Maria I Morasso

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium
    Mahua Mukhopadhyay
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Development 133:2149-54. 2006
  2. pmc Dlx genes, p63, and ectodermal dysplasias
    Maria I Morasso
    Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Birth Defects Res C Embryo Today 75:163-71. 2005
  3. doi request reprint The Influence of Flightless I: regeneration versus wound healing
    Maria I Morasso
    Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 131:816-7. 2011
  4. pmc Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing
    Maria I Morasso
    Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Cell 97:173-83. 2005
  5. pmc Cutaneous retinoic acid levels determine hair follicle development and downgrowth
    Junko Okano
    Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:39304-15. 2012
  6. pmc Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:12230-40. 2012
  7. pmc In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS, NIH, Bethesda, Maryland
    J Cell Physiol 228:654-64. 2013
  8. pmc Dlx3 is a crucial regulator of hair follicle differentiation and cycling
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:3149-59. 2008
  9. ncbi request reprint Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias
    Nadezda Radoja
    Developmental Skin Biology Unit, NIAMS, NIH, Bethesda, MD 20892, USA
    Development 134:13-8. 2007
  10. ncbi request reprint Role of Scarf and its binding target proteins in epidermal calcium homeostasis
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, and Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:18645-53. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium
    Mahua Mukhopadhyay
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Development 133:2149-54. 2006
    ..We show that Dkk2 is a key regulator of the corneal versus epidermal fate of the ocular surface epithelium...
  2. pmc Dlx genes, p63, and ectodermal dysplasias
    Maria I Morasso
    Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Birth Defects Res C Embryo Today 75:163-71. 2005
    ....
  3. doi request reprint The Influence of Flightless I: regeneration versus wound healing
    Maria I Morasso
    Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 131:816-7. 2011
    ..Still to be investigated are the specific pathways through which Flii influences regeneration as compared with wound healing...
  4. pmc Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing
    Maria I Morasso
    Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biol Cell 97:173-83. 2005
    ..This review focuses on the most recent findings on epidermal stem cells, and their potential role in initial epidermal commitment, differentiation and wound healing processes in the skin...
  5. pmc Cutaneous retinoic acid levels determine hair follicle development and downgrowth
    Junko Okano
    Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:39304-15. 2012
    ..Our results establish that proper RA distribution is essential for morphogenesis, development, and differentiation of hfs...
  6. pmc Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 287:12230-40. 2012
    ..This establishes a regulatory pathway where the transcription factor Dlx3 is essential in dentin formation by directly regulating a crucial matrix protein...
  7. pmc In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS, NIH, Bethesda, Maryland
    J Cell Physiol 228:654-64. 2013
    ..This study provides new downstream targets for Dlx3 in craniofacial bone, and gives additional evidence of the complex regulation of bone formation and homeostasis in the adult skeleton...
  8. pmc Dlx3 is a crucial regulator of hair follicle differentiation and cycling
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:3149-59. 2008
    ....
  9. ncbi request reprint Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias
    Nadezda Radoja
    Developmental Skin Biology Unit, NIAMS, NIH, Bethesda, MD 20892, USA
    Development 134:13-8. 2007
    ..Our results unravel aspects of the transcriptional cascade of events that contribute to ectoderm development and pathogenesis associated with p63 mutations...
  10. ncbi request reprint Role of Scarf and its binding target proteins in epidermal calcium homeostasis
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, and Proteomics and Mass Spectrometry Facility, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:18645-53. 2007
    ....
  11. pmc Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation
    Joonsung Hwang
    Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:11566-71. 2011
    ..This model provides a platform that will allow the systematic exploration of the contributions of keratinocytes to cutaneous inflammation...
  12. pmc Molecular consequences of a frameshifted DLX3 mutant leading to Tricho-Dento-Osseous syndrome
    Olivier Duverger
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 283:20198-208. 2008
    ..Moreover, the transcriptional activity of DLX3(WT) is significantly reduced in the presence of the mutated isoform, indicating that DLX3(TDO) has a dominant negative effect on DLX3(WT) transcriptional activity...
  13. pmc The novel murine Ca2+-binding protein, Scarf, is differentially expressed during epidermal differentiation
    Meeyul Hwang
    Developmental Skin Biology Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:47827-33. 2003
    ..The functional Scarf Ca2+-binding domains suggest a role in the regulation of epidermal differentiation through the control of Ca2+-mediated signaling...
  14. pmc SUMOylation of DLX3 by SUMO1 promotes its transcriptional activity
    Olivier Duverger
    Developmental Skin Biology Section, NIAMS NIH, Bethesda, Maryland 20892, USA
    J Cell Biochem 112:445-52. 2011
    ..We identified a new level of regulation in the activity of DLX3 that may play a crucial role in the regulation of hair, teeth, and bone development...
  15. pmc Bone morphogenetic protein-2 (BMP-2) transactivates Dlx3 through Smad1 and Smad4: alternative mode for Dlx3 induction in mouse keratinocytes
    Geon Tae Park
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Nucleic Acids Res 30:515-22. 2002
    ..In the hair follicle, where Dlx3 is expressed in the hair matrix cells, BMP-2 also activates Dlx3 transcription. These results provide a possible mechanism of action for the BMP signaling pathway on the regulation of Dlx3...
  16. pmc Epidermal patterning and induction of different hair types during mouse embryonic development
    Olivier Duverger
    Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
    Birth Defects Res C Embryo Today 87:263-72. 2009
    ..Here, we review the mechanisms involved in the patterning of different hair types during mouse embryonic development as well as the influence of the body axes on hair patterning...
  17. pmc Increased retinoic acid levels through ablation of Cyp26b1 determine the processes of embryonic skin barrier formation and peridermal development
    Junko Okano
    Developmental Skin Biology Section, NIAMS, NIH, Bethesda, MD 20892, USA
    J Cell Sci 125:1827-36. 2012
    ..These results are important in understanding pathologies associated with abnormal embryonic skin development and barrier dysfunction...
  18. pmc Abnormal placental development and early embryonic lethality in EpCAM-null mice
    Keisuke Nagao
    Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e8543. 2009
    ..EpCAM has been extensively studied as a potential tumor marker and immunotherapy target, and more recent studies suggest that EpCAM expression may be characteristic of cancer stem cells...
  19. pmc Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor
    Geon Tae Park
    Developmental Skin Biology Unit, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:45195-202. 2002
    ..Cross-linking experiments indicate that suprabasin is a substrate for transglutaminase 2 and 3 activity. Altogether, these results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation...
  20. pmc Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals
    Olivier Duverger
    Developmental Skin Biology Unit, National Institute of Arthritis Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland, USA
    J Cell Physiol 216:337-46. 2008
    ..In this review, we summarize the expression pattern, loss- and/or gain-of-function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages...
  21. doi request reprint Detection of gene expression in embryonic tissues and stratified epidermis by in situ hybridization
    Maria I Morasso
    Developmental Skin Biology Section, NIH NIAMS, Bethesda, MD, USA
    Methods Mol Biol 585:253-60. 2010
    ..In this chapter, I review protocols designed to determine mRNA expression by in situ hybridization techniques, in particular, focusing on the developing stratified epidermis...
  22. ncbi request reprint BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network
    Mohammad Q Hassan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 281:40515-26. 2006
    ..We propose that the three homeodomain proteins MSX2, DLX3, and DLX5 provide a key series of molecular switches that regulate expression of Runx2 throughout bone formation...
  23. pmc Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
    Mohammad Q Hassan
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655 0106, USA
    Mol Cell Biol 24:9248-61. 2004
    ..We propose that multiple HD proteins in osteoblasts constitute a regulatory network that mediates development of the bone phenotype through the sequential association of distinct HD proteins with promoter regulatory elements...
  24. doi request reprint Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects
    Nadia Lo Iacono
    Dulbecco Telethon Institute, Molecular Biotechnology Center, University of Torino, Via Nizza 52, Torino, 10126, Italy
    Development 135:1377-88. 2008
    ..ChIP analysis shows that p63 is directly associated with the Dlx5 and Dlx6 promoters. Thus, our data strongly implicate p63 and the Dlx5-Dlx6 locus in a pathway relevant in the aetio-pathogenesis of SHFM...