Edward Mitre

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:2439-45. 2004
  2. pmc Saturation of immunoglobulin E (IgE) binding sites by polyclonal IgE does not explain the protective effect of helminth infections against atopy
    Edward Mitre
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 4 Center Lane, Room 4 126, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 73:4106-11. 2005
  3. ncbi request reprint Basophils, basophilia and helminth infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Chem Immunol Allergy 90:141-56. 2006
  4. doi request reprint Vaccination with intestinal tract antigens does not induce protective immunity in a permissive model of filariasis
    C Paul Morris
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD 20852, USA
    Exp Parasitol 135:87-95. 2013
  5. pmc Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Vaccine 28:1746-57. 2010
  6. pmc Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner
    David Larson
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Immunol 188:4188-99. 2012
  7. pmc Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 188:559-68. 2012
  8. pmc Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice
    Marc P Hübner
    Dept of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Clin Immunol 141:205-17. 2011
  9. ncbi request reprint IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 117:939-45. 2006
  10. doi request reprint Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis
    Marina N Torrero
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 185:7426-34. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Parasite antigen-driven basophils are a major source of IL-4 in human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:2439-45. 2004
    ....
  2. pmc Saturation of immunoglobulin E (IgE) binding sites by polyclonal IgE does not explain the protective effect of helminth infections against atopy
    Edward Mitre
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, 4 Center Lane, Room 4 126, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 73:4106-11. 2005
    ....
  3. ncbi request reprint Basophils, basophilia and helminth infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Chem Immunol Allergy 90:141-56. 2006
    ....
  4. doi request reprint Vaccination with intestinal tract antigens does not induce protective immunity in a permissive model of filariasis
    C Paul Morris
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of Health Sciences, Bethesda, MD 20852, USA
    Exp Parasitol 135:87-95. 2013
    ..sigmodontis have some qualities of 'hidden' antigens, but they still sensitize mice to allergic reactions and fail to protect against future infection when given as a vaccine adsorbed to alum/CPG...
  5. pmc Type 2 immune-inducing helminth vaccination maintains protective efficacy in the setting of repeated parasite exposures
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Vaccine 28:1746-57. 2010
    ..These results demonstrate that vaccines which induce type 2 immune responses can maintain their efficacy in the setting of repeated parasite exposures...
  6. pmc Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner
    David Larson
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA
    J Immunol 188:4188-99. 2012
    ....
  7. pmc Helminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-β
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 188:559-68. 2012
    ..This study demonstrates that L. sigmodontis-mediated protection against diabetes in NOD mice is not dependent on the induction of a type 2 immune shift but does require TGF-β...
  8. pmc Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice
    Marc P Hübner
    Dept of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Clin Immunol 141:205-17. 2011
    ..These results demonstrate that anti-FcεR1 therapy delays diabetes onset in NOD mice and suggest that chronic basophil and mast cell activation may represent a new avenue of therapy for Th1-associated autoimmune diseases...
  9. ncbi request reprint IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 117:939-45. 2006
    ..Although it is well established that IgG humoral immunity can persist for years, as yet there have been no longitudinal studies of antigen-specific IgE responses to helminth infection in the absence of re-exposure to pathogen...
  10. doi request reprint Basophils amplify type 2 immune responses, but do not serve a protective role, during chronic infection of mice with the filarial nematode Litomosoides sigmodontis
    Marina N Torrero
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 185:7426-34. 2010
    ..These results demonstrate that basophils amplify type 2 immune responses, but do not serve a protective role, in chronic infection of mice with the filarial nematode L. sigmodontis...
  11. pmc Histamine release and surface CD200R1 staining as sensitive methods for assessing murine mast cell activation
    David Larson
    Department of Microbiology and Immunology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD, USA
    J Immunol Methods 379:15-22. 2012
    ..Further, both approaches can be done on unpurified peritoneal cell populations. By requiring low numbers of cells, these approaches are ideal for investigating mast cell activation in murine models of disease...
  12. pmc Inhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cells
    Marc P Hübner
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Immunology 127:512-22. 2009
    ..This protection is associated with a Th2 shift, as demonstrated by cytokine and antibody production, and with an increase in CD4(+) CD25(+) FoxP3(+) regulatory T cells...
  13. pmc Induction of type 2 responses by schistosome worms during prepatent infection
    Lucia Alves de Oliveira Fraga
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Infect Dis 201:464-72. 2010
    ....
  14. pmc Basophils help establish protective immunity induced by irradiated larval vaccination for filariasis
    Marina N Torrero
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Vaccine 31:3675-82. 2013
    ..These findings demonstrate that basophils help establish the immune responses responsible for irradiated L3 vaccine protection. ..
  15. pmc Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization
    Helton C Santiago
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 130:248-56.e9. 2012
    ..The extensive similarities between helminth proteins and allergens are thought to contribute to helminth-driven allergic sensitization...
  16. doi request reprint CD4(+) (and not CD25+) T cells are the predominant interleukin-10-producing cells in the circulation of filaria-infected patients
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 197:94-101. 2008
    ..Interleukin (IL)-10 plays an important role in down-regulating the immune response to filarial parasites. The goal of this study was to characterize the predominant cellular source of IL-10 in human filarial infections...
  17. pmc A comprehensive, model-based review of vaccine and repeat infection trials for filariasis
    C Paul Morris
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Clin Microbiol Rev 26:381-421. 2013
    ..Additionally, we provide information on the life cycle, disease phenotype, concomitant immunity, and natural immunity during primary and secondary infections for 24 different filaria models. ..
  18. ncbi request reprint Lack of basophilia in human parasitic infections
    Edward Mitre
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Trop Med Hyg 69:87-91. 2003
    ..Thus, basophilia occurs only rarely in human parasitic infections and is consequently not a useful clinical marker in the evaluation of suspected parasitic disease...
  19. pmc Litomosoides sigmodontis: a simple method to infect mice with L3 larvae obtained from the pleural space of recently infected jirds (Meriones unguiculatus)
    Marc P Hübner
    Dept of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Exp Parasitol 123:95-8. 2009
    ..Additionally, this method allows for geographical separation of the facility maintaining the L. sigmodontis life cycle from the institution at which mice are infected...
  20. ncbi request reprint Majority of interferon-gamma-producing CD4+ cells in patients infected with human T cell lymphotrophic virus do not express tax protein
    Edward Mitre
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 188:428-32. 2003
    ..In the patients with HTLV-1 with detectable Tax, the majority of CD4(+) cells making IFN-gamma did not express Tax...
  21. pmc Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics
    Philip J Cooper
    Laboratorio de Investigaciones, Hospital Pedro Vicente Maldonado, Pichincha Province, Quito, Ecuador
    J Infect Dis 197:1333-40. 2008
    ..This study investigated whether IL-10 and populations of IL-10+ T cells may modulate atopy in children living in an area where intestinal helminth infections are endemic...
  22. pmc Microfilariae of the filarial nematode Litomosoides sigmodontis exacerbate the course of lipopolysaccharide-induced sepsis in mice
    Marc P Hübner
    Institute of Tropical Medicine, University of Tubingen, 72074 Tubingen, Germany
    Infect Immun 76:1668-77. 2008
    ....