H C Morse

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells
    Dong Mi Shin
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e27384. 2011
  2. ncbi request reprint Cells of the marginal zone--origins, function and neoplasia
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Building 7, Room 304, 7 Center Drive MSC 0760, Bethesda, MD 20892 0760, USA
    Leuk Res 25:169-78. 2001
  3. ncbi request reprint Untying the gordian knot of autoimmunity and b cell lineage lymphomas
    Herbert C Morse
    NIAID, NIAMS, NHLBI, NIH, MD, USA
    Autoimmun Rev 3:S10-1. 2004
  4. ncbi request reprint Bethesda proposals for classification of lymphoid neoplasms in mice
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Blood 100:246-58. 2002
  5. ncbi request reprint Differential regulation of germinal center genes, BCL6 and SWAP-70, during the course of MAIDS
    C F Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Mol Immunol 36:1043-53. 1999
  6. ncbi request reprint Biologic and molecular genetic characteristics of a unique MCF virus that is highly leukemogenic in ecotropic virus-negative mice
    S K Chattopadhyay
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    Virology 168:90-100. 1989
  7. ncbi request reprint Functional and phenotypic alterations in T cell subsets during the course of MAIDS, a murine retrovirus-induced immunodeficiency syndrome
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
    J Immunol 143:844-50. 1989
  8. pmc Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility
    S L Zhang
    Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 21:310-8. 2001
  9. ncbi request reprint Retrovirus-induced lymphoproliferation as a model for developing diagnostic criteria for malignant lymphoma in mice
    T N Fredrickson
    Registry of Experimental Cancers, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Toxicol Pathol 21:219-28. 1993
  10. pmc Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice
    S K Chattopadhyay
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 65:4232-41. 1991

Collaborators

Detail Information

Publications98

  1. pmc IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells
    Dong Mi Shin
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e27384. 2011
    ..We also showed that IRF8 target genes contributes to multiple aspects of the biology of mature B cells including critical components of the molecular crosstalk among GC B cells, T follicular helper cells, and follicular dendritic cells...
  2. ncbi request reprint Cells of the marginal zone--origins, function and neoplasia
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Building 7, Room 304, 7 Center Drive MSC 0760, Bethesda, MD 20892 0760, USA
    Leuk Res 25:169-78. 2001
    ..Only splenic MZL are seen in mice. A reduced threshold for triggering to proliferation may predispose the marginal zone B cell to neoplasia with mutations in genes regulating apoptosis playing a leading role...
  3. ncbi request reprint Untying the gordian knot of autoimmunity and b cell lineage lymphomas
    Herbert C Morse
    NIAID, NIAMS, NHLBI, NIH, MD, USA
    Autoimmun Rev 3:S10-1. 2004
  4. ncbi request reprint Bethesda proposals for classification of lymphoid neoplasms in mice
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Blood 100:246-58. 2002
    ..The classification should facilitate communications about mouse models of human lymphoid diseases...
  5. ncbi request reprint Differential regulation of germinal center genes, BCL6 and SWAP-70, during the course of MAIDS
    C F Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Mol Immunol 36:1043-53. 1999
    ....
  6. ncbi request reprint Biologic and molecular genetic characteristics of a unique MCF virus that is highly leukemogenic in ecotropic virus-negative mice
    S K Chattopadhyay
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    Virology 168:90-100. 1989
    ..Nucleotide sequence analysis established that the U3 region of each of the two LTRs of clone 15 has a 53-bp duplication which includes "enhancer elements," but that the single LTR of clone 19 has no such duplication...
  7. ncbi request reprint Functional and phenotypic alterations in T cell subsets during the course of MAIDS, a murine retrovirus-induced immunodeficiency syndrome
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
    J Immunol 143:844-50. 1989
    ..However, this phenotypic change did not appear to correlate with major functional defects...
  8. pmc Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility
    S L Zhang
    Laboratory of Genetics, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 21:310-8. 2001
    ..We propose that the BALB/c susceptibility/modifier locus, Pctr1, is an "efficiency" allele of the p16(INK4a) gene...
  9. ncbi request reprint Retrovirus-induced lymphoproliferation as a model for developing diagnostic criteria for malignant lymphoma in mice
    T N Fredrickson
    Registry of Experimental Cancers, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Toxicol Pathol 21:219-28. 1993
    ..Thus, the precision of diagnosis of mouse lymphomas can be considerably enhanced by augmenting histopathologic examination with antigenic and molecular characterizations that can define malignant populations...
  10. pmc Characteristics and contributions of defective, ecotropic, and mink cell focus-inducing viruses involved in a retrovirus-induced immunodeficiency syndrome of mice
    S K Chattopadhyay
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 65:4232-41. 1991
    ..Finally, mRNA crosshybridizing with a probe for BM5d was present in spleen but not kidney cells of uninfected B6 mice...
  11. ncbi request reprint Non-Hodgkin lymphomas of mice
    M Hori
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Blood Cells Mol Dis 27:217-22. 2001
    ..Finally, Burkitt lymphoma does not appear to occur naturally in mice, but it can be induced with appropriately engineered transgenes...
  12. pmc Ectopic expression of wild-type FGFR3 cooperates with MYC to accelerate development of B-cell lineage neoplasms
    A Zingone
    Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20889 5105, USA
    Leukemia 24:1171-8. 2010
    ..This suggests that dysregulated FGFR3 expression is likely to be essential at least for the early stages of pathogenesis of MM tumors that have a t(4;14) translocation...
  13. ncbi request reprint Influence of H-2 class II antigens on the development of murine AIDS
    M Makino
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    J Immunol 152:4157-64. 1994
    ..E alpha d-mediated resistance to MAIDS was associated with decreased levels of the BM5def genome in splenic DNA, suggesting that E alpha genes exert their effect by enhancing antiviral activity...
  14. ncbi request reprint Accelerated development of neurochemical and behavioral deficits in LP-BM5 infected mice with targeted deletions of the IFN-gamma gene
    E Koustova
    Laboratory of Bioorganic Chemistry, Building 8, Room 1A15, MSC 0826, NIDDK, NIH, Bethesda, MD 20892, USA
    J Neuroimmunol 108:112-21. 2000
    ..These results suggest that the presence of IFN-gamma is necessary at some points in the inflammatory process to protect against neurodegeneration...
  15. pmc IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages
    C Contursi
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:91-6. 2000
    ....
  16. ncbi request reprint Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS
    Y Sei
    Laboratory of Neuroscience, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    Eur J Pharmacol 325:81-4. 1997
    ..62; P < 0.01). This study demonstrates that pentoxifylline treatment was effective in decreasing the levels of TNF-alpha in the serum and PAF levels in the brain of mice infected with the LP-BM5 MuLV...
  17. ncbi request reprint Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
    T A Wynn
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 159:5014-23. 1997
    ..Together, these results argue first that IL-10 is an important endogenous down-regulator of type 2 as well as type 1 cytokine synthesis, and second, that its induction is critical for type 2 response polarization in vivo...
  18. pmc Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages
    M Principato
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    Mol Cell Biol 10:3562-8. 1990
    ..This system should facilitate studies of developmental relationships in hematopoietic differentiation and analysis of lineage determination...
  19. ncbi request reprint Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 7/304, 7 Center Drive, Bethesda, MD 20892-0760, USA
    Leuk Res 25:719-33. 2001
    ..DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements...
  20. ncbi request reprint Phenylhydrazine stimulates lymphopoiesis and accelerates Abelson murine leukemia virus-induced pre-B cell lymphomas
    S P Klinken
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892
    J Immunol 139:3091-8. 1987
    ....
  21. ncbi request reprint Accelerated appearance of multiple B cell lymphoma types in NFS/N mice congenic for ecotropic murine leukemia viruses
    J W Hartley
    The Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0760, USA
    Lab Invest 80:159-69. 2000
    ..The mechanism remains undefined, because only rare rearrangements were detected in several cellular loci previously associated with MuLV insertional mutagenesis...
  22. pmc Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein
    L Gabriele
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0760, USA
    J Exp Med 190:411-21. 1999
    ..These data suggest that ICSBP modulates survival of myeloid cells by regulating expression of apoptosis-related genes...
  23. pmc Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Immunology 87:467-74. 1996
    ..These studies suggest that continuing low-level expression of IFN-gamma, stimulated by IL-12 and TNF-alpha, contributes to the susceptibility of B6 mice to MAIDS but is not required for the resistance of BALB/c mice to disease...
  24. pmc Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein
    W Kim
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 72:6898-901. 1998
    ..KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane...
  25. ncbi request reprint Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 15:2545-7. 2001
    ..Moreover, they illustrate the potential of genome-wide approaches for generating comprehensive views on the molecular and biochemical mechanisms regulating infectious disease pathogenesis...
  26. pmc STAT6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses
    H C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:7093-5. 1999
    ..In addition, serum IgE levels were indistinguishable in mice of either genotype. We conclude that B cells from mice with MAIDS activate unique IL-4- and STAT6-independent signaling pathways for B-cell activation and differentiation...
  27. pmc The histopathologic and molecular basis for the diagnosis of histiocytic sarcoma and histiocyte-associated lymphoma of mice
    X Hao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    Vet Pathol 47:434-45. 2010
    ..The second appeared to be composites of lymphoma and HS. Several cases suggestive of B myeloid-lineage plasticity were also observed...
  28. ncbi request reprint The encephalopathy associated with murine acquired immunodeficiency syndrome
    Y Sei
    Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 840:822-34. 1998
    ....
  29. pmc Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0760, USA
    J Exp Med 186:1535-46. 1997
    ..This indicates that ICSBP is a deciding factor in Th responses governing humoral and cellular immunity through its role in regulating IL-12 expression...
  30. ncbi request reprint The influence of a targeted deletion of the IFNgamma gene on emotional behaviors
    Y Kustova
    Laboratory of Bio organic Chemistry, NIDDK, Bethesda, MD 20892, USA
    Brain Behav Immun 12:308-24. 1998
    ....
  31. ncbi request reprint Relationship of cytokines and cytokine signaling to immunodeficiency disorders in the mouse
    R A Morawetz
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Braz J Med Biol Res 31:61-7. 1998
    ..ICSBP is thus an important determinant of hematopoietic growth and differentiation as well as a prominent signaling molecule for IFNs...
  32. pmc Burkitt lymphoma in the mouse
    A L Kovalchuk
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:1183-90. 2000
    ....
  33. pmc Cellular motor protein KIF-4 associates with retroviral Gag
    Y Tang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 73:10508-13. 1999
    ..The binding of Gag is mediated by a domain of KIF-4 proximal to the C terminus. These results, and our previous studies, raise the possibility that KIF-4 may play an important role in retrovirus Gag protein transport...
  34. pmc Lymphomas and high-level expression of murine leukemia viruses in CFW mice
    L Taddesse Heath
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0760, USA
    J Virol 74:6832-7. 2000
    ..Lymphomas were induced in NIH Swiss mice infected as neonates with tissue culture-propagated MuLVs isolated from normal and tumor tissue of CFW mice...
  35. pmc Citrobacter-induced colitis in mice with murine acquired immunodeficiency syndrome
    T N Fredrickson
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Vet Pathol 47:312-7. 2010
    ..Thus, mice with MAIDS can develop severe disease following opportunistic infection with an environmental contaminant of the colony that is nonpathogenic for normal adult mice...
  36. ncbi request reprint Cloning, expression and genetic mapping of the mouse SH3 domain protein, SH3D2B
    T Torrey
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 9:74-5. 1998
  37. ncbi request reprint DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus
    C Jhappan
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Nat Genet 17:483-6. 1997
    ..15)...
  38. ncbi request reprint Impact of MHC class I gene on resistance to murine AIDS
    M Makino
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA
    Scand J Immunol 42:368-72. 1995
    ..A(18R) mice. These results suggest that the MAIDS resistance associated with the D end loci is dependent on the level of expression of an MHC class I gene...
  39. pmc Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5819-24. 1994
    ..These results indicate that induction of MAIDS by BM5def is antigen driven and is dependent on expression of major histocompatibility complex class II molecules on antigen-presenting cells and the presence of CD4+ T cells...
  40. ncbi request reprint Proviral integrations at the Evi5 locus disrupt a novel 90 kDa protein with homology to the Tre2 oncogene and cell-cycle regulatory proteins
    X Liao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    Oncogene 14:1023-9. 1997
    ..Evi5 thus encodes a gene separate from Gfi1 that may also be involved in T-cell disease...
  41. ncbi request reprint Altered brain fyn kinase in a murine acquired immunodeficiency syndrome
    Y Sei
    Laboratory of Neuroscience, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 10:339-44. 1996
    ..These findings suggest that virus-associated disruption of fyn kinase-mediated signaling contributes to the cognitive deficits observed in mice with MAIDS and other retrovirus-induced encephalopathies...
  42. ncbi request reprint Contribution of B cell subsets to delayed development of MAIDS in xid mice
    Y Tang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell Immunol 165:1-6. 1995
    ..Both sets of recipients developed advanced disease by 10 weeks post infection, suggesting that resistance to MAIDS in xid mutants may be due to effects of B cells other than the CD5+ subset...
  43. pmc Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10
    M Connors
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5321-5. 1994
    ..It is possible that this process played a role in enhanced disease observed in infants and children immunized with FI-RSV...
  44. ncbi request reprint Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein
    M S Lyu
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 329, Bethesda, Maryland 20892 0460, USA
    Mamm Genome 8:541. 1997
  45. pmc Susceptibility to raf and raf/myc retroviruses is governed by different genetic loci
    S P Klinken
    Laboratory of Immunopathology, National Institutes of Health, Bethesda, Maryland 20892
    J Virol 63:2411-4. 1989
    ..From these data and the susceptibility of C x B recombinant inbred strains, it appears that very few genes (perhaps even a single gene) may govern susceptibility to raf/myc lymphomas and that resistance is the dominant trait...
  46. pmc Identification of two murine loci homologous to the v-cbl oncogene
    D C Regnier
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 63:3678-82. 1989
    ..Analyses of Mus domesticus/M. spretus interspecific backcross mice showed that Cbl-1 maps between the immunoglobulin kappa light chain and T-cell receptor beta chain loci and that Cbl-2 is tightly linked to Thy-1...
  47. ncbi request reprint Histologic and molecular characterizations of megakaryocytic leukemia in mice
    Xingpei Hao
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, MD 20852, USA
    Leuk Res 30:397-406. 2006
    ..This is the first report of spontaneous MKL in mice, defining VWF as a biomarker for diagnosis and suggesting possible involvement of a series of genes in disease pathogenesis...
  48. ncbi request reprint Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Twinbrook I, Room 1421, National Institutes of Health, Rockville, MD, USA
    Leuk Res 30:153-63. 2006
    ..Here, p27 was complexed with D-type cyclins 1 and 3 and with the COPS9 protein, JAB1. In addition, we found cytoplasmic sequestration following phosphorylation by activated AKT...
  49. pmc Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Genetics 175:545-51. 2007
    ..This new strain thus provides a new model for studying the functions of IL-7 on a pure C57BL/6 background...
  50. pmc Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl
    Jian Qiao Zhang
    Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    J Exp Med 200:1467-78. 2004
    ..Our findings provide a strong case for targeted transformation of autoreactive B cells in gld mice and establish a valuable model for understanding the relationship between systemic autoimmunity and B cell neoplasia...
  51. ncbi request reprint Evi3, a zinc-finger protein related to EBFAZ, regulates EBF activity in B-cell leukemia
    Kathryn E Hentges
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 24:1220-30. 2005
    ..Further, these data imply that Evi3 misexpression initiates tumorigenesis by perturbing B-cell development via an interaction with EBF...
  52. pmc TNF receptor-associated factor (TRAF) domain and Bcl-2 cooperate to induce small B cell lymphoma/chronic lymphocytic leukemia in transgenic mice
    Juan M Zapata
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:16600-5. 2004
    ..Given that many human chronic lymphocytic leukemias overexpress TRAF1 and Bcl-2, our findings suggest that cooperation between Bcl-2 and TRAF pathways contributes to the development of this type of leukemia...
  53. pmc Immunoglobulin class switch recombination is impaired in Atm-deficient mice
    Joanne M Lumsden
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Room 4B10, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:1111-21. 2004
    ..These findings suggest a role of ATM in DNA DSB recognition and/or repair during CSR...
  54. ncbi request reprint Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892, USA
    J Immunol 173:5361-71. 2004
    ..Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease...
  55. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
    ..These results suggest previously unappreciated roles for IRF8 in the transcriptional regulation of B cell GC reactions that include direct regulation of AICDA and BCL6...
  56. ncbi request reprint Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters
    Silvia Calpe
    Division of Immunology BIDMC, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Immunogenetics 58:15-25. 2006
    ..Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src kinases to SLAM family receptors using a mechanism that is distinct from that of SAP...
  57. pmc Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation
    Rhine R Shen
    Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1732, USA
    Blood 108:1991-8. 2006
    ..We conclude that pEmu-B29-TCL1 transgenic B cells primed for transformation must experience the GC environment and, for at least some, develop genome instability to become fully malignant...
  58. pmc TRIM family proteins and their emerging roles in innate immunity
    Keiko Ozato
    Program of Genomics and Differentiation, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, Maryland 20892 2753, USA
    Nat Rev Immunol 8:849-60. 2008
    ..In this Review, we describe recent data that reveal broader antiviral and antimicrobial activities of TRIM proteins and discuss their involvement in the regulation of pathogen-recognition and transcriptional pathways in host defence...
  59. pmc An ENU-induced mutation in the lymphotoxin alpha gene impairs organogenesis of lymphoid tissues in C57BL/6 mice
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers LN, TB1, Rm 1518, Rockville, MD 20852, USA
    Biochem Biophys Res Commun 370:461-7. 2008
    ..This new strain provides opportunities for understanding the full range of Lta gene function on a pure C57BL/6 background...
  60. ncbi request reprint Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues
    Palash Bhattacharya
    Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612 7344, USA
    Eur J Immunol 38:227-39. 2008
    ....
  61. pmc The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse
    Prafullakumar Tailor
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2753, USA
    Blood 111:1942-5. 2008
    ..Together, this work indicates that IRF8-partner interactions play different roles in CD8alpha(+) DCs and pDCs, revealing a mechanistic separation that underlies development of these DC subsets...
  62. ncbi request reprint Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 179:7544-52. 2007
    ..Our results support the idea that transitional B cells lose the capacity to edit, but are sensitive to positive and negative selection...
  63. ncbi request reprint Axon growth and guidance genes identify T-dependent germinal centre B cells
    Di Yu
    Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, Australia
    Immunol Cell Biol 86:3-14. 2008
    ..Finally we show some of the axon growth genes upregulated in TD-GC B cells including Basp1, Shh, Sult4alpha, Sc4mol are also preferentially expressed in post-GC B cell neoplasms...
  64. pmc A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling
    Katherine Bessette
    White River Junction Veteran s Association, White River Junction, VT, USA
    Blood 111:344-50. 2008
    ....
  65. ncbi request reprint Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
    Cancer Res 67:2439-47. 2007
    ..Selecting specific types of mouse plasmacytomas that relate most closely to subtypes of human multiple myeloma may provide new opportunities for preclinical testing of drugs for treatment of the human disease...
  66. ncbi request reprint Insertion of c-Myc into Igh induces B-cell and plasma-cell neoplasms in mice
    Sung Sup Park
    Laboratory of Genetics, Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 65:1306-15. 2005
    ....
  67. ncbi request reprint CD19 signaling pathways play a major role for murine AIDS induction and progression
    Sonja M Knoetig
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA
    J Immunol 169:5607-14. 2002
    ..Finally, CD22 deficiency was found to accelerate MAIDS development. These results provide novel insights into the B cell signaling pathways required for normal induction and progression of MAIDS...
  68. pmc Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, and AIDS Institute, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 99:14392-7. 2002
    ..Together these data demonstrate that TCL1 is a powerful oncogene that, when overexpressed in both B and T cells, predominantly yields mature B cell lymphomas...
  69. ncbi request reprint c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene
    Kou Juey Wu
    Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
    Oncogene 21:7872-82. 2002
    ..These results indicate that, by activating PKA, c-MYC can provide endogenous activation of the cAMP signal transduction pathway independently of extracellular signals...
  70. ncbi request reprint A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  71. ncbi request reprint The Bcl6 locus is not mutated in mouse B-cell lineage lymphomas
    Mitsuo Hori
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, 7 Centre Drive, Room 304, MSC 0760, Bethesda, MD 20892, USA
    Leuk Res 26:739-43. 2002
    ..The mouse Bcl6 locus must be inaccessible to the mutational machinery responsible for somatic mutations of Ig and BCL6 in humans...
  72. pmc CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells
    Chen Feng Qi
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:633-8. 2003
    ..Rapid activation of CTCF by BCR ligation or treatment with TGF-beta was suppressed by ligation of CD40. These results demonstrate that CTCF is a common determinant to different pathways of death signaling in immature B cells...
  73. ncbi request reprint Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment
    Loretta L Doan
    Institute for Cellular Therapeutics and Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 170:2356-66. 2003
    ..These data show that GFI1 and GFI1B are functionally unique, and implicate a role for GFI1 in the integration of activation and survival signals...
  74. pmc Stat5 synergizes with T cell receptor/antigen stimulation in the development of lymphoblastic lymphoma
    John A Kelly
    Laboratory of Molecular Immunology, National Heart and Blood Institute, National Cancer Institute, Bethesda, MD 20892 1674, USA
    J Exp Med 198:79-89. 2003
    ..These data demonstrate the oncogenic potential of dysregulated expression of a STAT protein that is not constitutively activated, and that TCR stimulation can contribute to this process...
  75. ncbi request reprint The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells
    Alex George
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 22:6764-73. 2003
    ..Our results demonstrate that Hex can act as a T lineage oncogene when misexpressed in hematopoietic precursor cells...
  76. ncbi request reprint High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas
    Min Sun Shin
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Rockville, Maryland 20852, USA
    Cancer Res 64:4419-27. 2004
    ..The combined use of proviral tagging and analyses of gene expression thus provides a powerful approach to understanding of genes that collaborate in tumorigenesis...
  77. ncbi request reprint Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity
    Galina N Filippova
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cancer Res 62:48-52. 2002
    ..These observations suggest that CTCF may represent a novel tumor suppressor gene that displays tumor-specific "change of function" rather than complete "loss of function."..
  78. pmc IL-6 transgenic mouse model for extraosseous plasmacytoma
    Alexander L Kovalchuk
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1509-14. 2002
    ..These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treatment and suggest a previously unappreciated role for IL-6 in the genesis of germinal center-derived lymphomas...
  79. ncbi request reprint ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 103:2221-8. 2004
    ..Together, these results indicate that ICSBP is critically required for the development and trafficking of skin DCs, thus playing a critical role in the DC-mediated initiation of T-cell immunity...
  80. ncbi request reprint Genomic instability in mouse Burkitt lymphoma is dominated by illegitimate genetic recombinations, not point mutations
    Lynne D Rockwood
    Laboratory of Genetics, Center for Cancer Research CCR, NCI, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:7235-40. 2002
    ..The results further suggest that a phenotype of hypermutability (elevated mutant frequency) may not always be required for oncogenesis to occur...
  81. ncbi request reprint Recognition and degradation of myelin basic protein peptides by serum autoantibodies: novel biomarker for multiple sclerosis
    Alexey A Belogurov
    Institute of Bioorganic Chemistry, Clinical Hospital, Russian Academy of Sciences, Moscow, Russia
    J Immunol 180:1258-67. 2008
    ..Thus, anti-MBP autoantibody-mediated, epitope-specific binding and cleavage may be regarded as a specific characteristic of MS compared with OND and healthy donors and may serve as an additional biomarker of disease progression...
  82. pmc BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma
    Dmitri I Loukinov
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0760, USA
    Proc Natl Acad Sci U S A 99:6806-11. 2002
    ..Because BORIS bears the same DNA-binding domain that CTCF employs for recognition of methylation marks in soma, BORIS is a candidate protein for the elusive epigenetic reprogramming factor acting in the male germ line...
  83. ncbi request reprint New genes involved in cancer identified by retroviral tagging
    Takeshi Suzuki
    Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702, USA
    Nat Genet 32:166-74. 2002
    ..Our studies demonstrate the power of retroviral tagging for cancer gene discovery in the post-genome era and indicate a largely unrecognized complexity in mouse and presumably human cancer...
  84. ncbi request reprint AID is required for germinal center-derived lymphomagenesis
    Laura Pasqualucci
    Institute for Cancer Genetics, the Departments of Pathology and Genetics and Development, and The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nat Genet 40:108-12. 2008
    ..These results show that AID is required for GC-derived lymphomagenesis, supporting the notion that errors in AID-mediated antigen-receptor gene modification processes are principal contributors to the pathogenesis of human B-NHL...
  85. ncbi request reprint The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer
    Elena M Klenova
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CQ4 3SQ, UK
    Semin Cancer Biol 12:399-414. 2002
    ..The sibling rivalry occasioned by aberrant expression of BORIS in cancer may interfere with normal functions of CTCF including growth suppression, and contribute to epigenetic dysregulation which is a common feature in human cancer...
  86. ncbi request reprint Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice
    Scott C Kogan
    Comprehensive Cancer Center and Department of Laboratory Medicine, University of California, San Francisco, 94143, USA
    Blood 100:238-45. 2002
    ..This classification will be of particular value to investigators seeking to develop, use, and communicate about mouse models of human hematopoietic neoplasms...
  87. ncbi request reprint A three-stage framework for gene expression data analysis by L1-norm support vector regression
    Hyunsoo Kim
    Department of Computer Science, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Bioinform Res Appl 1:51-62. 2005
    ..The experimental results show a significant improvement over the current state-of-the-art approach, i.e., the two-stage process, which consists of the gene selection based on L1-SVR and the third stage of the proposed method...
  88. pmc Characterization of a novel murine retrovirus mixture that facilitates hematopoiesis
    Lauren M Hook
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Virol 76:12112-22. 2002
    ..Thus, multiple pregnancies and allostimuli appear to have provided the signals required for activation of and recombination among endogenous viruses and could have resulted in generation of the Rauscher-like MuLV mixture...
  89. ncbi request reprint Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays
    Petra HÃ¥kansson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Exp Hematol 32:476-82. 2004
    ..A wide range of signal transduction molecules are activated by BCR/ABL1, including MYC, PI-3 kinase, and different STAT molecules. In contrast, relatively few genes are known to be regulated by BCR/ABL1 at the level of transcription...
  90. ncbi request reprint Deregulated expression of the Myc cellular oncogene drives development of mouse "Burkitt-like" lymphomas from naive B cells
    Delin Zhu
    Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospitals Trust, Southampton SO16 6YD, United Kingdom
    Blood 105:2135-7. 2005
    ..In contrast, human eBL development occurs in a GC or post-GC site with a likely contribution to pathogenesis from Epstein-Barr virus (EBV) and other epigenetic factors...
  91. ncbi request reprint B lymphoid neoplasms of mice: characteristics of naturally occurring and engineered diseases and relationships to human disorders
    Herbert C Morse
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Adv Immunol 81:97-121. 2003
  92. pmc Endophilins interact with Moloney murine leukemia virus Gag and modulate virion production
    Margaret Q Wang
    Department of Microbiology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Biol 3:4. 2003
    ..Recent evidence suggests that Gag may co-opt the host cell's endocytic machinery to facilitate retroviral assembly and release...
  93. pmc Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen
    Natalia A Ponomarenko
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10, Miklukho Maklaya Street, Moscow 117997, Russia
    Proc Natl Acad Sci U S A 103:281-6. 2006
    ..Thus, the discovered epitope-specific antibody-mediated degradation of MBP suggests a mechanistic explanation of the slow development of neurodegeneration associated with MS...
  94. pmc ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Exp Med 196:1415-25. 2002
    ....
  95. ncbi request reprint ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ T cells
    Fabrizio Mattei
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Blood 108:609-17. 2006
    ..Together, these results indicate that, throughout the developmental program of DCs, ICSBP differentially controls Ag uptake and MHC class II (MHC-II) presentation affecting both functions only in differentiated peripheral DCs...
  96. ncbi request reprint CpG DNA induced IL-12 p40 gene activation is independent of STAT1 activation or production of interferon consensus sequence binding protein
    Mary Bradford
    Department of Veterans Affairs Medical Center, University of Iowa, College of Medicine, Iowa City, Iowa 52246, USA
    J Biomed Sci 9:688-96. 2002
    ..Thus, CpG DNA-induced IL-12 p40 secretion is mediated by one or more signaling elements distinct from those induced by either LPS or IFN-gamma...
  97. ncbi request reprint Mouse models of human cancers (part 3)
    Alexander D Borowsky
    Center for Comparative Medicine, University of California Davis, 95615, USA
    Comp Med 54:258-70. 2004
  98. ncbi request reprint Overexpression of Eg5 causes genomic instability and tumor formation in mice
    Andrew Castillo
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 67:10138-47. 2007
    ....