F G Miller

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Debriefing and accountability in deceptive research
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 18:235-51. 2008
  2. doi request reprint Clinical equipoise and risk-benefit assessment
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Clin Trials 9:621-7. 2012
  3. doi request reprint The enduring legacy of sham-controlled trials of internal mammary artery ligation
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Prog Cardiovasc Dis 55:246-50. 2012
  4. doi request reprint Homage to Henry Beecher (1904-1976)
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Perspect Biol Med 55:218-29. 2012
  5. pmc The power of context: reconceptualizing the placebo effect
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, USA
    J R Soc Med 101:222-5. 2008
  6. doi request reprint Deception of subjects in neuroscience: an ethical analysis
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    J Neurosci 28:4841-3. 2008
  7. ncbi request reprint Clinical equipoise and the incoherence of research ethics
    Franklin G Miller
    Department of Clinical Bioethics Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    J Med Philos 32:151-65. 2007
  8. pmc Acupuncture trials and informed consent
    F G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, Maryland, USA
    J Med Ethics 33:43-4. 2007
  9. doi request reprint The dead donor rule: can it withstand critical scrutiny?
    Franklin G Miller
    National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Med Philos 35:299-312. 2010
  10. ncbi request reprint The nature and power of the placebo effect
    Franklin G Miller
    Intramural Research Program, National Institute of Mental Health, Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    J Clin Epidemiol 59:331-5. 2006

Detail Information

Publications93

  1. ncbi request reprint Debriefing and accountability in deceptive research
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 18:235-51. 2008
    ..We also present recommendations concerning the discussion of deception in scientific articles reporting the results of research using deception...
  2. doi request reprint Clinical equipoise and risk-benefit assessment
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Clin Trials 9:621-7. 2012
    ..Each of these arguments fails to support clinical equipoise, leading to the conclusion that we should dispense with this principle in risk-benefit assessment of RCTs...
  3. doi request reprint The enduring legacy of sham-controlled trials of internal mammary artery ligation
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Prog Cardiovasc Dis 55:246-50. 2012
    ..Revisiting the story of internal mammary artery ligation offers valuable insights into the ethics of sham-controlled trials and the implications of the placebo effect for thinking about risk-benefit assessment of sham procedures...
  4. doi request reprint Homage to Henry Beecher (1904-1976)
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Perspect Biol Med 55:218-29. 2012
    ..To appreciate Beecher's legacy, it is salutary to explicate the significance of his enduring contributions and to critically evaluate their limitations...
  5. pmc The power of context: reconceptualizing the placebo effect
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, USA
    J R Soc Med 101:222-5. 2008
  6. doi request reprint Deception of subjects in neuroscience: an ethical analysis
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    J Neurosci 28:4841-3. 2008
  7. ncbi request reprint Clinical equipoise and the incoherence of research ethics
    Franklin G Miller
    Department of Clinical Bioethics Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    J Med Philos 32:151-65. 2007
    ..In the final sections of the article, we elaborate on the non-exploitation framework for the ethics clinical research and indicate issues that warrant further inquiry...
  8. pmc Acupuncture trials and informed consent
    F G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, Maryland, USA
    J Med Ethics 33:43-4. 2007
    ..Participants in placebo-controlled acupuncture trials should be provided an accurate disclosure regarding the use of sham acupuncture, consistent with the practice of placebo-controlled drug trials...
  9. doi request reprint The dead donor rule: can it withstand critical scrutiny?
    Franklin G Miller
    National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Med Philos 35:299-312. 2010
    ..This leaves the current practice of organ transplantation based on the "moral fiction" that donors are dead when vital organs are procured...
  10. ncbi request reprint The nature and power of the placebo effect
    Franklin G Miller
    Intramural Research Program, National Institute of Mental Health, Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    J Clin Epidemiol 59:331-5. 2006
    ....
  11. ncbi request reprint Ethical issues in surgical research
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Thorac Surg Clin 15:543-54. 2005
    ....
  12. pmc The relevance of empirical research in bioethics
    Franklin G Miller
    Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Schizophr Bull 32:37-41. 2006
    ..In order to examine the value and limitations of ethics-related empirical research, we discuss 3 case studies involving research with stored biological samples, placebo-controlled trials, and the idea of the therapeutic misconception...
  13. ncbi request reprint Viewpoint: professional integrity in industry-sponsored clinical trials
    Franklin G Miller
    Unit on Clinical Research, Department of Clinical Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, Maryland 20892, USA
    Acad Med 80:899-904. 2005
    ..Educational interventions promoting integrity in clinical research may be one part of affecting such change...
  14. pmc Deception in research on the placebo effect
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Med 2:e262. 2005
  15. doi request reprint Is it ethical to keep interim findings of randomised controlled trials confidential?
    F G Miller
    Department of Clinical Bioethics, NIH Clinical Center, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    J Med Ethics 34:198-201. 2008
    ..Taken together, these considerations suggest confidential data monitoring, subject to adequate safeguards, is ethically acceptable...
  16. ncbi request reprint William James, faith, and the placebo effect
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Perspect Biol Med 48:273-81. 2005
    ....
  17. doi request reprint Coverage with evidence development: ethical issues and policy implications
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Med Care 46:746-51. 2008
    ..In this article we review the policy rationale for CED and present a normative analysis that addresses ethical concerns and policy implications...
  18. doi request reprint An apology for Socratic bioethics
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Am J Bioeth 8:3-7. 2008
    ..In this article we explore tensions between these two dimensions of bioethics and examine the merits and perils of a "Socratic" approach to bioethics that challenges "the conventional wisdom."..
  19. doi request reprint Dispensing with equipoise
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Am J Med Sci 342:276-81. 2011
    ..I conclude that it is time to dispense with equipoise. The principles of research ethics are sufficient to provide adequate guidance to protect subjects and to promote socially valuable research without any appeal to equipoise...
  20. doi request reprint Research and complicity: the case of Julius Hallervorden
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Med Ethics 38:53-6. 2012
    ..It is argued that this case constitutes a paradigm of complicity in research that is useful in assessing complicity in contemporary research ethics...
  21. doi request reprint The placebo phenomenon and medical ethics: rethinking the relationship between informed consent and risk-benefit assessment
    Franklin G Miller
    Department of Bioethics Clinical Center, National Institutes of Health, Building 10, Bethesda, MD 20892 1156, USA
    Theor Med Bioeth 32:229-43. 2011
    ..In this paper we discuss the implications of placebo and nocebo research for risk-benefit assessment and informed consent...
  22. doi request reprint Understanding and harnessing placebo effects: clearing away the underbrush
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892, USA
    J Med Philos 36:69-78. 2011
    ..Clearing away the conceptual underbrush is needed to lay down a path to understanding and harnessing placebo effects in clinical medicine...
  23. doi request reprint Semiotics and the placebo effect
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Perspect Biol Med 53:509-16. 2010
    ..The semiotic approach dovetails with the various psychological mechanisms invoked to account for placebo effects, such as conditioning and expectation, and bridges the biological and cultural dimensions of this fascinating phenomenon...
  24. doi request reprint Decapitation and the definition of death
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Med Ethics 36:632-4. 2010
    ..In this article we refute this 'decapitation gambit.' We argue that decapitated animals are not necessarily dead, and that, moreover, the analogy between decapitation and the clinical syndrome of brain death is flawed...
  25. doi request reprint The legitimacy of placebo treatments in clinical practice: evidence and ethics
    Franklin G Miller
    Department of Bioethics Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Am J Bioeth 9:39-47. 2009
    ..The conclusion is reached that based on currently available evidence, it is premature to judge whether placebo treatments are ethically justifiable, with the possible exception of acupuncture for pain relief...
  26. pmc The placebo effect: illness and interpersonal healing
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Perspect Biol Med 52:518-39. 2009
    ..Finally, we argue that research on the placebo effect has the potential to revitalize the art of medicine...
  27. doi request reprint Death and organ donation: back to the future
    F G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    J Med Ethics 35:616-20. 2009
    ..To understand the ethical situation that we now face, it is helpful to revisit the writings of the philosopher Hans Jonas, who forcefully challenged the emerging effort to redefine death in the late 1960s...
  28. doi request reprint Moral fictions and medical ethics
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Bioethics 24:453-60. 2010
    ..When these moral fictions are exposed, it becomes apparent that conventional medical ethics relating to end-of-life decisions is radically mistaken...
  29. doi request reprint Limits to research risks
    F G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Building 10, Bethesda, Maryland 208921 156, USA
    J Med Ethics 35:445-9. 2009
    ..However, attention to the uncertainty of potential social benefit that can be derived from any particular study warrants caution in exposing prospective research participants to a substantial likelihood of serious harm...
  30. doi request reprint Benefit in phase 1 oncology trials: therapeutic misconception or reasonable treatment option?
    Franklin G Miller
    Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Clin Trials 5:617-23. 2008
    ..Motivation to enroll in these studies to receive personal benefit does not, in itself, compromise informed consent...
  31. pmc Sham procedures and the ethics of clinical trials
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    J R Soc Med 97:576-8. 2004
  32. ncbi request reprint When do the federal regulations allow placebo-controlled trials in children?
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, Maryland, USA
    J Pediatr 142:102-7. 2003
  33. ncbi request reprint Unnecessary use of placebo controls: the case of asthma clinical trials
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Arch Intern Med 162:1673-7. 2002
  34. ncbi request reprint Sham surgery: an ethical analysis
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Sci Eng Ethics 10:157-66. 2004
    ....
  35. ncbi request reprint Ethical issues in research with healthy volunteers: risk-benefit assessment
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bldg 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Clin Pharmacol Ther 74:513-5. 2003
  36. ncbi request reprint The ethical relevance of the standard of care in the design of clinical trials
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Am J Respir Crit Care Med 169:562-4. 2004
  37. ncbi request reprint Ethical assessment of industry-sponsored clinical trials: a case analysis
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Chest 121:1337-42. 2002
    ....
  38. ncbi request reprint Clinical research with healthy volunteers: an ethical framework
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Building 10, Room 1C118, Bethesda, MD 20892 1156, USA
    J Investig Med 51:S2-5. 2003
    ....
  39. ncbi request reprint The therapeutic orientation to clinical trials
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    N Engl J Med 348:1383-6. 2003
  40. ncbi request reprint The ethical challenge of infection-inducing challenge experiments
    F G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Clin Infect Dis 33:1028-33. 2001
    ....
  41. ncbi request reprint Reporting of ethical issues in publications of medical research
    Franklin G Miller
    Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Lancet 360:1326-8. 2002
    ..We recommend a policy of extensive reporting of pertinent ethical issues to promote public accountability for clinical research. Guidelines are presented, and possible objections to this recommended policy are addressed...
  42. ncbi request reprint Does research ethics rest on a mistake?
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, USA
    Am J Bioeth 5:34-6; author reply W15-8. 2005
  43. ncbi request reprint Assessing the ethics of ethics research: a case study
    Franklin G Miller
    Unit on Clinical Research, Department of Clinical Bioethics, National Institutes of Health, USA
    IRB 26:9-12. 2004
  44. pmc Assessing research risks systematically: the net risks test
    D Wendler
    Department of Clinical Bioethics, The NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA
    J Med Ethics 33:481-6. 2007
    ....
  45. ncbi request reprint Equipoise and the ethics of clinical research revisited
    Franklin G Miller
    National Institutes of Health, USA
    Am J Bioeth 6:59-61; discussion W42-5. 2006
  46. ncbi request reprint Principles of early stopping of randomized trials for efficacy: a critique of equipoise and an alternative nonexploitation ethical framework
    David Buchanan
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 15:161-78. 2005
    ....
  47. ncbi request reprint The incoherence of determining death by neurological criteria: a commentary on "Controversies in the determination of death", a White Paper by the President's Council on Bioethics
    Franklin G Miller
    Department of Bioethics, National Institute of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 19:185-93. 2009
    ..According to the position of this committee, patients diagnosed with the cessation of brain function are dead, despite the fact that they breathe and circulate blood with the aid of mechanical ventilation...
  48. ncbi request reprint Is placebo surgery unethical?
    Sam Horng
    National Institutes of Health, Bethesda, MD 20892 1156, USA
    N Engl J Med 347:137-9. 2002
  49. ncbi request reprint The internal morality of medicine: an evolutionary perspective
    F G Miller
    Intramural Research Program, Department of Clinical Bioethics, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    J Med Philos 26:581-99. 2001
    ....
  50. ncbi request reprint Ethical aspects of research into the etiology of autism
    Donna T Chen
    Office of Clinical Director, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Ment Retard Dev Disabil Res Rev 9:48-53. 2003
    ....
  51. ncbi request reprint Clinical research and the physician-patient relationship
    Donna T Chen
    Department of Clinical Bioethics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Ann Intern Med 138:669-72. 2003
    ..In addition, we suggest how preparation for advising patients about clinical research participation can be incorporated into the medical education process...
  52. ncbi request reprint National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders
    Dennis S Charney
    Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:262-70. 2002
    ..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research...
  53. ncbi request reprint Ethical framework for the use of sham procedures in clinical trials
    Sam Horng
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Crit Care Med 31:S126-30. 2003
    ....
  54. ncbi request reprint Enrolling decisionally impaired adults in clinical research
    Donna T Chen
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1156, USA
    Med Care 40:V20-9. 2002
    ....
  55. ncbi request reprint Enrolling the uninsured in clinical trials: an ethical perspective
    Christine Pace
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Crit Care Med 31:S121-5. 2003
    ..We discuss these competing issues and make recommendations for how investigators can both protect uninsured research participants and provide the uninsured with fair access to research in their recruitment and enrollment strategies...
  56. ncbi request reprint Rethinking the ethics of vital organ donations
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, USA
    Hastings Cent Rep 38:38-46. 2008
    ..Explicitly jettisoning the rule -- allowing vital organs to be extracted, under certain conditions, from living patients -- is a radical change only at the conceptual level. But it would expand the pools of eligible organ donors...
  57. doi request reprint When scientists deceive: applying the federal regulations
    Collin C O'Neil
    Department of Bioethics, National Institutes of Health, USA
    J Law Med Ethics 37:344-50. 2009
    ..To illustrate our interpretation, we apply the conditions to a recent study that used deception to show that subjects judged the same wine as more enjoyable when they believed it had a higher price...
  58. doi request reprint Role of expectations in health
    Luana Colloca
    National Center for Complementary and Alternative Medicine NCCAM, National Institutes of Health, USA
    Curr Opin Psychiatry 24:149-55. 2011
    ..We selected recent laboratory and clinical studies in the field of the placebo effect, with a particular focus on psychiatric disorders...
  59. ncbi request reprint Ethical considerations in psychopharmacological research involving decisionally impaired subjects
    Donald L Rosenstein
    National Institute of Mental Health, Building 10, Room 3N242, 10 Center Drive MSC 1276, MD 20892 1276, Bethesda, USA
    Psychopharmacology (Berl) 171:92-7. 2003
    ....
  60. ncbi request reprint Responding to medical pluralism in practice: a principled ethical approach
    Jon C Tilburt
    Department of Clinical Bioethics, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD 20892, USA
    J Am Board Fam Med 20:489-94. 2007
    ..In this way, recognition of medical pluralism can help clinicians enhance patient care in a manner consistent with basic ethical principles...
  61. ncbi request reprint Deception in the pursuit of science
    David Wendler
    Department of Clinical Bioethics, National Institutes of Health, Bldg 10, Room 1C118, Bethesda, MD 20892, USA
    Arch Intern Med 164:597-600. 2004
  62. ncbi request reprint Evaluating the therapeutic misconception
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 16:353-66. 2006
    ..After clarifying the ethical significance of the therapeutic misconception with respect to the decision making of patients, we offer policy recommendations for obtaining informed consent to participation in clinical trials...
  63. ncbi request reprint Money and distorted ethical judgments about research: ethical assessment of the TeGenero TGN1412 trial
    Ezekiel J Emanuel
    Department of Clinical Bioethics, The Clinical Center, National Institutes of Health, Bethesda, MD 20892 1156, USA
    Am J Bioeth 7:76-81. 2007
    ....
  64. ncbi request reprint Ethical issues concerning research in complementary and alternative medicine
    Franklin G Miller
    Department of Clinical Bioethics, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 291:599-604. 2004
    ..In addition, we explore the legitimacy of providing CAM and conventional therapies that have been demonstrated to be effective only by virtue of the placebo effect...
  65. ncbi request reprint The state of research ethics: a tribute to John C. Fletcher
    Franklin G Miller
    Unit on Clinical Research, Department of Clinical Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Clin Ethics 16:355-64. 2005
  66. doi request reprint Quality-improvement research and informed consent
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 358:765-7. 2008
  67. doi request reprint Payment for research participation: a coercive offer?
    A Wertheimer
    Department of Bioethics, Clinical Center, National Institutes of Health, Building 10, Bethesda, Maryland 20892 1156, USA
    J Med Ethics 34:389-92. 2008
    ..In this article we analyse the concept of coercion, refute mistaken conceptions of coercion and explain why the offer of payment for research participation is never coercive but in some cases may produce undue inducement...
  68. ncbi request reprint A response to commentators on "Sham surgery: an ethical analysis"
    Franklin G Miller
    Department of Clinical Bioethics, National Institutes of Health
    Am J Bioeth 3:W36. 2003
  69. ncbi request reprint A normative justification for distinguishing the ethics of clinical research from the ethics of medical care
    Paul Litton
    Department of Clinical Bioethics, National Institutes of Health, USA
    J Law Med Ethics 33:566-74. 2005
  70. ncbi request reprint Facing up to paternalism in research ethics
    Franklin G Miller
    National Institutes of Health, USA
    Hastings Cent Rep 37:24-34. 2007
    ..Paternalism has limits, however. Getting clear on the paternalism of research ethics may mean some kinds of prohibited research should be reassessed...
  71. doi request reprint Is emergency research without initial consent justified?: the consent substitute model
    Emily A Largent
    National Institutes of Health, 10 Center Dr, Bldg 10, Room 1C118, Bethesda, MD 20892 1156, USA
    Arch Intern Med 170:668-74. 2010
    ..Together, these conditions constitute an ethical substitute for informed consent in emergency research-forming the consent substitute model...
  72. doi request reprint Research on medical records without informed consent
    Franklin G Miller
    Department of Bioethics, National Institutes of Health, USA
    J Law Med Ethics 36:560-6. 2008
    ..This article analyzes the scope of these norms and provides an ethical justification for research using personally identifiable medical information without consent...
  73. ncbi request reprint Research with stored biological samples: what do research participants want?
    Donna T Chen
    Department of Clinical Bioethics, Warren G Magnuson Clinical Center, and National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Intern Med 165:652-5. 2005
    ..Many believe consent for each future use is required to respect individuals. Others worry this approach may block important research...
  74. ncbi request reprint A curriculum for teaching psychiatric research bioethics
    D L Rosenstein
    National Institute of Mental Health, Bethesda, Maryland 20892-1277, USA
    Biol Psychiatry 50:802-8. 2001
    ..Our initial experience with a formal curriculum in psychiatric research bioethics suggests that this educational activity has been both meaningful and relevant for psychiatrists training to be clinical investigators...
  75. ncbi request reprint The ethics of research on enhancement interventions
    Ori Lev
    Department of Bioethics, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA
    Kennedy Inst Ethics J 20:101-13. 2010
    ..Instead, like any other clinical research, each proposed enhancement study should be reviewed individually to assess whether it fulfills the ethical requirements that make a clinical study permissible...
  76. ncbi request reprint Enhancement technologies and professional integrity
    Franklin G Miller
    National Institutes of Health, USA
    Am J Bioeth 5:15-7; discussion W4-9. 2005
  77. ncbi request reprint Medicare's requirement for research participation as a condition of coverage: is it ethical?
    Steven D Pearson
    Department of Clinical Bioethics, National Institutes of Health, Bethesda, MD 20892, USA
    JAMA 296:988-91. 2006
  78. ncbi request reprint What makes placebo-controlled trials unethical?
    Franklin G Miller
    National Institutes of Health
    Am J Bioeth 2:3-9. 2002
    ..Placebo controls are ethically justifiable when they are supported by sound methodological considerations and their use does not expose research participants to excessive risks of harm...
  79. ncbi request reprint The clinician-investigator: unavoidable but manageable tension
    Howard Brody
    Center for Ethics and Humanities in the Life Sciences, Michigan State University, East Lansing, Michigan, USA
    Kennedy Inst Ethics J 13:329-46. 2003
    ..The difference position provides a sound ethical framework within which to manage those tensions, while the similarity position is unsatisfactory because it seeks to deny the existence of the tensions...
  80. ncbi request reprint Placebo research and the spirit of informed consent
    Franklin G Miller
    Psychosom Med 67:678; author reply 678. 2005
  81. ncbi request reprint Twenty-five years of therapeutic misconception
    Franklin G Miller
    Hastings Cent Rep 38:6; author reply 6-7. 2008
  82. ncbi request reprint Sham surgery: an ethical analysis
    Franklin G Miller
    National Institutes of Health
    Am J Bioeth 3:41-8. 2003
    ....
  83. ncbi request reprint Bench to bedside: mapping the moral terrain of clinical research
    Steven Joffe
    Hastings Cent Rep 38:30-42. 2008
    ..We need an entirely new conception of clinical research ethics - one that looks to science instead of the doctor-patient relationship...
  84. pmc Communicating the results of clinical research to participants: attitudes, practices, and future directions
    David I Shalowitz
    Bioethics Program, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS Med 5:e91. 2008
  85. doi request reprint A plea for pragmatism in clinical research ethics
    David H Brendel
    Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA
    Am J Bioeth 8:24-31. 2008
    ....
  86. pmc Clinical trials and medical care: defining the therapeutic misconception
    Gail E Henderson
    University of North Carolina at ChapelHill, Chapel Hill, North Carolina, United Statesof America
    PLoS Med 4:e324. 2007
  87. doi request reprint The dead donor rule and organ transplantation
    Robert D Truog
    Department of Anesthesia, Harvard Medical School and Division of Critical Care Medicine, Children s Hospital Boston, USA
    N Engl J Med 359:674-5. 2008
  88. doi request reprint Deceptive research
    Franklin G Miller
    Arch Gen Psychiatry 65:1225-6; author reply 1226. 2008
  89. ncbi request reprint A critique of clinical equipoise. Therapeutic misconception in the ethics of clinical trials
    Franklin G Miller
    Hastings Cent Rep 33:19-28. 2003
    ..quot;Clinical equipoise" is necessary. But this perspective is flawed. The ethics of research and of therapy are fundamentally different, and clinical equipoise should be abandoned...
  90. ncbi request reprint Rethinking risk-benefit assessment for phase I cancer trials
    Steven Joffe
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA
    J Clin Oncol 24:2987-90. 2006
  91. ncbi request reprint Painful deception
    Franklin G Miller
    Science 304:1109-11; author reply 1109-11. 2004
  92. ncbi request reprint Ethical significance of ethics-related empirical research
    Franklin G Miller
    J Natl Cancer Inst 94:1821-2. 2002
  93. ncbi request reprint Control group selection in critical care randomized controlled trials evaluating interventional strategies: An ethical assessment
    Henry J Silverman
    University of Maryland School of Medicine, Baltimore, MD, USA
    Crit Care Med 32:852-7. 2004
    ....