Research Topics
| L M MofensonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Advances and research directions in the prevention of mother-to-child HIV-1 transmissionL M Mofenson
Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
Lancet 355:2237-44. 2000..The challenge for the next decade is to simultaneously address questions relevant to both epidemics while bridging the gap in prevention of perinatal transmission between more-developed and less-developed countries...- Characteristics of acute pneumonia in human immunodeficiency virus-infected children and association with long term mortality risk. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study GroupL M Mofenson
Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
Pediatr Infect Dis J 17:872-80. 1998..To describe the epidemiologic, clinical, radiologic, laboratory and treatment characteristics of acute pneumonia and its association with mortality in HIV-infected children... 
Antiretroviral drugs to prevent breastfeeding HIV transmissionLynne M Mofenson
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA
Antivir Ther 15:537-53. 2010..Thus, there is a crucial need for interventions to allow safer and more prolonged breastfeeding. This paper will critically review the results of studies of postnatal antiretroviral prophylaxis to prevent breast milk HIV transmission...- Antiretroviral Prophylaxis to Reduce Breast Milk Transmission of HIV Type 1: New Data but Still QuestionsLynne M Mofenson
Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
J Acquir Immune Defic Syndr 48:237-40. 2008 - Treating opportunistic infections among HIV-exposed and infected children: recommendations from CDC, the National Institutes of Health, and the Infectious Diseases Society of AmericaLynne M Mofenson
National Institutes of Health, Bethesda, Maryland, USA
Clin Infect Dis 40:S1-84. 2005..This report focuses on treatment of opportunistic infections that are common in HIV-exposed and infected infants, children, and adolescents in the United States... - Advances in the prevention of vertical transmission of human immunodeficiency virusLynne M Mofenson
Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
Semin Pediatr Infect Dis 14:295-308. 2003..This review summarizes recent advances made in prevention of mother-to-child transmission of HIV in the United States and other resource-rich countries, as well as progress in resource-limited countries... - Prevention in neglected subpopulations: prevention of mother-to-child transmission of HIV infectionLynne M Mofenson
Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
Clin Infect Dis 50:S130-48. 2010..This article will review the research on prevention of MTCT of HIV infection in resource-limited countries and the challenges to expansion of the benefits of preventive interventions for MTCT throughout the world... - Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infantsLynne M Mofenson
Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
J Acquir Immune Defic Syndr 30:200-15. 2002..This article focuses on a review of what is known about safety of antiretroviral regimens used to interrupt mother-to-child transmission for women and their children... - Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 TeamL M Mofenson
Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
N Engl J Med 341:385-93. 1999..The risk factors for transmission when women and infants receive zidovudine are not well characterized... - Alternatives to HIV-1 RNA concentration and CD4 count to predict mortality in HIV-1-infected children in resource-poor settingsL M Mofenson
Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852, USA
Lancet 362:1625-7. 2003..0001) and serum albumin (p=0.0107) independently predicted mortality. Further assessment of these markers is warranted in resource-poor settings... 
Treatment interruption after pregnancy: effects on disease progression and laboratory findingsD H Watts
Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Infect Dis Obstet Gynecol 2009:456717. 2009..To assess clinical progression and inflammatory markers among women stopping or continuing antiretroviral therapy (ART) after pregnancy...- Serum vitamin A concentrations in a North American cohort of human immunodeficiency virus type 1-infected children. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study GroupJ S Read
Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
Pediatr Infect Dis J 18:134-42. 1999.... - U.S. Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United StatesLynne M Mofenson
Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, USA
MMWR Recomm Rep 51:1-38; quiz CE1-4. 2002..Standard antiretroviral therapy should be discussed with and offered to HIV-1-infected pregnant women. Additionally, to prevent perinatal transmission, ZDV chemoprophylaxis should be incorporated into the antiretroviral regimen... - Quantification of human immunodeficiency virus type 1 p24 antigen and antibody rivals human immunodeficiency virus type 1 RNA and CD4+ enumeration for prognosis. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical J S Read
Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
Pediatr Infect Dis J 19:544-51. 2000.... - Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316D Heather Watts
National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
Am J Obstet Gynecol 190:506-16. 2004..The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy... - Growing up with HIV: children, adolescents, and young adults with perinatally acquired HIV infectionRohan Hazra
Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Center for Research for Mothers and Children, National Institutes of Health, Rockville, Maryland 20852, USA
Annu Rev Med 61:169-85. 2010.... - Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, tLynne M Mofenson
National Institutes of Health, Bethesda, Maryland, USA
MMWR Recomm Rep 58:1-166. 2009..nih.gov... - Efavirenz reclassified as FDA pregnancy category DLynne M Mofenson
Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
AIDS Clin Care 17:17. 2005 - Risk factors for Kaposi's sarcoma-associated herpesvirus infection among HIV-1-infected pregnant women in the USAJames J Goedert
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
AIDS 17:425-33. 2003..Large formal studies to evaluate whether KSHV transmission occurs via transfusion are needed to inform decisions regarding screening volunteer blood donors to protect the blood supply... - Treating opportunistic infections among HIV-exposed and infected children: recommendations from CDC, the National Institutes of Health, and the Infectious Diseases Society of AmericaLynne M Mofenson
Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20852, USA
MMWR Recomm Rep 53:1-92. 2004..This report focuses on treatment of opportunistic infections that are common in HIV-exposed and infected infants, children, and adolescents in the United States... - Successes and challenges in the perinatal HIV-1 epidemic in the United States as illustrated by the HIV-1 Serosurvey of childbearing womenLynne M Mofenson
Arch Pediatr Adolesc Med 158:422-5. 2004 - Recommendations for human immunodeficiency virus screening, prophylaxis, and treatment for pregnant women in the United StatesDenise J Jamieson
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA 30341, USA
Am J Obstet Gynecol 197:S26-32. 2007..For women with HIV RNA levels of < 1000 copies/mL, a 3-part zidovudine prophylaxis regimen (prenatal, intrapartum, and neonatal) should be used alone or in combination with other antiretroviral drugs... - Tale of two epidemics--the continuing challenge of preventing mother-to-child transmission of human immunodeficiency virusLynne M Mofenson
J Infect Dis 187:721-4. 2003 - Nevirapine concentrations in newborns receiving an extended prophylactic regimenMark Mirochnick
Department of Pediatrics, Boston University School of Medicine, Boston, MA 02118, USA
J Acquir Immune Defic Syndr 47:334-7. 2008..The optimal neonatal antiretroviral (ARV) regimen for prevention of HIV mother-to-child transmission (MTCT) is unknown for infants born to mothers who receive no ARVs during pregnancy... - Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmissionNewton I Kumwenda
Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
N Engl J Med 359:119-29. 2008..Effective strategies are urgently needed to reduce mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) through breast-feeding in resource-limited settings... - Effect of cessation of zidovudine prophylaxis to reduce vertical transmission on maternal HIV disease progression and survivalArlene D Bardeguez
University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
J Acquir Immune Defic Syndr 32:170-81. 2003.... - Early antiretroviral therapy of HIV-infected infants in resource-limited countries: possible, feasible, effective and challengingRenaud Becquet
AIDS 22:1365-8. 2008 - Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan childrenPhilippa M Musoke
Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda
J Acquir Immune Defic Syndr 49:171-8. 2008..To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %... - Osteonecrosis of the hip (Legg-Calvé-Perthes disease) in human immunodeficiency virus-infected childrenDenise M Gaughan
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, USA
Pediatrics 109:E74-4. 2002.... - Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected childrenJoseph A Church
Department of Pediatrics, Children s Hospital Los Angeles and Keck School of Medicine, University of Southern California, 90027, USA
Pediatr Infect Dis J 21:653-9. 2002..The fusion inhibitor T-20 is the first in this new class, and the present study is the first to examine chronic s.c. administration of T-20 to HIV-1-infected children... - Antiretroviral therapy during pregnancy and the risk of an adverse outcomeRuth E Tuomala
Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston 02115, USA
N Engl J Med 346:1863-70. 2002..Some studies suggest that combination antiretroviral therapy in pregnant women with human immunodeficiency virus type 1 (HIV-1) infection increases the risk of premature birth and other adverse outcomes of pregnancy... - Antiretroviral prophylaxis of perinatal HIV-1 transmission and the potential impact of antiretroviral resistanceMonica Nolan
Epidemiology Branch, Division of HIV AIDS, NCHSTP, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Acquir Immune Defic Syndr 30:216-29. 2002.... - In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected childrenSusan B Brogly
Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, USA
AIDS 21:929-38. 2007..There is equivocal evidence of in utero nucleoside reverse transcriptase inhibitor (NRTI) exposure and the occurrence of mitochondrial dysfunction (MD) in HIV-uninfected children born of HIV-infected women... - Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant womenJashvant D Unadkat
Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
Antimicrob Agents Chemother 51:783-6. 2007..Indinavir area under the plasma concentration-time curve was 68% lower antepartum versus postpartum, suggesting increased intestinal and/or hepatic CYP3A activity during pregnancy... - Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected childrenJoseph A Church
Childrens Hospital Los Angeles, Division of Clinical Immunology and Allergy, CA 90027, USA
Pediatr Infect Dis J 23:713-8. 2004..The safety and antiretroviral activity of enfuvirtide treatment of 24 weeks in HIV-1-infected children has been previously documented. Here we present the long term tolerability and safety of enfuvirtide... - Hepatitis C prevalence in children with perinatal human immunodeficiency virus infection enrolled in a long-term follow-up protocolSusan Schuval
Schneider Children s Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
Arch Pediatr Adolesc Med 158:1007-13. 2004..To evaluate the prevalence of hepatitis C virus (HCV) infection in children with perinatal human immunodeficiency virus (HIV) infection... - Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysisJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
AIDS 18:99-108. 2004.... - Performance characteristics of HIV-1 culture and HIV-1 DNA and RNA amplification assays for early diagnosis of perinatal HIV-1 infectionJohn S Lambert
Institute of Human Virology, University of Maryland, Baltimore, USA
J Acquir Immune Defic Syndr 34:512-9. 2003..Given that RNA assays require less blood volume and yield rapid results, our study adds to existing data suggesting that RNA assays may be used for early diagnosis of HIV-1 infection in infants... - Safety and trough concentrations of nevirapine prophylaxis given daily, twice weekly, or weekly in breast-feeding infants from birth to 6 monthsAvinash K Shetty
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
J Acquir Immune Defic Syndr 34:482-90. 2003..A phase 3 study is planned to assess the efficacy of OD infant NVP regimen to prevent breast-feeding HIV-1 transmission... - International recommendations on antiretroviral drugs for treatment of HIV-infected women and prevention of mother-to-child HIV transmission in resource-limited settings: 2006 updateHalima Dao
Centers for Disease Control and Prevention, National Center for HIV, Hepatitis, STD, TB Prevention, Atlanta, GA, USA
Am J Obstet Gynecol 197:S42-55. 2007..HIV transmission through breastfeeding remains a problem, and several interventions are under evaluation that include maternal and/or infant antiretroviral prophylaxis during breastfeeding... - Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficiency virus transmission and infant infectionJohn S Lambert
Institute of Human Virology, University of Maryland, Baltimore, USA
Clin Diagn Lab Immunol 12:622-31. 2005..Detailed immunophenotyping may be useful in supporting the diagnosis of HIV infection in infants with perinatal HIV exposure... - Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapineEsther J Lee
Center for AIDS Research, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USA
J Infect Dis 192:1260-4. 2005..In 20 paired BM and plasma samples, 65% of BM and 50% of plasma RT sequences had NNRTI-resistance mutations, with divergent mutation patterns... - Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children: An analysis of the women and infants transmission studySusan E Pacheco
Baylor College of Medicine, Houston, Texas, USA
J Infect Dis 194:1089-97. 2006..These results indicate the need for long-term follow-up of uninfected infants with ARV exposure... - Cotrimoxazole prophylaxis in HIV-infected pregnant women: only a first stepD Heather Watts
J Infect Dis 194:1478-80. 2006 - A behavioral and cognitive profile of clinically stable HIV-infected childrenMolly L Nozyce
Department of Pediatrics, Bronx Lebanon Hospital Center, Bronx, New York, USA
Pediatrics 117:763-70. 2006..The purpose of this research was to characterize behavioral and cognitive profiles of clinically and immunologically stable antiretroviral-experienced HIV-infected children... - Human immunodeficiency virus, mycobacterium tuberculosis, and pregnancy: a deadly combinationLynne M Mofenson
Clin Infect Dis 45:250-3. 2007 - GB virus C infection in children with perinatal human immunodeficiency virus infectionSusan Schuval
Schneider Children s Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
Pediatr Infect Dis J 24:417-22. 2005..GB virus C (GBV-C) infection occurs in 20-40% of human immunodeficiency virus (HIV)-infected adults, and coinfection is associated with improved HIV disease outcome...