Research Topics
Genomes and Genes | D K MorrisonSummaryAffiliation: National Cancer Institute Country: USA Publications
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Publications
Raf-1 without MEK?M S Murakami
Regulation of Cell Growth Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
Sci STKE 2001:pe30. 2001..Murakami and Morrison examine these recent findings and discuss their implications, as well as other possible conclusions that may be drawn from the published data...- KSR: a MAPK scaffold of the Ras pathway?D K Morrison
Regulation of Cell Growth Laboratory, National Cancer Institute, Frederick Cancer Reseach and Development Center, Frederick, MD 21702, USA
J Cell Sci 114:1609-12. 2001..Thus, while Kinase Suppressor of Ras may be its name, phosphorylation may not be its game... - C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1J Muller
Regulation of Cell Growth Laboratory, Center for Cancer Research, NCI Frederick, Frederick, MD 21702, USA
Mol Cell 8:983-93. 2001.... 
Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpressionA M Cacace
Molecular Basis of Carcinogenesis Laboratory, ABL Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Mol Cell Biol 19:229-40. 1999..Therefore, the biological function of KSR as a positive effector of Ras-dependent signaling appears to be dependent on maintaining KSR protein expression at low or near-physiological levels...- Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signalingJ Muller
Regulation of Cell Growth Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Mol Cell Biol 20:5529-39. 2000.... - The complexity of Raf-1 regulationD K Morrison
Molecular Basis of Carcinogenesis Laboratory, ABL Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
Curr Opin Cell Biol 9:174-9. 1997..The picture clearly emerging is that Raf-1 activity can be regulated by multiple mechanisms... - Mammalian Raf-1 is activated by mutations that restore Raf signaling in DrosophilaR E Cutler
Molecular Basis of Carcinogenesis Laboratory, ABL Basic Research Program, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702, USA
EMBO J 16:1953-60. 1997..Finally, we present evidence that the most activating suppressor mutation (G498S) increases Raf-1 activity by introducing a novel phosphorylation site into the L12 activation loop of the Raf-1 kinase domain... - Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathwayV Cleghon
Molecular Basis of Carcinogenesis Laboratory, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
Mol Cell 2:719-27. 1998..The opposing actions of CSW and RasGAP modulate the strength of the Torso signal, contributing to the establishment of precise boundaries for terminal structure development... - Autoregulation of the Raf-1 serine/threonine kinaseR E Cutler
Molecular Basis of Carcinogenesis Laboratory, Advanced BioSciences Laboratories Basic Research Program, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
Proc Natl Acad Sci U S A 95:9214-9. 1998.... - Integrating signals from RTKs to ERK/MAPKM M McKay
Laboratory of Cell and Developmental Signaling, NCI Frederick, Frederick, MD 21702, USA
Oncogene 26:3113-21. 2007..Together, these factors contribute to the diversity of biological responses generated by RTK signaling... - Sequential modification of serines 621 and 624 in the Raf-1 carboxyl terminus produces alterations in its electrophoretic mobilityA F Ferrier
Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4040, USA
J Biol Chem 272:2136-42. 1997..These results demonstrate that a mitogen-activated protein kinase kinase-induced event involving modification of serines 621 and 624 leads to the mobility shift of Raf-1... - Signal transduction downstream from Ras in DrosophilaG M Rubin
Howard Hughes Medical Institute, University of California, Berkeley 94720-3200, USA
Cold Spring Harb Symp Quant Biol 62:347-52. 1997 - A genetic screen for modifiers of a kinase suppressor of Ras-dependent rough eye phenotype in DrosophilaM Therrien
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3200, USA
Genetics 156:1231-42. 2000..One of them corresponds to the kismet locus, which encodes a putative chromatin remodeling factor. The relevance of these loci with respect to the function of KSR and the Ras1 pathway in general is discussed... - KSR modulates signal propagation within the MAPK cascadeM Therrien
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California at Berkeley, 94720 3200, USA
Genes Dev 10:2684-95. 1996..Together, our findings indicate that mKSR1 is an integral component of the MAPK module functioning via a novel mechanism to modulate signal propagation between Raf-1, MEK1, and MAPK... - The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseT F Franke
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Cell 81:727-36. 1995..These results identify Akt as a novel target of PI 3-kinase and suggest that the Akt PH domain may be a mediator of PI 3-kinase signaling... - Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptorD K Morrison
Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco 94143
Cell 58:649-57. 1989..This is the first demonstration of the direct modulation of a protein activity by a growth factor receptor tyrosine kinase... - 95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation siteR M Stephens
Molecular Mechanisms of Carcinogenesis Laboratory, National Cancer Institute Frederick Cancer Research and Development Center, Maryland
Mol Cell Biol 12:3733-42. 1992..A threonine residue is present at similar positions in all three mammalian Raf family members and may represent a regulatory site for these proteins...