Research Topics
Genomes and Genes
| L E MooreSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumorsMichael L Nickerson
Transgenomic, Gaithersburg, Maryland, USA
Clin Cancer Res 14:4726-34. 2008..Identify relationships between the prevalence of VHL gene alterations and alteration subtypes with patient and tumor characteristics...
Occupational trichloroethylene exposure and kidney cancer risk: a meta-analysisSara Karami
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, 6120 Executive Blvd, EPS 8102, Rockville, MD 20852, USA
Occup Environ Med 69:858-67. 2012..We updated meta-analyses of published case-control and cohort studies exploring occupational TCE exposure and kidney cancer risk, incorporating new analytical results from three recently published cohort studies and a case-control study...- Cell-cycle control in urothelial carcinoma: large-scale tissue array analysis of tumor tissue from Maine and VermontPetra Lenz
Division of Cancer Epidemiology and Genetics, Science Applications International Corporation Frederick, Inc, National Cancer Institute Frederick, Frederick, MD, USA
Cancer Epidemiol Biomarkers Prev 21:1555-64. 2012..Cell-cycle proteins are important predictive markers in urothelial carcinoma but may also exhibit exposure-specific heterogeneity... - Correlation of LINE-1 methylation levels in patient-matched buffy coat, serum, buccal cell, and bladder tumor tissue DNA samplesDana Van Bemmel
Occupational and Environmental Epidemiology Branch, Epidemiology and Biostatistics Program, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 21:1143-8. 2012..To date, most studies have used genomic DNA isolated from blood or urine as a surrogate marker of global DNA methylation levels in bladder tumor tissue... 
Identification of biomarkers of arsenic exposure and metabolism in urine using SELDI technologyL E Moore
Occupational and Environmental Epidemiology Branch, National Cancer Institute, Rockville, MD 20892, USA
J Biochem Mol Toxicol 19:176. 2005- Occupational trichloroethylene exposure and renal carcinoma risk: evidence of genetic susceptibility by reductive metabolism gene variantsLee E Moore
Division of Cancer Epidemiology and Genetics, NIH, National Cancer Institute, NIH, Bethesda, Maryland 20852, USA
Cancer Res 70:6527-36. 2010.... - Evaluation of apolipoprotein A1 and posttranslationally modified forms of transthyretin as biomarkers for ovarian cancer detection in an independent study populationLee E Moore
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, EPS 8118, Bethesda, MD 20852 7240, USA
Cancer Epidemiol Biomarkers Prev 15:1641-6. 2006..A previous study by Zhang et al. reported identification and validation of three biomarkers using proteomic profiling that together improved early-stage ovarian cancer detection... - Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancerLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA
Int J Cancer 120:2452-8. 2007..Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk... - Whole genome amplification of buccal cytobrush DNA collected for molecular epidemiology studiesL E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852 7240, USA
Biomarkers 12:303-12. 2007..To reduce genotype misclassification when cytobrush wgaDNA is used, inclusion of paired gDNA/wgaDNA and/or duplicate wgaDNA samples is critical to monitor data quality... - Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer StudyL E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Carcinogenesis 28:1960-4. 2007..49; 95% CI: 1.08-5.77; P-interaction = 0.05). These data provide additional evidence for the role of cruciferous vegetables in cancer prevention among individuals with common, functional genetic polymorphisms... - Folate metabolism genes, vegetable intake and renal cancer risk in central EuropeLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Int J Cancer 122:1710-5. 2008..04 for all). In summary, these findings suggest that common variation in MTHFR and TYMS genes may be associated with RCC risk, particularly when vegetable intake is low... - Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control studyLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD, USA
Lancet Oncol 9:359-66. 2008..DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer... - Apolipoprotein E/C1 locus variants modify renal cell carcinoma riskLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
Cancer Res 69:8001-8. 2009..In two large case-control studies, our findings further define a functional region of interest at the APOE locus that increases RCC susceptibility... - GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysisL E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 32:182-9. 2011..Findings from this large USA population-based study provided evidence that the NAT2 slow acetylation genotype interacts with tobacco smoking as a function of exposure intensity... - GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenomaLee E Moore
National Cancer Institute, 6120 Executive Boulevard, EPS 7034, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 14:1823-7. 2005..These findings only became apparent using a newly developed assay able to distinguish heterozygous from wild-type individuals. Our data provide evidence that phenotypic differences between these two groups exist... - Childhood cancer incidence and arsenic exposure in drinking water in NevadaLee E Moore
School of Public Health University of California at Berkeley, Berkeley, California, USA
Arch Environ Health 57:201-6. 2002..Nonetheless, the results raise the possibility that there are increased risks for nonleukemic childhood cancers that require confirmation in other studies, particularly those in which higher exposures are addressed... - Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancerLee E Moore
Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Ann N Y Acad Sci 983:181-96. 2003..Methods for incorporating markers of DNA methylation status into etiologic investigations of the impact of environmental exposures on disease (e.g., cancer) are discussed... - Arsenic-related chromosomal alterations in bladder cancerLee E Moore
L E Moore, A H Smith, University of California at Berkeley School of Public Health, Berkeley, USA
J Natl Cancer Inst 94:1688-96. 2002..This study was designed to compare chromosomal alterations in bladder cancers of arsenic-exposed individuals to provide insight into the mechanism of how arsenic may induce or promote cancer... - Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factorsLee E Moore
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 7:e1002312. 2011..A proportion of tumors from current smokers lacked VHL alterations and may represent a biologically distinct clinical entity from inactivated cases... - Parental occupational exposures and Ewing's sarcomaLee E Moore
Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892 7249, USA
Int J Cancer 114:472-8. 2005.... - Lifestyle factors, exposures, genetic susceptibility, and renal cell cancer risk: a reviewLee E Moore
Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
Cancer Invest 23:240-55. 2005.... - Proteomic biomarkers in combination with CA 125 for detection of epithelial ovarian cancer using prediagnostic serum samples from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening TrialLee E Moore
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Cancer 118:91-100. 2012..Several biomarkers were evaluated alone and in combination with CA 125 in prediagnostically collected sera from women in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial... - Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphismsS Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 29:1567-71. 2008..These findings further support the hypothesis that glutathione S-transferase polymorphisms can modify RCC risk associated with occupational pesticide exposure... - Occupational exposure to dusts and risk of renal cell carcinomaS Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Occupational and Environmental Epidemiology Branch, 6120 Executive Boulevard, EPS 8121, Rockville, MD 20852, USA
Br J Cancer 104:1797-803. 2011..We investigated whether asbestos, as well as 20 other occupational dust exposures, were associated with RCC risk in a large European, multi-center, hospital-based renal case-control study... - Vitamin D receptor polymorphisms and renal cancer risk in Central and Eastern EuropeS Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA karamis mail nih gov
J Toxicol Environ Health A 71:367-72. 2008..60; 95% CI: 0.33-1.1; P trend = 0.05). Genotype associations with these subgroups were not modified when dietary sources of vitamin D or calcium were considered. Additional studies of genetic variation in the VDR gene are warranted... - Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in ArgentinaLee E Moore
School of Public Health, Arsenic Health Effects Research Program, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
Cancer Lett 211:199-207. 2004..Having both null polymorphisms conferred the highest risks. The MTHFR 677 CT and TT polymorphisms appeared protective against bladder cancer... - Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenicCraig Steinmaus
Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, California, USA
J Toxicol Environ Health A 70:159-70. 2007..Overall, this study provides evidence that MTHFR and GSTM1 are involved in arsenic metabolism in humans, and polymorphisms in the genes that encode these enzymes may play a role in susceptibility to arsenic-induced cancer... - Case-control study of bladder cancer and exposure to arsenic in ArgentinaMichael N Bates
Arsenic Health Effects Research Group, School of Public Health, University of California, Berkeley, CA 94720-7360, USA
Am J Epidemiol 159:381-9. 2004..This study suggests lower bladder cancer risks for arsenic than predicted from other studies but adds to evidence that the latency for arsenic-induced bladder cancers may be longer than previously thought... - Vitamin d pathway genes, diet, and risk of renal cell carcinomaS Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
Int J Endocrinol 2010:879362. 2010..Results suggest that variants in the RXRA gene modified the associations observed between RCC risk and calcium and vitamin D intake... - Quantitation of DNA in buccal cell samples collected in epidemiological studiesM Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Biomarkers 11:472-9. 2006.... - Simulation and parameter estimation study of a simple neuronal model of rhythm generation: role of NMDA and non-NMDA receptorsJ Tabak
Equipe de Neurobiologie, CNRS URA 256, Universite de Rennes, France
J Comput Neurosci 5:209-35. 1998..1993), gives a better understanding of the parameter subspace describing network activity than a standard fit with a sensitivity analysis for an individual solution... - Parameter estimation methods for single neuron modelsJ Tabak
Equipe de Neurobiologie, CNRS URA 256, Universite de Rennes 1
J Comput Neurosci 9:215-36. 2000..This analysis indicates how well a parameter is likely to be estimated and helps choose an optimal stimulation protocol. Finally, the tests suggest a strategy for fitting single-cell models using the two methods examined... - Renal cancer risk and occupational exposure to polycyclic aromatic hydrocarbons and plasticsSara Karami
National Cancer Institute, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, 6120 Executive Blvd, EPS 8121, Rockville, MD 20852, USA
J Occup Environ Med 53:218-23. 2011..To investigate whether occupational exposure to polycyclic aromatic hydrocarbons and certain plastic monomers increased renal cell carcinoma (RCC) risk... - Simultaneous recovery of DNA and RNA from formalin-fixed paraffin-embedded tissue and application in epidemiologic studiesWen Yi Huang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 8110, MSC 7240, Bethesda, MD 20892 7240, USA
Cancer Epidemiol Biomarkers Prev 19:973-7. 2010..Here, we report the method that we used to simultaneously recover DNA and RNA from FFPE tissue specimens with appreciable quantity and quality and discuss briefly the application of tumor markers in epidemiologic studies... - A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancerClaire S Zhu
Division of Cancer Prevention, National Cancer Institute, National Institute of Health, Bethesda, MD 20892 7346, USA
Cancer Prev Res (Phila) 4:375-83. 2011..Thus, biomarker panels discovered in diagnostic samples may not validate in prediagnostic samples; utilizing prediagnostic samples for discovery may be helpful in developing validated early detection panels... - Occupational exposures and salivary gland cancer mortality among African American and white workers in the United StatesRobin T Wilson
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, DHHS, Bethesda, Maryland 20892 7240, USA
J Occup Environ Med 46:287-97. 2004..0 or greater among African American women, although not statistically significant. These findings suggest occupational and demographic factors needing further investigation... - Occupational sunlight exposure and risk of renal cell carcinomaSara Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer 116:2001-10. 2010.... - Variants in blood pressure genes and the risk of renal cell carcinomaGabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852 4906, USA
Carcinogenesis 31:614-20. 2010..003). Our findings suggest that common genetic variants of AGT, particularly those in the promoter, increase RCC risk among subjects who are hypertensive or overweight... - Analysis of SNPs and haplotypes in vitamin D pathway genes and renal cancer riskSara Karami
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, Maryland, USA
PLoS ONE 4:e7013. 2009..This study comprehensively evaluated genetic variation across eight vitamin D pathway genes in relation to RCC risk. We found increased risk associated with VDR and RXRA. Replication studies are warranted to confirm these findings... - An analysis of growth, differentiation and apoptosis genes with risk of renal cancerLinda M Dong
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 4:e4895. 2009..In conclusion, our evaluation has identified common genetic variants in CASP1, CASP5, EGFR, and IGFBP3 that could be associated with renal cancer risk... - Respiratory cancer and inhaled inorganic arsenic in copper smelters workers: a linear relationship with cumulative exposure that increases with concentrationJay H Lubin
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
Environ Health Perspect 116:1661-5. 2008.... - Occupation and bladder cancer in a population-based case-control study in Northern New EnglandJoanne S Colt
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 7240, USA
Occup Environ Med 68:239-49. 2011..We used data from a large, population-based case-control study in Maine, New Hampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk... - Bladder cancer and mate consumption in Argentina: a case-control studyMichael N Bates
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Cancer Lett 246:268-73. 2007..77, 95% confidence interval: 1.17-12.1), but not in never-smokers. Mate cocido was not associated with bladder cancer. These results are consistent with a previous study in Uruguay... - Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United StatesCraig Steinmaus
Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA 94720-7360, USA
J Occup Environ Med 48:478-88. 2006..70 (95% CI = 0.39-18.6). CONCLUSIONS: Overall, these results are consistent with data from Taiwan suggesting that some individuals who excrete a higher proportion of ingested arsenic as MMA are more susceptible to arsenic-related cancer... - Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cellsLuoping Zhang
School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
Cancer Epidemiol Biomarkers Prev 19:80-8. 2010.... - Decreased urinary beta-defensin-1 expression as a biomarker of response to arsenicChristine M Hegedus
School of Public Health, University of California, Berkeley, California 94720 7356, USA
Toxicol Sci 106:74-82. 2008..Further studies are warranted to investigate the role of HBD-1 in As-related toxicity... - P53 alterations in bladder tumors from arsenic and tobacco exposed patientsLee E Moore
Arsenic Health Effects Research Program, School of Public Health, University of California, 140 Warren Hall 7360, Berkeley, CA 7360, USA
Carcinogenesis 24:1785-91. 2003..Arsenic exposure was not associated with an increased prevalence of p53 mutation or P53 immunopositivity and there was no evidence of interaction between arsenic and smoking with these outcome variables... - Blood concentrations of methionine, selenium, beta-carotene, and other micronutrients in a case-control study of arsenic-induced skin lesions in West Bengal, IndiaJoyce S Chung
Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA 94720, USA
Environ Res 101:230-7. 2006..The emphasis of interventions should be on reducing arsenic exposure... 
Family correlations of arsenic methylation patterns in children and parents exposed to high concentrations of arsenic in drinking waterJoyce S Chung
School of Public Health, University of California, Berkeley, California 94720, USA
Environ Health Perspect 110:729-33. 2002..Larger studies with more extensive pedigrees will need to be conducted to confirm these findings...- Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic InuitJennifer A Rusiecki
Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
Environ Health Perspect 116:1547-52. 2008..DNA methylation, an epigenetic mechanism, has been associated with cancer initiation and progression. Greenlandic Inuit have some of the highest reported POP levels worldwide... - Measurement of urine pH for epidemiological studies on bladder cancerJuan Alguacil
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Eur J Epidemiol 22:91-8. 2007....