Mehdi Mollapour

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Hsp90 phosphorylation, Wee1 and the cell cycle
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Cell Cycle 9:2310-6. 2010
  2. pmc Post-translational modifications of Hsp90 and their contributions to chaperone regulation
    Mehdi Mollapour
    National Cancer Institute, Bethesda, MD, USA
    Biochim Biophys Acta 1823:648-55. 2012
  3. pmc Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Oncotarget 2:407-17. 2011
  4. pmc Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cell 41:672-81. 2011
  5. pmc Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine
    Wanping Xu
    Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cell 47:434-43. 2012
  6. pmc Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
    Shinji Tsutsumi
    Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:2937-42. 2012
  7. pmc Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells
    Aki Iwai
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Cell Cycle 11:3649-55. 2012
  8. ncbi request reprint The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models
    Naoto Miyajima
    Authors Affiliations Urologic Oncology Branch and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Departments of Urology, Biochemistry, and Molecular Biology, Cancer Research Institute, SUNY Upstate Medical University, Syracuse, New York and Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cancer Res 73:7022-33. 2013
  9. pmc Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors
    Kristin Beebe
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Oncotarget 4:1065-74. 2013
  10. pmc Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors
    Mehdi Mollapour
    Department of Urology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Cancer Research Institute, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA Electronic address
    Mol Cell 53:317-29. 2014

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Hsp90 phosphorylation, Wee1 and the cell cycle
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Cell Cycle 9:2310-6. 2010
    ..These findings demonstrate the importance of Hsp90 phosphorylation for proper cell cycle regulation...
  2. pmc Post-translational modifications of Hsp90 and their contributions to chaperone regulation
    Mehdi Mollapour
    National Cancer Institute, Bethesda, MD, USA
    Biochim Biophys Acta 1823:648-55. 2012
    ..This article is part of a Special Issue entitled: Heat Shock Protein 90 (HSP90)...
  3. pmc Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Oncotarget 2:407-17. 2011
    ..We also provide evidence that T22 is an important determinant of Hsp90 inhibitor sensitivity in yeast and we show that T22 phosphorylation status contributes to drug sensitivity in vivo...
  4. pmc Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Mol Cell 41:672-81. 2011
    ..Overexpression of Aha1 stimulates the ATPase activity, restores cochaperone interactions, and compensates for the functional defects of these Hsp90 mutants...
  5. pmc Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine
    Wanping Xu
    Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cell 47:434-43. 2012
    ..Finally, at completion of the chaperone cycle, Hsp90 Y627 phosphorylation induces dissociation of the client and remaining cochaperones...
  6. pmc Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
    Shinji Tsutsumi
    Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 109:2937-42. 2012
    ..We propose that the charged linker, in addition to providing the flexibility necessary for Hsp90 domain rearrangements--likely its original purpose--has evolved in eukaryotes to serve as a rheostat for the Hsp90 chaperone machine...
  7. pmc Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells
    Aki Iwai
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Cell Cycle 11:3649-55. 2012
    ....
  8. ncbi request reprint The HSP90 inhibitor ganetespib synergizes with the MET kinase inhibitor crizotinib in both crizotinib-sensitive and -resistant MET-driven tumor models
    Naoto Miyajima
    Authors Affiliations Urologic Oncology Branch and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Departments of Urology, Biochemistry, and Molecular Biology, Cancer Research Institute, SUNY Upstate Medical University, Syracuse, New York and Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Cancer Res 73:7022-33. 2013
    ....
  9. pmc Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors
    Kristin Beebe
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Oncotarget 4:1065-74. 2013
    ..A more complete understanding of the impact of the cellular milieu on small molecule inhibitor binding to Hsp90 should facilitate their more effective use in the clinic. ..
  10. pmc Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors
    Mehdi Mollapour
    Department of Urology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Cancer Research Institute, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA Electronic address
    Mol Cell 53:317-29. 2014
    ....
  11. doi request reprint Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity
    Annerleim Walton-Diaz
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 1107, USA
    Future Med Chem 5:1059-71. 2013
    ..Here, the impact of post-translational modifications and co-chaperones on the efficacy of Hsp90 inhibitors are reviewed...
  12. doi request reprint Detecting HSP90 phosphorylation
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 787:67-74. 2011
    ..Yeast can be used to express and purify HSP90 and also detect its phosphorylation by pan-phosphoserine or phosphothreonine antibodies...
  13. ncbi request reprint Targeting the dynamic HSP90 complex in cancer
    Jane Trepel
    Medical Oncology Branch Center for Cancer Research, National Cancer Institute, Building 10, Room 1 5940, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Nat Rev Cancer 10:537-49. 2010
    ....
  14. pmc Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
    Sunil Sudarshan
    Urologic Oncology Branch, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Mol Cell Biol 29:4080-90. 2009
    ..These data reveal that the obligate glycolytic switch present in HLRCC is critical to HIF stabilization via ROS generation...
  15. pmc Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function
    Mehdi Mollapour
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Mol Cell 37:333-43. 2010
    ....
  16. doi request reprint The complex dance of the molecular chaperone Hsp90
    Len Neckers
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Trends Biochem Sci 34:223-6. 2009
    ..The conformational program of Hsp90 is conserved from bacteria to humans, although the population dynamics are species specific...
  17. doi request reprint Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain
    Shinji Tsutsumi
    Urologic Oncology Branch, National Cancer Institute, Bethesda, Maryland, USA
    Nat Struct Mol Biol 16:1141-7. 2009
    ..These data underscore the importance of beta-strand 8 for Hsp90 function and demonstrate that the functional consequences of weakened hydrophobic contacts in this region are reversed by charged-linker truncation...