Lisa Mirabello

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Int J Cancer 132:1412-22. 2013
  2. pmc Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 7101, Rockville, MD 20892, USA
    J Natl Cancer Inst 104:556-65. 2012
  3. pmc A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    BMC Cancer 11:209. 2011
  4. pmc Height at diagnosis and birth-weight as risk factors for osteosarcoma
    Lisa Mirabello
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 22:899-908. 2011
  5. pmc The association of telomere length and genetic variation in telomere biology genes
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Hum Mutat 31:1050-8. 2010
  6. pmc Genetic variation at chromosome 8q24 in osteosarcoma cases and controls
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
    Carcinogenesis 31:1400-4. 2010
  7. pmc Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations
    Laura S Burke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 8:e71121. 2013
  8. doi request reprint LINE-1 methylation in peripheral blood and the risk of melanoma in melanoma-prone families with and without CDKN2A mutations
    Paula L Hyland
    Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute NCI, National Institutes of Health NIH, DHHS, Division of Cancer Prevention, NCI, NIH, Bethesda, Maryland, USA
    Melanoma Res 23:55-60. 2013
  9. pmc Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:1738-49. 2012
  10. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009

Detail Information

Publications22

  1. pmc Elevated methylation of HPV16 DNA is associated with the development of high grade cervical intraepithelial neoplasia
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Int J Cancer 132:1412-22. 2013
    ..Higher methylation in CIN2+ cases was not explained by higher viral load. We conclude that elevated levels of HPV16 DNA methylation may be useful to predict concurrently diagnosed as well as future CIN2+...
  2. pmc Methylation of human papillomavirus type 16 genome and risk of cervical precancer in a Costa Rican population
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS 7101, Rockville, MD 20892, USA
    J Natl Cancer Inst 104:556-65. 2012
    ....
  3. pmc A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA
    BMC Cancer 11:209. 2011
    ..We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways...
  4. pmc Height at diagnosis and birth-weight as risk factors for osteosarcoma
    Lisa Mirabello
    Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Causes Control 22:899-908. 2011
    ..Osteosarcoma typically occurs during puberty. Studies of the association between height and/or birth-weight and osteosarcoma are conflicting. Therefore, we conducted a large pooled analysis of height and birth-weight in osteosarcoma...
  5. pmc The association of telomere length and genetic variation in telomere biology genes
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Hum Mutat 31:1050-8. 2010
    ..The combination of limited diversity and evolutionary conservation suggest that these genes may be under selective pressure. More work is needed to explore the role of genetic variants in telomere length regulation...
  6. pmc Genetic variation at chromosome 8q24 in osteosarcoma cases and controls
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
    Carcinogenesis 31:1400-4. 2010
    ..Future large studies of osteosarcoma genetic risk factors are warranted to improve our understanding of the genetic contribution to this cancer of adolescents and young adults...
  7. pmc Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations
    Laura S Burke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America
    PLoS ONE 8:e71121. 2013
    ..The goal of this study was to examine whether TL modified the risk of melanoma in melanoma-prone families with and without CDKN2A germline mutations...
  8. doi request reprint LINE-1 methylation in peripheral blood and the risk of melanoma in melanoma-prone families with and without CDKN2A mutations
    Paula L Hyland
    Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute NCI, National Institutes of Health NIH, DHHS, Division of Cancer Prevention, NCI, NIH, Bethesda, Maryland, USA
    Melanoma Res 23:55-60. 2013
    ..Our findings did not support a significant association between constitutional LINE-1 methylation in PBMCs and risk of CMM in melanoma-prone families with or without CDKN2A mutations...
  9. pmc Methylation of HPV18, HPV31, and HPV45 genomes and cervical intraepithelial neoplasia grade 3
    Nicolas Wentzensen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Room 5024, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 104:1738-49. 2012
    ..However, the extent of methylation in other HPV types and its role in progression to cancer is poorly understood...
  10. pmc A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma
    Maria Teresa Landi
    Division of Cancer Epidemiology, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Hum Genet 85:679-91. 2009
    ..In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma...
  11. pmc Genome-wide association study identifies two susceptibility loci for osteosarcoma
    Sharon A Savage
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, MD, USA
    Nat Genet 45:799-803. 2013
    ..2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma...
  12. pmc Human papillomavirus DNA methylation as a potential biomarker for cervical cancer
    Megan A Clarke
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 21:2125-37. 2012
    ..To follow the promising leads, we suggest future studies to validate the use of methylated carcinogenic HPV DNA as a predictive and/or diagnostic biomarker for risk of cervical cancer among HPV-positive women...
  13. pmc The association between leukocyte telomere length and cigarette smoking, dietary and physical variables, and risk of prostate cancer
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Aging Cell 8:405-13. 2009
    ..However, correlations of telomere length with healthy lifestyles were noted, suggesting the role of these factors in telomere biology maintenance and potentially impacting overall health status...
  14. pmc Leukocyte telomere length in a population-based case-control study of ovarian cancer: a pilot study
    Lisa Mirabello
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA
    Cancer Causes Control 21:77-82. 2010
    ..Ovarian cancer tissues also have shortened telomeres and increased telomerase activity, suggesting that telomere abnormalities may be related to ovarian cancer...
  15. pmc Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Cancer 115:1531-43. 2009
    ..Detailed descriptions of osteosarcoma incidence and survival with direct comparisons among patients of all ages and ethnicities are not available...
  16. pmc LINE-1 methylation is inherited in familial testicular cancer kindreds
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    BMC Med Genet 11:77. 2010
    ..Global DNA hypomethylation has been associated with the risk of cancers of the bladder and head/neck...
  17. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  18. pmc International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons
    Lisa Mirabello
    Department of Health and Human Services, Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20892, USA
    Int J Cancer 125:229-34. 2009
    ..Overall, worldwide osteosarcoma incidence rates were quite similar in the younger age groups. The greatest variation in incidence rates was observed in the elderly...
  19. pmc The association of telomere length and cancer: a meta-analysis
    Ingrid M Wentzensen
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, Maryland 20852, USA
    Cancer Epidemiol Biomarkers Prev 20:1238-50. 2011
    ..Short telomeres in surrogate tissues (e.g., blood cells) are associated with increased cancer risk in several case-control studies, but findings are inconsistent in prospective studies...
  20. pmc Promoter methylation of candidate genes associated with familial testicular cancer
    Lisa Mirabello
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, Maryland, USA
    Int J Mol Epidemiol Genet 3:213-27. 2012
    ..Our results suggest that familial TGCT susceptibility may be associated with promoter methylation of previously-identified TGCT risk-modifying genes. Larger studies are warranted...
  21. pmc Nucleotide diversity and population differentiation of the melanocortin 1 receptor gene, MC1R
    Sharon A Savage
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, USA
    BMC Genet 9:31. 2008
    ..The melanocortin 1 receptor gene (MC1R) is responsible for normal pigment variation in humans and is highly polymorphic with numerous population-specific alleles. Some MC1R variants have been associated with skin cancer risk...
  22. pmc Using epidemiology and genomics to understand osteosarcoma etiology
    Sharon A Savage
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, EPS 7018, Rockville, MD 20892, USA
    Sarcoma 2011:548151. 2011
    ..Herein, we review the epidemiology of osteosarcoma as well as its known and suspected risk factors in an effort to gain insight into its etiology...