D S Miller

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier
    David S Miller
    Laboratory of Toxicology and Pharmacology National Institute of Environmental Health, Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Curr Pharm Des 20:1463-71. 2014
  2. ncbi request reprint Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule
    D S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 299:567-74. 2001
  3. ncbi request reprint Confocal imaging of xenobiotic transport across the blood-brain barrier
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Exp Zool A Comp Exp Biol 300:84-90. 2003
  4. ncbi request reprint Confocal imaging of xenobiotic transport across the choroid plexus
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Adv Drug Deliv Rev 56:1811-24. 2004
  5. ncbi request reprint Regulation of MRP2-mediated transport in shark rectal salt gland tubules
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Regul Integr Comp Physiol 282:R774-81. 2002
  6. ncbi request reprint Xenobiotic efflux pumps in isolated fish brain capillaries
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Regul Integr Comp Physiol 282:R191-8. 2002
  7. pmc Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Pharmacol Rev 60:196-209. 2008
  8. ncbi request reprint Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants--a case of molecular hijacking
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biochem Mol Toxicol 16:121-7. 2002
  9. pmc Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
    David S Miller
    Laboratory of Toxicology and Pharmacology, NIH NIEHS, P O Box 12233, Research Triangle Park, NC 27709, USA
    Trends Pharmacol Sci 31:246-54. 2010
  10. ncbi request reprint Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
    D S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 58:1357-67. 2000

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier
    David S Miller
    Laboratory of Toxicology and Pharmacology National Institute of Environmental Health, Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Curr Pharm Des 20:1463-71. 2014
    ..Translation of these results to the clinic could provide improved pharmacotherapy for a number of CNS diseases, including, brain cancer, neuroAIDS and epilepsy...
  2. ncbi request reprint Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule
    D S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 299:567-74. 2001
    ..Comparison of the inhibitory potencies of the nucleoside phosphonates with other substrates and inhibitors showed them to be moderate inhibitors of OAT1- and Mrp2-mediated transport...
  3. ncbi request reprint Confocal imaging of xenobiotic transport across the blood-brain barrier
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Exp Zool A Comp Exp Biol 300:84-90. 2003
    ....
  4. ncbi request reprint Confocal imaging of xenobiotic transport across the choroid plexus
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, Research Triangle Park, NC 27709, USA
    Adv Drug Deliv Rev 56:1811-24. 2004
    ....
  5. ncbi request reprint Regulation of MRP2-mediated transport in shark rectal salt gland tubules
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Regul Integr Comp Physiol 282:R774-81. 2002
    ..In addition, cAMP affects transporter function through a PKA-independent mechanism, possibly by competition for transport...
  6. ncbi request reprint Xenobiotic efflux pumps in isolated fish brain capillaries
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Regul Integr Comp Physiol 282:R191-8. 2002
    ....
  7. pmc Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Pharmacol Rev 60:196-209. 2008
    ..Finally, several steps in signaling are potential therapeutic targets that could be used to modulate P-glycoprotein activity in the clinic...
  8. ncbi request reprint Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants--a case of molecular hijacking
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Biochem Mol Toxicol 16:121-7. 2002
    ..These findings suggest a new common mechanism by which nephrotoxicants may act to disrupt renal tubular function...
  9. pmc Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
    David S Miller
    Laboratory of Toxicology and Pharmacology, NIH NIEHS, P O Box 12233, Research Triangle Park, NC 27709, USA
    Trends Pharmacol Sci 31:246-54. 2010
    ..A detailed understanding of such regulation can provide the basis for improved neuroprotection and enhanced therapeutic drug delivery to the brain...
  10. ncbi request reprint Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
    D S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Mol Pharmacol 58:1357-67. 2000
    ..These results validate a new method for studying drug transport in isolated brain capillaries and implicate both P-glycoprotein and one or more members of the Mrp family in drug transport from central nervous system to blood...
  11. ncbi request reprint Dual pathways for organic anion secretion in renal proximal tubule
    D S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Exp Zool 279:462-70. 1997
    ..Thus, FL-MTX secretion is specific, but largely Na-independent and ouabain-insensitive. Both the basolateral and luminal steps in FL-MTX transport differ from those associated with fluorescein and P-aminohippurate secretion...
  12. ncbi request reprint Organic cation transport in rat choroid plexus cells studied by fluorescence microscopy
    D S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol 276:C955-68. 1999
    ..endosomes. Finally, quinacrine-loaded vesicles were seen to move within the cytoplasm and to abruptly release their contents at the blood side of the cell; the rate of release was greatly reduced by the microtubule disrupter nocodazole...
  13. ncbi request reprint MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus)
    David S Miller
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 97:103-10. 2007
    ..Thus, chronic in vivo exposure to arsenic induces mechanisms that protect proximal tubules during subsequent arsenic exposure. Upregulation of MRP2 expression and activity is one likely contributing factor...
  14. pmc Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier
    Xueqian Wang
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 78:376-83. 2010
    ..Thus, CAR activation selectively tightens the blood-brain barrier by increasing transport activity and protein expression of three xenobiotic efflux pumps...
  15. pmc Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor
    Brian T Hawkins
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 30:1417-25. 2010
    ....
  16. ncbi request reprint Fluorescein-methotrexate transport in rat choroid plexus analyzed using confocal microscopy
    Christopher M Breen
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Renal Physiol 287:F562-9. 2004
    ..Thus transepithelial FL-MTX transport involved the following two mediated steps: Na-dependent uptake at the apical membrane and electroneutral efflux at the basolateral membrane, possibly on Oatp2 and Mrp1...
  17. pmc Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain
    Robert R Rigor
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Cereb Blood Flow Metab 30:1373-83. 2010
    ..Targeting PKCbeta(I) at the BBB may prove to be an effective strategy for enhancing the delivery of small molecule therapeutics to the brain...
  18. ncbi request reprint Renal secretion of organic anions and cations
    J B Pritchard
    Laboratory of Cellular and Molecular Pharmacology, National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Kidney Int 49:1649-54. 1996
    ..Thus, although much detailed information has been added over the last 50 years, it is not yet possible to provide a detailed, quantitative understanding of these important excretory systems...
  19. ncbi request reprint Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic
    J Liu
    Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute for Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 60:302-9. 2001
    ..Thus, acquired tolerance to arsenic is associated with increased expression GST-Pi, Mrp1/Mrp2 and P-glycoprotein, which function together to reduce cellular arsenic accumulation...
  20. ncbi request reprint Confocal imaging of organic anion transport in intact rat choroid plexus
    Christopher M Breen
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Am J Physiol Renal Physiol 282:F877-85. 2002
    ....
  21. ncbi request reprint Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1
    Anika M S Hartz
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 66:387-94. 2004
    ..Inhibition of NO synthase (NOS) or PKC abolished the ET-1 effects. Thus, ET-1, acting through an ET(B) receptor, NOS, and PKC rapidly and reversibly reduced transport mediated by P-glycoprotein at the blood-brain barrier...
  22. ncbi request reprint Expression systems for cloned xenobiotic transporters
    John B Pritchard
    Laboratory of Pharmacology and Chemistry, NIH National Institute of Environmental Health Sciences, 110 Alexander Drive, MD F1 03, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 204:256-62. 2005
    ..This choice requires well-defined goals, as well as an understanding of the strengths and weaknesses of candidate expression systems...
  23. ncbi request reprint Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier
    Bjorn Bauer
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 71:667-75. 2007
    ..Moreover, involvement of NF-kappaB raises the possibility that other effectors acting through this transcription factor may have similar effects on this key blood-brain barrier transporter...
  24. ncbi request reprint Multidrug resistance-associated proteins: expression and function in the central nervous system
    Shannon Dallas
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Pharmacol Rev 58:140-61. 2006
    ..The present review summarizes recent knowledge in this area and emphasizes the clinical significance of MRP transporter expression in a variety of neurological disorders...
  25. ncbi request reprint Mechanism of organic anion transport across the apical membrane of choroid plexus
    J B Pritchard
    Laboratory of Pharmacology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:33382-7. 1999
    ..As predicted by the functional studies, the fluorescently tagged transporter was seen in apical but not basolateral membranes of the CP...
  26. ncbi request reprint Modulation of p-glycoprotein transport function at the blood-brain barrier
    Bjorn Bauer
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Exp Biol Med (Maywood) 230:118-27. 2005
    ..Each has the potential to specifically reduce p-glycoprotein function and thus selectively increase brain permeability of p-glycoprotein substrates...
  27. ncbi request reprint Pregnane X receptor up-regulation of P-glycoprotein expression and transport function at the blood-brain barrier
    Bjorn Bauer
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 66:413-9. 2004
    ..These results imply selective tightening of the barrier in patients exposed to the wide range of xenobiotics that are PXR/SXR ligands, including drugs, dietary constituents, and toxicants...
  28. pmc Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier
    Anika M S Hartz
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    FASEB J 22:2723-33. 2008
    ..These experiments disclose a novel blood-brain barrier signaling pathway, with clear implications for environmental toxicology, CNS pathology, and the pharmacotherapy of CNS disorders...
  29. ncbi request reprint Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus
    D H Sweet
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 276:41611-9. 2001
    ..These data indicate that OCT2 mediates choline transport across the ventricular membrane of CP...
  30. ncbi request reprint In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation
    Bjorn Bauer
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 70:1212-9. 2006
    ..This is the first demonstration of the ability of blood-brain barrier PXR to alter the efficacy of a CNS-acting drug...
  31. doi request reprint Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier
    Bjorn Bauer
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Cereb Blood Flow Metab 28:1222-34. 2008
    ..These findings indicate that, as in hepatocytes, brain capillaries possess a regulatory network consisting of nuclear receptors, metabolizing enzymes, and efflux transporters, which modulate blood-brain barrier function...
  32. pmc Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay
    Brian T Hawkins
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Cereb Blood Flow Metab 30:1593-7. 2010
    ..Activation of PKCbeta1 did not protect P-glycoprotein. Thus, VEGF and PKCbeta1 reduce P-glycoprotein activity by distinct mechanisms...
  33. ncbi request reprint Organic anion transport in choroid plexus from wild-type and organic anion transporter 3 (Slc22a8)-null mice
    Destiny Sykes
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 286:F972-8. 2004
    ....
  34. ncbi request reprint Rapid modulation of P-glycoprotein-mediated transport at the blood-brain barrier by tumor necrosis factor-alpha and lipopolysaccharide
    Anika M S Hartz
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Pharmacol 69:462-70. 2006
    ..They show that this key component of the selective/active blood-brain barrier is an early target of cytokine signaling during the innate immune response and suggest ways to manipulate the barrier for improved CNS pharmacotherapy...
  35. pmc Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier
    Xueqian Wang
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    FASEB J 25:644-52. 2011
    ....
  36. ncbi request reprint Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:533-42. 2005
    ..Finally, NADPH oxidase could be an ideal target for potential pharmaceutical intervention, given that it plays a critical role in alpha-synuclein-mediated microglial activation and associated neurotoxicity...
  37. ncbi request reprint Multiple components of 2,4-dichlorophenoxyacetic acid uptake by rat choroid plexus
    Simon Lowes
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 315:136-43. 2005
    ..Thus, the first step in transport of 2,4-D from cerebrospinal fluid to blood involves two transporters: Oat3 and a PAH-insensitive, sodium-independent transporter. Based on inhibitor profile, the latter may be Oatp3...
  38. ncbi request reprint Transepithelial organic anion transport by shark choroid plexus
    Alice R A Villalobos
    Mount Desert Island Biological Laboratory, Salisbury Cove, Maine 04672, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1308-16. 2002
    ..Collectively, these data indicate that shark CP actively removes OAs from CSF by a process that is specific and active...
  39. pmc Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes
    Daniel A J Bow
    Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, CB 7360 Kerr Hall, Chapel Hill, NC 27599 7360, USA
    Drug Metab Dispos 36:198-202. 2008
    ..Drug efflux from freshly isolated hepatocytes as an estimate of apical efflux/biliary excretion would give an inaccurate assessment of true apical elimination and, as such, should not be used to make in vivo extrapolations...
  40. ncbi request reprint Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling
    Bjorn Bauer
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University Munich, Koeniginstr 16, 80539 Munich, Germany
    Mol Pharmacol 73:1444-53. 2008
    ..Moreover, they provide insight into one mechanism that underlies drug resistance in epilepsy and possibly other central nervous system disorders...
  41. pmc Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries
    Bernhard Erdlenbruch
    Kinderklinik der Universität at Göttingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Br J Pharmacol 140:1201-10. 2003
    ..005). 4. In conclusion, 1-O-pentylglycerol increases delivery of small and large compounds to normal brain and brain tumors and this effect is mediated at least in part by enhanced permeability of tight junctions...
  42. ncbi request reprint Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system
    Bjorn Bauer
    Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, INF 366 69120 Heidelberg, Germany
    Pharm Res 20:1170-6. 2003
    ....
  43. ncbi request reprint The xenobiotic transporter, MRP2, in epithelia from insects, sharks, and the human breast: implications for health and disease
    Karl John Karnaky
    Departments of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Exp Zool A Comp Exp Biol 300:91-7. 2003
    ..Transport substrates of MRP2 include carcinogens as well as antioxidants and other salutary molecules. Thus, in the breast ductule, MRP2 may play a significant role in breast epithelial cell health and cancer carcinogenesis...
  44. ncbi request reprint Role of NO in endothelin-regulated drug transport in the renal proximal tubule
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 282:F458-64. 2002
    ..Together, the data show that NO generation follows ET binding to the basolateral ET(B) receptor and that, in activating the ET-signaling pathway, nephrotoxicants produce NO, a molecule that could contribute to subsequent toxic effects...
  45. ncbi request reprint Relevance of multidrug resistance proteins for intestinal drug absorption in vitro and in vivo
    Gert Fricker
    Institute for Pharmaceutics and Biopharmacy, University of Heidelberg, Germany
    Pharmacol Toxicol 90:5-13. 2002
    ....
  46. pmc Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
    Stephan Fellner
    Institute of Pharmacy, University of Regensburg, Regensburg, Germany
    J Clin Invest 110:1309-18. 2002
    ..Thus, p-gp is an important obstacle preventing paclitaxel entry into the brain, and inhibition of this transporter allows the drug to reach sensitive tumors within the CNS...
  47. pmc Permeability of porcine blood brain barrier to somatostatin analogues
    Gert Fricker
    Institute of Pharmaceutical Technology and Biopharmacy, University of Heidelberg, D 69120 Heidelberg, Germany
    Br J Pharmacol 135:1308-14. 2002
    ....
  48. ncbi request reprint Transport of a fluorescent cAMP analog in teleost proximal tubules
    Valeska Reichel
    Institute of Pharmacy and Molecular Biotechnology, INF 366, 69120 Heidelberg, Germany
    Am J Physiol Regul Integr Comp Physiol 293:R2382-9. 2007
    ..Thus, based on inhibitor specificity and regulatory signaling, cell-to-lumen transport of fluo-cAMP in killifish renal tubules is mediated by a transporter distinct from Mrp2, presumably a teleost form of Mrp4...
  49. ncbi request reprint Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule
    Sylvie A Terlouw
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Pharmacol Exp Ther 301:578-85. 2002
    ..Together, these findings indicate that exposure of renal proximal tubules to heavy metals initially leads to reduced Mrp2 function but is followed by an induction in Mrp2-mediated transport after long-term exposure...
  50. ncbi request reprint Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, The Netherlands
    J Pharmacol Exp Ther 315:912-20. 2005
    ..Thus, short-term exposure to ET-1 or gentamicin resulted in long-term protection against a second insult...
  51. ncbi request reprint Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice
    Douglas H Sweet
    Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Biol Chem 277:26934-43. 2002
    ..These data indicate a key role for Oat3 in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid...
  52. ncbi request reprint Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule
    Sylvia Notenboom
    Department of Pharmacology and Toxicology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 287:F33-8. 2004
    ..Together, these data indicate that ET regulation of Mrp2 involves activation of guanylyl cyclase and generation of cGMP. Signaling by cGMP follows NO release and precedes PKC activation...
  53. ncbi request reprint Fluorescein-methotrexate transport in dogfish shark (Squalus acanthias) choroid plexus
    Carsten H Baehr
    Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, Germany
    Am J Physiol Regul Integr Comp Physiol 291:R464-72. 2006
    ..Finally, FL-MTX accumulation in both tissue compartments was reduced by phorbol ester and increased by forskolin, indicating antagonistic modulation by protein kinase C and protein kinase A...
  54. ncbi request reprint Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport
    Kim E Wever
    Dept of Animal Physiology, Institute for Neuroscience Faculty of Science, Radboud Univ Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Am J Physiol Renal Physiol 292:F38-46. 2007
    ..A highly significant 40% inhibition of Mrp2-mediated transport was observed with PTHrP in sea bream tubules. In conclusion, ET-regulated Mrp2 transport is influenced by calciotropic hormones and involves PKC and cGMP signaling...
  55. pmc Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron
    Xueqian Wang
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Toxicol Appl Pharmacol 230:167-74. 2008
    ..The intracellular trafficking of metal transporters in the choroid plexus following Mn exposure may partially contribute to Mn-induced disruption in Fe homeostasis in the cerebrospinal fluid (CSF) following Mn exposure...
  56. ncbi request reprint Mercuric chloride acting through Mg stimulates protein synthesis in Xenopus oocytes
    David M Barnes
    Department of Animal Sciences, University of Wisconsin, Madison 53706, USA
    J Toxicol Environ Health A 65:617-29. 2002
    ..Together these data indicate that inorganic mercury activates translation in the oocyte through an Mg-dependent mechanism, possibly increased Mg2+ influx...
  57. ncbi request reprint Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group Study
    Harry J Long
    Mayo Clinic College of Medicine, Rochester, MN, USA
    J Clin Oncol 23:4626-33. 2005
    ....
  58. ncbi request reprint Postmolar surveillance at a trophoblastic disease center that serves indigent women
    Jennifer E Allen
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Southwestern Trophoblastic Disease Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, J7 124, Dallas, TX 75390 9032, USA
    Am J Obstet Gynecol 188:1151-3. 2003
    ..The purpose of this study was to determine compliance with postmolar pregnancy surveillance in our indigent population...
  59. ncbi request reprint Clinical results and quality of life analysis for the MVAC combination (methotrexate, vinblastine, doxorubicin, and cisplatin) in carcinoma of the uterine cervix: A Gynecologic Oncology Group study
    Harry J Long
    Mayo Clinic, Department of Medical Oncology, East 12B Mayo Building, 200 First Street, Southwest, Rochester, MN 55905 0001, USA
    Gynecol Oncol 100:537-43. 2006
    ..The primary endpoint was overall survival (OS), with response rate, progression-free survival (PFS), and quality of life (QOL) as secondary objectives...
  60. doi request reprint Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status
    William T Festuccia
    Laval Hospital Research Centre, Faculty of Medicine, Laval University, Laval Hospital d Youville Y3110, 2725 Chemin Sainte Foy, Quebec, Canada G1V 4G5
    Endocrinology 149:2121-30. 2008
    ....
  61. ncbi request reprint Modulation of drug transporters at the blood-brain barrier
    Gert Fricker
    Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
    Pharmacology 70:169-76. 2004
    ..We describe novel approaches to (1). modulate carrier protein function, and (2). circumvent the transporter-based carrier by targeted site-specific drug delivery systems, such as immunoliposome and nanoparticulate systems...
  62. ncbi request reprint Management of low-risk gestational trophoblastic neoplasia in indigent women
    John O Schorge
    Southwestern Trophoblastic Disease Center, Division of Gynecologic Oncology, Dep of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, 75390 9032, USA
    J Reprod Med 48:780-4. 2003
    ..To identify the most effective dosing regimen for indigent patients with low-risk gestational trophoblastic neoplasia (GTN) at high risk of noncompliance...