Leah E Mechanic

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Next generation analytic tools for large scale genetic epidemiology studies of complex diseases
    Leah E Mechanic
    Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Genet Epidemiol 36:22-35. 2012
  2. pmc Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA
    BMC Bioinformatics 9:146. 2008
  3. ncbi request reprint Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, NCI NIH, 37 Convent Drive MSC 4255, Bldg 37 Rm 3060, Bethesda, MD 20892 4255, USA
    Carcinogenesis 27:1377-85. 2006
  4. ncbi request reprint Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland 20892 4258, USA
    Cancer Epidemiol Biomarkers Prev 16:214-22. 2007
  5. ncbi request reprint Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene
    Sharon R Pine
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 99:1401-9. 2007
  6. pmc Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk
    Susan E Olivo-Marston
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD 20892 4258, USA
    Cancer Epidemiol Biomarkers Prev 18:3375-83. 2009
  7. pmc Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer
    Sharon R Pine
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 103:1112-22. 2011
  8. ncbi request reprint MDM2 SNP309 and SNP354 are not associated with lung cancer risk
    Sharon R Pine
    Laboratory of Human Carcinogenesis, National Cancer Institute, Room 3068, Building 37, 37 Convent Drive, Bethesda, MD 20892 4258, USA
    Cancer Epidemiol Biomarkers Prev 15:1559-61. 2006
  9. ncbi request reprint TP53 mutation spectrum in lung cancer is not different in women and men
    Aizen J Marrogi
    Laboratory of Carcinogenesis and Biomarkers, Clinical Breast Care Project Immunology and Research Center, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 14:1031-3. 2005
  10. pmc Association of MTHFR gene polymorphisms with breast cancer survival
    Damali N Martin
    Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Cancer 6:257. 2006

Detail Information

Publications24

  1. pmc Next generation analytic tools for large scale genetic epidemiology studies of complex diseases
    Leah E Mechanic
    Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Genet Epidemiol 36:22-35. 2012
    ..Specific needs to advance the field were identified during each session and are summarized...
  2. pmc Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA
    BMC Bioinformatics 9:146. 2008
    ..Investigating associations for each individual SNP or interactions between SNPs using traditional approaches is inefficient and prone to false positives...
  3. ncbi request reprint Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, NCI NIH, 37 Convent Drive MSC 4255, Bldg 37 Rm 3060, Bethesda, MD 20892 4255, USA
    Carcinogenesis 27:1377-85. 2006
    ..These results are consistent with previous evidence of exposure-specific p53 mutations in breast tumors from current and former smokers, suggesting that smoking may play a role in breast cancer etiology...
  4. ncbi request reprint Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland 20892 4258, USA
    Cancer Epidemiol Biomarkers Prev 16:214-22. 2007
    ..In conclusion, common genetic variation in TP53 could modulate lung cancer pathways, as suggested by the association with lung cancer in African Americans and somatic TP53 mutation frequency in lung tumors...
  5. ncbi request reprint Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene
    Sharon R Pine
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 99:1401-9. 2007
    ..e., LYB, LYC, HYD, and LXA) or higher (i.e., HYA and LYA) serum MBL concentrations. We investigated whether survival of patients with lung cancer was associated with these polymorphisms...
  6. pmc Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk
    Susan E Olivo-Marston
    Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD 20892 4258, USA
    Cancer Epidemiol Biomarkers Prev 18:3375-83. 2009
    ....
  7. pmc Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer
    Sharon R Pine
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 103:1112-22. 2011
    ..Previous studies that were based primarily on small numbers of patients suggested that certain circulating proinflammatory cytokines may be associated with lung cancer; however, large independent studies are lacking...
  8. ncbi request reprint MDM2 SNP309 and SNP354 are not associated with lung cancer risk
    Sharon R Pine
    Laboratory of Human Carcinogenesis, National Cancer Institute, Room 3068, Building 37, 37 Convent Drive, Bethesda, MD 20892 4258, USA
    Cancer Epidemiol Biomarkers Prev 15:1559-61. 2006
    ..In addition, this is the first MDM2 SNP309 report on a population consisting of Caucasians in the United States and African-Americans. A strength of the study design is that the controls consist of both population and hospital controls...
  9. ncbi request reprint TP53 mutation spectrum in lung cancer is not different in women and men
    Aizen J Marrogi
    Laboratory of Carcinogenesis and Biomarkers, Clinical Breast Care Project Immunology and Research Center, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 14:1031-3. 2005
    ..Our results are consistent with a recent large cohort study and summary of previous cohort studies, suggesting that women likely have equivalent susceptibility to lung cancer as men...
  10. pmc Association of MTHFR gene polymorphisms with breast cancer survival
    Damali N Martin
    Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    BMC Cancer 6:257. 2006
    ..We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-American and Caucasian women...
  11. pmc Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women
    Susan E Olivo-Marston
    Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 31:1778-86. 2010
    ..Understanding the genetic control of estrogen biosynthesis and response in lung cancer could lead to improved prognosis and therapy...
  12. pmc EGFR somatic mutations in lung tumors: radon exposure and passive smoking in former- and never-smoking U.S. women
    Masataka Taga
    Department of Radiobiology, National Cancer Institute, NIH, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 21:988-92. 2012
    ..Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis when treated with EGFR inhibitors. We hypothesized that EGFR mutations may be related to residential radon or passive tobacco smoke...
  13. pmc Association of matrix metalloproteinase-1 polymorphisms with risk of COPD and lung cancer and survival in lung cancer
    Lindsey Enewold
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Anticancer Res 32:3917-22. 2012
    ....
  14. pmc Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis
    Julie E Goodman
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Int J Cancer 118:1790-7. 2006
    ..Our results suggest that PIA is a valid method for suggesting SNP-SNP interactions that may be validated in future studies, using more traditional statistical methods on different datasets...
  15. pmc SERPINA1 and ELA2 polymorphisms are not associated with COPD or lung cancer
    Lindsey Enewold
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Anticancer Res 32:3923-8. 2012
    ....
  16. pmc Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report
    Carolyn M Hutter
    Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    Genet Epidemiol 37:643-57. 2013
    ..Additional designs, exposure assessments, and analytical approaches need to be considered as we move from the current small number of success stories to a fuller understanding of the interplay of genetic and environmental factors. ..
  17. ncbi request reprint Quantitative detection of p53 mutations in plasma DNA from tobacco smokers
    Nobutoshi Hagiwara
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892 4258, USA
    Cancer Res 66:8309-17. 2006
    ..04). In summary, we were able to detect p53 mutations in plasma DNA from healthy individuals and our data suggest that p53 mutations in plasma DNA may be a marker of carcinogen exposure from tobacco smoke...
  18. ncbi request reprint Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier
    Masahiro Seike
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4258, USA
    J Natl Cancer Inst 99:1257-69. 2007
    ..We examined whether the cytokine gene expression profile of noncancerous lung tissue could predict the metastatic capability of adjacent lung adenocarcinoma...
  19. ncbi request reprint Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer
    Sei Hoon Yang
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute NIH, 41 Library Drive, Bethesda, MD 20892, USA
    Clin Cancer Res 11:2106-10. 2005
    ..Screening subjects with EGFR mutations may identify patients whose tumors could respond to targeted therapy using tyrosine kinase inhibitors...
  20. pmc A review of NCI's extramural grant portfolio: identifying opportunities for future research in genes and environment in cancer
    Armen A Ghazarian
    Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 22:501-7. 2013
    ..Genetic and environmental factors jointly influence cancer risk. The NIH has made the study of gene-environment (GxE) interactions a research priority since the year 2000...
  21. ncbi request reprint Nitric oxide, a mediator of inflammation, suppresses tumorigenesis
    S Perwez Hussain
    Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    Cancer Res 64:6849-53. 2004
    ..Furthermore, mice deficient in both p53 and NOS2 produced a high level of anti-inflammatory interleukin 10 when compared with p53-deficient mice. These studies provide genetic and mechanistic evidence that NO* can suppress tumorigenesis...
  22. ncbi request reprint Polymorphisms in XPD and TP53 and mutation in human lung cancer
    Leah E Mechanic
    Laboratory of Human Carcinogenesis, NCI Center for Cancer Research, 37 Convent Drive, Bethesda, MD 20892 4255, USA
    Carcinogenesis 26:597-604. 2005
    ..In conclusion, differences in TP53 mutation spectra in lung tumors are associated with several genetic factors and may reflect differences in lung cancer susceptibility and carcinogenesis...
  23. pmc The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation
    Lorne J Hofseth
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    J Clin Invest 112:1887-94. 2003
    ....
  24. ncbi request reprint The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women
    Toralf Bernig
    Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research CCR, National Cancer Institute NCI, National Institutes of Health NIH Bethesda, MD 20892 4258, USA
    Carcinogenesis 28:828-36. 2007
    ....