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Genomes and GenesSpecies | Edgar R MillerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
The effects of macronutrients on blood pressure and lipids: an overview of the DASH and OmniHeart trialsEdgar R Miller
National Institute on Aging, National Institutes of Health, 3001 South Hanover Street, 5th Floor, Room NM 530, Baltimore, MD 21225, USA
Curr Atheroscler Rep 8:460-5. 2006..Furthermore, these results also document substantial flexibility that should enhance the ability of individuals to consume a heart-healthy diet...
Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney diseaseJulia J Scialla
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Clin J Am Soc Nephrol 6:1526-32. 2011..We tested the association between estimated NEAP and serum bicarbonate in patients with CKD...- Prevalence of chronic kidney disease in persons with undiagnosed or prehypertension in the United StatesDeidra C Crews
Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA
Hypertension 55:1102-9. 2010..37 [95% CI: 2.00 to 2.81]). Chronic kidney disease is prevalent in undiagnosed and prehypertension. Earlier identification and treatment of both these conditions may prevent or delay morbidity and mortality from chronic kidney disease... 
Intensive blood-pressure control in hypertensive chronic kidney diseaseLawrence J Appel
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
N Engl J Med 363:918-29. 2010..Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients...- Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial diseaseJared P Reis
Welch Center for Prevention, Epidemiology, and Clinical Research and the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA
Am J Clin Nutr 88:1469-77. 2008..Racial differences in cardiovascular risk factors do not fully explain the higher prevalence of lower-extremity peripheral arterial disease (PAD) in black adults... - Do african american women require fewer calories to maintain weight?: results from a controlled feeding trialLaPrincess C Brewer
Department of Internal Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD, USA
Nutr Clin Pract 27:561-7. 2012..If true, AA women should require fewer calories than non-AA women to maintain weight. Our objective was to determine in the setting of a controlled feeding study, if AA women required fewer calories than non-AA women to maintain weight... - Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trialLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
JAMA 294:2455-64. 2005..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain... - Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosisJared P Reis
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, USA
Atherosclerosis 207:585-90. 2009..Additional research is needed to determine whether vitamin D may influence the progression of atherosclerosis, including the effects of supplementation on the atherosclerotic process... - Uric acid level and elevated blood pressure in US adolescents: National Health and Nutrition Examination Survey, 1999-2006Lauren F Loeffler
Johns Hopkins University School of Medicine, 200 North Wolfe St, Room 3055, Baltimore, MD 21287, USA
Hypertension 59:811-7. 2012..Additional prospective studies and clinical trials are needed to determine whether uric acid is merely a marker in a complex metabolic pathway or causal of hypertension and, thus, a potential screening and therapeutic target... - A dietary pattern that lowers oxidative stress increases antibodies to oxidized LDL: results from a randomized controlled feeding studyEdgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 2 624, Baltimore, MD 21205 2223, USA
Atherosclerosis 183:175-82. 2005..We tested the hypothesis that consumption of a healthy diet rich in fruits and vegetables and reduced in saturated fat, total fat, and cholesterol will concomitantly reduce oxidative stress and Ab-oxLDL... - Serum potassium and the racial disparity in diabetes risk: the Atherosclerosis Risk in Communities (ARIC) StudyRanee Chatterjee
Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Am J Clin Nutr 93:1087-91. 2011..Low serum potassium appears to be independently associated with incident type 2 diabetes, and low dietary potassium is more common in African Americans than in whites... - Vitamin-mineral supplementation and the progression of atherosclerosis: a meta-analysis of randomized controlled trialsJoachim Bleys
Department of Epidemiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Am J Clin Nutr 84:880-7; quiz 954-5. 2006.... - Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trialsStephen P Juraschek
Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Am J Clin Nutr 95:1079-88. 2012..However, evidence for blood pressure-lowering effects of vitamin C in clinical trials is inconsistent... - Patient awareness of chronic kidney disease: trends and predictorsLaura C Plantinga
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Arch Intern Med 168:2268-75. 2008..The impact of recent guidelines for early detection and prevention of chronic kidney disease (CKD) on patient awareness of disease and factors that might be associated with awareness have not been well described... - The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trialsEdgar R Miller
Johns Hopkins School of Medicine, The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
Am J Clin Nutr 89:1937-45. 2009..Although epidemiologic and experimental studies suggest that n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation may prevent or slow the progression of kidney disease, evidence from clinical trials is inconsistent... - Vitamin D status and cardiometabolic risk factors in the United States adolescent populationJared P Reis
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Pediatrics 124:e371-9. 2009..We examined whether low serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) are associated with cardiovascular risk factors in US adolescents aged 12 to 19 years... - Comparative effectiveness of weight-loss interventions in clinical practiceLawrence J Appel
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
N Engl J Med 365:1959-68. 2011..Obesity and its cardiovascular complications are extremely common medical problems, but evidence on how to accomplish weight loss in clinical practice is sparse... - Blood pressure control among persons without and with chronic kidney disease: US trends and risk factors 1999-2006Laura C Plantinga
Departments of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Hypertension 54:47-56. 2009..Although some improvement has occurred over time, uncontrolled blood pressure remains highly prevalent, especially in subjects with chronic kidney disease and in nonwhites, older persons, and women. Therapy appears suboptimal... - Inflammation modifies the effects of a reduced-fat low-cholesterol diet on lipids: results from the DASH-sodium trialThomas P Erlinger
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Circulation 108:150-4. 2003..Inflammatory mediators regulate key aspects of lipid metabolism. We hypothesized that inflammation could diminish the cholesterol-lowering effect of a reduced-fat/low-cholesterol diet... - Changes in serum potassium mediate thiazide-induced diabetesTariq Shafi
Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21224 2780, USA
Hypertension 52:1022-9. 2008..Potassium supplementation might prevent thiazide-induced diabetes. This hypothesis can and should be tested in a randomized trial... - Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levelsEdgar R Miller
The Johns Hopkins School of Medicine, Baltimore, MD, USA
Am J Cardiol 106:517-27. 2010..This interaction may have important implications for recommendations of FA supplement use. In the meantime, FA supplementation should not be recommended as a means to prevent or treat CVD or stroke... - Effect of oral vitamin C supplementation on serum uric acid: a meta-analysis of randomized controlled trialsStephen P Juraschek
Johns Hopkins University School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21224, USA
Arthritis Care Res (Hoboken) 63:1295-306. 2011..To assess the effect of vitamin C supplementation on serum uric acid (SUA) by pooling the findings from published randomized controlled trials (RCTs)... - A randomized trial to improve patient-centered care and hypertension control in underserved primary care patientsLisa A Cooper
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, MD 21287, USA
J Gen Intern Med 26:1297-304. 2011..Moreover, continuing medical education (CME) and patient-activation interventions have infrequently been directed to improve the processes of care for these populations... - Low income and albuminuria among REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participantsDeidra C Crews
Division of Nephrology, Department of Medicine, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA
Am J Kidney Dis 60:779-86. 2012..We sought to determine the association between low income and albuminuria and whether this association differs for blacks and whites... - New high blood pressure guidelines create new at-risk classification: changes in blood pressure classification by JNC 7Edgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Cardiovasc Nurs 19:367-71; quiz 372-3. 2004..Recognition of prehypertension provides important opportunities to prevent hypertension and cardiovascular disease... - The rationale and design of the AASK cohort studyLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
J Am Soc Nephrol 14:S166-72. 2003..Such results might eventually lead to new strategies that delay or prevent ESRD... - Dietary recommendations for obese patients with chronic kidney diseaseCheryl A M Anderson
Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA
Adv Chronic Kidney Dis 13:394-402. 2006..This review describes dietary factors important in optimizing nutritional status of obese patients with CKD. Additionally, current clinical practice guidelines and strategies for meeting them are discussed... - The effect of ambient temperature and barometric pressure on ambulatory blood pressure variabilityMegan Jehn
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument Street, Baltimore, MD 21205-2223, USA
Am J Hypertens 15:941-5. 2002..CONCLUSIONS: During periods of cold weather, an increase in BP variability may complicate the diagnosis and management of hypertension and may contribute to the high cardiovascular mortality observed in the winter... - Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT)Edgar R Miller
Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, MD 21205 2223, USA
Hypertension 40:612-8. 2002..001), net of control. In conclusion, among hypertensive overweight adults already on antihypertensive medication, a comprehensive lifestyle intervention can substantially lower blood pressure and improve blood pressure control... - The effects of macronutrient intake on total and high-molecular weight adiponectin: results from the OMNI-Heart trialEdwina H Yeung
Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland, USA
Obesity (Silver Spring) 18:1632-7. 2010..A diet rich in MUFA was associated with higher levels of total and HMW adiponectin in comparison to a carbohydrate- or protein-rich diet. Effects seen in adiponectin paralleled those found with HDL cholesterol... - Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US populationBrad C Astor
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
Am J Epidemiol 167:1226-34. 2008..These data support recent recommendations defining chronic kidney disease and stratifying subsequent risks based on both decreased GFR and albuminuria... - Left ventricular dysfunction as a risk factor for cardiovascular and noncardiovascular hospitalizations in African AmericansSaul Blecker
Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am Heart J 160:488-95. 2010..We assessed whether left ventricular (LV) systolic dysfunction was associated with increased risk of both cardiovascular and noncardiovascular hospitalizations in a community sample of African Americans... - The effects of vitamin C supplementation on serum concentrations of uric acid: results of a randomized controlled trialHan Yao Huang
Johns Hopkins University, Baltimore, Maryland 21205, USA
Arthritis Rheum 52:1843-7. 2005..Previous studies have suggested a uricosuric effect of vitamin C. Whether vitamin C reduces serum uric acid is unknown. We undertook this study to determine the effects of vitamin C supplementation on serum uric acid concentrations... - Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortalityEdgar R Miller
The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
Ann Intern Med 142:37-46. 2005..However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality... - Independent but coordinated trials: insights from the practice-based Opportunities for Weight Reduction Trials Collaborative Research GroupHsin Chieh Yeh
Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
Clin Trials 7:322-32. 2010..Still, efforts were made to coordinate and standardize several aspects of the trials. The three trials formed a collaborative group, the 'Practice-based Opportunities for Weight Reduction (POWER) Trials Collaborative Research Group.'.. - Racial differences in urinary potassium excretionSharon Turban
Division of Nephrology, Johns Hopkins University School of Medicine, 1830 E Monument Street, Suite 416, Baltimore, MD 21205, USA
J Am Soc Nephrol 19:1396-402. 2008..39), and 903 mg/d in the DASH group (P < 0.001). Racial differences in urinary K excretion seem to reflect more than intake differences; further studies are needed to understand their potential impact on clinical outcomes... - Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adultsJared P Reis
Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Eur J Endocrinol 159:41-8. 2008..This study examined the combined association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetSyn among a nationally representative sample of US adults... - Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularizationEdgar R Miller
Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2233, USA
Coron Artery Dis 14:163-9. 2003..While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent of LDL-c levels remains to be established... - Nurse case management of hypercholesterolemia in patients with coronary heart disease: results of a randomized clinical trialJerilyn K Allen
School of Nursing, Johns Hopkins University, Baltimore, MD 21205 2110, USA
Am Heart J 144:678-86. 2002..This study tested the effectiveness of a nurse case management program to lower blood lipids in patients with CHD... - Effect of protein, unsaturated fat, and carbohydrate intakes on plasma apolipoprotein B and VLDL and LDL containing apolipoprotein C-III: results from the OmniHeart TrialJeremy D Furtado
Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 87:1623-30. 2008..Dietary intake affects lipoprotein concentration and composition related to those apolipoproteins... - Roundtable discussion: hypertension, renal disease, and diabetesMarvin Moser
J Clin Hypertens (Greenwich) 4:113-9. 2002..Following a symposium on Hypertension in Atlanta, Georgia on April 25, 2001, which was sponsored by the National Heart, Lung, and Blood Institute, a panel was convened to discuss the problems of renal disease and hypertension... - The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trialsSun Ha Jee
Department of Epidemiology and Disease Control, Yonsei University Graduate School of Health Science and Management, Seoul, Korea
Am J Hypertens 15:691-6. 2002..However, adequately powered trials with sufficiently high doses of magnesium supplements need to be performed to confirm this relationship... - Serum selenium and serum lipids in US adultsJoachim Bleys
Departments of Epidemiology and Medicine, The Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD, Madrid, Spain
Am J Clin Nutr 88:416-23. 2008..However, the effects of selenium intake on the lipid profile in selenium-replete populations, such as the United States, are largely unknown... - The DASH diet enhances the blood pressure response to losartan in hypertensive patientsPaul R Conlin
Division of Endocrinology, Diabetes and Hypertension PRC, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Hypertens 16:337-42. 2003..We conducted a clinical trial to assess the BP response to the DASH diet with an antihypertensive medication, losartan, in participants with essential hypertension... - Direct, progressive association of cardiovascular risk factors with incident proteinuria: results from the Korea Medical Insurance Corporation (KMIC) studySun Ha Jee
Department of Epidemiology and Health Promotion, Graduate School of Public Health, The Yonsei University, Seoul, South Korea
Arch Intern Med 165:2299-304. 2005..These associations were present even at low levels of exposure, emphasizing the importance of early detection and management of these modifiable risk factors... - Effect of dietary sodium intake on blood lipids: results from the DASH-sodium trialDavid W Harsha
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Hypertension 43:393-8. 2004..There were no significant interactions between the effects of sodium and the DASH diet on serum lipids. In conclusion, changes in dietary sodium intake over the range of 50 to 150 mmol/d did not affect blood lipid concentrations... - The DASH diet for high blood pressure: from clinical trial to dinner tableNjeri Karanja
Kaiser Permanente Center for Health Research, Portland, OR 97227, USA
Cleve Clin J Med 71:745-53. 2004..These studies have greatly expanded our knowledge of nonpharmacologic interventions to prevent and manage hypertension. They also underscore the need for diet and lifestyle counseling in the primary care setting... - Blood pressure control, drug therapy, and kidney diseaseGabriel Contreras
University of Miami, Miami, FL, USA
Hypertension 46:44-50. 2005..These secondary analyses suggest a benefit of the low BP goal among patients assigned to amlodipine, but they must be interpreted cautiously... - Metabolic syndrome, proteinuria, and the risk of progressive CKD in hypertensive African AmericansJanice Lea
Emory University, Atlanta, GA 30322, USA
Am J Kidney Dis 51:732-40. 2008..The purpose of this study is to examine whether metabolic syndrome is associated with kidney disease progression in hypertensive African Americans...