Genomes and Genes
L E Moore
Affiliation: National Institutes of Health
- Moore L, Nickerson M, Brennan P, Toro J, Jaeger E, Rinsky J, et al. Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors. PLoS Genet. 2011;7:e1002312 pubmed publisher..A proportion of tumors from current smokers lacked VHL alterations and may represent a biologically distinct clinical entity from inactivated cases. ..
- Moore L, Malats N, Rothman N, Real F, Kogevinas M, Karami S, et al. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer. Int J Cancer. 2007;120:2452-8 pubmed..Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk. ..
- Moore L, Huang W, Chatterjee N, Gunter M, Chanock S, Yeager M, et al. GSTM1, GSTT1, and GSTP1 polymorphisms and risk of advanced colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2005;14:1823-7 pubmed..These findings only became apparent using a newly developed assay able to distinguish heterozygous from wild-type individuals. Our data provide evidence that phenotypic differences between these two groups exist. ..
- Moore L, Brennan P, Karami S, Hung R, Hsu C, Boffetta P, et al. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis. 2007;28:1960-4 pubmed..49; 95% CI: 1.08-5.77; P-interaction = 0.05). These data provide additional evidence for the role of cruciferous vegetables in cancer prevention among individuals with common, functional genetic polymorphisms. ..
- Moore L, Hung R, Karami S, Boffetta P, Berndt S, Hsu C, et al. Folate metabolism genes, vegetable intake and renal cancer risk in central Europe. Int J Cancer. 2008;122:1710-5 pubmed..04 for all). In summary, these findings suggest that common variation in MTHFR and TYMS genes may be associated with RCC risk, particularly when vegetable intake is low. ..
- Moore L, Brennan P, Karami S, Menashe I, Berndt S, Dong L, et al. Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. Cancer Res. 2009;69:8001-8 pubmed publisher..In two large case-control studies, our findings further define a functional region of interest at the APOE locus that increases RCC susceptibility. ..
- Moore L, Baris D, Figueroa J, Garcia Closas M, Karagas M, Schwenn M, et al. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. Carcinogenesis. 2011;32:182-9 pubmed publisher..Findings from this large USA population-based study provided evidence that the NAT2 slow acetylation genotype interacts with tobacco smoking as a function of exposure intensity. ..