Pablo R Moya

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder
    Pablo R Moya
    National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Mov Disord 28:1263-70. 2013
  2. pmc Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes
    Pablo R Moya
    Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD 20819, USA
    Eur J Hum Genet 21:850-4. 2013
  3. doi request reprint miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells
    Pablo R Moya
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Bethesda, MD 20892, USA
    Int J Neuropsychopharmacol 16:621-9. 2013
  4. pmc Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011
  5. pmc A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:408-16. 2009
  6. pmc How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
  7. pmc Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD 20892, USA
    Curr Opin Pharmacol 11:3-10. 2011
  8. pmc Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity
    Dennis L Murphy
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120435. 2013
  9. ncbi request reprint A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:717-23. 2008

Detail Information

Publications9

  1. pmc Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder
    Pablo R Moya
    National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Mov Disord 28:1263-70. 2013
    ..Thus, altered SERT activity represents a potential contributor to serotonergic abnormalities in TD. The present results call for replication in a similarly intensively evaluated sample. © 2013 Movement Disorder Society. ..
  2. pmc Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes
    Pablo R Moya
    Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD 20819, USA
    Eur J Hum Genet 21:850-4. 2013
    ....
  3. doi request reprint miR-15a and miR-16 regulate serotonin transporter expression in human placental and rat brain raphe cells
    Pablo R Moya
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Bethesda, MD 20892, USA
    Int J Neuropsychopharmacol 16:621-9. 2013
    ..These findings represent a novel layer of complexity for SERT expression regulation exerted by the mir-15a/16 cluster, whose genes are adjacently located at human chromosome 13q14.3...
  4. pmc Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice
    Pablo R Moya
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    BMC Pharmacol 11:3. 2011
    ..In this study, we determined the responsiveness of 5-HT2CR in serotonin transporter (SERT) knockout (-/-) mice, a model characterized by increased anxiety-like and stress-responsive behaviors...
  5. pmc A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 66:408-16. 2009
    ..Recent evidence from linkage analyses and follow-up candidate gene studies supports the involvement of SLC1A1, which encodes the neuronal glutamate transporter, in the development of obsessive-compulsive disorder (OCD)...
  6. pmc How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, NIH, Building 10, Room 3D41, 10 Center Drive, MSC 1264, Bethesda, MD 20892, USA
    Neuropharmacology 55:932-60. 2008
    ..We provide in-depth examples of gene-based discoveries primarily related to SLC6A4 that have clarified serotonin's many important homeostatic functions in humans, non-human primates, mice and other species...
  7. pmc Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease
    Dennis L Murphy
    Laboratory of Clinical Science, NIMH Intramural Research Program, Bethesda, MD 20892, USA
    Curr Opin Pharmacol 11:3-10. 2011
    ....
  8. pmc Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity
    Dennis L Murphy
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120435. 2013
    ..OCD resembles disorders such as depression, in which gene × gene interactions, gene × environment interactions and stress elements coalesce to yield OC symptoms and, in some individuals, full-blown OCD with multiple comorbid disorders...
  9. ncbi request reprint A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder
    Jens R Wendland
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 17:717-23. 2008
    ..Our results contribute to a better understanding of SLC6A4 expression genetics and provide a functional haplotype framework for future serotonin-related studies...