Research Topics
Genomes and GenesSpecies | Kathrin MueggeSummaryAffiliation: National Cancer Institute Country: USA Publications
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Detail Information
Publications
The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinaseM S Schlissel
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
J Exp Med 191:1045-50. 2000..We found a reduction in chromatin accessibility for Rag-mediated cleavage in IL-7R-/- thymocytes compared with wild-type. Thus, IL-7 controls recombination at the TCR-gamma locus by regulating locus accessibility...
Lsh, a guardian of heterochromatin at repeat elementsKathrin Muegge
Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21701, USA
Biochem Cell Biol 83:548-54. 2005..Thus, Lsh is a major epigenetic regulator crucial for normal heterochromatin structure and function...- Lsh participates in DNA methylation and silencing of stem cell genesSichuan Xi
Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21701, USA
Stem Cells 27:2691-702. 2009..Our results indicate that Lsh is involved in the control of stem cell genes and suggest that Lsh is an important epigenetic modulator during early stem cell differentiation... - Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequencesYongguang Tao
Basic Science Program, Laboratory of Cancer Prevention, Advanced Biomedical Computing Center, and Data Management Services, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 108:5626-31. 2011..Our data indicate that Lsh is an epigenetic modulator that is critical for normal distribution of cytosine methylation throughout the murine genome... - Lsh controls Hox gene silencing during developmentSichuan Xi
Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
Proc Natl Acad Sci U S A 104:14366-71. 2007..Moreover, Lsh can associate with PRC1 components and influence PRC-mediated histone modifications. Thus Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of PRC targets... - Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSSYongguang Tao
Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21701, USA
Nucleic Acids Res 39:9508-20. 2011..Thus release of Pol II stalling can act as a mechanism for gene reactivation at specific target genes after DNA demethylating treatment in cancer cells... - Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylationYongguang Tao
Laboratory of Cancer Prevention, SAIC Frederick, National Cancer Institute, Frederick, Maryland, United States of America
PLoS ONE 5:e9163. 2010..Taken together, the data suggests that DNA methylation can be compatible with Pol II binding at selected genes and Pol II stalling can act as alternate mechanism to explain transcriptional silencing associated with DNA methylation... - DNA hypomethylation caused by Lsh deletion promotes erythroleukemia developmentTao Fan
Laboratory of Cancer Prevention, SAIC FCRDC, Basic Research Program, National Cancer Institute, Frederick, Maryland, USA
Epigenetics 3:134-42. 2008..Thus DNA hypomethylation caused by Lsh depletion is linked to transcriptional upregulation of retroviral elements and oncogenes such as PU.1 which in turn may promote the development of erythroleukemia in mice... - Lsh, an epigenetic guardian of repetitive elementsJiaqiang Huang
Laboratory of Molecular Immunoregulation, SAIC Basic Research Program, National Cancer Institute, Frederick, MD 21701, USA
Nucleic Acids Res 32:5019-28. 2004..These data suggest that the repetitive sites are direct targets of Lsh action and that Lsh plays an important role as 'epigenetic guardian' of the genome to protect against deregulation of parasitic retroviral elements... - Lsh controls silencing of the imprinted Cdkn1c geneTao Fan
Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
Development 132:635-44. 2005..Furthermore, it suggests that Lsh is not required for maintenance of imprinting marks in general, but is only crucial for imprinting at distinct genomic sites... - Lsh is involved in de novo methylation of DNAHeming Zhu
Laboratory of Cancer Prevention, SAIC FCRDC, Basic Research Program, National Cancer Institute, Frederick, MD 21701 1201, USA
EMBO J 25:335-45. 2006..Finally, we demonstrate that Lsh associates with Dnmt3a or Dnmt3b but not with Dnmt1 in embryonic cells. These results suggest that the epigenetic regulator, Lsh, is directly involved in the control of de novo methylation of DNA... 
The see-saw of differentiation: tipping the chromatin balanceKathrin Muegge
Laboratory of Cancer Prevention, SAIC FCRDC, National Cancer Institute, Frederick, MD 21701, USA
Mol Interv 8:15-8, 2. 2008..This switch in chromatin states may be key to our understanding of developmental and tissue specific regulation of gene expression and may be therapeutically useful in regenerative medicine...- DNA methylation in early developmentTheresa M Geiman
Laboratory of Cancer Prevention, National Cancer Institute Frederick, SAIC Frederick, MD 21702, USA
Mol Reprod Dev 77:105-13. 2010..This review looks at the role of DNA methylation in early embryonic development, as well as how this epigenetic mark affects stem cell differentiation and tissue-specific gene expression in somatic cells... - Modifications of histone cores and tails in V(D)J recombinationKathrin Muegge
Laboratory of Molecular Immunoregulation, SAIC Basic Science Program, National Cancer Institute, Frederick, MD 21701, USA
Genome Biol 4:211. 2003..A recent study shows that methylated lysine 79 in the core region of histone H3 also plays a role by providing a euchromatic 'mark' that may regulate access of the V(D)J recombinase... - Lsh, a modulator of CpG methylation, is crucial for normal histone methylationQingsheng Yan
Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
EMBO J 22:5154-62. 2003..Thus, Lsh is crucial for the formation of normal heterochromatin, implying a functional role for Lsh in the regulation of transcription and mitosis... - Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatinQingsheng Yan
Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, Maryland 21702, USA
Mol Cell Biol 23:8416-28. 2003..These results are consistent with a model in which Lsh is recruited by intact heterochromatin structure and then assists in maintaining heterochromatin organization by establishing CpG methylation patterns... - Epigenetic control during lymphoid development and immune responses: aberrant regulation, viruses, and cancerKathrin Muegge
Laboratories of Molecular Immunoregulation, SAIC, Frederick, Maryland 21702, USA
Ann N Y Acad Sci 983:55-70. 2003..Aberrations in epigenetic machinery, either by genetic mutations or by somatic changes such as viral infections, are associated with early alterations in chronic diseases such as immunodeficiency and cancer... - Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosisTao Fan
Laboratory of Molecular Immunoregulation, Basic Research Program, Science Applications International Corporation-Frederick, Inc, National Cancer Institute, Building 469, Frederick, MD 21702-1201, USA
Cancer Res 63:4677-83. 2003..Because supernumerary centrosomes are a common feature in cancer cells, this Lsh-dependent pathway has the potential to contribute to genetic instability and chromosomal aberrations during tumor progression... - Preparing the target for the bulletKathrin Muegge
Nat Immunol 3:16-7. 2002 - Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cellsRabindranath De La Fuente
Female Germ Cell Biology Group, Department of Clinical Studies, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, PA 19348, USA
Nat Cell Biol 8:1448-54. 2006.... - Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogoniaClaudia Baumann
Female Germ Cell Biology Group, Department of Clinical Studies, Center for Animal Transgenesis and Germ Cell Research, School of Veterinary Medicine, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA
BMC Mol Biol 9:29. 2008.... - Bax deficiency partially corrects interleukin-7 receptor alpha deficiencyAnnette R Khaled
Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, MD 21702, USA
Immunity 17:561-73. 2002..The BH3 only proteins, Bad and Bim, were also part of the death pathway repressed by IL-7. Thus, in young mice, Bax emerges as an essential protein in the death pathway induced by IL-7 deficiency...