Research Topics
| Scott E McNeilSummaryAffiliation: National Cancer Institute Country: USA Publications
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Detail Information
Publications
Analysis of fullerene-based nanomaterial in serum matrix by CEKing C Chan
Laboratory of Proteomics and Analytical Technologies, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Electrophoresis 28:1518-24. 2007..The quantitation of the nanoparticles was linear from 0-500 microg/mL with detection limits ranging from 0.5 to 6 microg/mL...- Nanotechnology for the biologistScott E McNeil
Nanotechnology Characterization Laboratory, 1050 Boyles St, Frederick, MD 21702 1201, USA
J Leukoc Biol 78:585-94. 2005..This article presents an overview of nanotechnology for the biologist and discusses "nanotech" strategies and constructs that have already demonstrated in vitro and in vivo efficacy... 
Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profilesMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
Nanomedicine 5:106-17. 2009..The difference in size measurements obtained from dynamic light scattering, electron microscopy, and scanning probe microscopy are also discussed...
Ambiguities in applying traditional Limulus amebocyte lysate tests to quantify endotoxin in nanoparticle formulationsMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Nanomedicine (Lond) 5:555-62. 2010..Here we report that nanoparticles often interfere with these traditional endotoxin detection tests and suggest approaches to detect and overcome such interferences...- Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunctionDenise N Johnson-Lyles
Nanotechnology Characterization Lab NCL, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Toxicol Appl Pharmacol 248:249-58. 2010..As nanoparticle-induced cytoskeleton disruption, autophagic vacuole accumulation and mitochondrial dysfunction are commonly reported in the literature, the proposed mechanism may be relevant for a variety of nanomaterials... - Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization LaboratoryRachael M Crist
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
Integr Biol (Camb) 5:66-73. 2013..While not exhaustive, this article aims to share some of the most common pitfalls observed by the NCL as they relate to nanoparticle synthesis, purification, characterization and analysis... - Nanoparticle size and surface charge determine effects of PAMAM dendrimers on human platelets in vitroMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, United States
Mol Pharm 9:382-93. 2012..Taken in context with previously reported studies, our data suggest that large cationic PAMAM dendrimers induce platelet aggregation through disruption of membrane integrity... - Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacyParag Aggarwal
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Adv Drug Deliv Rev 61:428-37. 2009..Understanding the nanoparticle-protein complex is necessary for control and manipulation of protein binding, and allows for improved engineering of nanoparticles with favorable bioavailability and biodistribution... - Unique benefits of nanotechnology to drug delivery and diagnosticsScott E McNeil
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD, USA
Methods Mol Biol 697:3-8. 2011..The remaining bulk of the volume provides the reader with protocols that have been tested against clinically relevant nanoparticles and describes some of the nuances of nanoparticle types and necessary controls... - Translational considerations for cancer nanomedicineStephan T Stern
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, PO Box B, Frederick, MD 21702, USA
J Control Release 146:164-74. 2010..Where possible, these recommendations are justified using the existing regulatory guidance literature... - Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials?Stephan T Stern
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
Toxicol Sci 106:140-52. 2008..These data suggest that QD cytotoxicity is dependent upon properties of the particle as a whole, and not exclusively the metal core materials... - Method for analysis of nanoparticle hemolytic properties in vitroMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, Maryland 21702, USA
Nano Lett 8:2180-7. 2008..We propose alternative methods to avoid misleading results from nanoparticles and discuss the potential relevance of nanoparticle in vitro hemolytic properties to in vivo systems... - Rapid distribution of liposomal short-chain ceramide in vitro and in vivoBanu S Zolnik
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, MD 21702, USA
Drug Metab Dispos 36:1709-15. 2008..Our studies suggest that this nanoscale PEGylated drug delivery system for short-chain ceramide offers rapid tissue distribution without adverse effects for a neoplastic-selective, insoluble agent... - Nanomaterial standards for efficacy and toxicity assessmentPavan P Adiseshaiah
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, National Cancer Institute at Frederick, Frederick, MD 21702, USA
Wiley Interdiscip Rev Nanomed Nanobiotechnol 2:99-112. 2010..Finally, we show how knowledge of these properties (both of the nanoparticle and the cancer/tumor under study) can be used to design meaningful in vivo tests to evaluate nanoparticle efficacy... - Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistributionMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick Inc, NCI Frederick, Frederick, MD 21702, USA
Mol Pharm 5:487-95. 2008..We will also provide an overview of in vitro methods useful in identifying interactions with components of the immune system and the potential effects of such interaction on particle distribution to tissues... - Immunological properties of engineered nanomaterialsMarina A Dobrovolskaia
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, NCI Frederick, 1050 Boyles St, Bldg 469, Frederick, Maryland 21702, USA
Nat Nanotechnol 2:469-78. 2007..Modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery... - Nanotechnology safety concerns revisitedStephan T Stern
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, Frederick, Maryland 21702, USA
Toxicol Sci 101:4-21. 2008..Until such time as the exposures, hazards, and environmental life cycle of nanomaterials have been more clearly defined, cautious development and implementation of nanotechnology is the most prudent course... - Challenges for nanoparticle characterizationScott E McNeil
Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC Frederick, Inc, National Cancer Institute at Frederick, Frederick, MD, USA
Methods Mol Biol 697:9-15. 2011..Additionally, we discuss ways to identify, avoid, and resolve such interference, with emphasis on the use of inhibition and enhancement controls...