L H Miller

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint CD36 peptides that block cytoadherence define the CD36 binding region for Plasmodium falciparum-infected erythrocytes
    D I Baruch
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 94:2121-7. 1999
  2. pmc B cell analysis of ethnic groups in Mali with differential susceptibility to malaria
    Silvia Portugal
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Malar J 11:162. 2012
  3. doi request reprint Malaria biology and disease pathogenesis: insights for new treatments
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA
    Nat Med 19:156-67. 2013
  4. pmc Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
    Amed Ouattara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, Bamako, Mali
    Malar J 9:175. 2010
  5. ncbi request reprint Evolution of the human genome under selective pressure from malaria: applications for control
    L H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Parassitologia 41:77-82. 1999
  6. pmc The Multilateral Initiative on Malaria: looking back and looking ahead
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Trends Parasitol 26:110-3. 2010
  7. ncbi request reprint Definition of the minimal domain of CIDR1alpha of Plasmodium falciparum PfEMP1 for binding CD36
    Louis H Miller
    Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook I, 5640 Fishers Lane, Rockville, MD 20852, USA
    Mol Biochem Parasitol 120:321-3. 2002
  8. pmc Artemisinin: discovery from the Chinese herbal garden
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Cell 146:855-8. 2011
  9. ncbi request reprint Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family
    J D Smith
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biochem Parasitol 110:293-310. 2000
  10. pmc The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes
    B Gamain
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:2664-9. 2001

Detail Information

Publications72

  1. ncbi request reprint CD36 peptides that block cytoadherence define the CD36 binding region for Plasmodium falciparum-infected erythrocytes
    D I Baruch
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 94:2121-7. 1999
    ..falciparum PE. Adherence blocking peptides from this region may be useful for modeling the PE/PfEMP1 interaction with CD36 and for development of potential anti-adhesion therapeutics...
  2. pmc B cell analysis of ethnic groups in Mali with differential susceptibility to malaria
    Silvia Portugal
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Malar J 11:162. 2012
    ..However, the proportions of B cell subsets in the Fulani and Dogon that may account for differences in the levels of Ig have not been characterized...
  3. doi request reprint Malaria biology and disease pathogenesis: insights for new treatments
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, USA
    Nat Med 19:156-67. 2013
    ..There is also a need for new therapies to reduce the high mortality of severe malaria. An understanding of the pathophysiology of severe disease may identify rational targets for drugs that improve survival...
  4. pmc Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine
    Amed Ouattara
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, Bamako, Mali
    Malar J 9:175. 2010
    ....
  5. ncbi request reprint Evolution of the human genome under selective pressure from malaria: applications for control
    L H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    Parassitologia 41:77-82. 1999
    ..Much of the work has important implications both for understanding pathogenesis and for applications for control of disease...
  6. pmc The Multilateral Initiative on Malaria: looking back and looking ahead
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Trends Parasitol 26:110-3. 2010
    ....
  7. ncbi request reprint Definition of the minimal domain of CIDR1alpha of Plasmodium falciparum PfEMP1 for binding CD36
    Louis H Miller
    Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook I, 5640 Fishers Lane, Rockville, MD 20852, USA
    Mol Biochem Parasitol 120:321-3. 2002
  8. pmc Artemisinin: discovery from the Chinese herbal garden
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Cell 146:855-8. 2011
    ....
  9. ncbi request reprint Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family
    J D Smith
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biochem Parasitol 110:293-310. 2000
    ..This information might be used to develop interventions targeting parasite binding variants that cause disease...
  10. pmc The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes
    B Gamain
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:2664-9. 2001
    ..The demonstration of cross-reactive epitopes on the PE surface provides further credence for development of effective vaccines against the variant antigen on the surface of P. falciparum-infected erythrocytes...
  11. pmc Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175
    D C Mayer
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4/126, Bethesda, MD 20892-0425, USA
    Proc Natl Acad Sci U S A 98:5222-7. 2001
    ..The interest in BAEBL's reduced binding to Gerbich erythrocytes derives from the high frequency of the Gerbich phenotype in some regions of Papua New Guinea where P. falciparum is hyperendemic...
  12. ncbi request reprint Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36
    B Gamain
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 97:3268-74. 2001
    ..These findings provide a molecular explanation for the inability of placental sequestered parasites to bind CD36 and provide additional insight into critical residues for the CIDR-1/CD36 interaction...
  13. ncbi request reprint P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1
    J A Rowe
    Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    Nature 388:292-5. 1997
    ..Thus we describe a new adhesive function for PfEMP1 and raise the possibility that CR1 polymorphisms in Africans that influence the interaction between erythrocytes and PfEMP1 may protect against severe malaria...
  14. pmc Efficacy of two alternate vaccines based on Plasmodium falciparum merozoite surface protein 1 in an Aotus challenge trial
    A W Stowers
    Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Inc, Rockville, Maryland 20852, USA
    Infect Immun 69:1536-46. 2001
    ..Vaccine formulation in an alternate adjuvant, MF59, resulted in significantly lower antibody titers and no protection...
  15. ncbi request reprint Are trials in New World monkeys on the critical path for blood-stage malaria vaccine development?
    A W Stowers
    Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infections Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Trends Parasitol 17:415-9. 2001
    ..Here, we argue that first proving efficacy in the New World monkey challenge model would accelerate development...
  16. ncbi request reprint International union of pharmacology. XXII. Nomenclature for chemokine receptors
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Pharmacol Rev 52:145-76. 2000
    ....
  17. pmc Evidence implicating MHC genes in the immunological nonresponsiveness to the Plasmodium falciparum CS protein
    M F Good
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD
    Bull World Health Organ 68:80-4. 1990
    ....
  18. ncbi request reprint Plasmodium falciparum protein associated with the invasion junction contains a conserved oxidoreductase domain
    D E Hudson-Taylor
    Laboratory of Malaria Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Microbiol 15:463-71. 1995
    ..By virtue of its positive charge, the C-terminal domain resembles domains in some cytoskeleton-associated proteins and may mediate the interaction of MCP-1 with cytoskeleton in Plasmodium...
  19. ncbi request reprint Plasmodium gallinaceum: differential killing of some mosquito stages of the parasite by insect defensin
    M Shahabuddin
    Medical Entomology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Exp Parasitol 89:103-12. 1998
    ....
  20. pmc The glycophorin C N-linked glycan is a critical component of the ligand for the Plasmodium falciparum erythrocyte receptor BAEBL
    D C Ghislaine Mayer
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 103:2358-62. 2006
    ..falciparum to recognize oligosaccharides on different erythrocyte surface glycoproteins or glycolipids, greatly increasing its invasion range...
  21. pmc Immunity to recombinant plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity
    Sanjay Singh
    Antigen Research Section, Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases National Institutes of Health, TW1, Rockville, Maryland 20852, USA
    Infect Immun 74:4573-80. 2006
    ....
  22. pmc Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex
    Yimin Wu
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 103:18243-8. 2006
    ..Protein antigen conjugation to OMPC or other protein carrier may have general application to a spectrum of protein subunit vaccines to increase immunogenicity without the need for potentially reactogenic adjuvants...
  23. ncbi request reprint Plasmodium falciparum: characterization of a late asexual stage golgi protein containing both ankyrin and DHHC domains
    Karl B Seydel
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Exp Parasitol 110:389-93. 2005
    ..falciparum. The timing of expression as well as the location of this protein suggests that it may play an important role in the sorting of proteins to the apical organelles during the development of the asexual stage of the parasite...
  24. ncbi request reprint Immunization of Aotus monkeys with recombinant cysteine-rich interdomain region 1 alpha protects against severe disease during Plasmodium falciparum reinfection
    Morris O Makobongo
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    J Infect Dis 193:731-40. 2006
    ..We determined whether a subunit vaccine to a portion of PfEMP1 could induce protection in nonhuman primates...
  25. ncbi request reprint Plasmodium vivax: transmission-blocking immunity in a malaria-endemic area of Colombia
    Myriam Arevalo-Herrera
    Instituto de Inmunología del Valle, Cali, Colombia
    Am J Trop Med Hyg 73:38-43. 2005
    ..This activity disappeared at a 1:4 dilution in most sera tested. Afro-Colombian individuals showed lower activity than other ethnic groups and febrile patients produced stronger inhibition than those without fever...
  26. ncbi request reprint Upregulation of expression of the reticulocyte homology gene 4 in the Plasmodium falciparum clone Dd2 is associated with a switch in the erythrocyte invasion pathway
    Deepak Gaur
    Laboratory of Malaria and Vector Research LMVR, National Institutes of Allergy and Infectious Diseases NIH, 12735 Twinbrook Parkway, Building Twinbrook III Room 3E 32D, Bethesda, MD 20892 8132, USA
    Mol Biochem Parasitol 145:205-15. 2006
    ..As Dd2(NM) is a selected subclone of Dd2, the marked upregulation of PfRH4 expression in Dd2(NM) suggests its role in erythrocyte invasion through the sialic acid independent pathway of Dd2(NM)...
  27. ncbi request reprint Overproduction of Pichia pastoris or Plasmodium falciparum protein disulfide isomerase affects expression, folding and O-linked glycosylation of a malaria vaccine candidate expressed in P. pastoris
    Chiawei W Tsai
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Disease, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA
    J Biotechnol 121:458-70. 2006
    ..The overproduction of PpPDI or PfPDI provides new platforms for expression of disulfide-rich malaria proteins...
  28. pmc posttranslational modification of recombinant Plasmodium falciparum apical membrane antigen 1: impact on functional immune responses to a malaria vaccine candidate
    Birgitte Giersing
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, Twinbrook I, Room 1210A, 5640 Fisher Lane, Rockville, Maryland 20852, USA
    Infect Immun 73:3963-70. 2005
    ..coli- and P. pastoris-derived antigens are immunologically and functionally equivalent and are unaffected by the posttranslational modification resulting from expression in these two systems...
  29. pmc Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria
    Elissa M Malkin
    Johns Hopkins University Bloomberg School of Public Health, Center for Immunization Research, 624 N Broadway, Room 217, Baltimore, MD 21205, USA
    Infect Immun 73:3677-85. 2005
    ..To our knowledge, this is the first AMA1 vaccine candidate to elicit functional immune responses in malaria-naive humans, and our results support the further development of this vaccine...
  30. pmc Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: a strategy for enhancing immunogenicity of malaria vaccine candidates
    Feng Qian
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA
    Vaccine 25:3923-33. 2007
    ..These conjugates now need to be tested in humans to determine if mice are predictive of the response in humans...
  31. pmc In immunization with Plasmodium falciparum apical membrane antigen 1, the specificity of antibodies depends on the species immunized
    Kazutoyo Miura
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
    Infect Immun 75:5827-36. 2007
    ....
  32. pmc The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure
    Michael M Klein
    Structural Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS Pathog 4:e1000147. 2008
    ..This new understanding of PfEMP1 structure will allow the use of better-defined PfEMP1 domains for functional studies, for the design of candidate vaccines, and for understanding the molecular basis of cytoadherence...
  33. pmc Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion
    Karen Hayton
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 8132, USA
    Cell Host Microbe 4:40-51. 2008
    ..nancymaae erythrocytes. Our results also suggest that PfRH5 is a parasite ligand for human infection, and that amino acid substitutions can cause its binding domain to recognize different human erythrocyte surface receptors...
  34. pmc Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51
    Yimin Wu
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, Rockville, Maryland, United States of America
    PLoS ONE 3:e2636. 2008
    ..This single blinded, dose escalating, controlled Phase 1 study assessed the safety and immunogenicity of recombinant Pfs25 and Pvs25 formulated with Montanide ISA 51, a water-in-oil emulsion...
  35. pmc Addition of CpG ODN to recombinant Pseudomonas aeruginosa ExoProtein A conjugates of AMA1 and Pfs25 greatly increases the number of responders
    Feng Qian
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Vaccine 26:2521-7. 2008
    ..The results obtained in this study indicate the potential use of a combination strategy to increase the number of responders to malarial antigens in humans...
  36. pmc Phase 1 study of a combination AMA1 blood stage malaria vaccine in Malian children
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
    PLoS ONE 3:e1563. 2008
    ..The aim of this study was to assess the safety and immunogenicity of this vaccine in young children in a malaria endemic area...
  37. ncbi request reprint Ex vivo cytokine and memory T cell responses to the 42-kDa fragment of Plasmodium falciparum merozoite surface protein-1 in vaccinated volunteers
    Maria Cecilia Huaman
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    J Immunol 180:1451-61. 2008
    ..The identification of human-specific CD4(+) memory T cells provides the foundation for future studies of these cells both after vaccination and in field studies...
  38. pmc Development and characterization of a standardized ELISA including a reference serum on each plate to detect antibodies induced by experimental malaria vaccines
    Kazutoyo Miura
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Vaccine 26:193-200. 2008
    ..Since this ELISA method gives reliable antibody titer with less labor than other methods, it can strongly support vaccine development...
  39. pmc Mononeme: a new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease
    Subhash Singh
    Malaria Cell Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 104:20043-8. 2007
    ..We have named this single thread-like organelle in merozoites, the mononeme...
  40. pmc Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion
    Deepak Gaur
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook III, 12735 Twinbrook Parkway, Bethesda, MD 20892 8132, USA
    Proc Natl Acad Sci U S A 104:17789-94. 2007
    ..These findings suggest that, although PfRH4 is required for invasion of neuraminidase-treated erythrocytes by Dd2/NM, it is inaccessible for antibody-mediated inhibition of the invasion process...
  41. pmc Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians
    Alassane Dicko
    Malaria Research and Training Center, Department of Hematology, University of Bamako, Bamako, Mali
    PLoS ONE 2:e1045. 2007
    ..After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels...
  42. pmc Long-lasting and transmission-blocking activity of antibodies to Plasmodium falciparum elicited in mice by protein conjugates of Pfs25
    Joanna Kubler-Kielb
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, 31 Center Drive, MSC 2423, Bethesda, MD 20892 2520, USA
    Proc Natl Acad Sci U S A 104:293-8. 2007
    ..The observed transmission-blocking activity of immune sera correlated with antibody levels measured by ELISA...
  43. ncbi request reprint Improved yield of recombinant merozoite Surface protein 3 (MSP3) from Pichia pastoris using chemically defined media
    Jin Wang
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, Maryland 20852, USA
    Biotechnol Bioeng 90:838-47. 2005
    ..pastoris biomass generated at a high specific growth rate (0.04/h) nor low induction temperatures during induction improved yield. Nitrogen source was the most important factor affecting expression of MSP3 in defined media...
  44. ncbi request reprint Progress in the development of recombinant and synthetic blood-stage malaria vaccines
    Siddhartha Mahanty
    Malaria Vaccine Development Unit, NIAID, NIH, Twin Brook I, 5640 Fishers Lane, Rockville, MD 20852, USA
    J Exp Biol 206:3781-8. 2003
    ..Results from trials of asexual blood stage vaccine that support the continued effort to develop these antigens as key ingredients of multicomponent, multistage malaria vaccines are documented...
  45. pmc DNA immunization with the cysteine-rich interdomain region 1 of the Plasmodium falciparum variant antigen elicits limited cross-reactive antibody responses
    Dror I Baruch
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 71:4536-43. 2003
    ..These sera also appeared to give limited low-titer variant transcending agglutination. Thus, DNA immunization appears to be a very useful tool for developing variant antigen vaccines...
  46. pmc Polymorphism in a Plasmodium falciparum erythrocyte-binding ligand changes its receptor specificity
    D C Ghislaine Mayer
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Building 4 Room B1 41, Bethesda, MD 20892, USA
    J Exp Med 196:1523-8. 2002
    ..These results suggest that P. falciparum has evolved multiple invasion pathways dependent on polymorphisms in the BAEBL ligand...
  47. pmc Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria
    Anthony W Stowers
    Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Infect Immun 70:6961-7. 2002
    ..The protection induced by a combination vaccine of AMA1 and MSP1 was not superior to the protection obtained with AMA1 alone, although the immunity generated appeared to operate against both vaccine components...
  48. pmc In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response
    Michael C Kennedy
    Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Infect Immun 70:6948-60. 2002
    ....
  49. ncbi request reprint Malaria--a shadow over Africa
    Louis H Miller
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 298:121-2. 2002
    ..The completed genomes of Plasmodium falciparum and its vector Anopheles gambiae represent a big step toward the discovery of these needed tools...
  50. ncbi request reprint A high malaria reinfection rate in children and young adults living under a low entomological inoculation rate in a periurban area of Bamako, Mali
    Issaka Sagara
    Malaria Research and Training Center, Département d épidémiologie des affections parasitaires, Faculte de Medicine, de Pharmacie et d Odonto Stomatologie, Université du Mali, Bamako
    Am J Trop Med Hyg 66:310-3. 2002
    ..5 infected bites/person/month. The finding that reinfection rates were high despite low EIRs suggests that a low EIR may be sufficient to support small sample size vaccine efficacy trials in mesoendemic areas...
  51. pmc Molecular basis for the dichotomy in Plasmodium falciparum adhesion to CD36 and chondroitin sulfate A
    Benoit Gamain
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:10020-4. 2002
    ..Furthermore, we propose a model explaining the requirement for structural dichotomy between placental and nonplacental isolates...
  52. ncbi request reprint Aotus New World monkeys: model for studying malaria-induced anemia
    Andrea F Egan
    Malaria Vaccines Section and Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 99:3863-6. 2002
    ..We demonstrate that Aotus monkeys are a nonhuman primate model to gain insight into the pathogenesis of severe anemia in African children...
  53. pmc Immunization of Aotus monkeys with a functional domain of the Plasmodium falciparum variant antigen induces protection against a lethal parasite line
    Dror I Baruch
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:3860-5. 2002
    ..The level of protection and the evidence of boosting during infection encourage further exploration of this concept for malaria vaccine development...
  54. ncbi request reprint Merozoite surface protein 3 and protection against malaria in Aotus nancymai monkeys
    Hajime Hisaeda
    Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIH, Rockville, MD 20852, USA
    J Infect Dis 185:657-64. 2002
    ..In the MSP3-vaccinated group, protection correlated with prechallenge titers of antibody to MSP3. In the MSP1 and control groups, protection correlated with antibody to MSP3 raised by challenge infection...
  55. ncbi request reprint The pathogenic basis of malaria
    Louis H Miller
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 415:673-9. 2002
    ..The inability of many countries to fund expensive campaigns and antimalarial treatment requires these tools to be highly effective and affordable...
  56. ncbi request reprint Two worlds of malaria
    Thomas E Wellems
    National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA
    N Engl J Med 349:1496-8. 2003
  57. pmc Induction of crossreactive antibodies against the Plasmodium falciparum variant protein
    Sylvie Gratepanche
    Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases National Institutes of Health, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 100:13007-12. 2003
    ..The induced crossreactivity suggests that an anti-PfEMP1 vaccine may be possible...
  58. pmc Plasmodium falciparum is able to invade erythrocytes through a trypsin-resistant pathway independent of glycophorin B
    Deepak Gaur
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Infect Immun 71:6742-6. 2003
    ..Thus, P. falciparum is able to invade erythrocytes through a glycophorin B-independent, trypsin-resistant pathway...
  59. ncbi request reprint Phase 1 vaccine trial of Pvs25H: a transmission blocking vaccine for Plasmodium vivax malaria
    Elissa M Malkin
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Twinbrook 1, Room 1123, Rockville, MD 20852, USA
    Vaccine 23:3131-8. 2005
    ..Pvs25H generates transmission blocking immunity in humans against P. vivax demonstrating the potential of this antigen as a component of a transmission blocking vaccine...
  60. pmc Domain III of Plasmodium falciparum apical membrane antigen 1 binds to the erythrocyte membrane protein Kx
    Kentaro Kato
    Laboratory of Malaria and Vector Research and Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Proc Natl Acad Sci U S A 102:5552-7. 2005
    ....
  61. ncbi request reprint Identification of multiple chondroitin sulfate A (CSA)-binding domains in the var2CSA gene transcribed in CSA-binding parasites
    Benoit Gamain
    Unité de Biologie des Interactions Hôte Parasite, URA 2581, Institut Pasteur, Paris, France
    J Infect Dis 191:1010-3. 2005
    ..The identification of multiple binding domains in var2CSA strengthens the evidence for their involvement in malaria during pregnancy and may have applications for the development of a vaccine against malaria in pregnancy...
  62. ncbi request reprint Parasite ligand-host receptor interactions during invasion of erythrocytes by Plasmodium merozoites
    Deepak Gaur
    Laboratory of Malaria and Vector Research, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Building Twinbrook III Room 3E 32D, Bethesda, MD 20892 8132, USA
    Int J Parasitol 34:1413-29. 2004
    ..Here we review the current state of knowledge about the receptor-ligand interactions that mediate merozoite invasion of erythrocytes...
  63. ncbi request reprint Identification of a 67-amino-acid region of the Plasmodium falciparum variant surface antigen that binds chondroitin sulphate A and elicits antibodies reactive with the surface of placental isolates
    Benoit Gamain
    Laboratory of Molecular and Vector Research, NIAID, NIH, Bethesda, MD 20892 0425, USA
    Mol Microbiol 53:445-55. 2004
    ..The identification of a minimal binding region from a highly variable cytoadherent family may have application for a vaccine against malaria in pregnancy...
  64. pmc Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites
    Puran S Sijwali
    Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143 0811, USA
    Proc Natl Acad Sci U S A 101:8721-6. 2004
    ..Our results indicate that although falcipain-1 is expressed by erythrocytic parasites, it is not essential for normal development during this stage or for erythrocyte invasion...
  65. pmc Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL/EBA-181 alters its receptor specificity
    D C Ghislaine Mayer
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Room 4126, Bethesda, MD 20892 0425, USA
    Proc Natl Acad Sci U S A 101:2518-23. 2004
    ..falciparum may have been successful in endemic areas because it has mutated the ligands of the DBL family to create multiple pathways of invasion, thus making selection of refractory erythrocytes unlikely...
  66. ncbi request reprint Infected erythrocyte binding to hyaluronic acid and malaria in pregnant women
    Joseph D Smith
    J Infect Dis 189:165-8. 2004
  67. ncbi request reprint Plasmodium biology: genomic gleanings
    L Aravind
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Cell 115:771-85. 2003
    ..Plasmodium possesses many cell surface molecules with "animal-like" adhesion modules. Potential genetic footprints of the ancestral eukaryotic algal precursor of the apicoplast are also detectable in its genome...
  68. pmc Biochemical and immunological characterization of bacterially expressed and refolded Plasmodium falciparum 42-kilodalton C-terminal merozoite surface protein 1
    Sanjay Singh
    Malaria Vaccine Development Unit, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA
    Infect Immun 71:6766-74. 2003
    ..falciparum. The protection correlated with antibody-dependent mechanisms. Thus, this new construct, E. coli MSP1(42), is a viable candidate for human vaccine trials...
  69. pmc A recombinant vaccine expressed in the milk of transgenic mice protects Aotus monkeys from a lethal challenge with Plasmodium falciparum
    Anthony W Stowers
    Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA
    Proc Natl Acad Sci U S A 99:339-44. 2002
    ..This study demonstrates the potential for producing efficacious malarial vaccines in transgenic animals...
  70. ncbi request reprint The etiology of severe anemia in a village and a periurban area in Mali
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, PO Box 1805, Bamako, Mali
    Blood 104:1198-200. 2004
    ..2 years of age. Raising the baseline hemoglobin level and lowering peak parasitemia in infants and young children may reduce the incidence of severe anemia resulting from malarial infection...
  71. ncbi request reprint Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity
    Alassane Dicko
    Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
    Am J Trop Med Hyg 77:1028-33. 2007
    ..Our results suggest that, although the age distribution of clinical malaria depends on transmission intensity, the total burden of disease may be similar or higher in settings of low transmission...
  72. ncbi request reprint Revisiting Freund's incomplete adjuvant for vaccines in the developing world
    Louis H Miller
    Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook 1, 5640 Fishers Lane, Rockville, MD 20818, USA
    Trends Parasitol 21:412-4. 2005
    ....