Daniel L Morgan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Disposition of inhaled mercury vapor in pregnant rats: maternal toxicity and effects on developmental outcome
    D L Morgan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 66:261-73. 2002
  2. ncbi request reprint Inhalation toxicity studies of the alpha,beta-unsaturated ketones: ethyl vinyl ketone
    D L Morgan
    National Institute of Environmental Health Sciences National Toxicology Program, PO Box 12233, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 13:633-58. 2001
  3. ncbi request reprint Alveolar macrophage cytotoxicity for normal lung fibroblasts is mediated by nitric oxide release
    Daniel L Morgan
    Respiratory Toxicology, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol In Vitro 18:139-46. 2004
  4. ncbi request reprint Upper respiratory tract toxicity of inhaled methylvinyl ketone in F344 rats and B6C3F1 mice
    D L Morgan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 58:182-94. 2000
  5. ncbi request reprint Chemical and physical characteristics of cellulose insulation particulates, and evaluation of potential acute pulmonary toxicity
    Daniel L Morgan
    National Institute of Environmental Health Sciences and the National Toxicology Program, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 46:554-69. 2004
  6. ncbi request reprint Characterization of inhaled alpha-methylstyrene vapor toxicity for B6C3F1 mice and F344 rats
    D L Morgan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 47:187-94. 1999
  7. pmc Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Am J Respir Cell Mol Biol 37:300-8. 2007
  8. pmc Prostaglandin E₂ protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction
    Ryan T Dackor
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 301:L645-55. 2011
  9. doi request reprint Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans
    Daniel L Morgan
    National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 40:448-65. 2012
  10. pmc Cyclooxygenase-1 overexpression decreases Basal airway responsiveness but not allergic inflammation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    J Immunol 177:4785-93. 2006

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Disposition of inhaled mercury vapor in pregnant rats: maternal toxicity and effects on developmental outcome
    D L Morgan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 66:261-73. 2002
    ..These data demonstrate that inhaled Hg0 vapor is distributed to all maternal and fetal tissues in a dose-dependent manner. Adverse effects of Hg on developmental outcome occurred only at a concentration that caused maternal toxicity...
  2. ncbi request reprint Inhalation toxicity studies of the alpha,beta-unsaturated ketones: ethyl vinyl ketone
    D L Morgan
    National Institute of Environmental Health Sciences National Toxicology Program, PO Box 12233, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 13:633-58. 2001
    ..EVK, like other alpha,beta-unsaturated ketones, is a reactive, direct-acting gaseous irritant with toxicity limited primarily to the upper respiratory tract...
  3. ncbi request reprint Alveolar macrophage cytotoxicity for normal lung fibroblasts is mediated by nitric oxide release
    Daniel L Morgan
    Respiratory Toxicology, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol In Vitro 18:139-46. 2004
    ..These data suggest that neither O2- nor PN contributed to the loss of cell viability. Activated AM may kill normal rat lung FB through a NO-mediated pathway that does not involve PN...
  4. ncbi request reprint Upper respiratory tract toxicity of inhaled methylvinyl ketone in F344 rats and B6C3F1 mice
    D L Morgan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 58:182-94. 2000
    ..MVK can be characterized as a reactive, direct-acting gaseous irritant. MVK exposure causes the same nasal cavity lesions as the cyclic alpha,beta-unsaturated ketone, 2-cyclohexen-1-one, although at lower exposure concentrations...
  5. ncbi request reprint Chemical and physical characteristics of cellulose insulation particulates, and evaluation of potential acute pulmonary toxicity
    Daniel L Morgan
    National Institute of Environmental Health Sciences and the National Toxicology Program, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 46:554-69. 2004
    ..This study characterized the chemical and physical properties, and potential acute pulmonary toxicity of CI...
  6. ncbi request reprint Characterization of inhaled alpha-methylstyrene vapor toxicity for B6C3F1 mice and F344 rats
    D L Morgan
    National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 47:187-94. 1999
    ..Although AMS and styrene are structurally very similar, AMS was considerably less toxic for mice and more toxic for male rats than styrene...
  7. pmc Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA
    Am J Respir Cell Mol Biol 37:300-8. 2007
    ..Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se...
  8. pmc Prostaglandin E₂ protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction
    Ryan T Dackor
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 301:L645-55. 2011
    ..In summary, PGE(2) prevented the decline in lung static compliance and protected against lung fibrosis when it was administered before bleomycin challenge but had no therapeutic effect when administered after bleomycin challenge...
  9. doi request reprint Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans
    Daniel L Morgan
    National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 40:448-65. 2012
    ..Significantly, PD also caused both intraluminal and intramural fibrotic airway lesions in rats. The histopathological and biological changes observed in rats raise concerns that PD inhalation may cause BO in exposed humans...
  10. pmc Cyclooxygenase-1 overexpression decreases Basal airway responsiveness but not allergic inflammation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709
    J Immunol 177:4785-93. 2006
    ..Collectively, these data indicate that COX-1 overexpression attenuates airway responsiveness under basal conditions but does not influence allergic airway inflammation...
  11. ncbi request reprint Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:118-35. 2007
    ..This series of experiments demonstrates that COS produces changes in brainstem auditory and cortical somatosensory neurophysiological responses that correlate with previously described histopathological damage...
  12. ncbi request reprint Contribution of magnetic resonance microscopy in the 12-week neurotoxicity evaluation of carbonyl sulfide in Fischer 344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 32:501-10. 2004
    ....
  13. ncbi request reprint Genomic analysis of the rat lung following elemental mercury vapor exposure
    Jie Liu
    Inorganic Carcinogenesis Section, NCI at NIEHS, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 74:174-81. 2003
    ..In summary, genomic analysis revealed an array of gene alterations in response to Hg0 vapor exposure, which could be important for the development of pulmonary adaptation to Hg during Hg0 vapor inhalation...
  14. pmc Gestational mercury vapor exposure and diet contribute to mercury accumulation in neonatal rats
    Daniel L Morgan
    National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 114:735-9. 2006
    ..These data indicate that dietary exposure to trace amounts of Hg can result in a significantly greater accumulation of Hg in neonates than gestational exposure to high concentrations of Hg0 vapor...
  15. pmc Modulation of allergic airway inflammation by the oral pathogen Porphyromonas gingivalis
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Infect Immun 78:2488-96. 2010
    ..Furthermore, a temporal importance of the establishment of infection relative to allergen sensitization is demonstrated for allergic outcomes...
  16. pmc Male sex hormones promote vagally mediated reflex airway responsiveness to cholinergic stimulation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, 111 T W Alexander Dr, Bldg 101, Rm D236, Research Triangle Park, NC 27709, USA
    Am J Physiol Lung Cell Mol Physiol 292:L908-14. 2007
    ..Together, these data indicate that male sex hormones promote cholinergic airway responsiveness via a vagally mediated reflex mechanism that may be important in the regulation of airway tone in the normal and diseased lung...
  17. ncbi request reprint Evaluation of sensory evoked potentials in Long Evans rats gestationally exposed to mercury (Hg0) vapor
    David W Herr
    Neurotoxicology Division, MD B105 05, NHEERL, ORD, U S Environmental Protection Agency, 109 T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicol Sci 82:193-206. 2004
    ..These results indicate that gestational exposure to 4 mg/m(3) Hg(0) did not result in changes in responses evoked from peripheral nerves, or the somatosensory, auditory, or visual modalities...
  18. pmc Severely blunted allergen-induced pulmonary Th2 cell response and lung hyperresponsiveness in type 1 transient receptor potential channel-deficient mice
    Eda Yildirim
    Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Am J Physiol Lung Cell Mol Physiol 303:L539-49. 2012
    ..Thus we propose that TRPC1 signaling is necessary in lymphocyte biology and in regulation of allergen-induced lung hyperresponsiveness, making TRPC1 a potential target for treatment of immune diseases and asthma...
  19. pmc Pleural effects of indium phosphide in B6C3F1 mice: nonfibrous particulate induced pleural fibrosis
    Patrick J Kirby
    Respiratory Toxicology, Laboratory of Molecular Toxicology, Environmental Toxicology Program National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Exp Lung Res 35:858-82. 2009
    ..This oropharyngeal aspiration model was used to provide an initial characterization of the progression of pleural lesions caused by InP...
  20. pmc Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice
    Stavros Garantziotis
    NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:11309-17. 2009
    ..These data support the conclusion that pulmonary matrix can contribute to the development of airway hyperresponsiveness...
  21. ncbi request reprint Interdisciplinary neurotoxicity inhalation studies: carbon disulfide and carbonyl sulfide research in F344 rats
    Robert C Sills
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, 111 Alexander Drive, South Campus, MD B3 08, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 207:245-50. 2005
    ..A decrease in cytochrome oxidase activity was considered to be a contributing factor to the pathogenesis of carbonyl sulfide neurotoxicity...
  22. pmc Gender differences in murine airway responsiveness and lipopolysaccharide-induced inflammation
    Jeffrey W Card
    Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Immunol 177:621-30. 2006
    ..These gender differences are mediated, at least in part, by effects of androgens...
  23. pmc Respiratory toxicity of diacetyl in C57BL/6 mice
    Daniel L Morgan
    Respiratory Toxicology, Laboratory of Molecular Toxicology, National Toxicology Program National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 103:169-80. 2008
    ..Collectively these results indicate that clinically relevant diacetyl exposures result in a pattern of injury that replicates features of human OB...
  24. ncbi request reprint Neurotoxicity of carbonyl sulfide in F344 rats following inhalation exposure for up to 12 weeks
    Daniel L Morgan
    Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 200:131-45. 2004
    ..Our studies demonstrate that this environmental air contaminant has the potential to cause a wide spectrum of brain lesions that are dependent on the degree and duration of exposure...
  25. ncbi request reprint Effect of mercury vapor exposure on metallothionein and glutathione s-transferase gene expression in the kidney of nonpregnant, pregnant, and neonatal rats
    Eduardo Brambila
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Toxicol Environ Health A 65:1273-88. 2002
    ..Activation of these genes could be part of a defensive response directed at decreasing renal mercury toxicity, and may help divert the metal away from the fetus...
  26. pmc Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis
    James C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Pathol 161:459-70. 2002
    ..These findings indicate that the COX-2 enzyme is protective against pulmonary fibrogenesis, and we suggest that COX-2 generation of PGE(2) is an important factor in resolving inflammation...
  27. ncbi request reprint Airway fibrosis in rats induced by vanadium pentoxide
    J C Bonner
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Lung Cell Mol Physiol 278:L209-16. 2000
    ..These data suggest that myofibroblasts are the principal proliferating cell type that contributes to the progression of airway fibrosis after V(2)O(5) injury...
  28. ncbi request reprint Genetic deletion of p21WAF1 enhances papilloma formation but not malignant conversion in experimental mouse skin carcinogenesis
    W C Weinberg
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4340, USA
    Cancer Res 59:2050-4. 1999
    ..Thus, p21WAF1 suppresses early stages of papilloma formation but not malignant progression in mouse skin carcinogenesis, and decreased levels of p21WAF1 do not account for the enhanced malignant conversion of p53 null epidermal tumors...
  29. ncbi request reprint Characterization of carbon disulfide neurotoxicity in C57BL6 mice: behavioral, morphologic, and molecular effects
    R C Sills
    Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 28:142-8. 2000
    ..These data provide supportive evidence that covalent cross-linking of neurofilament proteins is a significant feature of the axonal swellings in mice produced by inhalation exposure to CS2...
  30. ncbi request reprint Inhalation toxicity studies of the alpha,beta-unsaturated ketones: 2-cyclohexene-1-one
    M L Cunningham
    Laboratory of Pharmacology and Chemistry, National Toxicology Program, Mail Drop B3 10, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Inhal Toxicol 13:25-36. 2001
    ..Dose-related hepatic centrilobular cytoplasmic vacuolation was seen in male rats only. These data suggest that CHX acts as an alkylating agent primarily producing toxicity at the exposure site...
  31. ncbi request reprint Mercury vapor and female reproductive toxicity
    B J Davis
    National Institute of Environmental Sciences, MD A2 01, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 59:291-6. 2001
    ..These studies indicate that exposure to Hg degrees vapor altered estrous cyclicity, but had no significant effect on ovulation, implantation, or maintenance of first pregnancy during exposure of short duration in female rats...
  32. doi request reprint Multisite carcinogenicity and respiratory toxicity of inhaled 1-bromopropane in rats and mice
    Daniel L Morgan
    National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 39:938-48. 2011
    ..Inflammatory lesions with Splendore Hoeppli (S-H) material were present primarily in the nose and skin of exposed male and female rats, indicating that 1-BP caused immunosuppression...
  33. ncbi request reprint Carbon monoxide neurotoxicity: transient inhibition of avoidance response and delayed microglia reaction in the absence of neuronal death
    Susan H Brunssen
    Laboratory of Molecular Toxicology, NIEHS, 111 TW Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, USA
    Toxicology 194:51-63. 2003
    ..This regional and focal response of microglia suggests the need for further study regarding such subtle cellular changes and their relationship with COHb levels...
  34. ncbi request reprint Thirteen-week toxicity studies of 3,3'-dimethoxybenzidene and C.I. Direct Blue 15 in the Fischer 344 rat
    D L Morgan
    National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709
    Toxicology 59:297-309. 1989
    ..Mild chronic nephropathy was the principal histological effect in Blue 15-treated rats surviving to study termination...
  35. ncbi request reprint Early changes in sex hormones are not evident in mice exposed to the uterine carcinogens chloroethane or bromoethane
    J R Bucher
    National Institute of Environmental Health Sciences, Mantech Inc, Research Triangle Park, North Carolina
    Toxicol Appl Pharmacol 130:169-73. 1995
    ..Thus, the findings suggest that early changes in circulating sex hormones are not important contributing factors in the uterine neoplasia caused by these chemicals...
  36. pmc Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice
    Hye Youn Cho
    Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Building 101, MD D 201, Research Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:829-39. 2007
    ..We previously determined that mice genetically deficient in TNF response are protected from lung inflammation and epithelial injury after O(3) exposure...
  37. pmc Reaction of the butter flavorant diacetyl (2,3-butanedione) with N-α-acetylarginine: a model for epitope formation with pulmonary proteins in the etiology of obliterative bronchiolitis
    James M Mathews
    RTI International, P O Box 12194, Research Triangle Park, North Carolina 27709, United States
    J Agric Food Chem 58:12761-8. 2010
    ..Open-chain pairs interconverted at pH 2, as did the cyclized, but all four interconverted at neutral pH. This is the first structural characterization of the covalent adducts between diacetyl and an arginine moiety...
  38. ncbi request reprint Cytogenetic effects in mice of divinylbenzene-55 inhalation
    A D Kligerman
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 370:107-13. 1996
    ..There was no indication of toxicity as measured by cell cycle kinetics in the splenocytes or the percentage of polychromatic erythrocytes in the peripheral blood smears. Thus, DVB-55 appears to be a weak genotoxicant in vivo...
  39. ncbi request reprint The role of Toll-like receptor 4 in environmental airway injury in mice
    John W Hollingsworth
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 170:126-32. 2004
    ..These data demonstrate in the mouse that the requirement of TLR4 for pulmonary inflammation depends on the nature of the toxin and appears specific to toxin and exposure conditions...
  40. ncbi request reprint Lung injury after ozone exposure is iron dependent
    Andrew J Ghio
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, 104 Mason Farm Rd, Chapel Hill, NC 27599 7315, USA
    Am J Physiol Lung Cell Mol Physiol 292:L134-43. 2007
    ..With exposure to O3, elevated DMT1 expression diminished oxidative stress (i.e., aldehyde generation) and IL-8 release. We conclude that iron participates critically in the oxidative stress and biological effects after O3 exposure...
  41. ncbi request reprint Effects of mercury vapor inhalation on reactive oxygen species and antioxidant enzymes in rat brain and kidney are minimal
    Peter L Goering
    Center for Devices and Radiological Health, Food and Drug Administration, Rockville, MD 20852, USA
    J Appl Toxicol 22:167-72. 2002
    ..The data indicate that oxidative stress and changes in GSH and activities of antioxidant enzymes do not play a major role in Hg(0) vapor toxicity in brain and kidney...
  42. ncbi request reprint [1,2-13C2]-D-glucose profiles of the serum, liver, pancreas, and DMBA-induced pancreatic tumors of rats
    Laszlo G Boros
    SIDMAP, LLC, and Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Pancreas 31:337-43. 2005
    ....
  43. ncbi request reprint Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor
    H Vasken Aposhian
    Department of Molecular and Cellular Biology, The University of Arizona, Tucson, Arizona 85721 0106, USA
    J Toxicol Clin Toxicol 41:339-47. 2003
    ..Some medical practitioners prescribe GSH and vitamin C alone or in combination with DMPS or DMSA for patients with mercury exposure that is primarily due to the mercury vapor emitted by dental amalgams...