Roger A Moore

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Prion protein misfolding and disease
    Roger A Moore
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, United States
    Curr Opin Struct Biol 19:14-22. 2009
  2. pmc Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure
    Roger A Moore
    Rocky Mountain Laboratories Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th St, Hamilton, MT 59840, USA
    Proteomics 11:3853-65. 2011
  3. pmc Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations
    Roger A Moore
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proteomics 10:2858-69. 2010
  4. doi request reprint Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, Montana 59840, USA
    Nat Methods 5:211-2. 2008
  5. pmc Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 86:11763-78. 2012
  6. ncbi request reprint Amyloid formation via supramolecular peptide assemblies
    Roger A Moore
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Biochemistry 46:7079-87. 2007
  7. ncbi request reprint Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Nat Methods 4:645-50. 2007
  8. ncbi request reprint Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Anal Biochem 363:154-6. 2007
  9. pmc Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity
    Andrew G Timmes
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 8:e71081. 2013
  10. pmc Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation
    Roger A Moore
    The Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Protein Sci 15:609-19. 2006

Collaborators

Detail Information

Publications12

  1. pmc Prion protein misfolding and disease
    Roger A Moore
    Rocky Mountain Laboratories, Laboratory of Persistent Viral Diseases, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, United States
    Curr Opin Struct Biol 19:14-22. 2009
    ..The purpose of this review is to provide an overview of the existing structural information for PrP within the context of what is known about the biology of prion disease...
  2. pmc Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure
    Roger A Moore
    Rocky Mountain Laboratories Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th St, Hamilton, MT 59840, USA
    Proteomics 11:3853-65. 2011
    ..Our results show that contaminating proteins alter the FTIR spectrum attributed to PrP(Sc) and suggest that the α-helical, loop/turn and β-sheet secondary structure that remains following their removal are derived from PrP(Sc) itself...
  3. pmc Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations
    Roger A Moore
    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Proteomics 10:2858-69. 2010
    ..The similarities between PrP(Sc) samples from 22L and Chandler TSE strains suggest that the non-PrP(Sc) protein components found in standard enrichment protocols are not strain specific...
  4. doi request reprint Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, 903 S 4th St, Hamilton, Montana 59840, USA
    Nat Methods 5:211-2. 2008
  5. pmc Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins
    Gregory J Raymond
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    J Virol 86:11763-78. 2012
    ..These observations provide insight into the minimal elements required to create prions in vitro and suggest that the PrP(C) GPI anchor can modulate the propagation of synthetic TSE strains...
  6. ncbi request reprint Amyloid formation via supramolecular peptide assemblies
    Roger A Moore
    Laboratory of Persistent Viral Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840, USA
    Biochemistry 46:7079-87. 2007
    ..Our data suggest that simply changing the physical microenvironment can profoundly influence the mechanism of amyloid formation and yield fibrils with novel ultrastructural properties...
  7. ncbi request reprint Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein
    Ryuichiro Atarashi
    Laboratory of Persistent Viral Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Nat Methods 4:645-50. 2007
    ..This method should facilitate the development of rapid, ultrasensitive prion assays and diagnostic tests, in addition to aiding fundamental studies of structure and mechanism of PrPSc formation...
  8. ncbi request reprint Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay
    David A Kocisko
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Anal Biochem 363:154-6. 2007
  9. pmc Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity
    Andrew G Timmes
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana, United States of America
    PLoS ONE 8:e71081. 2013
    ..They suggest that the presence of RNA and lipid cofactors may facilitate the spontaneous refolding of PrP into an infectious form while also allowing the de novo formation of self-propagating, but non-infectious, rPrP-res. ..
  10. pmc Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation
    Roger A Moore
    The Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S 4th Street, Hamilton, Montana 59840, USA
    Protein Sci 15:609-19. 2006
    ..Our data from both models support the hypothesis that extra octapeptide repeats in PrP increase the rate at which protease resistant PrP is formed which in turn may affect the rate of disease onset in familial forms of CJD...
  11. pmc Role of cyclophilin A from brains of prion-infected mice in stimulation of cytokine release by microglia and astroglia in vitro
    Déborah Tribouillard-Tanvier
    From the Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840
    J Biol Chem 287:4628-39. 2012
    ....
  12. ncbi request reprint Hemin interactions and alterations of the subcellular localization of prion protein
    Kil S Lee
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, National Institutes of Health, Hamilton, Montana 59840, USA
    J Biol Chem 282:36525-33. 2007
    ..These hemin-PrPC interactions suggest that PrPC may participate in hemin homeostasis, sensing, and/or uptake and that hemin might affect PrPC functions...