Research Topics
Genomes and Genes
| Maria I MorassoSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Dkk2 plays an essential role in the corneal fate of the ocular surface epitheliumMahua Mukhopadhyay
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Development 133:2149-54. 2006..We show that Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium...
Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healingMaria I Morasso
Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biol Cell 97:173-83. 2005..This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin...- Dlx genes, p63, and ectodermal dysplasiasMaria I Morasso
Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Birth Defects Res C Embryo Today 75:163-71. 2005.... 
The Influence of Flightless I: regeneration versus wound healingMaria I Morasso
Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Invest Dermatol 131:816-7. 2011..Still to be investigated are the specific pathways through which Flii influences regeneration as compared with wound healing...- Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of DsppOlivier Duverger
Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 287:12230-40. 2012..This establishes a regulatory pathway where the transcription factor Dlx3 is essential in dentin formation by directly regulating a crucial matrix protein... - In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bonesOlivier Duverger
Developmental Skin Biology Section, NIAMS, NIH, Bethesda, Maryland
J Cell Physiol 228:654-64. 2013..This study provides new downstream targets for Dlx3 in craniofacial bone, and gives additional evidence of the complex regulation of bone formation and homeostasis in the adult skeleton... - Dlx3 is a crucial regulator of hair follicle differentiation and cyclingJoonsung Hwang
Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
Development 135:3149-59. 2008.... - Role of Scarf and its binding target proteins in epidermal calcium homeostasisJoonsung Hwang
Developmental Skin Biology Unit, NIAMS, and Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 282:18645-53. 2007.... - Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasiasNadezda Radoja
Developmental Skin Biology Unit, NIAMS, NIH, Bethesda, MD 20892, USA
Development 134:13-8. 2007..Our results unravel aspects of the transcriptional cascade of events that contribute to ectoderm development and pathogenesis associated with p63 mutations... - Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammationJoonsung Hwang
Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 108:11566-71. 2011..This model provides a platform that will allow the systematic exploration of the contributions of keratinocytes to cutaneous inflammation... - The novel murine Ca2+-binding protein, Scarf, is differentially expressed during epidermal differentiationMeeyul Hwang
Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:47827-33. 2003..The functional Scarf Ca2+-binding domains suggest a role in the regulation of epidermal differentiation through the control of Ca2+-mediated signaling... - Molecular consequences of a frameshifted DLX3 mutant leading to Tricho-Dento-Osseous syndromeOlivier Duverger
Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
J Biol Chem 283:20198-208. 2008..Moreover, the transcriptional activity of DLX3(WT) is significantly reduced in the presence of the mutated isoform, indicating that DLX3(TDO) has a dominant negative effect on DLX3(WT) transcriptional activity... - SUMOylation of DLX3 by SUMO1 promotes its transcriptional activityOlivier Duverger
Developmental Skin Biology Section, NIAMS NIH, Bethesda, Maryland 20892, USA
J Cell Biochem 112:445-52. 2011..We identified a new level of regulation in the activity of DLX3 that may play a crucial role in the regulation of hair, teeth, and bone development... - Cutaneous retinoic acid levels determine hair follicle development and downgrowthJunko Okano
Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 287:39304-15. 2012..Our results establish that proper RA distribution is essential for morphogenesis, development, and differentiation of hfs... - Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytesGeon Tae Park
Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
Nucleic Acids Res 30:515-22. 2002..In the hair follicle, where Dlx3 is expressed in the hair matrix cells, BMP-2 also activates Dlx3 transcription. These results provide a possible mechanism of action for the BMP signaling pathway on the regulation of Dlx3... - Epidermal patterning and induction of different hair types during mouse embryonic developmentOlivier Duverger
Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
Birth Defects Res C Embryo Today 87:263-72. 2009..Here, we review the mechanisms involved in the patterning of different hair types during mouse embryonic development as well as the influence of the body axes on hair patterning... - Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursorGeon Tae Park
Developmental Skin Biology Unit, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:45195-202. 2002..Cross-linking experiments indicate that suprabasin is a substrate for transglutaminase 2 and 3 activity. Altogether, these results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation... - Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammalsOlivier Duverger
Developmental Skin Biology Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
J Cell Physiol 216:337-46. 2008..In this review, we summarize the expression pattern, loss- and/or gain-of-function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages... - Abnormal placental development and early embryonic lethality in EpCAM-null miceKeisuke Nagao
Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
PLoS ONE 4:e8543. 2009..EpCAM has been extensively studied as a potential tumor marker and immunotherapy target, and more recent studies suggest that EpCAM expression may be characteristic of cancer stem cells... - Detection of gene expression in embryonic tissues and stratified epidermis by in situ hybridizationMaria I Morasso
Developmental Skin Biology Section, NIH NIAMS, Bethesda, MD, USA
Methods Mol Biol 585:253-60. 2010..In this chapter, I review protocols designed to determine mRNA expression by in situ hybridization techniques, in particular, focusing on the developing stratified epidermis... - Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal developmentJunko Okano
Developmental Skin Biology Section, NIAMS, NIH, Bethesda, MD 20892, USA
J Cell Sci 125:1827-36. 2012..These results are important in understanding pathologies associated with abnormal embryonic skin development and barrier dysfunction... - Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defectsNadia Lo Iacono
Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
Development 135:1377-88. 2008..ChIP analysis shows that p63 is directly associated with the Dlx5 and Dlx6 promoters. Thus, our data strongly implicate p63 and the Dlx5-Dlx6 locus in a pathway relevant in the aetio-pathogenesis of SHFM... - Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin geneMohammad Q Hassan
Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655 0106, USA
Mol Cell Biol 24:9248-61. 2004..We propose that multiple HD proteins in osteoblasts constitute a regulatory network that mediates development of the bone phenotype through the sequential association of distinct HD proteins with promoter regulatory elements... - BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional networkMohammad Q Hassan
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Biol Chem 281:40515-26. 2006..We propose that the three homeodomain proteins MSX2, DLX3, and DLX5 provide a key series of molecular switches that regulate expression of Runx2 throughout bone formation...