Research Topics
Genomes and GenesSpecies | Lisa MirabelloSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasiaLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
Int J Cancer 132:1412-22. 2013..Higher methylation in CIN2+ cases was not explained by higher viral load. We conclude that elevated levels of HPV16 DNA methylation may be useful to predict concurrently diagnosed as well as future CIN2+...- Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican populationLisa Mirabello
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 7101, Rockville, MD 20892, USA
J Natl Cancer Inst 104:556-65. 2012.... - A comprehensive candidate gene approach identifies genetic variation associated with osteosarcomaLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
BMC Cancer 11:209. 2011..We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways... - The association of telomere length and genetic variation in telomere biology genesLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Hum Mutat 31:1050-8. 2010..The combination of limited diversity and evolutionary conservation suggest that these genes may be under selective pressure. More work is needed to explore the role of genetic variants in telomere length regulation... - Height at diagnosis and birth-weight as risk factors for osteosarcomaLisa Mirabello
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Cancer Causes Control 22:899-908. 2011..Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma... - Genetic variation at chromosome 8q24 in osteosarcoma cases and controlsLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
Carcinogenesis 31:1400-4. 2010..Future large studies of osteosarcoma genetic risk factors are warranted to improve our understanding of the genetic contribution to this cancer of adolescents and young adults... - Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3Nicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
J Natl Cancer Inst 104:1738-49. 2012..However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood... - A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinomaMaria Teresa Landi
Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Hum Genet 85:679-91. 2009..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma... - The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancerLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Aging Cell 8:405-13. 2009..However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status... 
Human papillomavirus DNA methylation as a potential biomarker for cervical cancerMegan A Clarke
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 21:2125-37. 2012..To follow the promising leads, we suggest future studies to validate the use of methylated carcinogenic HPV DNA as a predictive and/or diagnostic biomarker for risk of cervical cancer among HPV-positive women...- Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results ProgramLisa Mirabello
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Cancer 115:1531-43. 2009..Detailed descriptions of osteosarcoma incidence and survival with direct comparisons among patients of all ages and ethnicities are not available... - Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot studyLisa Mirabello
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA
Cancer Causes Control 21:77-82. 2010..Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer... - Detectable clonal mosaicism and its relationship to aging and cancerKevin B Jacobs
Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
Nat Genet 44:651-8. 2012..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases... - LINE-1 methylation is inherited in familial testicular cancer kindredsLisa Mirabello
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
BMC Med Genet 11:77. 2010..Global DNA hypomethylation has been associated with the risk of cancers of the bladder and head/neck... - International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly personsLisa Mirabello
Department of Health and Human Services, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
Int J Cancer 125:229-34. 2009..Overall, worldwide osteosarcoma incidence rates were quite similar in the younger age groups. The greatest variation in incidence rates was observed in the elderly... - The association of telomere length and cancer: a meta-analysisIngrid M Wentzensen
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
Cancer Epidemiol Biomarkers Prev 20:1238-50. 2011..Short telomeres in surrogate tissues (e.g., blood cells) are associated with increased cancer risk in several case-control studies, but findings are inconsistent in prospective studies... - LINE-1 methylation in peripheral blood and the risk of melanoma in melanoma-prone families with and without CDKN2A mutationsPaula L Hyland
Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute NCI, National Institutes of Health NIH, DHHS, Division of Cancer Prevention, NCI, NIH, Bethesda, Maryland, USA
Melanoma Res 23:55-60. 2013..Our findings did not support a significant association between constitutional LINE-1 methylation in PBMCs and risk of CMM in melanoma-prone families with or without CDKN2A mutations... - Promoter methylation of candidate genes associated with familial testicular cancerLisa Mirabello
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA
Int J Mol Epidemiol Genet 3:213-27. 2012..Our results suggest that familial TGCT susceptibility may be associated with promoter methylation of previously-identified TGCT risk-modifying genes. Larger studies are warranted... - Nucleotide diversity and population differentiation of the melanocortin 1 receptor gene, MC1RSharon A Savage
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, USA
BMC Genet 9:31. 2008..The melanocortin 1 receptor gene (MC1R) is responsible for normal pigment variation in humans and is highly polymorphic with numerous population-specific alleles. Some MC1R variants have been associated with skin cancer risk... - Using epidemiology and genomics to understand osteosarcoma etiologySharon A Savage
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20892, USA
Sarcoma 2011:548151. 2011..Herein, we review the epidemiology of osteosarcoma as well as its known and suspected risk factors in an effort to gain insight into its etiology...