Herbert C Morse
Affiliation: National Institutes of Health
Yan M, Wang H, Sun J, Liao W, Li P, Zhu Y, et al
. Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection. J Immunol. 2016;196:1999-2003 pubmed publisher
..Our results identify the IRF8-IFN-Î³ circuit as a novel gastric innate immune mechanism in the host defense against infection with H. pylori. ..
Wang H, Yan M, Sun J, Jain S, Yoshimi R, Abolfath S, et al
. A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation. J Immunol. 2014;193:1766-77 pubmed publisher
Miyazaki T, Kim Y, Yoon J, Wang H, Suzuki T, Morse H. The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response. J Biol Chem. 2014;289:32548-58 pubmed publisher
..These results provide new insights into the mechanisms of single-stranded DNA repair following DNA damage and alterations induced by gene mutations. ..
Jain S, Chen J, Nicolae A, Wang H, Shin D, Adkins E, et al
. IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma. Am J Pathol. 2015;185:3102-14 pubmed publisher
..These results identify a mouse model with features of AITL and suggest that patients with the disease might benefit from therapeutic interventions that interrupt IL-21 signaling. ..
Didion J, Buus R, Naghashfar Z, Threadgill D, Morse H, de Villena F. SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy. BMC Genomics. 2014;15:847 pubmed publisher
..Laboratories can mitigate these risks by regular authentication of their cell cultures. Our results demonstrate that SNP array profiling is an effective method to combat cell line misidentification. ..
Sakai T, Miyazaki T, Shin D, Kim Y, Qi C, Fariss R, et al
. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. J Autoimmun. 2017;81:13-23 pubmed publisher
..Together, our study presents two new mouse models based on TREX1 frame-shift mutations with a unique set of serologic autoimmune-like phenotypes. ..
Wang H, Gonzalez Garcia I, Traba J, Jain S, Conteh S, Shin D, et al
. ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells. Sci Rep. 2017;7:17867 pubmed publisher
..Moreover, Enpp1 -/- PCs took up less glucose and had lower levels of glycolysis than those of wild-type controls. Thus, ENPP1 deficiency confers an energetic disadvantage to PCs for long-term survival and antibody production. ..
Morse H, Anver M, Fredrickson T, Haines D, Harris A, Harris N, et al
. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood. 2002;100:246-58 pubmed
..The classification should facilitate communications about mouse models of human lymphoid diseases. ..
Yoon J, Feng X, Kim Y, Shin D, Hatzi K, Wang H, et al
. Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR. J Biol Chem. 2014;289:34250-7 pubmed publisher
..Taken together, these data suggest that a complex comprising BCOR-BCL6-IRF8 modulates BCL6-associated transcriptional regulation of germinal center B cell function. ..