Muhammad M Mohiuddin

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation
    Muhammad M Mohiuddin
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md Electronic address
    J Thorac Cardiovasc Surg 148:1106-13; discussion 1113-4. 2014
  2. pmc Clinical xenotransplantation of organs: why aren't we there yet?
    Muhammad M Mohiuddin
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Med 4:e75. 2007
  3. pmc B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months
    M M Mohiuddin
    Cardiothoracic Surgery Research Program, National Heart Lung and Blood Institute NIH, Bethesda, MD, USA
    Am J Transplant 12:763-71. 2012
  4. doi request reprint Ex-vivo expanded baboon CD4+ CD25 Hi Treg cells suppress baboon anti-pig T and B cell immune response
    Avneesh K Singh
    Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, MD 20892, USA
    Xenotransplantation 19:102-11. 2012
  5. doi request reprint Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model
    Muhammad M Mohiuddin
    Cardiothoracic Surgery Research Laboratory, NHLBI, NIH, Bethesda, MD, USA
    Xenotransplantation 21:35-45. 2014
  6. ncbi request reprint Characterization and expansion of baboon CD4+CD25+ Treg cells for potential use in a non-human primate xenotransplantation model
    Cynthia M Porter
    Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, Mayland 20892, USA
    Xenotransplantation 14:298-308. 2007
  7. pmc Regulatory T cells enhance mesenchymal stem cell survival and proliferation following autologous cotransplantation in ischemic myocardium
    Yifu Zhou
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md Electronic address
    J Thorac Cardiovasc Surg 148:1131-7; discussiom 1117. 2014
  8. ncbi request reprint Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen
    Muhammad M Mohiuddin
    Department of Cardiovascular Thoracic Surgery, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Transplantation 75:258-62. 2003
  9. ncbi request reprint Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance
    Haruko Ogawa
    Department of Cardiovascular Thoracic Surgery Rush University, Chicago, IL 60612, USA
    Transplantation 77:366-73. 2004

Detail Information

Publications9

  1. pmc Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation
    Muhammad M Mohiuddin
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md Electronic address
    J Thorac Cardiovasc Surg 148:1106-13; discussion 1113-4. 2014
    ..We have recently seen significant prolongation of heterotopic cardiac xenograft survival from 3 to 12 months and beyond...
  2. pmc Clinical xenotransplantation of organs: why aren't we there yet?
    Muhammad M Mohiuddin
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Med 4:e75. 2007
  3. pmc B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months
    M M Mohiuddin
    Cardiothoracic Surgery Research Program, National Heart Lung and Blood Institute NIH, Bethesda, MD, USA
    Am J Transplant 12:763-71. 2012
    ....
  4. doi request reprint Ex-vivo expanded baboon CD4+ CD25 Hi Treg cells suppress baboon anti-pig T and B cell immune response
    Avneesh K Singh
    Cardiothoracic Surgery Research Program, NHLBI, NIH, Bethesda, MD 20892, USA
    Xenotransplantation 19:102-11. 2012
    ..In this study, we evaluated the role of these Treg cells in suppressing proliferative response of baboon T and B cells to pig xenoantigens...
  5. doi request reprint Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibody production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model
    Muhammad M Mohiuddin
    Cardiothoracic Surgery Research Laboratory, NHLBI, NIH, Bethesda, MD, USA
    Xenotransplantation 21:35-45. 2014
    ..hCD46Tg pig-to-baboon heterotopic xenotransplantation model. Unfortunately, many coagulation disorders were observed with the use of anti-CD154 antibody, and recipient survival was markedly reduced by these complications...
  6. ncbi request reprint Characterization and expansion of baboon CD4+CD25+ Treg cells for potential use in a non-human primate xenotransplantation model
    Cynthia M Porter
    Division of Cellular and Gene Therapy, CBER, FDA, Bethesda, Mayland 20892, USA
    Xenotransplantation 14:298-308. 2007
    ..Baboons are a preferred preclinical animal model for xenogeneic organ transplantation experiments, and the characterization of baboon Treg cells will be beneficial to future tolerance studies in this animal model...
  7. pmc Regulatory T cells enhance mesenchymal stem cell survival and proliferation following autologous cotransplantation in ischemic myocardium
    Yifu Zhou
    Cardiothoracic Surgery Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md Electronic address
    J Thorac Cardiovasc Surg 148:1131-7; discussiom 1117. 2014
    ..We sought to investigate if autologous freshly isolated regulatory T cells (Tregs) provide a protective and supportive role when cotransplanted with mesenchymal stem cells (MSCs)...
  8. ncbi request reprint Antibody-mediated accommodation of heart grafts expressing an incompatible carbohydrate antigen
    Muhammad M Mohiuddin
    Department of Cardiovascular Thoracic Surgery, Rush University, 1653 West Congress Parkway, Chicago, IL 60612, USA
    Transplantation 75:258-62. 2003
    ..The present study describes an experimental model for antibody-mediated accommodation of organs expressing incompatible carbohydrate antigens...
  9. ncbi request reprint Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance
    Haruko Ogawa
    Department of Cardiovascular Thoracic Surgery Rush University, Chicago, IL 60612, USA
    Transplantation 77:366-73. 2004
    ..KO mice lack the alpha-gal epitope and can produce the anti-Gal antibody against it after immunization with pig kidney membranes (PKM) that express this epitope...