Joy G Mohanty

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Do red blood cell-beta-amyloid interactions alter oxygen delivery in Alzheimer's disease?
    Joy G Mohanty
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD, USA
    Adv Exp Med Biol 614:29-35. 2008
  2. pmc SOD2 deficiency in hematopoietic cells in mice results in reduced red blood cell deformability and increased heme degradation
    Joy G Mohanty
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Exp Hematol 41:316-21. 2013
  3. pmc A fluorimetric semi-microplate format assay of protein carbonyls in blood plasma
    Joy G Mohanty
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD 21224, USA
    Anal Biochem 400:289-94. 2010
  4. pmc Alterations in the red blood cell membrane proteome in alzheimer's subjects reflect disease-related changes and provide insight into altered cell morphology
    Joy G Mohanty
    National Institute on Aging, Baltimore, MD, USA
    Proteome Sci 8:11. 2010
  5. pmc Role of the membrane in the formation of heme degradation products in red blood cells
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, 251 Bay View Blvd, Baltimore, MD 21224, United States
    Life Sci 86:133-8. 2010
  6. pmc Racial discrimination is associated with a measure of red blood cell oxidative stress: a potential pathway for racial health disparities
    Sarah L Szanton
    Johns Hopkins University, Baltimore, MD 21205, USA
    Int J Behav Med 19:489-95. 2012
  7. ncbi request reprint Red cell interactions with amyloid-beta(1-40) fibrils in a murine model
    Luke B Ravi
    Molecular Dynamics Section, Gerontology Research Center, National Institute on Aging Fully accredited by the American Association for the Accreditation of Laboratory Animal Care, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Dis 19:28-37. 2005
  8. pmc Nitrite enhances RBC hypoxic ATP synthesis and the release of ATP into the vasculature: a new mechanism for nitrite-induced vasodilation
    Zeling Cao
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Heart Circ Physiol 297:H1494-503. 2009
  9. ncbi request reprint Influence of beta-amyloid fibrils on the interactions between red blood cells and endothelial cells
    Luke B Ravi
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD, USA
    Neurol Res 26:579-85. 2004
  10. doi request reprint Nitroprusside inhibits calcium-induced impairment of red blood cell deformability
    Viachaslau Barodka
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins Hospital Molecular Dynamics Section, National Institute on Aging, National Institutes of Health The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Transfusion 54:434-44. 2014

Collaborators

Detail Information

Publications14

  1. doi request reprint Do red blood cell-beta-amyloid interactions alter oxygen delivery in Alzheimer's disease?
    Joy G Mohanty
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD, USA
    Adv Exp Med Biol 614:29-35. 2008
    ..These results suggest that Abeta interactions with RBCs in AD subjects can result in impaired oxygen transport and delivery, which will have important implications for AD...
  2. pmc SOD2 deficiency in hematopoietic cells in mice results in reduced red blood cell deformability and increased heme degradation
    Joy G Mohanty
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Exp Hematol 41:316-21. 2013
    ....
  3. pmc A fluorimetric semi-microplate format assay of protein carbonyls in blood plasma
    Joy G Mohanty
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD 21224, USA
    Anal Biochem 400:289-94. 2010
    ..992) with the direct spectrophotometric method. It has a coefficient of variation of 4.99% and is at least 100 times more sensitive than the spectrophotometric method...
  4. pmc Alterations in the red blood cell membrane proteome in alzheimer's subjects reflect disease-related changes and provide insight into altered cell morphology
    Joy G Mohanty
    National Institute on Aging, Baltimore, MD, USA
    Proteome Sci 8:11. 2010
    ....
  5. pmc Role of the membrane in the formation of heme degradation products in red blood cells
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, 251 Bay View Blvd, Baltimore, MD 21224, United States
    Life Sci 86:133-8. 2010
    ..We investigated the possibility that the observed heme degradation results from ROS generated on the membrane surface that are relatively inaccessible to the cellular antioxidants...
  6. pmc Racial discrimination is associated with a measure of red blood cell oxidative stress: a potential pathway for racial health disparities
    Sarah L Szanton
    Johns Hopkins University, Baltimore, MD 21205, USA
    Int J Behav Med 19:489-95. 2012
    ..Small clinical studies suggest that psychological stress may increase oxidative stress. However, confirmation of this association in epidemiological studies has been limited by homogenous populations and unmeasured potential confounders...
  7. ncbi request reprint Red cell interactions with amyloid-beta(1-40) fibrils in a murine model
    Luke B Ravi
    Molecular Dynamics Section, Gerontology Research Center, National Institute on Aging Fully accredited by the American Association for the Accreditation of Laboratory Animal Care, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Dis 19:28-37. 2005
    ..Heme staining further indicates that the binding of A beta(1-40) to red blood cells enhances red cell phagocytosis by the spleen...
  8. pmc Nitrite enhances RBC hypoxic ATP synthesis and the release of ATP into the vasculature: a new mechanism for nitrite-induced vasodilation
    Zeling Cao
    Molecular Dynamics Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Heart Circ Physiol 297:H1494-503. 2009
    ..These results thus provide a new mechanism to explain nitrite-induced vasodilation...
  9. ncbi request reprint Influence of beta-amyloid fibrils on the interactions between red blood cells and endothelial cells
    Luke B Ravi
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD, USA
    Neurol Res 26:579-85. 2004
    ..These results suggest that amyloidosis may affect the flow of RBCs through the microcirculation and that RBCs may play a role in propagating amyloidosis through the vasculature...
  10. doi request reprint Nitroprusside inhibits calcium-induced impairment of red blood cell deformability
    Viachaslau Barodka
    Department of Anesthesiology Critical Care Medicine, The Johns Hopkins Hospital Molecular Dynamics Section, National Institute on Aging, National Institutes of Health The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland
    Transfusion 54:434-44. 2014
    ..Abnormalities in RBC deformability have been observed in aging, sickle cell disease, diabetes, and preeclampsia. Although nitric oxide (NO) prevents decreases in RBC deformability, the underlying mechanism is unknown...
  11. doi request reprint New insights provided by a comparison of impaired deformability with erythrocyte oxidative stress for sickle cell disease
    Viachaslau M Barodka
    Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States
    Blood Cells Mol Dis 52:230-5. 2014
    ..These findings provide insights into the relative contributions of erythrocyte oxidative stress and membrane damage during the progression of SCD providing a better understanding of the pathophysiology of SCD. ..
  12. ncbi request reprint Redox reactions of hemoglobin
    Joseph M Rifkind
    Molecular Dynamics Section, National Institute on Aging, Baltimore, MD 21224, USA
    Antioxid Redox Signal 6:657-66. 2004
    ..We have shown how EPR not only identifies the paramagnetic species formed but can also be used to provide insights into the mechanism involved in the redox reactions...
  13. pmc Oxidative damage to DNA and single strand break repair capacity: relationship to other measures of oxidative stress in a population cohort
    Andrzej R Trzeciak
    National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Mutat Res 736:93-103. 2012
    ..The data from the literature and from our very limited study suggest a complex relationship between measures of oxidative stress and frequently used clinical parameters believed to reflect inflammation or oxidative stress...
  14. doi request reprint Association of the red cell distribution width with red blood cell deformability
    Kushang V Patel
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging NIH, Bethesda, MD 20814, USA
    Adv Exp Med Biol 765:211-6. 2013
    ..The resultant hypoxia may help to explain the previously reported increased risk for CVD events associated with elevated RDW...