Herbert C Morse


Affiliation: National Institutes of Health
Country: USA


  1. Yan M, Wang H, Sun J, Liao W, Li P, Zhu Y, et al. Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection. J Immunol. 2016;196:1999-2003 pubmed publisher
    ..Our results identify the IRF8-IFN-γ circuit as a novel gastric innate immune mechanism in the host defense against infection with H. pylori. ..
  2. Wang H, Yan M, Sun J, Jain S, Yoshimi R, Abolfath S, et al. A reporter mouse reveals lineage-specific and heterogeneous expression of IRF8 during lymphoid and myeloid cell differentiation. J Immunol. 2014;193:1766-77 pubmed publisher
  3. Miyazaki T, Kim Y, Yoon J, Wang H, Suzuki T, Morse H. The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response. J Biol Chem. 2014;289:32548-58 pubmed publisher
    ..These results provide new insights into the mechanisms of single-stranded DNA repair following DNA damage and alterations induced by gene mutations. ..
  4. Jain S, Chen J, Nicolae A, Wang H, Shin D, Adkins E, et al. IL-21-driven neoplasms in SJL mice mimic some key features of human angioimmunoblastic T-cell lymphoma. Am J Pathol. 2015;185:3102-14 pubmed publisher
    ..These results identify a mouse model with features of AITL and suggest that patients with the disease might benefit from therapeutic interventions that interrupt IL-21 signaling. ..
  5. Didion J, Buus R, Naghashfar Z, Threadgill D, Morse H, de Villena F. SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy. BMC Genomics. 2014;15:847 pubmed publisher
    ..Laboratories can mitigate these risks by regular authentication of their cell cultures. Our results demonstrate that SNP array profiling is an effective method to combat cell line misidentification. ..
  6. Sakai T, Miyazaki T, Shin D, Kim Y, Qi C, Fariss R, et al. DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice. J Autoimmun. 2017;81:13-23 pubmed publisher
    ..Together, our study presents two new mouse models based on TREX1 frame-shift mutations with a unique set of serologic autoimmune-like phenotypes. ..
  7. Wang H, Gonzalez Garcia I, Traba J, Jain S, Conteh S, Shin D, et al. ATP-degrading ENPP1 is required for survival (or persistence) of long-lived plasma cells. Sci Rep. 2017;7:17867 pubmed publisher
    ..Moreover, Enpp1 -/- PCs took up less glucose and had lower levels of glycolysis than those of wild-type controls. Thus, ENPP1 deficiency confers an energetic disadvantage to PCs for long-term survival and antibody production. ..
  8. request reprint
    Morse H, Anver M, Fredrickson T, Haines D, Harris A, Harris N, et al. Bethesda proposals for classification of lymphoid neoplasms in mice. Blood. 2002;100:246-58 pubmed
    ..The classification should facilitate communications about mouse models of human lymphoid diseases. ..
  9. Yoon J, Feng X, Kim Y, Shin D, Hatzi K, Wang H, et al. Interferon regulatory factor 8 (IRF8) interacts with the B cell lymphoma 6 (BCL6) corepressor BCOR. J Biol Chem. 2014;289:34250-7 pubmed publisher
    ..Taken together, these data suggest that a complex comprising BCOR-BCL6-IRF8 modulates BCL6-associated transcriptional regulation of germinal center B cell function. ..

More Information


  1. Saloustros E, Salpea P, Qi C, Gugliotti L, Tsang K, Liu S, et al. Hematopoietic neoplasms in Prkar2a-deficient mice. J Exp Clin Cancer Res. 2015;34:143 pubmed publisher
    ..Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIα's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms. ..
  2. Jain S, Ward J, Shin D, Wang H, Naghashfar Z, Kovalchuk A, et al. Associations of Autoimmunity, Immunodeficiency, Lymphomagenesis, and Gut Microbiota in Mice with Knockins for a Pathogenic Autoantibody. Am J Pathol. 2017;187:2020-2033 pubmed publisher
  3. Marnik E, Wang X, Sproule T, Park G, Christianson G, Lane Reticker S, et al. Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease. Cell Rep. 2017;21:208-221 pubmed publisher
    ..These studies link IL-21 to T cell ontogeny, self-reactivity, and humoral autoimmunity. ..