S Moir

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Pathogenic mechanisms of HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Pathol 6:223-48. 2011
  2. doi request reprint Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 254:207-24. 2013
  3. pmc Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cells
    Susan Moir
    Laboratories of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
    Blood 120:4850-8. 2012
  4. pmc Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 122:12-9; quiz 20-1. 2008
  5. pmc Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:1797-805. 2008
  6. ncbi request reprint Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
  7. pmc Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
  8. pmc B cells in HIV infection and disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:235-45. 2009
  9. pmc B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
    Susan Moir
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:5571-9. 2010
  10. doi request reprint Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 197:572-9. 2008

Collaborators

Detail Information

Publications35

  1. doi request reprint Pathogenic mechanisms of HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Pathol 6:223-48. 2011
    ..Further advances in therapeutics and informative technologies, combined with a better understanding of the immunologic and virologic components of HIV disease, hold promise for new preventative and even curative strategies...
  2. doi request reprint Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 254:207-24. 2013
    ..Finally, we consider how knowledge gained by investigating B cells in HIV-infected individuals may help inform the development of an effective antibody-based HIV vaccine...
  3. pmc Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cells
    Susan Moir
    Laboratories of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
    Blood 120:4850-8. 2012
    ..Together, these findings show that, despite reduced circulating CD27(+) memory B cells, CGD patients maintain an intact humoral immunologic memory, with potential contribution from CD27(-) B cells...
  4. pmc Pathogenic mechanisms of B-lymphocyte dysfunction in HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 122:12-9; quiz 20-1. 2008
    ....
  5. pmc Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 205:1797-805. 2008
    ..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals...
  6. ncbi request reprint Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
    ....
  7. pmc Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamily
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Dr, Bethesda, MD 20892, USA
    J Exp Med 200:587-99. 2004
    ....
  8. pmc B cells in HIV infection and disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 9:235-45. 2009
    ..This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction...
  9. pmc B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
    Susan Moir
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:5571-9. 2010
    ..These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage...
  10. doi request reprint Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV disease
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 197:572-9. 2008
    ..However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell numbers and subpopulations...
  11. pmc Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals
    Susan Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:6057-62. 2003
    ..These data provide new insight into the mechanisms associated with ineffective humoral responses in HIV disease...
  12. pmc B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:637-46. 2000
    ..Furthermore, B cells possess the added capability of circulating in peripheral blood and migrating through tissues where they can potentially interact with and pass virus to T cells...
  13. pmc HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
    S Moir
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:10362-7. 2001
    ..These results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease...
  14. ncbi request reprint Deleterious effect of HIV-1 plasma viremia on B cell costimulatory function
    Angela Malaspina
    Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:5965-72. 2003
    ....
  15. pmc Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategies
    T W Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:253-8. 2001
    ....
  16. ncbi request reprint Compromised B cell responses to influenza vaccination in HIV-infected individuals
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Infect Dis 191:1442-50. 2005
    ..We assessed the impact of HIV disease on B cell responses to influenza vaccination...
  17. pmc Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7
    Angela Malaspina
    Laboratory of Immunoregulation, and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:2262-7. 2006
    ..Taken together, these data offer insight into human B cell development as well as B cell dysfunction in advanced HIV disease that may be linked to IL-7-dependent homeostatic events...
  18. pmc Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 76:8855-63. 2002
    ..These findings also indicate that most of the virus in plasma originates from cells other than CD4(+) T cells in the peripheral blood and lymph nodes...
  19. pmc Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitro
    A Oliva
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 102:223-31. 1998
    ..These data suggest that activated NK cells may be an important source of CC-chemokines in vivo and may suppress HIV replication by CC-chemokine-mediated mechanisms in addition to classic NK-mediated lytic mechanisms...
  20. ncbi request reprint Detection of HIV DNA and RNA using PCR
    S Moir
    National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    Curr Protoc Immunol . 2001
    ..The schemes for both techniques include isolation of nucleic acids, PCR reactions and detection of amplified products using Southern blotting...
  21. ncbi request reprint Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virus
    Tae Wook Chun
    Laboratory of Immunoregulation, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Infect Dis 195:1762-4. 2007
    ..6 months. It is projected that it will take up to 7.7 years of continuous therapy to completely eliminate latently infected resting CD4+ T cells in infected individuals who initiate antiviral therapy early in HIV infection...
  22. pmc Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:1908-13. 2003
    ....
  23. ncbi request reprint Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function
    Shyam Kottilil
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, 9000 Wiscoinsin Avenue, Building 10, Room 6A08A, Bethesda, MD 20892, USA
    J Infect Dis 187:1038-45. 2003
    ....
  24. pmc Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    AIDS 24:2803-8. 2010
    ..It is of great interest to identify individuals who had received ART for prolonged periods of time with extremely low or undetectable HIV reservoirs and monitor plasma viremia following discontinuation of therapy...
  25. pmc Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic area
    Greta E Weiss
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 183:2176-82. 2009
    ..This is the first description of an atypical MBC phenotype associated with malaria. Understanding the origin and function of these MBCs could be important in informing the design of malaria vaccines...
  26. pmc IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection
    Irini Sereti
    National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Blood 113:6304-14. 2009
    ..Thus, rhIL-7 has a biologic and toxicity profile suggesting a potential for therapeutic trials in HIV infection and other settings of lymphopenia. This clinical trial has been registered at http://www.clinicaltrials.gov under NCT0099671...
  27. pmc Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:2464-9. 2004
    ....
  28. pmc HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir
    Tae Wook Chun
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:3250-5. 2005
    ..Such events may allow continual replenishment of the CD4+ T cell reservoir and resetting of the half-life of the latently infected, resting CD4+ T cells despite prolonged periods of aviremia...
  29. pmc CpG oligonucleotides enhance proliferative and effector responses of B Cells in HIV-infected individuals
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1199-206. 2008
    ....
  30. doi request reprint Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapy
    Tae Wook Chun
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 197:714-20. 2008
    ....
  31. pmc Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cells
    Jennifer Hartt Meyers
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, Maryland, United States of America
    PLoS ONE 2:e458. 2007
    ..Elucidation of the mechanism by which pDCs suppress HIV replication in vivo may have clinically relevant implications for future therapeutic strategies...
  32. pmc Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanisms
    Jason Ho
    Laboratory of Immunoregulation and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:19436-41. 2006
    ..Our data suggest that two distinct mechanisms of apoptosis are associated with B cells of HIV-infected individuals, and both may contribute to the depletion and dysfunction of B cells in these individuals...
  33. pmc Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7
    Angela Malaspina
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
    Blood 109:2086-8. 2007
    ....
  34. ncbi request reprint Role for CD21 in the establishment of an extracellular HIV reservoir in lymphoid tissues
    Jason Ho
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:6968-74. 2007
    ..Our findings demonstrate a critical role for CD21 in HIV trapping by LN cells and suggest a new therapeutic avenue for reducing HIV reservoirs...
  35. ncbi request reprint Continuous flow leukapheresis induces expression of stress genes in lymphocytes: impact on microarray analyses
    Susan Moir
    Blood 102:3852-3. 2003