Mol Reprod Dev 77:105-13. 2010
    ..This review looks at the role of DNA methylation in early embryonic development, as well as how this epigenetic mark affects stem cell differentiation and tissue-specific gene expression in somatic cells...
  18. pmc Modifications of histone cores and tails in V(D)J recombination
    Kathrin Muegge
    Laboratory of Molecular Immunoregulation, SAIC Basic Science Program, National Cancer Institute, Frederick, MD 21701, USA
    Genome Biol 4:211. 2003
    ..A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase...
  19. ncbi request reprint Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis
    Tao Fan
    Laboratory of Molecular Immunoregulation, Basic Research Program, Science Applications International Corporation Frederick, Inc, National Cancer Institute, Building 469, Frederick, MD 21702 1201, USA
    Cancer Res 63:4677-83. 2003
    ..Because supernumerary centrosomes are a common feature in cancer cells, this Lsh-dependent pathway has the potential to contribute to genetic instability and chromosomal aberrations during tumor progression...
  20. ncbi request reprint Epigenetic control during lymphoid development and immune responses: aberrant regulation, viruses, and cancer
    Kathrin Muegge
    Laboratories of Molecular Immunoregulation, SAIC, Frederick, Maryland 21702, USA
    Ann N Y Acad Sci 983:55-70. 2003
    ..Aberrations in epigenetic machinery, either by genetic mutations or by somatic changes such as viral infections, are associated with early alterations in chronic diseases such as immunodeficiency and cancer...
  21. ncbi request reprint Preparing the target for the bullet
    Kathrin Muegge
    Nat Immunol 3:16-7. 2002
  22. pmc Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia
    Claudia Baumann
    Female Germ Cell Biology Group, Department of Clinical Studies, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
    BMC Mol Biol 9:29. 2008
    ....
  23. ncbi request reprint Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells
    Rabindranath De La Fuente
    Female Germ Cell Biology Group, Department of Clinical Studies, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, PA 19348, USA
    Nat Cell Biol 8:1448-54. 2006
    ....
  24. ncbi request reprint Bax deficiency partially corrects interleukin-7 receptor alpha deficiency
    Annette R Khaled
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, MD 21702, USA
    Immunity 17:561-73. 2002
    ..The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7. Thus, in young mice, Bax emerges as an essential protein in the death pathway induced by IL-7 deficiency...