Markku Miettinen

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 37:234-40. 2013
  2. pmc Gastrointestinal stromal tumors
    Markku Miettinen
    Laboratory of Pathology, NCI NIH, Bethesda, MD 20892, USA
    Gastroenterol Clin North Am 42:399-415. 2013
  3. doi request reprint Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas
    Markku Miettinen
    National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 35:1848-56. 2011
  4. doi request reprint A simple method for generating multitissue blocks without special equipment
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Appl Immunohistochem Mol Morphol 20:410-2. 2012
  5. pmc Vascular endothelial growth factor receptor 2 as a marker for malignant vascular tumors and mesothelioma: an immunohistochemical study of 262 vascular endothelial and 1640 nonvascular tumors
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 36:629-39. 2012
  6. pmc Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda 20892, MD, USA
    Am J Surg Pathol 36:351-9. 2012
  7. doi request reprint Histopathology of gastrointestinal stromal tumor
    Markku Miettinen
    National Cancer Institute, Laboratory of Pathology, Bethesda, Maryland 20892, USA
    J Surg Oncol 104:865-73. 2011
  8. pmc Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, 20892, USA
    Am J Surg Pathol 35:1712-21. 2011
  9. pmc GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors
    Markku Miettinen
    Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD Department of Pathology, Cell Biology and Anatomy, Jefferson Medical College of Thomas Jefferson University and University Hospital, Philadelphia, PA Department of Pathology Haartman Institute and HusLab, Helsinki University Hospital, Helsinki, Finland Department of Tumor Pathology, Centre of Oncology, Maria Sklodowska Curie Memorial Institute, Krakow Branch Department of Pathomorphology, Medical University of Gdansk, Gdansk Department of Pathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw Independent Laboratory of Pathology, Zdunomed, Szczecin, Poland
    Am J Surg Pathol 38:13-22. 2014
  10. pmc SALL4 expression in germ cell and non-germ cell tumors: a systematic immunohistochemical study of 3215 cases
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD Department of Pathology, Cell Biology and Anatomy, Jefferson Medical College of Thomas Jefferson University and University Hospital, Philadelphia, PA Department of Pathology Haartman Institute and HusLab, Helsinki University Hospital, Helsinki, Finland Department of Tumor Pathology, Centre of Oncology, Maria Sklodowska Curie Memorial Institute, Krakow Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland
    Am J Surg Pathol 38:410-20. 2014

Collaborators

Detail Information

Publications22

  1. pmc Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 37:234-40. 2013
    ..SDHA-negative GISTs comprise approximately 30% of SDHB-negative/SDH-deficient GISTs, and SDHA loss generally correlates with SDHA mutations...
  2. pmc Gastrointestinal stromal tumors
    Markku Miettinen
    Laboratory of Pathology, NCI NIH, Bethesda, MD 20892, USA
    Gastroenterol Clin North Am 42:399-415. 2013
    ..These are related to deficiencies in the succinate dehydrogenase complex, NF1-gene alterations in connection with neurofibromatosis type 1 tumor syndrome, and mutational activation of the BRAF oncogene in very rare cases...
  3. doi request reprint Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas
    Markku Miettinen
    National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 35:1848-56. 2011
    ....
  4. doi request reprint A simple method for generating multitissue blocks without special equipment
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Appl Immunohistochem Mol Morphol 20:410-2. 2012
    ..This technique is especially suitable when abundant tissue is available, for example, generating blocks containing libraries of normal tissues or defined tumors for antibody screening or tumor immunophenotyping...
  5. pmc Vascular endothelial growth factor receptor 2 as a marker for malignant vascular tumors and mesothelioma: an immunohistochemical study of 262 vascular endothelial and 1640 nonvascular tumors
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 36:629-39. 2012
    ..Information on VEGFR2 tissue expression may be useful in development of targeted oncologic therapy through VEGFR2-specific tyrosine kinase inhibitors...
  6. pmc Prox1 transcription factor as a marker for vascular tumors-evaluation of 314 vascular endothelial and 1086 nonvascular tumors
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda 20892, MD, USA
    Am J Surg Pathol 36:351-9. 2012
    ..Its patterns of expression in hemangiomas and angiosarcoma may be diagnostically useful and offer a new parameter in the biological classification of vascular tumors...
  7. doi request reprint Histopathology of gastrointestinal stromal tumor
    Markku Miettinen
    National Cancer Institute, Laboratory of Pathology, Bethesda, Maryland 20892, USA
    J Surg Oncol 104:865-73. 2011
    ..GISTs in NF1 patients and children are distinctive clinicopathologic groups. Immunohistochemical testing for KIT and sometimes for DOG1/Ano 1 is essential in confirming the diagnosis...
  8. pmc Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, 20892, USA
    Am J Surg Pathol 35:1712-21. 2011
    ....
  9. pmc GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors
    Markku Miettinen
    Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD Department of Pathology, Cell Biology and Anatomy, Jefferson Medical College of Thomas Jefferson University and University Hospital, Philadelphia, PA Department of Pathology Haartman Institute and HusLab, Helsinki University Hospital, Helsinki, Finland Department of Tumor Pathology, Centre of Oncology, Maria Sklodowska Curie Memorial Institute, Krakow Branch Department of Pathomorphology, Medical University of Gdansk, Gdansk Department of Pathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw Independent Laboratory of Pathology, Zdunomed, Szczecin, Poland
    Am J Surg Pathol 38:13-22. 2014
    ..The multiple specificities of GATA3 should be taken into account when using this marker to detect metastatic mammary or urothelial carcinomas. ..
  10. pmc SALL4 expression in germ cell and non-germ cell tumors: a systematic immunohistochemical study of 3215 cases
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD Department of Pathology, Cell Biology and Anatomy, Jefferson Medical College of Thomas Jefferson University and University Hospital, Philadelphia, PA Department of Pathology Haartman Institute and HusLab, Helsinki University Hospital, Helsinki, Finland Department of Tumor Pathology, Centre of Oncology, Maria Sklodowska Curie Memorial Institute, Krakow Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland
    Am J Surg Pathol 38:410-20. 2014
    ..Observed lack of other pluripotency factors, OCT4 and NANOG, in SALL4-positive non-germ cell tumors can also be diagnostically helpful...
  11. ncbi request reprint No KRAS mutations found in gastrointestinal stromal tumors (GISTs): molecular genetic study of 514 cases
    Jerzy Lasota
    Laboratory of Pathology, National Cancer Institute NCI, Bethesda, MD, USA
    Mod Pathol 26:1488-91. 2013
    ..No KRAS mutations were found. In GIST, KRAS mutations are extremely rare if they exist (<0.2%). Thus, mutational activation of KRAS does not seem to play any significant role in the development and progression of this type of cancer. ..
  12. pmc ERG expression in epithelioid sarcoma: a diagnostic pitfall
    Markku Miettinen
    Laboratory of Pathology, National Cancer Institute, Bethesda Joint Pathology Center, Silver Spring, MD HUSLab, Helsinki, Finland
    Am J Surg Pathol 37:1580-5. 2013
    ..General lack of endothelial cell-specific markers in epithelioid sarcoma helps in this distinction. ..
  13. doi request reprint Myxoinflammatory fibroblastic sarcoma: a clinicopathologic analysis of 104 cases, with emphasis on predictors of outcome
    William B Laskin
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL Department of Soft Tissue Pathology, Joint Pathology Center, Silver Spring Laboratory of Pathology, National Institutes of Health National Cancer Institute, Bethesda, MD
    Am J Surg Pathol 38:1-12. 2014
    ..35). Our study shows that histologic features often associated with more aggressive sarcomas do not substantially impact the morbidity of MIFS, and complete surgical excision provides the best chance for disease-free survival. ..
  14. pmc Expression of the receptor for type i insulin-like growth factor (IGF1R) in gastrointestinal stromal tumors: an immunohistochemical study of 1078 cases with diagnostic and therapeutic implications
    Jerzy Lasota
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 37:114-9. 2013
    ..Because inhibition of IGF1R signaling might become a therapeutic target in GISTs, screening for IGF1R expression may become important in the near future...
  15. ncbi request reprint Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor
    J Keith Killian
    National Cancer Institute Center for Cancer Research, Bethesda, MD 20892 4265, USA
    Cancer Discov 3:648-57. 2013
    ..These data expose a vital connection between succinate metabolism and genomic DNA methylation during tumorigenesis, and generally implicate the mitochondrial Krebs cycle in nuclear epigenomic maintenance...
  16. pmc Gastrointestinal histopathology in chronic granulomatous disease: a study of 87 patients
    Meghna Alimchandani
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, National Cancer Institute National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, MD
    Am J Surg Pathol 37:1365-72. 2013
    ..We found that mild to severe GI pathology was common in CGD. In addition, microgranulomas, pigmented macrophages, and eosinophilia are not associated with acute (neutrophilic) inflammation. ..
  17. pmc Mapping of succinate dehydrogenase losses in 2258 epithelial neoplasms
    Markku Miettinen
    Laboratory of Surgical Pathology, National Cancer Institute, Bethesda, MD Department of Pathology Haartman Institute and HusLab, Helsinki University Hospital, Helsinki, Finland Department of Pathology and Cell Biology, Jefferson Medical College of Thomas Jefferson University and University Hospital, Philadelphia, PA Department of Pathomorphology, Medical University of Gdansk, Gdansk Department of Pathology, National Tuberculosis and Lung Diseases Research Institute, Warsaw Independent Laboratory of Pathology, Zdunomed, Szczecin, Poland
    Appl Immunohistochem Mol Morphol 22:31-6. 2014
    ..6% of renal cell carcinomas and extremely rarely in other carcinomas. Some of these renal carcinomas may be clinically aggressive. The clinical significance and molecular genetics of these SDHB-negative tumors requires further study...
  18. ncbi request reprint Characterization of fibroblast growth factor receptor 1 in small-cell lung cancer
    Anish Thomas
    Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland and Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
    J Thorac Oncol 9:567-71. 2014
    ..We and others have reported high frequency of copy number gains in cytogenetic bands encoding fibroblast growth factor receptor 1 (FGFR1) in SCLC tumors and cell lines...
  19. pmc CD30 expression in malignant vascular tumors and its diagnostic and clinical implications: a study of 146 cases
    Meghna Alimchandani
    Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Appl Immunohistochem Mol Morphol 22:358-62. 2014
    ..It remains to be determined whether patients with strongly CD30-positive ASs could be candidates for targeted therapy using the recently introduced CD30 antibody drug conjugates. ..
  20. pmc KBA62 and PNL2: 2 new melanoma markers-immunohistochemical analysis of 1563 tumors including metastatic, desmoplastic, and mucosal melanomas and their mimics
    Phyu Phyu Aung
    Laboratory of Pathology, National Institutes of Health, NCI, 10 Center Drive, Room 2B50, Bethesda, MD 20892, USA
    Am J Surg Pathol 36:265-72. 2012
    ..PNL2 is highly specific for melanomas but lacks reactivity with desmoplastic melanomas. It is also an excellent supplementary marker for perivascular epitheloid cell tumor at various sites...
  21. ncbi request reprint [Gastrointestinal stromal tumor]
    Markku Miettinen
    Laboratory of Pathology National Cancer Institute NIH, Bethesda, Maryland, USA
    Duodecim 128:1441-50. 2012
    ..Loss of succinate dehydrogenase complex is a newly understood pathogenesis for 5% of GIST, associated with early onset of disease...
  22. doi request reprint Immunoreactivity for calretinin and keratins in desmoid fibromatosis and other myofibroblastic tumors: a diagnostic pitfall
    Stephanie Barak
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Surg Pathol 36:1404-9. 2012
    ....