Joshua D Milner

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases
    Joshua D Milner
    Allergic Inflammation Unit, Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 13:635-48. 2013
  2. doi request reprint IL-17 producing cells in host defense and atopy
    Joshua D Milner
    Laboratory of Allergic Diseases, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States
    Curr Opin Immunol 23:784-8. 2011
  3. pmc Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, Bethesda, MD 20892, USA
    Blood 116:2476-83. 2010
  4. pmc Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:6569-73. 2010
  5. ncbi request reprint Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma
    Joshua D Milner
    Department of Pediatrics, Children s National Medical Center, Washington, DC, USA
    Pediatrics 114:27-32. 2004
  6. ncbi request reprint Transient environmental exposures on the developing immune system: implications for allergy and asthma
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892 1892, USA
    Curr Opin Allergy Clin Immunol 5:235-40. 2005
  7. pmc Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
    Andrea M Siegel
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD
    J Allergy Clin Immunol 132:1388-96. 2013
  8. pmc Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases
    John S Barber
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:8164-9. 2013
  9. pmc Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis
    Elizabeth P Sampaio
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 131:1624-34. 2013
  10. doi request reprint Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism
    Amy P Hsu
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 131:1586-93. 2013

Detail Information

Publications26

  1. doi request reprint The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases
    Joshua D Milner
    Allergic Inflammation Unit, Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 13:635-48. 2013
    ....
  2. doi request reprint IL-17 producing cells in host defense and atopy
    Joshua D Milner
    Laboratory of Allergic Diseases, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, United States
    Curr Opin Immunol 23:784-8. 2011
    ..The connection between IL-17 and atopic disease, in particular, is complex, but it merits further study which may ultimately lead to therapies targeting the Th17 pathway in infectious and/or allergic settings...
  3. pmc Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, Bethesda, MD 20892, USA
    Blood 116:2476-83. 2010
    ..These data describe a novel pathophysiologic pathway for erythrophagocytosis in the context of tissue macrophage accumulation and inflammation involving elevations in IL-4 and alternative macrophage activation...
  4. pmc Cutting edge: lack of high affinity competition for peptide in polyclonal CD4+ responses unmasks IL-4 production
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:6569-73. 2010
    ..These results indicate that cells bearing TCRs that are weakly stimulated by their cognate Ag preferentially adopt a Th2 phenotype when primed in the absence of competition from cells with higher affinity receptors...
  5. ncbi request reprint Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma
    Joshua D Milner
    Department of Pediatrics, Children s National Medical Center, Washington, DC, USA
    Pediatrics 114:27-32. 2004
    ..The objective of this study was to determine whether early vitamin supplementation during infancy affects the risk for asthma and allergic disease during early childhood...
  6. ncbi request reprint Transient environmental exposures on the developing immune system: implications for allergy and asthma
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892 1892, USA
    Curr Opin Allergy Clin Immunol 5:235-40. 2005
    ..Some progress, however, has been made and some more candidates for study may be emerging. Of particular interest are micronutrients, whose ever-changing use and immunomodulatory capabilities make them prime targets for study...
  7. pmc Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation
    Andrea M Siegel
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD
    J Allergy Clin Immunol 132:1388-96. 2013
    ....
  8. pmc Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases
    John S Barber
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:8164-9. 2013
    ..These findings provide unique insight into the pathophysiology and functional consequences of abnormal T-cell repertoires and into differentiation of human naive T-cells...
  9. pmc Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis
    Elizabeth P Sampaio
    Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 131:1624-34. 2013
    ..Dominant gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1) have been associated with chronic mucocutaneous candidiasis...
  10. doi request reprint Intermediate phenotypes in patients with autosomal dominant hyper-IgE syndrome caused by somatic mosaicism
    Amy P Hsu
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 131:1586-93. 2013
    ..Autosomal dominant hyper-IgE syndrome (AD-HIES) is caused by mutations in signal transducer and activator of transcription 3 (STAT3). We describe 2 subjects in whom somatic mosaicism was associated with intermediate phenotypes...
  11. pmc Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:576-81. 2007
    ..Limited repertoire complexity of Tregs may lead to a failure to control induction of immunopathologic responses, and limitation in repertoire complexity of conventional cells may be responsible for the Th2 phenotype...
  12. ncbi request reprint Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development
    Xiaomin Yu
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    J Allergy Clin Immunol 133:1109-15. 2014
    ....
  13. ncbi request reprint A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3
    Scott M Steward-Tharp
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
    Blood 123:2978-87. 2014
    ..We found that these mice were susceptible to bacterial infection that was partially corrected by HSCT using wild-type bone marrow, emphasizing the role played by the epithelium in the pathophysiology of HIES. ..
  14. pmc Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions
    Michael J Ombrello
    Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 366:330-8. 2012
    ..Mendelian analysis of disorders of immune regulation can provide insight into molecular pathways associated with host defense and immune tolerance...
  15. pmc A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency
    Qing Zhou
    Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Am J Hum Genet 91:713-20. 2012
    ..Our results highlight the utility of exome-sequencing technology in finding causal mutations in nuclear families with dominantly inherited traits otherwise intractable by linkage analysis...
  16. pmc Altered T-cell receptor signaling in the pathogenesis of allergic disease
    Shrimati Datta
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    J Allergy Clin Immunol 127:351-4. 2011
    ..It is therefore important to attempt to identify a role for defects in TCR signaling in the pathogenesis of common atopic diseases...
  17. pmc Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome
    Gulbu Uzel
    Laboratory of Clinical Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1684, USA
    J Allergy Clin Immunol 131:1611-23. 2013
    ..The hypermorphic mutations are also associated with arterial aneurysms, autoimmunity, and squamous cell cancers...
  18. ncbi request reprint Th17 cells, Job's syndrome and HIV: opportunities for bacterial and fungal infections
    Joshua D Milner
    Allergic Inflammation Unit, Laboratory of Allergic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Curr Opin HIV AIDS 5:179-83. 2010
    ..This review highlights the underlying pathogenesis of these diseases and their relevance to HIV infection...
  19. pmc A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
    Andrea M Siegel
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 35:806-18. 2011
    ..These data point to a specific role for STAT3 in human central memory T cell formation and in control of certain chronic viruses...
  20. pmc Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease
    Kiyoshi Hirahara
    Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1930, USA
    J Allergy Clin Immunol 131:1276-87. 2013
    ..Finally, we will discuss factors, including epigenetic regulation and metabolic alterations, that contribute to helper cell specificity and plasticity...
  21. pmc Hypomorphic Rag mutations can cause destructive midline granulomatous disease
    Suk See De Ravin
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 116:1263-71. 2010
    ..This study was registered at www.clinicaltrials.gov as #NCT00128973...
  22. ncbi request reprint Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment
    Yu Zhang
    Laboratory of Host Defenses, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD
    J Allergy Clin Immunol 133:1400-9, 1409.e1-5. 2014
    ..Identifying genetic syndromes that lead to significant atopic disease can open new pathways for investigation and intervention in allergy...
  23. pmc Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management
    Linda M Griffith
    Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Allergy Clin Immunol 124:1152-60.e12. 2009
    ..Finally, we discuss the role of high-quality databases in treatment of PIDs and HCT as an element of the infrastructure that will be needed for productive multicenter clinical trials in these rare diseases...
  24. doi request reprint Autoimmunity in severe combined immunodeficiency (SCID): lessons from patients and experimental models
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, NIAID, NIH, Bethesda, MD, USA
    J Clin Immunol 28:S29-33. 2008
    ..It is thus of no surprise when both central and peripheral tolerance are impaired that autoimmunity can be observed in SCID...
  25. ncbi request reprint Does the experience with the use of nasal continuous positive airway pressure improve over time in extremely low birth weight infants?
    Hany Aly
    Departments of Pediatrics, George Washington University Medical Center and the Children s National Medical Center, Washington, DC, USA
    Pediatrics 114:697-702. 2004
    ..Our center has implemented this strategy of care over the past 4 years, and the objective of this study was to evaluate the impact of experience over time with the use of ENCPAP on outcomes of ELBW infants...
  26. ncbi request reprint Exogenous vitamin D might contribute to geographic variations in epinephrine prescriptions
    Joshua D Milner
    J Allergy Clin Immunol 121:265-6; author reply 266. 2008