Jan Joseph Melenhorst

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation
    Jan Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Haematologica 97:867-73. 2012
  2. ncbi request reprint Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:6484-9. 2008
  3. pmc Alloreactivity across HLA barriers is mediated by both naïve and antigen-experienced T cells
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
    Biol Blood Marrow Transplant 17:800-9. 2011
  4. ncbi request reprint Robust expansion of viral antigen-specific CD4+ and CD8+ T cells for adoptive T cell therapy using gene-modified activated T cells as antigen presenting cells
    Jan Joseph Melenhorst
    Stem Cell Allogeneic Transplantation Section, Hematology Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892 1202, USA
    J Immunother 29:436-43; discussion 365-6. 2006
  5. doi request reprint Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture
    J J Melenhorst
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1202, USA
    Cytotherapy 10:152-64. 2008
  6. pmc High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:2238-44. 2009
  7. pmc Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant
    Zachariah McIver
    Allogeneic Stem Cell Transplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Haematologica 98:346-52. 2013
  8. ncbi request reprint Large granular lymphocyte leukaemia is characterized by a clonal T-cell receptor rearrangement in both memory and effector CD8(+) lymphocyte populations
    J J Melenhorst
    Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 112:189-94. 2001
  9. ncbi request reprint CD8+ T cells in large granular lymphocyte leukemia are not defective in activation- and replication-related apoptosis
    J J Melenhorst
    Bone Marrow Transplant Unit, Hematology Branch, NHLBI, National Institutes of Health, Building 10, Room 7C103, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Leuk Res 25:699-708. 2001
  10. pmc Ultra-low Dose Interleukin-2 Promotes Immune-modulating Function of Regulatory T Cells and Natural Killer Cells in Healthy Volunteers
    Sawa Ito
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Ther 22:1388-95. 2014

Detail Information

Publications13

  1. pmc Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation
    Jan Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Haematologica 97:867-73. 2012
    ..The aim of this study was to examine the contributions of the conditioning regimen, donor engraftment, infections, and graft-versus-host disease to fluctuations in cytokines involved in homeostasis and inflammation...
  2. ncbi request reprint Contribution of TCR-beta locus and HLA to the shape of the mature human Vbeta repertoire
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:6484-9. 2008
    ..We therefore conclude that the correlation in Vbeta expression patterns between CD4(+) and CD8(+) T cells can be explained predominantly by germline TCR-beta locus factors and not TCR-beta allelic or HLA effects...
  3. pmc Alloreactivity across HLA barriers is mediated by both naïve and antigen-experienced T cells
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1202, USA
    Biol Blood Marrow Transplant 17:800-9. 2011
    ....
  4. ncbi request reprint Robust expansion of viral antigen-specific CD4+ and CD8+ T cells for adoptive T cell therapy using gene-modified activated T cells as antigen presenting cells
    Jan Joseph Melenhorst
    Stem Cell Allogeneic Transplantation Section, Hematology Branch, NHLBI, NIH, 10 Center Drive, Bethesda, MD 20892 1202, USA
    J Immunother 29:436-43; discussion 365-6. 2006
    ..The approach has the advantage of using a single leukocyte collection from the donor to generate large numbers of CMV-specific T cells within a total 3-week culture period using only one stimulation of antigen...
  5. doi request reprint Regulatory T-cell depletion does not prevent emergence of new CD25+ FOXP3+ lymphocytes after antigen stimulation in culture
    J J Melenhorst
    Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1202, USA
    Cytotherapy 10:152-64. 2008
    ..The removal of human regulatory T (T(reg)) cells from a cellular product prior to the induction of a T-cell response has the potential to boost the total yield of antigen (Ag)-specific CD4(+) and CD8(+) T cells...
  6. pmc High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow
    J Joseph Melenhorst
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 113:2238-44. 2009
    ..These data suggest that concomitant examination of bone marrow specimens in patients with myeloid leukemias might yield more definitive information in the search for immunologic prognosticators of clinical outcome...
  7. pmc Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant
    Zachariah McIver
    Allogeneic Stem Cell Transplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Haematologica 98:346-52. 2013
    ..The study reported here was performed using peripheral blood samples drawn from donors and patients enrolled in the ClinicalTrials.gov-registered trials NCT00001623, NCT00001873, NCT00353860, NCT00066300, NCT00079391, and NCT00398346...
  8. ncbi request reprint Large granular lymphocyte leukaemia is characterized by a clonal T-cell receptor rearrangement in both memory and effector CD8(+) lymphocyte populations
    J J Melenhorst
    Bone Marrow Transplant Unit, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Br J Haematol 112:189-94. 2001
    ..These results suggest that LGL disease originates in a CD57(-) memory T-cell compartment that continually generates CD57(+) (effector cell) progeny...
  9. ncbi request reprint CD8+ T cells in large granular lymphocyte leukemia are not defective in activation- and replication-related apoptosis
    J J Melenhorst
    Bone Marrow Transplant Unit, Hematology Branch, NHLBI, National Institutes of Health, Building 10, Room 7C103, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Leuk Res 25:699-708. 2001
    ..Together, these data indicate that activation- and proliferation-related cell death mechanisms are functional in LGL cells...
  10. pmc Ultra-low Dose Interleukin-2 Promotes Immune-modulating Function of Regulatory T Cells and Natural Killer Cells in Healthy Volunteers
    Sawa Ito
    Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Mol Ther 22:1388-95. 2014
    ..This is the first study to evaluate global immune-modulating function of ULD IL-2 in healthy subjects and to support the future studies administrating ULD IL-2 to stem cell donors. ..
  11. pmc Bone marrow mesenchymal stromal cells to treat tissue damage in allogeneic stem cell transplant recipients: correlation of biological markers with clinical responses
    Fang Yin
    Hematology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland, USA
    Stem Cells 32:1278-88. 2014
    ..However, BMSCs were ineffective in patients with prolonged GVHD with lower lymphocyte counts, which suggest that effective GVHD control by BMSCs requires a relatively intact immune system...
  12. ncbi request reprint Flow cytometric quantitation and characterization of the T-lymphocyte memory response to CMV in healthy donors
    N Hensel
    Stem Cell Transplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cytotherapy 4:29-40. 2002
    ..Levels of circulating CMV Ag-specific lymphocytes determine CMV reactivation risk in immunocompromised individuals...
  13. ncbi request reprint An APC for every occasion: induction and expansion of human Ag-specific CD4 and CD8 T cells using cellular and non-cellular APC
    M Grube
    Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, MD 20892, USA
    Cytotherapy 6:440-9. 2004
    ..In this review we outline the functional requirements of APC for the induction of T cells, classify the APC in common use and describe their laboratory and clinical applications...