L M Mofenson

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Advances and research directions in the prevention of mother-to-child HIV-1 transmission
    L M Mofenson
    Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Lancet 355:2237-44. 2000
  2. ncbi request reprint Characteristics of acute pneumonia in human immunodeficiency virus-infected children and association with long term mortality risk. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group
    L M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Pediatr Infect Dis J 17:872-80. 1998
  3. doi request reprint Antiretroviral drugs to prevent breastfeeding HIV transmission
    Lynne M Mofenson
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA
    Antivir Ther 15:537-53. 2010
  4. doi request reprint Antiretroviral Prophylaxis to Reduce Breast Milk Transmission of HIV Type 1: New Data but Still Questions
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    J Acquir Immune Defic Syndr 48:237-40. 2008
  5. ncbi request reprint Treating opportunistic infections among HIV-exposed and infected children: recommendations from CDC, the National Institutes of Health, and the Infectious Diseases Society of America
    Lynne M Mofenson
    National Institutes of Health, Bethesda, Maryland, USA
    Clin Infect Dis 40:S1-84. 2005
  6. ncbi request reprint Advances in the prevention of vertical transmission of human immunodeficiency virus
    Lynne M Mofenson
    Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Semin Pediatr Infect Dis 14:295-308. 2003
  7. doi request reprint Prevention in neglected subpopulations: prevention of mother-to-child transmission of HIV infection
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
    Clin Infect Dis 50:S130-48. 2010
  8. ncbi request reprint Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infants
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
    J Acquir Immune Defic Syndr 30:200-15. 2002
  9. ncbi request reprint Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team
    L M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 341:385-93. 1999
  10. ncbi request reprint Alternatives to HIV-1 RNA concentration and CD4 count to predict mortality in HIV-1-infected children in resource-poor settings
    L M Mofenson
    Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852, USA
    Lancet 362:1625-7. 2003

Detail Information

Publications47

  1. ncbi request reprint Advances and research directions in the prevention of mother-to-child HIV-1 transmission
    L M Mofenson
    Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Lancet 355:2237-44. 2000
    ..The challenge for the next decade is to simultaneously address questions relevant to both epidemics while bridging the gap in prevention of perinatal transmission between more-developed and less-developed countries...
  2. ncbi request reprint Characteristics of acute pneumonia in human immunodeficiency virus-infected children and association with long term mortality risk. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group
    L M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Pediatr Infect Dis J 17:872-80. 1998
    ..To describe the epidemiologic, clinical, radiologic, laboratory and treatment characteristics of acute pneumonia and its association with mortality in HIV-infected children...
  3. doi request reprint Antiretroviral drugs to prevent breastfeeding HIV transmission
    Lynne M Mofenson
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA
    Antivir Ther 15:537-53. 2010
    ..Thus, there is a crucial need for interventions to allow safer and more prolonged breastfeeding. This paper will critically review the results of studies of postnatal antiretroviral prophylaxis to prevent breast milk HIV transmission...
  4. doi request reprint Antiretroviral Prophylaxis to Reduce Breast Milk Transmission of HIV Type 1: New Data but Still Questions
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    J Acquir Immune Defic Syndr 48:237-40. 2008
  5. ncbi request reprint Treating opportunistic infections among HIV-exposed and infected children: recommendations from CDC, the National Institutes of Health, and the Infectious Diseases Society of America
    Lynne M Mofenson
    National Institutes of Health, Bethesda, Maryland, USA
    Clin Infect Dis 40:S1-84. 2005
    ..This report focuses on treatment of opportunistic infections that are common in HIV-exposed and infected infants, children, and adolescents in the United States...
  6. ncbi request reprint Advances in the prevention of vertical transmission of human immunodeficiency virus
    Lynne M Mofenson
    Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD 20852, USA
    Semin Pediatr Infect Dis 14:295-308. 2003
    ..This review summarizes recent advances made in prevention of mother-to-child transmission of HIV in the United States and other resource-rich countries, as well as progress in resource-limited countries...
  7. doi request reprint Prevention in neglected subpopulations: prevention of mother-to-child transmission of HIV infection
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
    Clin Infect Dis 50:S130-48. 2010
    ..This article will review the research on prevention of MTCT of HIV infection in resource-limited countries and the challenges to expansion of the benefits of preventive interventions for MTCT throughout the world...
  8. ncbi request reprint Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infants
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20852, USA
    J Acquir Immune Defic Syndr 30:200-15. 2002
    ..This article focuses on a review of what is known about safety of antiretroviral regimens used to interrupt mother-to-child transmission for women and their children...
  9. ncbi request reprint Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. Pediatric AIDS Clinical Trials Group Study 185 Team
    L M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 341:385-93. 1999
    ..The risk factors for transmission when women and infants receive zidovudine are not well characterized...
  10. ncbi request reprint Alternatives to HIV-1 RNA concentration and CD4 count to predict mortality in HIV-1-infected children in resource-poor settings
    L M Mofenson
    Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Boulevard, Rockville, MD 20852, USA
    Lancet 362:1625-7. 2003
    ..0001) and serum albumin (p=0.0107) independently predicted mortality. Further assessment of these markers is warranted in resource-poor settings...
  11. pmc Treatment interruption after pregnancy: effects on disease progression and laboratory findings
    D H Watts
    Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Infect Dis Obstet Gynecol 2009:456717. 2009
    ..To assess clinical progression and inflammatory markers among women stopping or continuing antiretroviral therapy (ART) after pregnancy...
  12. ncbi request reprint Serum vitamin A concentrations in a North American cohort of human immunodeficiency virus type 1-infected children. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group
    J S Read
    Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Pediatr Infect Dis J 18:134-42. 1999
    ....
  13. ncbi request reprint U.S. Public Health Service Task Force recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States
    Lynne M Mofenson
    Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, USA
    MMWR Recomm Rep 51:1-38; quiz CE1-4. 2002
    ..Standard antiretroviral therapy should be discussed with and offered to HIV-1-infected pregnant women. Additionally, to prevent perinatal transmission, ZDV chemoprophylaxis should be incorporated into the antiretroviral regimen...
  14. ncbi request reprint Quantification of human immunodeficiency virus type 1 p24 antigen and antibody rivals human immunodeficiency virus type 1 RNA and CD4+ enumeration for prognosis. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical
    J S Read
    Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892 7510, USA
    Pediatr Infect Dis J 19:544-51. 2000
    ....
  15. ncbi request reprint Maternal toxicity and pregnancy complications in human immunodeficiency virus-infected women receiving antiretroviral therapy: PACTG 316
    D Heather Watts
    National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Am J Obstet Gynecol 190:506-16. 2004
    ..The purpose of this study was to evaluate rates of maternal toxicity, pregnancy complications, and peripartum morbidity by type and duration of antiretroviral therapy (ART) during pregnancy...
  16. doi request reprint Growing up with HIV: children, adolescents, and young adults with perinatally acquired HIV infection
    Rohan Hazra
    Pediatric, Adolescent and Maternal AIDS Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Center for Research for Mothers and Children, National Institutes of Health, Rockville, Maryland 20852, USA
    Annu Rev Med 61:169-85. 2010
    ....
  17. pmc Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, t
    Lynne M Mofenson
    National Institutes of Health, Bethesda, Maryland, USA
    MMWR Recomm Rep 58:1-166. 2009
    ..nih.gov...
  18. ncbi request reprint Efavirenz reclassified as FDA pregnancy category D
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA
    AIDS Clin Care 17:17. 2005
  19. ncbi request reprint Risk factors for Kaposi's sarcoma-associated herpesvirus infection among HIV-1-infected pregnant women in the USA
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA
    AIDS 17:425-33. 2003
    ..We sought to identify risk factors for infection with the Kaposi's Sarcoma-associated herpesvirus (KSHV) among pregnant women and to examine a reported association of KSHV with injecting drug use (IDU) and hepatitis C virus (HCV) infection...
  20. ncbi request reprint Treating opportunistic infections among HIV-exposed and infected children: recommendations from CDC, the National Institutes of Health, and the Infectious Diseases Society of America
    Lynne M Mofenson
    Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20852, USA
    MMWR Recomm Rep 53:1-92. 2004
    ..This report focuses on treatment of opportunistic infections that are common in HIV-exposed and infected infants, children, and adolescents in the United States...
  21. ncbi request reprint Successes and challenges in the perinatal HIV-1 epidemic in the United States as illustrated by the HIV-1 Serosurvey of childbearing women
    Lynne M Mofenson
    Arch Pediatr Adolesc Med 158:422-5. 2004
  22. ncbi request reprint Recommendations for human immunodeficiency virus screening, prophylaxis, and treatment for pregnant women in the United States
    Denise J Jamieson
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA 30341, USA
    Am J Obstet Gynecol 197:S26-32. 2007
    ..For women with HIV RNA levels of < 1000 copies/mL, a 3-part zidovudine prophylaxis regimen (prenatal, intrapartum, and neonatal) should be used alone or in combination with other antiretroviral drugs...
  23. ncbi request reprint Tale of two epidemics--the continuing challenge of preventing mother-to-child transmission of human immunodeficiency virus
    Lynne M Mofenson
    J Infect Dis 187:721-4. 2003
  24. ncbi request reprint Nevirapine concentrations in newborns receiving an extended prophylactic regimen
    Mark Mirochnick
    Department of Pediatrics, Boston University School of Medicine, Boston, MA 02118, USA
    J Acquir Immune Defic Syndr 47:334-7. 2008
    ..The optimal neonatal antiretroviral (ARV) regimen for prevention of HIV mother-to-child transmission (MTCT) is unknown for infants born to mothers who receive no ARVs during pregnancy...
  25. doi request reprint Extended antiretroviral prophylaxis to reduce breast-milk HIV-1 transmission
    Newton I Kumwenda
    Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    N Engl J Med 359:119-29. 2008
    ..Effective strategies are urgently needed to reduce mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) through breast-feeding in resource-limited settings...
  26. ncbi request reprint Effect of cessation of zidovudine prophylaxis to reduce vertical transmission on maternal HIV disease progression and survival
    Arlene D Bardeguez
    University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    J Acquir Immune Defic Syndr 32:170-81. 2003
    ....
  27. pmc Early antiretroviral therapy of HIV-infected infants in resource-limited countries: possible, feasible, effective and challenging
    Renaud Becquet
    AIDS 22:1365-8. 2008
  28. pmc Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children
    Philippa M Musoke
    Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda
    J Acquir Immune Defic Syndr 49:171-8. 2008
    ..To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %...
  29. ncbi request reprint Osteonecrosis of the hip (Legg-Calvé-Perthes disease) in human immunodeficiency virus-infected children
    Denise M Gaughan
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts, USA
    Pediatrics 109:E74-4. 2002
    ....
  30. ncbi request reprint Safety and antiretroviral activity of chronic subcutaneous administration of T-20 in human immunodeficiency virus 1-infected children
    Joseph A Church
    Department of Pediatrics, Children s Hospital Los Angeles and Keck School of Medicine, University of Southern California, 90027, USA
    Pediatr Infect Dis J 21:653-9. 2002
    ..The fusion inhibitor T-20 is the first in this new class, and the present study is the first to examine chronic s.c. administration of T-20 to HIV-1-infected children...
  31. ncbi request reprint Antiretroviral therapy during pregnancy and the risk of an adverse outcome
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston 02115, USA
    N Engl J Med 346:1863-70. 2002
    ..Some studies suggest that combination antiretroviral therapy in pregnant women with human immunodeficiency virus type 1 (HIV-1) infection increases the risk of premature birth and other adverse outcomes of pregnancy...
  32. ncbi request reprint Antiretroviral prophylaxis of perinatal HIV-1 transmission and the potential impact of antiretroviral resistance
    Monica Nolan
    Epidemiology Branch, Division of HIV AIDS, NCHSTP, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Acquir Immune Defic Syndr 30:216-29. 2002
    ....
  33. ncbi request reprint In utero nucleoside reverse transcriptase inhibitor exposure and signs of possible mitochondrial dysfunction in HIV-uninfected children
    Susan B Brogly
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    AIDS 21:929-38. 2007
    ..There is equivocal evidence of in utero nucleoside reverse transcriptase inhibitor (NRTI) exposure and the occurrence of mitochondrial dysfunction (MD) in HIV-uninfected children born of HIV-infected women...
  34. pmc Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 51:783-6. 2007
    ..Indinavir area under the plasma concentration-time curve was 68% lower antepartum versus postpartum, suggesting increased intestinal and/or hepatic CYP3A activity during pregnancy...
  35. ncbi request reprint Long term tolerability and safety of enfuvirtide for human immunodeficiency virus 1-infected children
    Joseph A Church
    Childrens Hospital Los Angeles, Division of Clinical Immunology and Allergy, CA 90027, USA
    Pediatr Infect Dis J 23:713-8. 2004
    ..The safety and antiretroviral activity of enfuvirtide treatment of 24 weeks in HIV-1-infected children has been previously documented. Here we present the long term tolerability and safety of enfuvirtide...
  36. ncbi request reprint Hepatitis C prevalence in children with perinatal human immunodeficiency virus infection enrolled in a long-term follow-up protocol
    Susan Schuval
    Schneider Children s Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
    Arch Pediatr Adolesc Med 158:1007-13. 2004
    ..To evaluate the prevalence of hepatitis C virus (HCV) infection in children with perinatal human immunodeficiency virus (HIV) infection...
  37. ncbi request reprint Maternal viral load and rate of disease progression among vertically HIV-1-infected children: an international meta-analysis
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    AIDS 18:99-108. 2004
    ....
  38. ncbi request reprint Performance characteristics of HIV-1 culture and HIV-1 DNA and RNA amplification assays for early diagnosis of perinatal HIV-1 infection
    John S Lambert
    Institute of Human Virology, University of Maryland, Baltimore, USA
    J Acquir Immune Defic Syndr 34:512-9. 2003
    ..Given that RNA assays require less blood volume and yield rapid results, our study adds to existing data suggesting that RNA assays may be used for early diagnosis of HIV-1 infection in infants...
  39. ncbi request reprint Safety and trough concentrations of nevirapine prophylaxis given daily, twice weekly, or weekly in breast-feeding infants from birth to 6 months
    Avinash K Shetty
    Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    J Acquir Immune Defic Syndr 34:482-90. 2003
    ..A phase 3 study is planned to assess the efficacy of OD infant NVP regimen to prevent breast-feeding HIV-1 transmission...
  40. ncbi request reprint International recommendations on antiretroviral drugs for treatment of HIV-infected women and prevention of mother-to-child HIV transmission in resource-limited settings: 2006 update
    Halima Dao
    Centers for Disease Control and Prevention, National Center for HIV, Hepatitis, STD, TB Prevention, Atlanta, GA, USA
    Am J Obstet Gynecol 197:S42-55. 2007
    ..HIV transmission through breastfeeding remains a problem, and several interventions are under evaluation that include maternal and/or infant antiretroviral prophylaxis during breastfeeding...
  41. pmc Association of selected phenotypic markers of lymphocyte activation and differentiation with perinatal human immunodeficiency virus transmission and infant infection
    John S Lambert
    Institute of Human Virology, University of Maryland, Baltimore, USA
    Clin Diagn Lab Immunol 12:622-31. 2005
    ..Detailed immunophenotyping may be useful in supporting the diagnosis of HIV infection in infants with perinatal HIV exposure...
  42. ncbi request reprint Breast-milk shedding of drug-resistant HIV-1 subtype C in women exposed to single-dose nevirapine
    Esther J Lee
    Center for AIDS Research, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Infect Dis 192:1260-4. 2005
    ..In 20 paired BM and plasma samples, 65% of BM and 50% of plasma RT sequences had NNRTI-resistance mutations, with divergent mutation patterns...
  43. ncbi request reprint Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children: An analysis of the women and infants transmission study
    Susan E Pacheco
    Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 194:1089-97. 2006
    ..With the increasing use of antiretroviral (ARV) drugs to prevent mother-to-child transmission of human immunodeficiency virus (HIV), large numbers of infants are exposed, with possible consequent toxicity...
  44. ncbi request reprint Cotrimoxazole prophylaxis in HIV-infected pregnant women: only a first step
    D Heather Watts
    J Infect Dis 194:1478-80. 2006
  45. ncbi request reprint A behavioral and cognitive profile of clinically stable HIV-infected children
    Molly L Nozyce
    Department of Pediatrics, Bronx Lebanon Hospital Center, Bronx, New York, USA
    Pediatrics 117:763-70. 2006
    ..The purpose of this research was to characterize behavioral and cognitive profiles of clinically and immunologically stable antiretroviral-experienced HIV-infected children...
  46. ncbi request reprint Human immunodeficiency virus, mycobacterium tuberculosis, and pregnancy: a deadly combination
    Lynne M Mofenson
    Clin Infect Dis 45:250-3. 2007
  47. ncbi request reprint GB virus C infection in children with perinatal human immunodeficiency virus infection
    Susan Schuval
    Schneider Children s Hospital, Long Island Jewish Medical Center, New Hyde Park, NY 11042, USA
    Pediatr Infect Dis J 24:417-22. 2005
    ..GB virus C (GBV-C) infection occurs in 20-40% of human immunodeficiency virus (HIV)-infected adults, and coinfection is associated with improved HIV disease outcome...