Research Topics
Species | S MoirSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Humans with chronic granulomatous disease maintain humoral immunologic memory despite low frequencies of circulating memory B cellsSusan Moir
Laboratories of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes ofHealth, Bethesda, MD 20892, USA
Blood 120:4850-8. 2012..Together, these findings show that, despite reduced circulating CD27(+) memory B cells, CGD patients maintain an intact humoral immunologic memory, with potential contribution from CD27(-) B cells...- Pathogenic mechanisms of B-lymphocyte dysfunction in HIV diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Allergy Clin Immunol 122:12-9; quiz 20-1. 2008.... 
Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamilySusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 200:587-99. 2004....- Decreased survival of B cells of HIV-viremic patients mediated by altered expression of receptors of the TNF superfamilySusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 10, Rm 6A02, 10 Center Dr, Bethesda, MD 20892, USA
J Exp Med 200:587-99. 2004.... - Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individualsSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 205:1797-805. 2008..These data suggest that HIV-associated premature exhaustion of B cells may contribute to poor antibody responses against HIV in infected individuals... - B cells in HIV infection and diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
Nat Rev Immunol 9:235-45. 2009..This Review focuses on advances in our understanding of the mechanisms of B-cell dysfunction in HIV-associated disease and discusses similarities with other diseases that are associated with B-cell dysfunction... 
Normalization of B cell counts and subpopulations after antiretroviral therapy in chronic HIV diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Infect Dis 197:572-9. 2008..However, little is known regarding the effect of antiretroviral therapy (ART)-induced decrease in HIV viremia on B cell numbers and subpopulations...- Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individualsSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:6057-62. 2003..These data provide new insight into the mechanisms associated with ineffective humoral responses in HIV disease... - B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapySusan Moir
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Blood 116:5571-9. 2010..These findings provide new insights on B cells in HIV infection and how early initiation of ART may prevent irreversible immune system damage... - Pathogenic mechanisms of HIV diseaseSusan Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Annu Rev Pathol 6:223-48. 2011..Further advances in therapeutics and informative technologies, combined with a better understanding of the immunologic and virologic components of HIV disease, hold promise for new preventative and even curative strategies... - HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individualsS Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, and Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:10362-7. 2001..These results indicate that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease... 
B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cellsS Moir
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 192:637-46. 2000..Furthermore, B cells possess the added capability of circulating in peripheral blood and migrating through tissues where they can potentially interact with and pass virus to T cells...- Deleterious effect of HIV-1 plasma viremia on B cell costimulatory functionAngela Malaspina
Department of Health and Human Services, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 170:5965-72. 2003.... - Suppression of HIV replication in the resting CD4+ T cell reservoir by autologous CD8+ T cells: implications for the development of therapeutic strategiesT W Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 98:253-8. 2001.... - Compromised B cell responses to influenza vaccination in HIV-infected individualsAngela Malaspina
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
J Infect Dis 191:1442-50. 2005..CD4+ T cell count is a critical determinant of responsiveness to influenza vaccination, and the contribution of plasma HIV RNA level is suggestive and warrants further investigation... - Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasmaAngela Malaspina
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 76:8855-63. 2002..These findings also indicate that most of the virus in plasma originates from cells other than CD4(+) T cells in the peripheral blood and lymph nodes... - Appearance of immature/transitional B cells in HIV-infected individuals with advanced disease: correlation with increased IL-7Angela Malaspina
Laboratory of Immunoregulation, and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:2262-7. 2006..Taken together, these data offer insight into human B cell development as well as B cell dysfunction in advanced HIV disease that may be linked to IL-7-dependent homeostatic events... - Natural killer cells from human immunodeficiency virus (HIV)-infected individuals are an important source of CC-chemokines and suppress HIV-1 entry and replication in vitroA Oliva
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Invest 102:223-31. 1998..These data suggest that activated NK cells may be an important source of CC-chemokines in vivo and may suppress HIV replication by CC-chemokine-mediated mechanisms in addition to classic NK-mediated lytic mechanisms... - Detection of HIV DNA and RNA using PCRS Moir
National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Curr Protoc Immunol . 2001..The schemes for both techniques include isolation of nucleic acids, PCR reactions and detection of amplified products using Southern blotting... - Decay of the HIV reservoir in patients receiving antiretroviral therapy for extended periods: implications for eradication of virusTae Wook Chun
Laboratory of Immunoregulation, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 195:1762-4. 2007..6 months. It is projected that it will take up to 7.7 years of continuous therapy to completely eliminate latently infected resting CD4+ T cells in infected individuals who initiate antiviral therapy early in HIV infection... - Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individualsTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:1908-13. 2003.... - Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradicationTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
AIDS 24:2803-8. 2010..It is of great interest to identify individuals who had received ART for prolonged periods of time with extremely low or undetectable HIV reservoirs and monitor plasma viremia following discontinuation of therapy... - Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell functionShyam Kottilil
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIH, 9000 Wiscoinsin Avenue, Building 10, Room 6A08A, Bethesda, MD 20892, USA
J Infect Dis 187:1038-45. 2003.... - Atypical memory B cells are greatly expanded in individuals living in a malaria-endemic areaGreta E Weiss
Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
J Immunol 183:2176-82. 2009..This is the first description of an atypical MBC phenotype associated with malaria. Understanding the origin and function of these MBCs could be important in informing the design of malaria vaccines... - IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infectionIrini Sereti
National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
Blood 113:6304-14. 2009..Thus, rhIL-7 has a biologic and toxicity profile suggesting a potential for therapeutic trials in HIV infection and other settings of lymphopenia. This clinical trial has been registered at http://www.clinicaltrials.gov under NCT0099671... - Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individualsTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:2464-9. 2004.... - CpG oligonucleotides enhance proliferative and effector responses of B Cells in HIV-infected individualsAngela Malaspina
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 181:1199-206. 2008.... - HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoirTae Wook Chun
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
J Clin Invest 115:3250-5. 2005..Such events may allow continual replenishment of the CD4+ T cell reservoir and resetting of the half-life of the latently infected, resting CD4+ T cells despite prolonged periods of aviremia... - Persistence of HIV in gut-associated lymphoid tissue despite long-term antiretroviral therapyTae Wook Chun
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 197:714-20. 2008.... - Impact of HIV on cell survival and antiviral activity of plasmacytoid dendritic cellsJennifer Hartt Meyers
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health NIH, Bethesda, Maryland, United States of America
PLoS ONE 2:e458. 2007..Elucidation of the mechanism by which pDCs suppress HIV replication in vivo may have clinically relevant implications for future therapeutic strategies... - Two overrepresented B cell populations in HIV-infected individuals undergo apoptosis by different mechanismsJason Ho
Laboratory of Immunoregulation and Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:19436-41. 2006..Our data suggest that two distinct mechanisms of apoptosis are associated with B cells of HIV-infected individuals, and both may contribute to the depletion and dysfunction of B cells in these individuals... - Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7Angela Malaspina
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Department of Health and Human Services DHHS, Bethesda, MD 20892, USA
Blood 109:2086-8. 2007.... - Role for CD21 in the establishment of an extracellular HIV reservoir in lymphoid tissuesJason Ho
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 178:6968-74. 2007..Our findings demonstrate a critical role for CD21 in HIV trapping by LN cells and suggest a new therapeutic avenue for reducing HIV reservoirs... - Continuous flow leukapheresis induces expression of stress genes in lymphocytes: impact on microarray analysesSusan Moir
Blood 102:3852-3. 2003