E Jeffrey Metter

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Arm-cranking muscle power and arm isometric muscle strength are independent predictors of all-cause mortality in men
    E Jeffrey Metter
    Clinical Research Branch, National Institute on Aging, NIA ASTRA, Harbor Hospital, Baltimore, Maryland 21225, USA
    J Appl Physiol (1985) 96:814-21. 2004
  2. ncbi request reprint Can a baseline prostate specific antigen level identify men who will have lower urinary tract symptoms later in life?
    H Ballentine Carter
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 173:2040-3. 2005
  3. pmc Falls in young, middle-aged and older community dwelling adults: perceived cause, environmental factors and injury
    Laura A Talbot
    Graduate School of Nursing, Uniformed Services University of the Health Sciences, Silver Spring, Maryland 20910, USA
    BMC Public Health 5:86. 2005
  4. ncbi request reprint Evaluation of movement speed and reaction time as predictors of all-cause mortality in men
    E Jeffrey Metter
    National Institute on Aging, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 60:840-6. 2005
  5. ncbi request reprint Skeletal muscle strength as a predictor of all-cause mortality in healthy men
    E Jeffrey Metter
    National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 57:B359-65. 2002
  6. ncbi request reprint Association of energy intake with prostate cancer in a long-term aging study: Baltimore Longitudinal Study of Aging (United States)
    Lillian J Hsieh
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 61:297-301. 2003
  7. doi request reprint Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
  8. pmc Intima-media thickness and regional cerebral blood flow in older adults
    Jitka Sojkova
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Stroke 41:273-9. 2010
  9. pmc Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Neuropsychology 25:763-70. 2011
  10. pmc PSA doubling time versus PSA velocity to predict high-risk prostate cancer: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Eur Urol 54:1073-80. 2008

Detail Information

Publications90

  1. ncbi request reprint Arm-cranking muscle power and arm isometric muscle strength are independent predictors of all-cause mortality in men
    E Jeffrey Metter
    Clinical Research Branch, National Institute on Aging, NIA ASTRA, Harbor Hospital, Baltimore, Maryland 21225, USA
    J Appl Physiol (1985) 96:814-21. 2004
    ..The impact is found with loads that do not generate maximal power, suggesting an important role for motor coordination and speed of movement...
  2. ncbi request reprint Can a baseline prostate specific antigen level identify men who will have lower urinary tract symptoms later in life?
    H Ballentine Carter
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 173:2040-3. 2005
    ..We evaluated the relationship between baseline prostate specific antigen (PSA) and subsequent lower urinary tract symptom development during 3 decades in unselected men in the Baltimore Longitudinal Study of Aging...
  3. pmc Falls in young, middle-aged and older community dwelling adults: perceived cause, environmental factors and injury
    Laura A Talbot
    Graduate School of Nursing, Uniformed Services University of the Health Sciences, Silver Spring, Maryland 20910, USA
    BMC Public Health 5:86. 2005
    ....
  4. ncbi request reprint Evaluation of movement speed and reaction time as predictors of all-cause mortality in men
    E Jeffrey Metter
    National Institute on Aging, 3001 South Hanover Street, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 60:840-6. 2005
    ..92-1.19) were associated with mortality after adjustments for age, neurological/psychiatric and neck/arm pain histories. Age-associated impairments in motor control systems but not the decision to move affects longevity...
  5. ncbi request reprint Skeletal muscle strength as a predictor of all-cause mortality in healthy men
    E Jeffrey Metter
    National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Gerontol A Biol Sci Med Sci 57:B359-65. 2002
    ..Strength and rate of change in strength contribute to the impact of sarcopenia on mortality. Although muscle mass and physical activity are important, they do not completely account for the impact of strength and changes in strength...
  6. ncbi request reprint Association of energy intake with prostate cancer in a long-term aging study: Baltimore Longitudinal Study of Aging (United States)
    Lillian J Hsieh
    Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Urology 61:297-301. 2003
    ..To examine the association of total energy intake and macronutrient contributors to energy with prostate cancer risk among men in the Baltimore Longitudinal Study of Aging...
  7. doi request reprint Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:101-4; discussion 105. 2009
    ..Prostate specific antigen is used for prostate cancer screening but its specificity is limited. Specificity might be increased by considering genotype associated prostate specific antigen levels...
  8. pmc Intima-media thickness and regional cerebral blood flow in older adults
    Jitka Sojkova
    National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Stroke 41:273-9. 2010
    ..Understanding the neural correlates of this vascular measure is important in view of emerging evidence linking poorer cognitive performance with increased IMT in individuals without clinical cerebrovascular disease...
  9. pmc Hearing loss and cognition in the Baltimore Longitudinal Study of Aging
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Neuropsychology 25:763-70. 2011
    ..We hypothesized a priori that greater hearing loss is associated with lower cognitive test scores on tests of memory and executive function...
  10. pmc PSA doubling time versus PSA velocity to predict high-risk prostate cancer: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Eur Urol 54:1073-80. 2008
    ..Less is known about the relative utility of pretreatment PSA doubling time (PSA DT) to predict tumor aggressiveness...
  11. pmc Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study
    Marcello Maggio
    National Institute on Aging, National Institutes of Health, NIA Clinical Research Branch at Harbor Hospital, 3001 S Hanover Street, Baltimore, MD 21225, USA
    Arch Intern Med 167:2249-54. 2007
    ..We hypothesized that in older men a parallel age-associated decline in bioavailable testosterone, IGF-1, and DHEA-S secretion is associated with higher mortality independent of potential confounders...
  12. ncbi request reprint Aging, androgens, and the metabolic syndrome in a longitudinal study of aging
    Annabelle Rodriguez
    Department of Medicine, Division of Endocrinology, Johns Hopkins Bayview Medical Center, B Building, Suite 114, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 92:3568-72. 2007
    ..The aim of this study was to evaluate the relationship between the MS and circulating androgen levels in a cohort of men in the Baltimore Longitudinal Study of Aging...
  13. pmc Detection of life-threatening prostate cancer with prostate-specific antigen velocity during a window of curability
    H Ballentine Carter
    Department of Urology, Marburg 403, Johns Hopkins School of Medicine, 600 N Wolfe St, Baltimore, MD 21287, USA
    J Natl Cancer Inst 98:1521-7. 2006
    ..The rate at which serum PSA levels change (PSA velocity) may be an important indicator of the presence of life-threatening disease...
  14. pmc Relationship between plasma ghrelin, insulin, leptin, interleukin 6, adiponectin, testosterone and longevity in the Baltimore Longitudinal Study of Aging
    Sari Stenholm
    National Institute on Aging, Clinical Research Branch, Longitudinal Studies Section, Baltimore, MD 21225, USA
    Aging Clin Exp Res 23:153-8. 2011
    ..In this study we examine the association between other potential biomarkers related to CR and extended lifespan in healthy humans...
  15. pmc Is longitudinal pulse pressure a better predictor of 24-hour urinary albumin excretion than other indices of blood pressure?
    S Morteza Farasat
    MedStar Research Institute, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Hypertension 55:415-21. 2010
    ..The pulsatile component of BP confers the highest risk for BP-induced renal microvascular injury. Future studies should examine whether PP reduction provides additional renoprotection beyond that attained by conventional BP goals alone...
  16. pmc Does prostate growth confound prostate specific antigen velocity? Data from the Baltimore longitudinal study of aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions and National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland, USA
    J Urol 180:1314-7; discussion 1317. 2008
    ..Thus, we investigated the relationship between changes in prostate size and prostate specific antigen changes in a large cohort of men without prostate cancer...
  17. ncbi request reprint Prediagnostic plasma vitamin C levels and the subsequent risk of prostate cancer
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Nutrition 21:686-90. 2005
    ..We assessed whether higher prediagnostic plasma concentrations of vitamin C were associated with a lower risk of prostate cancer in a well-nourished cohort of men...
  18. pmc Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults
    Ramona Ramachandran
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Geriatr Soc 60:707-12. 2012
    ..To study the relationships between muscle mass, regional adiposity, and adipokines and glucose disposal in an older population...
  19. pmc White blood cell count and mortality in the Baltimore Longitudinal Study of Aging
    Carmelinda Ruggiero
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    J Am Coll Cardiol 49:1841-50. 2007
    ..We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002...
  20. ncbi request reprint Association of prostate cancer risk with insulin, glucose, and anthropometry in the Baltimore longitudinal study of aging
    J Slade Hubbard
    Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Urology 63:253-8. 2004
    ..To examine the relationship of insulin, glucose, and anthropometry with the subsequent risk of prostate cancer...
  21. doi request reprint Prostate volume changes over time: results from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 182:1458-62. 2009
    ..Although there is an abundance of literature describing prostatic enlargement in association with benign prostatic hyperplasia, less is known about the phenomenon of prostate atrophy...
  22. ncbi request reprint Bone mineral content and prostate cancer risk: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, and the National Institute on Ageing, National Institutes of Health Clinical Research Branch, Baltimore, MD, USA
    BJU Int 106:28-31. 2010
    ..Aetiology (inception cohort) Level of Evidence 2b...
  23. ncbi request reprint Nonsteroidal anti-inflammatory drugs and risk of prostate cancer in the Baltimore Longitudinal Study of Aging
    Elizabeth A Platz
    Department of Epidemiology, Room E6138, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 14:390-6. 2005
    ..We evaluated the association of aspirin and nonaspirin NSAIDs with subsequent prostate cancer in a prospective study. We also assessed whether use of these drugs influences serum prostate-specific antigen (PSA) concentration...
  24. pmc Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction
    E Jeffrey Metter
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21225, USA
    Diabetes Care 31:1026-30. 2008
    ..To verify what information from oral glucose tolerance tests (OGTTs) independently predicts mortality...
  25. ncbi request reprint High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging
    Carmelinda Ruggiero
    National Institute on Aging, NIH, Harbor Hospital, Baltimore, MD 21225, USA
    J Gerontol A Biol Sci Med Sci 63:698-706. 2008
    ..We evaluate the longitudinal changes in BMR and the relationship between BMR and mortality in the Baltimore Longitudinal Study of Aging (BLSA) participants...
  26. pmc Hearing loss and incident dementia
    Frank R Lin
    Department of Otolaryngology Head and Neck Surgery, The Johns Hopkins School of Medicine, JHOC 6120, 601 N Caroline St, Baltimore, MD 21287, USA
    Arch Neurol 68:214-20. 2011
    ..To determine whether hearing loss is associated with incident all-cause dementia and Alzheimer disease (AD)...
  27. ncbi request reprint Comparison of cardiorespiratory fitness versus leisure time physical activity as predictors of coronary events in men aged < or = 65 years and > 65 years
    Laura A Talbot
    The Johns Hopkins University, School of Nursing, Baltimore, Maryland 21205 2110, USA
    Am J Cardiol 89:1187-92. 2002
    ..For older men, high-intensity LTPA and fitness appear to be of similar importance in reducing coronary risk...
  28. pmc Glucose and insulin measurements from the oral glucose tolerance test and relationship to muscle mass
    Rita R Kalyani
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Gerontol A Biol Sci Med Sci 67:74-81. 2012
    ..We sought to determine the relationship of insulin and glucose measurements from the oral glucose tolerance test (OGTT) with muscle mass in persons without diabetes...
  29. ncbi request reprint Relationship between androgenic hormones and arterial stiffness, based on longitudinal hormone measurements
    Hidetaka Hougaku
    Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 290:E234-42. 2006
    ..05). Thus the adverse influence of low T on the cardiovascular system in men may be mediated in part via the effects of T on vascular structure and function...
  30. ncbi request reprint Age-associated changes in motor unit physiology: observations from the Baltimore Longitudinal Study of Aging
    Shari M Ling
    Clinical Research Branch, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA
    Arch Phys Med Rehabil 90:1237-40. 2009
    ..To examine motor unit characteristics (size and firing rate) associated with aging...
  31. pmc Prostate specific antigen testing among the elderly--when to stop?
    Edward M Schaeffer
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    J Urol 181:1606-14; discussion 1613-4. 2009
    ..We evaluated the relationship between prostate specific antigen and the risk of aggressive prostate cancer developing in men of various ages...
  32. pmc Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal Study of Aging
    Phillip M Pierorazio
    Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    BJU Int 105:824-9. 2010
    ..Prognosis (inception cohort)...
  33. pmc Carotid intimal medial thickness predicts cognitive decline among adults without clinical vascular disease
    Carrington Rice Wendell
    Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    Stroke 40:3180-5. 2009
    ....
  34. pmc Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men
    Dawn E Alley
    Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Am J Epidemiol 172:558-65. 2010
    ..Results suggest that weight loss in older persons may begin earlier than previously believed. The duration of weight loss for noncancer deaths suggests that even distal changes in energy balance may be linked to risk of death...
  35. doi request reprint The relationship between prostate volume and prostate-specific antigen variability: data from the Baltimore Longitudinal Study of Aging and the Johns Hopkins Active Surveillance Program
    John H Nichols
    School of Medicine, Johns Hopkins, Baltimore, MD, USA
    BJU Int 109:1304-8. 2012
    ..The results of the study suggest that baseline PSA, not prostate volume, is the primary driver of PSA variability in these populations...
  36. pmc Sarcopenic obesity and inflammation in the InCHIANTI study
    Matthew A Schrager
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21225, USA
    J Appl Physiol 102:919-25. 2007
    ..These results suggest that proinflammatory cytokines may be critical in both the development and progression of sarcopenic obesity...
  37. pmc Absence of relation between depressive symptoms and carotid intimal medial thickness in the Baltimore Longitudinal Study of Aging
    S Carrington Rice
    Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    Psychosom Med 71:70-6. 2009
    ..Prior literature has identified inconsistent cross-sectional associations between depressive symptoms and carotid IMT in healthy persons, and existing longitudinal work has relied on depression assessment at a single time point...
  38. pmc Association of hormonal dysregulation with metabolic syndrome in older women: data from the InCHIANTI study
    Marcello Maggio
    National Institute on Aging, NIH, NIA ASTRA Unit at Harbor Hospital, 3001 S Hanover St, Baltimore, MD 21225, USA
    Am J Physiol Endocrinol Metab 292:E353-8. 2007
    ..Further studies are needed to support the notion that raising SHBG is a potential therapeutic target for prevention and treatment of MetS...
  39. pmc Nonsteroidal anti-inflammatory drugs, aspirin, and cognitive function in the Baltimore longitudinal study of aging
    Shari R Waldstein
    Department of Psychology, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    J Am Geriatr Soc 58:38-43. 2010
    ..To examine the relations between the use of nonaspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin and age-related change in multiple domains of cognitive function in community-dwelling individuals without dementia...
  40. pmc Prostate-specific antigen velocity risk count assessment: a new concept for detection of life-threatening prostate cancer during window of curability
    H Ballentine Carter
    Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Urology 70:685-90. 2007
    ..To determine whether the number of times the prostate-specific antigen (PSA) velocity (PSAV) exceeds a threshold (PSAV risk count) is predictive of high-risk prostate cancer...
  41. doi request reprint Should prostate specific antigen be adjusted for body mass index? Data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 182:2646-51. 2009
    ..We examined the relationship between body mass index and prostate specific antigen by age in men without prostate cancer in a longitudinal aging study to determine whether prostate specific antigen must be adjusted for body mass index...
  42. ncbi request reprint Serum testosterone and the risk of prostate cancer: potential implications for testosterone therapy
    J Kellogg Parsons
    The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Cancer Epidemiol Biomarkers Prev 14:2257-60. 2005
    ..We prospectively evaluated serum androgen concentrations and prostate cancer risk...
  43. ncbi request reprint Effect of light-to-moderate alcohol consumption on age-associated arterial stiffening
    Hidetaka Hougaku
    Clinical Research Branch, Laboratory of Cardiovascular Science, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA
    Am J Cardiol 95:1006-10. 2005
    ..A U-shaped relation was found between alcohol intake and a stiffness index, with the lowest index in moderate drinkers, which may partially explain the relation between alcohol and cardiovascular disease...
  44. ncbi request reprint The effect of neuromuscular electrical stimulation on arthritis knee pain in older adults with osteoarthritis of the knee
    Jean M Gaines
    Geriatric Medicine and Gerontology, The Erickson Foundation, 701 Maiden Choice Lane, Baltimore, MD 21228, USA
    Appl Nurs Res 17:201-6. 2004
    ..These findings indicate that a home-based NMES intervention reduced arthritis knee pain 15 minutes after a NMES treatment...
  45. ncbi request reprint Regional bone mineral density after resistive training in young and older men and women
    Alice S Ryan
    Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, Baltimore, MD 21201, USA
    Scand J Med Sci Sports 14:16-23. 2004
    ..The purpose of this study was to determine the effects of 6 months of whole-body resistive training (RT) on total and regional bone mineral density (BMD) and bone mineral content (BMC) by age and gender in young and older men and women...
  46. pmc Interpretation of the prostate-specific antigen history in assessing life-threatening prostate cancer
    Anna E Kettermann
    Department of Urology, The Johns Hopkins University School of Medicine, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, MD, USA
    BJU Int 106:1284-90; discussion 1290-2. 2010
    ..e. PSA velocity (PSAV). This longitudinal approach might also be extendible to other biomarkers...
  47. pmc What is the true number needed to screen and treat to save a life with prostate-specific antigen testing?
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 29:464-7. 2011
    ..Our objective was to re-examine the effect of varying follow-up times on NNS and NNT using data extrapolated from the ERSPC report...
  48. ncbi request reprint A home-based protocol of electrical muscle stimulation for quadriceps muscle strength in older adults with osteoarthritis of the knee
    Laura A Talbot
    The Johns Hopkins University, School of Nursing, Baltimore, Maryland 21205 2110, USA
    J Rheumatol 30:1571-8. 2003
    ..To determine whether home-based neuromuscular electrical stimulation (NMES) applied to the quadriceps femoris (QF) muscle increases strength, physical activity, and physical performance in older adults with knee osteoarthritis (OA)...
  49. ncbi request reprint Secular trends in leisure-time physical activity in men and women across four decades
    Laura A Talbot
    The Johns Hopkins University, School of Nursing, Baltimore, MD 21205 2110, USA
    Prev Med 37:52-60. 2003
    ..We examined secular trends in leisure-time physical activities (LTPA) in health-conscious men (n = 1359) from 1958 to 1998 and in women (n = 839) from 1978 to 1998, who were participants of the Baltimore Longitudinal Study of Aging (BLSA)...
  50. pmc Cross-sectional evidence of a signaling pathway from bone homeostasis to glucose metabolism
    Kristofer S Gravenstein
    National Institute on Aging, Clinical Research Branch, 3001 South Hanover Street, Baltimore, Maryland 21225, USA
    J Clin Endocrinol Metab 96:E884-90. 2011
    ..Supposedly leptin modulates osteocalcin bioactivity, which in turn stimulates insulin and adiponectin secretion, and β-cell proliferation...
  51. doi request reprint Distribution of PSA velocity by total PSA levels: data from the Baltimore Longitudinal Study of Aging
    Stacy Loeb
    James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Urology 77:143-7. 2011
    ..35 and >2.0 ng/mL/y have been associated with an increased risk of prostate cancer (CaP) death more than 10 years and 1 year before diagnosis, respectively. It is unknown how frequently PSAVs of this magnitude occur in community men...
  52. pmc Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease
    May A Beydoun
    Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Epidemiol 168:1179-89. 2008
    ..70, 95% CI: 1.43, 9.56). Future studies should identify age- and gender-specific optimal weights and weight-loss strategies for preventing AD and investigate potential mechanisms...
  53. ncbi request reprint A home-based pedometer-driven walking program to increase physical activity in older adults with osteoarthritis of the knee: a preliminary study
    Laura A Talbot
    Johns Hopkins University, School of Nursing, 525 North Wolfe Street, Rm 445, Baltimore, MD 21205, USA
    J Am Geriatr Soc 51:387-92. 2003
    ....
  54. ncbi request reprint Suppressed anger is associated with increased carotid arterial stiffness in older adults
    David E Anderson
    Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland 21224, USA
    Am J Hypertens 19:1129-34. 2006
    ..The present study investigated associations of anger frequency and expression style with carotid artery intima-media thickness (IMT) and stiffness in healthy adults older than 50 years...
  55. ncbi request reprint Calcium intake and prostate cancer risk in a long-term aging study: the Baltimore Longitudinal Study of Aging
    Sonja I Berndt
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Urology 60:1118-23. 2002
    ..To investigate the association between prostate cancer and calcium and other nutrients thought to influence the synthesis of 1,25-dihydroxyvitamin D [1,25(OH)2D]...
  56. ncbi request reprint PSA velocity for assessing prostate cancer risk in men with PSA levels between 2.0 and 4.0 ng/ml
    Junyong Fang
    Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA
    Urology 59:889-93; discussion 893-4. 2002
    ..To evaluate the use of prostate-specific antigen (PSA) velocity (PSAV) in assessing prostate cancer risk among men with PSA levels less than 4.0 ng/mL...
  57. pmc The relationship between ciliary neurotrophic factor (CNTF) genotype and motor unit physiology: preliminary studies
    Robin A Conwit
    National Institute on Neurological Disorders and Stroke, Rockville, MD 20892, USA
    BMC Physiol 5:15. 2005
    ..The purpose of this study is to examine whether CNTF genotype differentially affects motor unit activation in the vastus medialis with increasing isometric force during knee extension...
  58. ncbi request reprint Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness
    Angelo Scuteri
    Laboratory of Cardiovascular Science, Laboratory of Clinical Investigation, Gerontology Research Center, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224 6825, USA
    J Am Coll Cardiol 43:1388-95. 2004
    ..We sought to evaluate whether the clustering of multiple components of the metabolic syndrome (MS) has a greater impact on these vascular parameters than individual components of MS...
  59. ncbi request reprint Biomarkers of caloric restriction may predict longevity in humans
    George S Roth
    National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Science 297:811. 2002
  60. ncbi request reprint Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men
    Scott D Moffat
    Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Clin Endocrinol Metab 87:5001-7. 2002
    ..These results suggest a possible beneficial relationship between circulating free T concentrations and specific domains of cognitive performance in older men...
  61. ncbi request reprint Prostate specific antigen predicts the long-term risk of prostate enlargement: results from the Baltimore Longitudinal Study of Aging
    E James Wright
    Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Urol 167:2484-7; discussion 2487-8. 2002
    ..Prostate specific antigen (PSA) is a predictor of prostate growth in men with lower urinary tract symptoms. The long-term risk of prostate enlargement as a function of PSA among community dwelling volunteers is unknown...
  62. ncbi request reprint Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy
    Marcello Maggio
    Longitudinal Studies Section, Clinical Research Branch and the Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Baltimore, MD, USA
    J Androl 27:725-8. 2006
    ..Prospective studies are needed to evaluate for any acute changes in these inflammatory markers that might occur after the initiation of ADT...
  63. pmc Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans
    Sean Walsh
    2134 HHP Bldg, Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, MD 20742 2611, and Clinical Research Branch, National Institute on Aging, Harbor Hospital, Baltimore, USA
    J Appl Physiol (1985) 102:2142-8. 2007
    ..These results indicate that haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength, although these data indicate sex-specific relationships...
  64. pmc Candidate gene polymorphisms for ischemic stroke
    Mar Matarin
    Molecular Genetics Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Stroke 40:3436-42. 2009
    ..We investigated the contribution of 67 candidate genes (369 single nucleotide polymorphisms [SNPs]) on the risk of IS in a North American population of European descent...
  65. ncbi request reprint The relationship of arthritis self-efficacy to functional performance in older men and women with osteoarthritis of the knee
    Jean M Gaines
    Geriatric Medicine and Gerontology, The Erickson Foundation, Baltimore, MD, USA
    Geriatr Nurs 23:167-70. 2002
    ..An older woman's confidence in her ability to perform tasks affects her perceived functional performance. However, this perception may not be true for older men with OA of the knee...
  66. ncbi request reprint Prostate-specific antigen and all-cause mortality: results from the Baltimore Longitudinal Study On Aging
    H Ballentine Carter
    J Natl Cancer Inst 96:557-8. 2004
  67. ncbi request reprint Interleukin-6 (IL6) genotype is associated with fat-free mass in men but not women
    Stephen M Roth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 58:B1085-8. 2003
    ..004). No significant genotype differences were observed in total body fat mass in either men or women. The results indicate that the IL6 G-174C polymorphism is significantly associated with FFM in men but not women...
  68. ncbi request reprint The carotid artery as a noninvasive window for cardiovascular risk in apparently healthy individuals
    Yoji Nagai
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Ultrasound Med Biol 28:1231-8. 2002
    ..This article reviews "potential" utilities of carotid US evaluation for cardiovascular risk assessment in apparently healthy individuals...
  69. ncbi request reprint Relationship between in vivo age and in vitro aging: assessment of 669 cell cultures derived from members of the Baltimore Longitudinal Study of Aging
    James R Smith
    Roy M and Phyllis Gough Huffington Center on Aging, Baylor College of Medicine, Houston, Texas 78245 3207, USA
    J Gerontol A Biol Sci Med Sci 57:B239-46. 2002
    ..The implications of these results for the use of cells derived from donors of different ages for aging research are discussed...
  70. ncbi request reprint Ciliary neurotrophic factor (CNTF) genotype and body composition
    Ashok C Jacob
    Department of Kinesiology, College of Health and Human Performance, University of Maryland, College Park, MD 20742, USA
    Eur J Hum Genet 12:372-6. 2004
    ..95) or fat-free mass (P=0.86) in the BLSA cohort. Our results do not support an effect of the CNTF null allele on body composition, contrary to previous findings...
  71. ncbi request reprint Insulin-like growth factor-2 genotype, fat-free mass, and muscle performance across the adult life span
    Matthew A Schrager
    Dept of Kinesiology, University of Maryland, College Park, MD 20742, USA
    J Appl Physiol (1985) 97:2176-83. 2004
    ..These results from cohort 2 support the hypothesis that variation within a gene known to influence developing muscle affects muscle mass and muscle function in later life...
  72. pmc TNF promoter polymorphisms associated with muscle phenotypes in humans
    Dongmei Liu
    Dept of Kinesiology, Univ of Maryland, College Park, MD 20742 2611, USA
    J Appl Physiol (1985) 105:859-67. 2008
    ..25.3 +/- 0.2 kg, P < 0.025), with tendencies for lower leg muscle mass and ASMI (P = 0.07 and 0.08). Results indicate that genetic variation in the TNF locus may contribute to the interindividual variation in muscle phenotypes in men...
  73. pmc Metabolic factors associated with benign prostatic hyperplasia
    J Kellogg Parsons
    Division of Urology, University of California San Diego, 200 West Arbor Drive, San Diego, California 21287, USA
    J Clin Endocrinol Metab 91:2562-8. 2006
    ..Obesity and associated abnormalities in glucose homeostasis may play a role in benign prostatic hyperplasia development by influencing prostate growth...
  74. pmc Activity restriction induced by fear of falling and objective and subjective measures of physical function: a prospective cohort study
    Nandini Deshpande
    Department of Physical Therapy and Rehabilitation Sciences, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Geriatr Soc 56:615-20. 2008
    ..To examine whether activity restriction specifically induced by fear of falling (FF) contributes to greater risk of disability and decline in physical function...
  75. pmc High-density lipoprotein cholesterol and objective measures of lower extremity performance in older nondisabled persons: the InChianti study
    Stefano Volpato
    Department of Clinical and Experimental Medicine, Section of Internal Medicine and Geriatrics, University of Ferrara, Ferrara, Italy
    J Am Geriatr Soc 56:621-9. 2008
    ..To evaluate the independent association between high-density lipoprotein cholesterol (HDL-C) levels and objective measures of lower extremity performance...
  76. ncbi request reprint Changes in leisure time physical activity and risk of all-cause mortality in men and women: the Baltimore Longitudinal Study of Aging
    Laura A Talbot
    Graduate School of Nursing, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814 4799, USA
    Prev Med 45:169-76. 2007
    ..Higher levels of leisure time physical activity (LTPA) are associated with reduced mortality. However it is unclear how changes in LTPA over time impact all-cause mortality in men and women...
  77. ncbi request reprint Age and sex affect human muscle fibre adaptations to heavy-resistance strength training
    Gregory F Martel
    Department of Physical Therapy, University of Maryland Eastern Shore, Princess Anne, MD 21853, USA
    Exp Physiol 91:457-64. 2006
    ..01). In summary, ST led to significant increases in 1-RM and type II fibre CSA in all groups; however, age and sex influence specific muscle fibre subtype responses to ST...
  78. pmc Psychological, physical, and sensory correlates of fear of falling and consequent activity restriction in the elderly: the InCHIANTI study
    Nandini Deshpande
    University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Phys Med Rehabil 87:354-62. 2008
    ..To identify psychological, physical, and sensory function parameters that are specifically associated with fear of falling (FF) and fear-induced activity restriction in a population-based sample of older adults...
  79. pmc The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes
    Stephen M Roth
    Department of Kinesiology, University of Maryland College Park School of Public Health, College Park, MD, USA
    Eur J Hum Genet 16:391-4. 2008
    ..8%; P=0.10). The results indicate that the ACTN3 R577X nonsense allele (X) is under-represented in elite strength athletes, consistent with previous reports indicating that alpha-actinin-3 deficiency appears to impair muscle performance...
  80. pmc Influence of age, sex, and strength training on human muscle gene expression determined by microarray
    Stephen M Roth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Physiol Genomics 10:181-90. 2002
    ..These significant differences suggest that in the analysis of skeletal muscle gene expression issues of sex, age, and habitual physical activity must be addressed, with sex being the most critical variable...
  81. ncbi request reprint Relationships between surface-detected EMG signals and motor unit activation
    Hiromasa Suzuki
    Department of Rehabilitation Medicine, Dokkyo University School of Medicine, 880 Shimotuga, Mibu, Tochigi 321 02, Japan
    Med Sci Sports Exerc 34:1509-17. 2002
    ..However, the relationship has not been studied between S-EMG signal amplitude and motor unit activation at different muscle force levels...
  82. ncbi request reprint Inflammatory factors in age-related muscle wasting
    Stephen M Roth
    Department of Kinesiology, University of Maryland, College Park, Maryland, USA
    Curr Opin Rheumatol 18:625-30. 2006
    ....
  83. ncbi request reprint Androgen receptor CAG repeat polymorphism is associated with fat-free mass in men
    Sean Walsh
    Dept of Kinesiology, University of Maryland, 2134 HHP Bldg, College Park, MD 20742 2611, USA
    J Appl Physiol (1985) 98:132-7. 2005
    ..07). In conclusion, the androgen receptor CAG repeat polymorphism is associated with FFM in men in two independent cohorts. Additional studies are needed to confirm this observation and to clarify the mechanisms involved...
  84. ncbi request reprint Decline in insulin-like growth factor-I levels across adult life span in two large population studies
    Marcello Maggio
    J Gerontol A Biol Sci Med Sci 61:182-3. 2006
  85. ncbi request reprint Myostatin gene expression is reduced in humans with heavy-resistance strength training: a brief communication
    Stephen M Roth
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA sroth
    Exp Biol Med (Maywood) 228:706-9. 2003
    ..Although further work is necessary to clarify the findings, these data demonstrate that myostatin mRNA levels are reduced in response to heavy-resistance ST in humans...
  86. pmc Insulin-like growth factors, their binding proteins, and prostate cancer risk: analysis of individual patient data from 12 prospective studies
    Andrew W Roddam
    Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Roosevelt Drive, Oxford OX3 7LF, United Kingdom
    Ann Intern Med 149:461-71, W83-8. 2008
    ..Some, but not all, published results have shown an association between circulating blood levels of some insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) and the subsequent risk for prostate cancer...
  87. ncbi request reprint Postflight balance control recovery in an elderly astronaut: a case report
    William H Paloski
    Neurosciences Laboratory, NASA Johnson Space Center, Houston, Texas 77058, USA
    Otol Neurotol 25:53-6. 2004
    ..To examine the sensorimotor adaptive response of a 77-year-old man exposed to the gravito-inertial challenges of orbital space flight...
  88. ncbi request reprint A statistical model for interpreting computerized dynamic posturography data
    Alan H Feiveson
    National Aeronautics and Space Administration, Johnson Space Center, Houston, TX 77058, USA
    IEEE Trans Biomed Eng 49:300-9. 2002
    ..An example is provided, using data from the NIH/NIA Baltimore Longitudinal Study on Aging...
  89. ncbi request reprint Age associated differences in postural equilibrium control: a comparison between EQscore and minimum time to contact (TTC(min))
    Katharine E Forth
    National Space Biomedical Research Institute, Baylor College of Medicine, Houston, TX, USA
    Gait Posture 25:56-62. 2007
    ..TTC may offer a more accurate estimate of postural stability (functional ability) than EQscore based on its inclusion of a velocity component to detect dynamic changes...
  90. ncbi request reprint Expectant management of prostate cancer with curative intent: an update of the Johns Hopkins experience
    H Ballentine Carter
    Department of Urology, The Johns Hopkins University School of Medicine and The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2101, UAS
    J Urol 178:2359-64; discussion 2364-5. 2007
    ..We updated our experience with a strategy of expectant treatment for men with stage T1c prostate cancer and evaluated predictors of disease intervention...