Research Topics
Genomes and Genes
| Lindsay M MortonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph)Lindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Blood 110:695-708. 2007....- Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphomaLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Carcinogenesis 28:1759-64. 2007..Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed... - Second malignancy risks after non-Hodgkin's lymphoma and chronic lymphocytic leukemia: differences by lymphoma subtypeLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
J Clin Oncol 28:4935-44. 2010.... - DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Pharmacogenet Genomics 16:901-10. 2006..To assess the specificity of genetic effects, we also investigated other reward-motivated characteristics (obesity, alcohol consumption)... - Reproductive factors, exogenous hormone use and risk of lymphoid neoplasms among women in the National Institutes of Health-AARP Diet and Health Study CohortLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Int J Cancer 124:2737-43. 2009..These data do not support an important role for reproductive factors or exogenous hormones in modulating lymphomagenesis... - Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphomaLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Pharmacogenet Genomics 16:537-45. 2006..15-5.20, P = 0.02). Our data provide evidence that NAT1 and NAT2 genotypes are associated with NHL risk and support a contributory role for carcinogenic aromatic and/or heterocyclic amines in the multi-factorial etiology of NHL... - Hepatitis C virus infection and risk of posttransplantation lymphoproliferative disorder among solid organ transplant recipientsLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Blood 110:4599-605. 2007..14-8.42; P interaction = .007). Our findings suggest that HCV is not a major risk factor for PTLD, which is consistent with the model in which an intact immune system is necessary for development of HCV-related lymphoproliferation... - Reporting participation in epidemiologic studies: a survey of practiceLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Am J Epidemiol 163:197-203. 2006..The authors conclude that epidemiologists need to address declining participation and to report participation consistently, including for biologic specimen collection... - Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001Lindsay M Morton
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 7055, Rockville, MD 20852, USA
Blood 107:265-76. 2006..We conclude that the striking differences in incidence patterns by histologic subtype strongly suggest that there is etiologic heterogeneity among lymphoid neoplasms and support the pursuit of epidemiologic analysis by subtype... - Etiologic heterogeneity among non-Hodgkin lymphoma subtypesLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Rockville, MD, USA
Blood 112:5150-60. 2008.... - Cigarette smoking and risk of non-Hodgkin lymphoma: a pooled analysis from the International Lymphoma Epidemiology Consortium (interlymph)Lindsay M Morton
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Conneticut, USA
Cancer Epidemiol Biomarkers Prev 14:925-33. 2005.... - Risk of non-Hodgkin lymphoma associated with germline variation in genes that regulate the cell cycle, apoptosis, and lymphocyte developmentLindsay M Morton
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:1259-70. 2009..Replication of our findings and further study to identify functional SNPs are warranted... - Menstrual and reproductive factors and risk of non-Hodgkin's lymphoma among Connecticut womenYawei Zhang
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
Am J Epidemiol 160:766-73. 2004..These findings support a reduced risk of non-Hodgkin's lymphoma associated with multiple pregnancies and an increased risk of non-Hodgkin's lymphoma associated with later age at menarche... - Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studiesMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Br J Haematol 151:239-44. 2010..These results support the hypothesis that common genetic polymorphisms in human DNA repair genes may modify the risk of NHL... - Immune mechanisms in non-Hodgkin lymphoma: joint effects of the TNF G308A and IL10 T3575A polymorphisms with non-Hodgkin lymphoma risk factorsSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland 20892 7234, USA
Cancer Res 67:5042-54. 2007.... - Genetic variation in N-acetyltransferases 1 and 2, cigarette smoking, and risk of non-Hodgkin lymphomaBriseis A Kilfoy
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Cancer Causes Control 21:127-33. 2010..We conclude that these findings require replication in larger studies and ultimately in pooled analyses... - Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphomaJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7240, USA
Blood 113:1899-905. 2009..This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL... - Common gene variants in the tumor necrosis factor (TNF) and TNF receptor superfamilies and NF-kB transcription factors and non-Hodgkin lymphoma riskSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
PLoS ONE 4:e5360. 2009..We hypothesized that the TNF and NF-kappaB pathways are important for NHL and that gene variations across the pathways may alter NHL risk... - A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Carcinogenesis 30:275-81. 2009..No associations with TLR4 variants were observed. This pooled analysis provides strong evidence that variation in the TLR10-TLR1-TLR6 region is associated with NHL risk and suggests that TLR2 variants may influence susceptibility to MZL... - SLC6A3 and body mass index in the Prostate, Lung, Colorectal and Ovarian Cancer Screening TrialElizabeth M Azzato
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland, USA
BMC Med Genet 10:9. 2009.... - Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studiesQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Blood 114:264-7. 2009..It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis... - Genetic variation in Th1/Th2 pathway genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studiesQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
Br J Haematol 153:341-50. 2011..This SNP was also associated specifically with risk of follicular lymphoma (allele risk OR= 1·26; P(trend)= 0·0012). These findings suggest that genetic variation in Th1/Th2 cytokine genes may contribute to lymphomagenesis... - Incidence of lymphoid neoplasms by subtype among six Asian ethnic groups in the United States, 1996-2004J Daniel Carreon
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Cancer Causes Control 19:1171-81. 2008..To establish baseline data for lymphoid neoplasm incidence by subtype for six Asian-American ethnic groups... - Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trialSophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 5104, MSC 7234, Rockville, MD 20852, USA
Hum Genet 122:41-9. 2007..Our results support a need for comprehensive evaluation of COMT variations and their functional relevance as COMT may be an important molecular target to evaluate for new treatments regarding obesity... - Census and geographic differences between respondents and nonrespondents in a case-control study of non-Hodgkin lymphomaMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Am J Epidemiol 167:350-61. 2008..The bias was 8%, indicating that the socioeconomic and demographic differences between respondents and nonrespondents did not result in a large bias in the risk estimate for education... - Alcohol consumption and risk of non-Hodgkin lymphoma: a pooled analysisLindsay M Morton
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
Lancet Oncol 6:469-76. 2005..Further study designs are needed to determine whether confounding lifestyle factors or immunomodulatory effects of alcohol explain this association... - Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphomaYawei Zhang
Environmental Science Division, School of Public Health, Yale University, New Haven, CT, USA
Am J Epidemiol 167:1321-31. 2008..1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded... - Alcohol, smoking, and body size in relation to incident Hodgkin's and non-Hodgkin's lymphoma riskUnhee Lim
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA
Am J Epidemiol 166:697-708. 2007..19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology... - A pooled analysis of three studies evaluating genetic variation in innate immunity genes and non-Hodgkin lymphoma riskH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, USA
Br J Haematol 152:721-6. 2011.... - A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA
Environ Health Perspect 119:232-8. 2011..Previous epidemiologic findings suggest an association between exposure to trichloroethylene (TCE), a chlorinated solvent primarily used for vapor degreasing of metal parts, and non-Hodgkin lymphoma (NHL)... - Increased risk for lymphoid and myeloid neoplasms in elderly solid-organ transplant recipientsScott C Quinlan
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7076, Rockville, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 19:1229-37. 2010.... - Dietary flavonoid intake and non-Hodgkin lymphoma riskCara L Frankenfeld
Division of Cancer, Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
Am J Clin Nutr 87:1439-45. 2008..Dietary flavonoids are polyphenolic compounds proposed to be anticarcinogenic. Flavonoids are well-characterized antioxidants and metal chelators, and certain flavonoids exhibit antiproliferative and antiestrogenic effects... - Hodgkin lymphoma among US solid organ transplant recipientsScott C Quinlan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
Transplantation 90:1011-5. 2010..To assess the risk and identify risk factors of Hodgkin lymphoma (HL) in solid organ transplant recipients. Prior research has been limited by the rarity of HL and the requirement for extended follow-up after transplantation... - Genetic variation in cell cycle and apoptosis related genes and multiple myeloma riskH Dean Hosgood
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States
Leuk Res 33:1609-14. 2009..005). Haplotype analyses supported the SNP findings. These findings suggest that genetic variation in cell cycle and apoptosis genes may play a key role in multiple myeloma and warrant further investigation through replication studies... - Hair dye use and risk of bladder cancer in the New England bladder cancer studyStella Koutros
Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Int J Cancer 129:2894-904. 2011..These results need confirmation with larger numbers, requiring pooling data from multiple studies... - Inherited genetic variation and overall survival following follicular lymphomaTodd M Gibson
Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
Am J Hematol 87:724-6. 2012..However, they require replication in independent populations, as well as assessment in rituximab-treated patients... - Spatial-temporal analysis of non-Hodgkin lymphoma in the NCI-SEER NHL case-control studyDavid C Wheeler
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD, USA
Environ Health 10:63. 2011..Little is known about the etiology of non-Hodgkin lymphoma (NHL), or the latency period that might be relevant for environmental exposures, and there are no published spatial-temporal cluster studies of NHL... - Risk factors for early-onset and late-onset post-transplant lymphoproliferative disorder in kidney recipients in the United StatesScott C Quinlan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Am J Hematol 86:206-9. 2011..We used these data to conduct a retrospective cohort study among kidney transplant recipients to examine differences in risk factors between early-onset PTLD and late-onset PTLD... - Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control studyCindy M Chang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA
Int J Cancer 129:938-47. 2011..Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14;18)-NHL subtypes... - A case-control study of occupational exposure to trichloroethylene and non-hodgkin lymphomaMark P Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA
Environ Health Perspect 119:232-8. 2010..However, we cannot rule out the possibility of confounding from other chlorinated solvents used for vapor degreasing and note that our exposure assessment methods have not been validated... - Population-based study of autoimmune conditions and the risk of specific lymphoid malignanciesLesley A Anderson
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Int J Cancer 125:398-405. 2009..These results support a mechanism whereby chronic antigenic stimulation leads to lymphoid malignancy... - Blood transfusion and risk of non-Hodgkin's lymphoma in Connecticut womenYawei Zhang
Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
Am J Epidemiol 160:325-30. 2004..In summary, the authors' findings do not support the hypothesis that allogeneic blood transfusion increases the risk of non-Hodgkin's lymphoma... - Meat intake is not associated with risk of non-Hodgkin lymphoma in a large prospective cohort of U.S. men and womenCarrie R Daniel
National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
J Nutr 142:1074-80. 2012..In this large U.S. cohort, meat intake was not associated with NHL or any histologic subtypes of NHL. Contrary to findings in animal models and other cancer sites, meat-cooking and -processing compounds did not increase NHL risk... - Proportions of Kaposi sarcoma, selected non-Hodgkin lymphomas, and cervical cancer in the United States occurring in persons with AIDS, 1980-2007Meredith S Shiels
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7059, Rockville, MD 20892, USA
JAMA 305:1450-9. 2011.... - Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignanciesUnhee Lim
Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Boulevard, EPN 4005, Rockville, MD 20852-7344, USA
Cancer Epidemiol Biomarkers Prev 15:1654-9. 2006..73; 95% CI, 0.46-1.15; P for inverse linear trend = 0.05), or their subtypes in men and women. CONCLUSIONS: Our findings do not support the hypothesis that aspartame increases hematopoietic or brain cancer risk... - Autoimmune disease and subsequent risk of developing alimentary tract cancers among 4.5 million US male veteransAnnelie M Landgren
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA
Cancer 117:1163-71. 2011..The authors therefore conducted the first systematic evaluation of a broad range of specific autoimmune diseases and risk for subsequent alimentary tract cancer... - Converting epidemiologic studies of cancer etiology to survivorship studies: approaches and challengesAmy Berrington de Gonzalez
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 21:875-80. 2012..In light of the costs and time required to build new cohorts, appropriately leveraging the existing studies offers an important opportunity to gain new insights into cancer survivorship for both clinicians and patients... - Changes in cancer registry coding for lymphoma subtypes: reliability over time and relevance for surveillance and studyChristina A Clarke
Northern California Cancer Center, Fremont, CA 94538, USA
Cancer Epidemiol Biomarkers Prev 15:630-8. 2006.... - Blood transfusion, anesthesia, surgery and risk of non-Hodgkin lymphoma in a population-based case-control studyJames R Cerhan
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 5905, USA
Int J Cancer 123:888-94. 2008..Multiple surgical procedures and/or repeated administration of anesthesia have not been previously reported to be associated with risk of NHL and these exposures warrant further evaluation... - Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab eraThomas M Habermann
Mayo Clinic College of Medicine, Rochester, MN, USA
Blood 112:2694-702. 2008..These data support a role for germ line variation in immune genes, particularly genes associated with a proinflammatory state, as predictors of late survival in DLBCL... - Re: Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma, author responseShelia Hoar Zahm
Carcinogenesis 29:1084-5. 2008 - Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology ConsortiumSilvia de Sanjose
Unit of Infections and Cancer, Catalan Institute of Oncology, Institut d Investigacio Biomedica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain
Clin Gastroenterol Hepatol 6:451-8. 2008..We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection... - Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph ConsortiumEleanor V Willett
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Heslington, York YO10 5DD, United Kingdom
Int J Cancer 122:2062-70. 2008.... - Prognostic significance of host immune gene polymorphisms in follicular lymphoma survivalJames R Cerhan
Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Blood 109:5439-46. 2007..Common variation in host immune genes warrants further evaluation as a promising class of prognostic factors in follicular lymphoma...