Research Topics
Genomes and Genes
| Maria J MerinoSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case reportPhuong L Mai
Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Med Case Reports 1:9. 2007..Familial testicular cancer in the presence of other findings in affected and unaffected family members might indicate a previously-unidentified hereditary cancer syndrome...
The morphologic spectrum of kidney tumors in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndromeMaria J Merino
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
Am J Surg Pathol 31:1578-85. 2007..At the moment, morphology is the best tool to recognize these tumors. Proper diagnosis of this syndrome by the pathologist may assist in early detection of these tumors...- UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancerYoufeng Yang
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1107, Bldg 10 CRC, Room 1 5942, Bethesda, MD 20892 1107
Cancer Genet Cytogenet 196:45-55. 2010..This tumor model is the embodiment of the Warburg effect. UOK 262 provides a unique in vitro and in vivo preclinical model for studying the bioenergetics of the Warburg effect in human cancer... - High frequency of somatic frameshift BHD gene mutations in Birt-Hogg-Dubé-associated renal tumorsCathy D Vocke
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Cancer Inst 97:931-5. 2005..These results support a role for BHD as a tumor suppressor gene that predisposes to the development of renal tumors when both copies are inactivated... - Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brainBrunilde Gril
Women s Cancers Section, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 1122, MSC 4254, Bethesda, MD 20892, USA
J Natl Cancer Inst 100:1092-103. 2008..We examined the efficacy of lapatinib, an inhibitor of the epidermal growth factor receptor (EGFR) and HER2 kinases, for preventing the outgrowth of breast cancer cells in the brain in a mouse xenograft model of brain metastasis... - The UOK 257 cell line: a novel model for studies of the human Birt-Hogg-Dubé gene pathwayYoufeng Yang
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1W 5888, Bethesda, MD 20892, USA
Cancer Genet Cytogenet 180:100-9. 2008..The result demonstrates that the established tumor cells consist of two cell populations, one containing four and one containing five copies of the MYC oncogene... - Proteomic identification of new biomarkers and application in thyroid cytologyCarlos Torres-Cabala
Surgical Pathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. 20892, USA
Acta Cytol 50:518-28. 2006..CONCLUSION: Immunohistochemical validation of potential markers is a crucial step before clinical application in diagnosis. Galectin-3, galectin-1 and S100C can be used to help in discriminating benign and malignant thyroid lesions... - Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signalingSeung Beom Hong
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 10 Center Drive MSC1107, 10 CRC 1W 5940, Bethesda, MD 20892, USA
Mol Cancer 9:160. 2010..Somatic mutations or loss of heterozygosity in the remaining wild type copy of the FLCN gene have been found in renal tumors from BHD patients suggesting that FLCN is a classic tumor suppressor gene... - Decision support system for localizing prostate cancer based on multiparametric magnetic resonance imagingVijay Shah
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Med Phys 39:4093-103. 2012..Our goal was to develop a decision support system (DSS) for detecting and localizing peripheral zone prostate cancers by using machine learning approach to calculate a cancer probability map from multiparametric MR images (MP-MRI)... - Use of patient-specific MRI-based prostate mold for validation of multiparametric MRI in localization of prostate cancerHari Trivedi
Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, Molecular Imaging Program, Urologic Oncology Branch, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 1088, USA
Urology 79:233-9. 2012..A significant difficulty to date has been accurate correlation between the magnetic resonance images and histopathologic specimens... 
Correlation of magnetic resonance imaging tumor volume with histopathologyBaris Turkbey
Molecular Imaging Program, National Cancer Institute, Bethesda, Maryland 20892 1210, USA
J Urol 188:1157-63. 2012..We determined the accuracy of magnetic resonance imaging for determining index tumor volume compared with volumes derived from histopathology...- Documenting the location of systematic transrectal ultrasound-guided prostate biopsies: correlation with multi-parametric MRIBaris Turkbey
National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Imaging 11:31-6. 2011.... - Is apparent diffusion coefficient associated with clinical risk scores for prostate cancers that are visible on 3-T MR images?Baris Turkbey
Molecular Imaging Program, Center for Interventional Oncology, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Bldg 10, Room B3B69F, Bethesda, MD 20892 1088, USA
Radiology 258:488-95. 2011.... - Association of germline mutations in the fumarate hydratase gene and uterine fibroids in women with hereditary leiomyomatosis and renal cell cancerLaveta Stewart
Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MD 20892 7231, USA
Arch Dermatol 144:1584-92. 2008..To investigate the risk of uterine fibroids and other reproductive risk factors in women with hereditary leiomyomatosis and renal cell cancer (HLRCC)... - Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosisDiane Palmieri
Women s Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 7322, USA
Mol Cancer Res 7:1438-45. 2009..028). The data suggest that HK2 overexpression is associated with metastasis to the brain in breast cancer and it may be a therapeutic target... - Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2Christine E Horak
Women s Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 67:11751-9. 2007..73; P = 0.004). The data indicate that Nm23-H1 down-regulation of EDG2 is functionally important to suppression of tumor metastasis... - MRI of localized prostate cancer: coming of age in the PSA eraBaris Turkbey
Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA
Diagn Interv Radiol 18:34-45. 2012..In this article, we introduce the reader to the expanding roles that MRI plays in the management of localized prostate cancer... - Multiparametric 3T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based moldsBaris Turkbey
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Urol 186:1818-24. 2011..Precise one-to-one histopathological correlation with magnetic resonance imaging was possible using prostate magnetic resonance imaging based custom printed specimen molds after radical prostatectomy... - 11C-Acetate PET/CT in localized prostate cancer: a study with MRI and histopathologic correlationEsther Mena
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Nucl Med 53:538-45. 2012.... - Documenting the location of prostate biopsies with image fusionBaris Turkbey
Molecular Imaging Program, NCI, NIH, Bethesda, MD, USA
BJU Int 107:53-7. 2011.... - Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2Yukiko Hasumi
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:18722-7. 2009.... - Role of chromogenic in situ hybridization (CISH) in the evaluation of HER2 status in breast carcinoma: comparison with immunohistochemistry and FISHElsa Li-Ning-T
Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
Int J Surg Pathol 13:343-51. 2005..Chromosome 17 analysis was necessary in cases with a low number of HER2 gene copies. CISH is a useful tool to evaluate breast cancer HER2 status that can be easily implemented in a laboratory of surgical pathology... - Loss of heterozygosity on chromosome 1 and 9 and hormone receptor analysis of metastatic malignant melanoma presenting in breastMichael W Beaty
Laboratory of Pathology, Surgical Pathology Section, National Cancer Institute, Bethesda, MD 20892, USA
Int J Surg Pathol 13:9-18. 2005..Additional LOH was observed at the 9q22.3-31 locus (40%). We suggest this locus to be investigated for harboring potential genes important in the tumorigenesis of cutaneous MM... - FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesionsMojgan Ahmadzadeh
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Blood 112:4953-60. 2008.... - Differential expression of S100C in thyroid lesionsCarlos Torres-Cabala
Surgical Pathology Section, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD, USA
Int J Surg Pathol 12:107-15. 2004.... - Characterization and management of testicular pathology in McCune-Albright syndromeAlison M Boyce
Skeletal Clinical Studies Unit, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Clin Endocrinol Metab 97:E1782-90. 2012..Radiographic and histological studies are limited to small series and case reports, which report testicular microlithiasis and Sertoli cell hyperplasia... - Identification of EpCAM as a molecular target of prostate cancer stromaSumana Mukherjee
Pathogenetics Unit, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4605, USA
Am J Pathol 175:2277-87. 2009..Since the stromal compartment may be particularly accessible to vascular-delivered agents, epithelial cell adhesion activating molecule could become a valuable molecular target for imaging or treatment of prostate cancer... - Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancerRobert L Grubb
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Urol 177:2074-9; discussion 2079-80. 2007..We report the clinical characteristics and urological treatment of patients with hereditary leiomyomatosis and renal cell cancer associated renal tumors... - Renal tumors in the Birt-Hogg-Dubé syndromeChristian P Pavlovich
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute/NIH, Bldg. 10 Rm. 2N212, Bethesda, MD 20892, USA
Am J Surg Pathol 26:1542-52. 2002..Recognition by the pathologist of the unusual renal tumors associated with BHD may assist in the clinical diagnosis of the syndrome... - Prostate cancer: value of multiparametric MR imaging at 3 T for detection--histopathologic correlationBaris Turkbey
Molecular Imaging Program, National Cancer Institute, National Institutes of Health, 10 Center Dr, MSC 1182, Bldg 10, Room 1B40, Bethesda, MD 20892 1088, USA
Radiology 255:89-99. 2010.... - T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitisMaria R Parkhurst
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Mol Ther 19:620-6. 2011..It also emphasizes the destructive power of small numbers of highly avid T cells and the limitations of using CEA as a target for cancer immunotherapy... - Successful treatment of periodontal mucormycosis: report of a case and literature reviewNancy E McDermott
National Institute of Dental and Craniofacial Research, Bethesda, Maryland 20892, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:e64-9. 2010..Calcofluor fluorescence microscopy is also proposed as a method for establishing a prompt diagnosis and guiding extent of intraoperative surgical debridement... - Predisposition to cancer caused by genetic and functional defects of mammalian Atad5Daphne W Bell
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Genet 7:e1002245. 2011..Taken together, our findings indicate that loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis... - Location, color, size, depth, and volume may predict endometriosis in lesions resected at surgeryPamela Stratton
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1853, USA
Fertil Steril 78:743-9. 2002..To correlate the diagnosis of endometriosis in lesions excised at laparoscopy with pathologic diagnosis... - CD10 immunohistochemical staining enhances the histological detection of endometriosisClariss Potlog-Nahari
Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 1583, USA
Fertil Steril 82:86-92. 2004..To determine whether the use of CD10 immunohistochemistry in addition to hematoxylin and eosin (H&E) staining would increase the sensitivity of surgically suspected endometriosis lesions... - Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancerChristopher J Ricketts
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
J Urol 188:2063-71. 2012..We report our experience with the diagnosis, evaluation and treatment of this novel form of hereditary kidney cancer... - Protein expression profiling in the spectrum of renal cell carcinomasVladimir A Valera
1 Surgical Pathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, USA
J Cancer 1:184-96. 2010..From these changes, Hsp27 and TPI-1 emerged as potential candidates for the differentiation and prognosis in RCC... - A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomasMeghan L Rudd
Cancer Genetics Branch, National Human Genome Research Institute, National Cancer Institute, Bethesda, Maryland, USA
Clin Cancer Res 17:1331-40. 2011..The goal of this study was to comprehensively define the incidence of mutations in all exons of PIK3CA in both endometrioid endometrial cancer (EEC) and nonendometrioid endometrial cancer (NEEC)... - Rab11a differentially modulates epidermal growth factor-induced proliferation and motility in immortal breast cellsDiane Palmieri
Women s Cancers Section, Laboratory of Molecular Pharmacology, Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20874, USA
Breast Cancer Res Treat 100:127-37. 2006..The data provide a first demonstration that Rab11a modulates EGFR recycling, and promotes the proliferation but inhibits the motility of an immortal breast line, consistent with the DCIS phenotype... - Noninvasive monitoring of a murine model of metastatic pheochromocytoma: a comparison of contrast-enhanced microCT and nonenhanced MRILucia Martiniova
Reproductive and Adult Endocrinology Program, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892 1109, USA
J Magn Reson Imaging 29:685-91. 2009..However, the choice of imaging modality is still evolving... - Microvessel density, expression of estrogen receptor alpha, MIB-1, p53, and c-erbB-2 in inflammatory breast cancerNicole J McCarthy
Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA
Clin Cancer Res 8:3857-62. 2002..02; Bonferroni test). CONCLUSIONS: These data suggest that there is an increased MVD in breast cancer with the inflammatory phenotype as compared with breast cancer without the inflammatory phenotype... - Expression of Birt-Hogg-Dubé gene mRNA in normal and neoplastic human tissuesMichelle B Warren
Laboratory of Immunobiology, Center for Cancer Research, NCI Frederick, Frederick, MD, USA
Mod Pathol 17:998-1011. 2004..These results indicate a wide expression pattern for BHD mRNA in many tissues, including skin, lung and kidney, which are involved in the BHD phenotype, and support a tumor suppressor role for BHD in renal cancer... - Role of metastasectomy in the management of thyroid carcinoma: the NIH experienceHo Pak
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1758, USA
J Surg Oncol 82:10-8. 2003.... - Enhanced homing permeability and retention of bone marrow stromal cells by noninvasive pulsed focused ultrasoundAli Ziadloo
Laboratory of Diagnostic Radiology Research, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA
Stem Cells 30:1216-27. 2012..pFUS could potentially improve cell-based therapies as a noninvasive modality to target homing by establishing local chemoattractant gradients and increasing expression of integrins to enhance tropism of cells toward treated tissues... - Misdiagnosis of clear cell renal cell carcinomaVladimir A Valera
Translational Surgical Pathology section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, MSC Room 2B44, Bethesda, MD 20892, USA
Nat Rev Urol 8:321-33. 2011.... - Mesothelial neoplasms presenting as, and mimicking, ovarian cancerHaresh Mani
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Int J Gynecol Pathol 29:523-8. 2010..Mesothelial neoplasms can present as ovarian masses in young women. Awareness of this presentation is important to establish appropriate management... - Randomized study of high-dose and low-dose interleukin-2 in patients with metastatic renal cancerJames C Yang
Surgery Branch, Biostatistics and Data Management Section, Department of Pathology, National Cancer Institute NIH, Room 2B 37, Building 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
J Clin Oncol 21:3127-32. 2003..This three-arm randomized study compares response rates and overall survival of patients with metastatic renal cell cancer (RCC) receiving high-dose or one of two low-dose interleukin-2 (IL-2) regimens... - miR-21 Expression in Pregnancy-Associated Breast Cancer: A Possible Marker of Poor PrognosisBeatriz A Walter
1 Laboratory of Pathology, National Institutes of Health, National Cancer Institute, Bethesda, MD, USA
J Cancer 2:67-75. 2011..Conclusion: Our study supports the involvement of miR-21 in breast cancer progression and metastasis formation in PABC implying a role of this miRNA as a marker for poor prognosis in PABC patients... - Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancerErin F Wolff
Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Diabetes, Digestive, and Kidney Diseases, NIH, Bethesda, MD 20892 1613, USA
Thyroid 20:981-7. 2010..Here we review this topic and illustrate major features by presenting multimodal management of a patient with BRAF-positive disseminated follicular thyroid cancer arising in an ovarian teratoma... - Primary synovial sarcoma of the kidney with rhabdoid featuresMauricio A Paláu L
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Int J Surg Pathol 15:421-8. 2007.... - A phase II trial of neoadjuvant docetaxel and capecitabine for locally advanced breast cancerPeter F Lebowitz
Medical Oncology Clinical Research Unit, Cancer Therapeutics Branch, Laboratory of Pathology, Biostatistics and Data Management, and Surgery Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
Clin Cancer Res 10:6764-9. 2004..CONCLUSIONS: Docetaxel/capecitabine is a highly active regimen in the neoadjuvant setting. Neoadjuvant therapy with 75 mg/m(2) docetaxel and 1600 mg/m(2)/day days 2-15 is recommended... - Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivoDaniel J Powell
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:4919-28. 2007.... - Endometrial endometrioid adenocarcinoma of the uterine corpus involving the cervix: some cases probably represent independent primariesLiuyan Jiang
Department of Pathology, National Cancer Institute, Bethesda, MD, USA
Int J Gynecol Pathol 29:146-56. 2010..HPV studies are important to identify endocervical tumors associated with high-risk HPV. However, endometrial tumors involving the cervix and endocervical tumors unrelated to HPV are both negative for high-risk HPV... - Juxtathyroidal neck soft tissue angiosarcoma presenting as an undifferentiated thyroid carcinomaJuan Yu
Division of Intramural Research, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Thyroid 12:427-32. 2002.... - Localization of medullary thyroid carcinoma metastasis in a multiple endocrine neoplasia type 2A patient by 6-[18F]-fluorodopamine positron emission tomographyLoukas Gourgiotis
Clinical Endocrinology Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
J Clin Endocrinol Metab 88:637-41. 2003.... - Ectopic growth hormone-releasing hormone secretion by a bronchial carcinoid tumor: clinical experience following tumor resection and long-acting octreotide therapyPeter W Butler
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, Bethesda, MD, USA
Pituitary 15:260-5. 2012..At 20 months, off octreotide, serum IGF-1 levels had normalized, acromegalic features were receding, and the patient's daily insulin requirements had decreased by 57%... - A gastrointestinal stromal tumor in a patient with multiple endocrine neoplasia type 2A and metastatic medullary thyroid cancer to the ovariesRana Malek
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, NIH, Bethesda, MD 20892, USA
Endocr Pract 14:898-901. 2008..To describe the first reported case of a patient with multiple endocrine neoplasia type 2A and a gastrointestinal stromal tumor, as well as the second reported case of metastatic medullary thyroid cancer to the ovary... - Corticotropin-producing pulmonary gangliocytic paraganglioma associated with Cushing's syndromeMauricio A Paláu
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Hum Pathol 37:623-6. 2006..After removal of the tumor, there was a significant drop in cortisol and corticotropin levels. To our knowledge, this is the first report of a GP causing Cushing's syndrome... - Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failureVladimir K Bakalov
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Fertil Steril 84:958-65. 2005..To assess the association between serum adrenal cortex autoantibodies and histologically confirmed autoimmune lymphocytic oophoritis... - Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancerDiane Palmieri
Women s Cancers Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
J Natl Cancer Inst 97:632-42. 2005..Here, we tested whether MPA treatment inhibits metastatic colonization of a hormone receptor-negative breast cancer cell line in vivo... - Thyroid carcinoma in the McCune-Albright syndrome: contributory role of activating Gs alpha mutationsMichael T Collins
Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4320, USA
J Clin Endocrinol Metab 88:4413-7. 2003..These findings suggest that the infrequent development of thyroid carcinoma in MAS patients involves additional mutational or epigenetic events... - Proteomics of human breast ductal carcinoma in situJulia D Wulfkuhle
Women's Cancers Section, Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892, USA
Cancer Res 62:6740-9. 2002..Proteomic analysis of DCIS revealed differential expression patterns distinct from previous nucleic acid-based studies and identified new facets of the earliest stage of breast cancer progression... - Evaluation of non-formalin tissue fixation for molecular profiling studiesJohn W Gillespie
Pathogenetics Unit, Laboratory of Pathology, National Cancer Institute, Rm. 2C500. Bldg. 10, 9000 Rockville Pike, Bethesda, MD 20892, USA
Am J Pathol 160:449-57. 2002..Complete protocols and additional discussion of relevant issues are available on an accompanying website (http://cgap-mf.nih.gov/)... - Successful outcome after surgical management in two cases of the "painful variant" of Hashimoto's thyroiditisLoukas Gourgiotis
Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1758, USA
Endocr Pract 8:259-65. 2002..Access to experienced endocrine surgeons is important in order to avoid postoperative complications because the thyroid gland may be small or fibrosed in this rare variant of HT... - Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndromeLaura S Schmidt
Basic Research Program, Science Applications International Corporation Frederick Inc, Frederick, MD, USA
Am J Hum Genet 76:1023-33. 2005..This study expands the BHD-mutation spectrum and evaluates genotype-phenotype correlations among families with BHD... - Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogeneLaura S Schmidt
Basic Research Program, SAIC Frederick, Inc, Frederick, Maryland, USA
J Urol 172:1256-61. 2004..In the current study we evaluated the clinical phenotype and germline MET mutation of 3 new HPRC families. We describe the early onset clinical features of HPRC... - Loss of heterozygosity of p53, BRCA1, VHL, and estrogen receptor genes in breast carcinoma: correlation with related protein products and morphologic featuresChristopher N Otis
Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA
Int J Surg Pathol 10:237-45. 2002..Missense or nonsense mutations may explain the absence of detectable p53 protein in 6 of 13 cases with p53 LOH. All 4 ER LOH cases expressed ER protein. BRCA1 and VHL LOH is infrequent in sporadic breast carcinoma... - Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndromeBerton Zbar
Laboratory of Immunobiology, Science Application International Corporation, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA
Cancer Epidemiol Biomarkers Prev 11:393-400. 2002..The Birt-Hogg-Dubé syndrome confers an increased risk for the development of renal tumors and spontaneous pneumothorax. We found no increase in risk for the development of colon polyps or colon carcinomas... - 3p21, 5q21, 9p21 and 17p13.1 allelic deletions are potential markers of individuals with a high risk of developing adenocarcinoma in Barrett's epithelium without dysplasiaJulian Sanz-Ortega
Departamento de Anatomía Patológica Hospital Clinico San Carlos, Martin Lagos s n, Madrid, Spain 28040
Hepatogastroenterology 50:404-7. 2003..We investigated 32 cases of Barrett's esophagus with no evidence of dysplasia for LOH at 5q21 (APC), 3p21, 9p21 (p16) and 17p13.1 (p53) chromosomal regions... - Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndromeChristian P Pavlovich
Urologic Oncology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute and Basic Research Program, SAIC-Frederick, Inc, Frederick, Maryland, USA
J Urol 173:1482-6. 2005..Individuals at risk or affected by BHD should be radiographically screened for renal tumors at periodic intervals and they are best treated with nephron sparing surgical approaches. Genetic testing for this syndrome is now available... - Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science ConferenceZubair W Baloch
Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Diagn Cytopathol 36:425-37. 2008..http://thyroidfna.cancer.gov/pages/info/agenda/)...