Alexandra C McPherron

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity
    Tingqing Guo
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4937. 2009
  2. ncbi Soluble activin receptor type IIB treatment does not cause fat loss in mice with diet-induced obesity
    A C McPherron
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Diabetes Obes Metab 14:279-82. 2012
  3. ncbi Redundancy of myostatin and growth/differentiation factor 11 function
    Alexandra C McPherron
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    BMC Dev Biol 9:24. 2009
  4. ncbi Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy
    Tingqing Guo
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 61:2414-23. 2012
  5. ncbi Endurance exercise training in myostatin null mice
    Kathleen J Savage
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Muscle Nerve 42:355-62. 2010
  6. ncbi Chronic myopathy due to immunoglobulin light chain amyloidosis
    Irini Manoli
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Mol Genet Metab 108:249-54. 2013
  7. ncbi Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation
    Qian Wang
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Physiol 590:2151-65. 2012

Collaborators

Detail Information

Publications7

  1. ncbi Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity
    Tingqing Guo
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 4:e4937. 2009
    ..These data suggest that increasing muscle mass by administration of myostatin antagonists may be a promising therapeutic target for treating patients with obesity or diabetes...
  2. ncbi Soluble activin receptor type IIB treatment does not cause fat loss in mice with diet-induced obesity
    A C McPherron
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Diabetes Obes Metab 14:279-82. 2012
    ..Glucose metabolism was also similar between groups. Our results suggest that MSTN inhibition may be ineffective at inducing weight loss in obese patients...
  3. ncbi Redundancy of myostatin and growth/differentiation factor 11 function
    Alexandra C McPherron
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    BMC Dev Biol 9:24. 2009
    ..In order to investigate the possible functional redundancy of myostatin and Gdf11, we analyzed the effect of eliminating the functions of both of these signaling molecules...
  4. ncbi Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy
    Tingqing Guo
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes 61:2414-23. 2012
    ..These results further suggest that muscle may play a heretofore unappreciated role in regulating food intake...
  5. ncbi Endurance exercise training in myostatin null mice
    Kathleen J Savage
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Muscle Nerve 42:355-62. 2010
    ..Non-trained Mstn(-/-) mice did, however, have lower maximal exercise capacity compared with Mstn(+/+) mice. These results show that Mstn(-/-) muscle retains the metabolic plasticity necessary to adapt normally to endurance training...
  6. ncbi Chronic myopathy due to immunoglobulin light chain amyloidosis
    Irini Manoli
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA
    Mol Genet Metab 108:249-54. 2013
    ..This case highlights the importance of early diagnosis and therapy for this treatable cause of a chronic myopathy with muscle hypertrophy...
  7. ncbi Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation
    Qian Wang
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Physiol 590:2151-65. 2012
    ..Studies of the metabolic and functional effects of postnatal MSTN inhibition are needed to determine the consequences of increasing the cytoplasm/myonuclear ratio after MSTN inhibition...