Francis McMahon

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment
    Francis J McMahon
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health, Bethesda, MD 20892 3719, USA
    Am J Hum Genet 78:804-14. 2006
  2. ncbi request reprint Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort
    Silvia Paddock
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Am J Psychiatry 164:1181-8. 2007
  3. ncbi request reprint Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    Victor A Lopez
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:181-6. 2007
  4. ncbi request reprint Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression
    Xian Zhang Hu
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:783-92. 2007
  5. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
  6. ncbi request reprint A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample
    Silvia Buervenich
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:74-8. 2005
  7. ncbi request reprint Genetic markers of suicidal ideation emerging during citalopram treatment of major depression
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders, NIMH, 35 Convent Dr, Rm 1A207, Bethesda, MD 20892 3719, USA
    Am J Psychiatry 164:1530-8. 2007
  8. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
  9. ncbi request reprint Genetic association studies in mood disorders: issues and promise
    Sevilla D Detera-Wadleigh
    Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
    Int Rev Psychiatry 16:301-10. 2004
  10. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007

Research Grants

  1. GENETIC LINKAGE STUDIES IN BIPOLAR DISORDERS
    Francis McMahon; Fiscal Year: 2000
  2. GENETIC LINKAGE STUDIES IN BIPOLAR DISORDERS
    Francis McMahon; Fiscal Year: 2001

Detail Information

Publications57

  1. pmc Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment
    Francis J McMahon
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health, Bethesda, MD 20892 3719, USA
    Am J Hum Genet 78:804-14. 2006
    ..Taken together with prior neurobiological findings, these new genetic data make a compelling case for a key role of HTR2A in the mechanism of antidepressant action...
  2. ncbi request reprint Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort
    Silvia Paddock
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Am J Psychiatry 164:1181-8. 2007
    ..The purpose of the present study was to utilize a second wave of genotype results, for a more powerful analysis, in the complete cohort of patients with available deoxyribonucleic acid (DNA) samples...
  3. ncbi request reprint Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    Victor A Lopez
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:181-6. 2007
    ..No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample...
  4. ncbi request reprint Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression
    Xian Zhang Hu
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:783-92. 2007
    ....
  5. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  6. ncbi request reprint A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample
    Silvia Buervenich
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:74-8. 2005
    ..In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample...
  7. ncbi request reprint Genetic markers of suicidal ideation emerging during citalopram treatment of major depression
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders, NIMH, 35 Convent Dr, Rm 1A207, Bethesda, MD 20892 3719, USA
    Am J Psychiatry 164:1530-8. 2007
    ..Genetic markers may shed light on the causes of treatment-emergent suicidal ideation and help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, or specialty care...
  8. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
    ..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
  9. ncbi request reprint Genetic association studies in mood disorders: issues and promise
    Sevilla D Detera-Wadleigh
    Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
    Int Rev Psychiatry 16:301-10. 2004
    ..Relating associated variants to the phenotype represents the next critical step toward establishing the pathogenic role of gene variants in mood disorders...
  10. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  11. ncbi request reprint G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis
    Sevilla D Detera-Wadleigh
    National Institute of Mental Health Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
    Biol Psychiatry 60:106-14. 2006
    ..The association findings in the G72/G30 region, among the most compelling in psychiatry, may expose an important molecular pathway involved in susceptibility to schizophrenia and bipolar disorder...
  12. ncbi request reprint Familiality of polarity at illness onset in bipolar affective disorder
    Layla Kassem
    Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
    Am J Psychiatry 163:1754-9. 2006
    ..The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder...
  13. pmc The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuropsychobiology 62:72-8. 2010
    ..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts...
  14. pmc Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:804-7. 2009
    ..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation...
  15. pmc Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Pharmacogenet Genomics 19:666-74. 2009
    ....
  16. pmc Pharmacogenetics studies in STAR*D: strengths, limitations, and results
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, Bethesda, MD 20892, USA
    Psychiatr Serv 60:1446-57. 2009
    ..Replication of these findings in independent samples could lead to the development of new treatments and to optimization of available treatments...
  17. pmc The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations
    Johannes Schumacher
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Hum Mol Genet 18:2719-27. 2009
    ..Furthermore, our phenotype-genotype results--including the consideration of sex-specific effects--highlight the value of homogenous samples in mapping risk genes for schizophrenia in general, and at the DISC locus in particular...
  18. doi request reprint Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB
    Gonzalo Laje
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
    Int J Neuropsychopharmacol 13:715-24. 2010
    ....
  19. pmc Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
    Francis J McMahon
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 42:128-31. 2010
    ..83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD...
  20. pmc A genome-wide association study of amygdala activation in youths with and without bipolar disorder
    Xinmin Liu
    National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 49:33-41. 2010
    ..We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype...
  21. ncbi request reprint The pharmacogenetics of major depression: past, present, and future
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Biol Psychiatry 62:1205-7. 2007
  22. pmc Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample
    Michael Cabanero
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
    Pharmacogenet Genomics 19:235-8. 2009
    ..We conclude that PDE11A, PDE9A, and PDE1A are unlikely to play an important role in antidepressant outcome in this sample...
  23. doi request reprint Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 10:38-44. 2008
    ..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees...
  24. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  25. ncbi request reprint Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: association with HMG2L1 and TOM1
    James B Potash
    Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21287 7419, USA
    Am J Med Genet B Neuropsychiatr Genet 147:59-67. 2008
    ..Further work is needed to confirm these results and uncover the functional variation underlying the association signal...
  26. doi request reprint Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20
    Jessica Ross
    Department of Psychiatry, University of California, San Francisco, CA 94132 0984, USA
    Psychiatr Genet 18:191-8. 2008
    ..Our aim is to map chromosomal regions that harbor loci that increase susceptibility to bipolar disorder...
  27. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  28. pmc The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort
    Magnus Lekman
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Biol Psychiatry 63:1103-10. 2008
    ..The present study aimed at studying the associated FKBP5 markers in the ethnically diverse Sequenced Treatment Alternatives to Relieve Depression (STAR*D) sample of non-hospitalized patients treated with citalopram...
  29. pmc Neurotransmission and bipolar disorder: a systematic family-based association study
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1270-7. 2008
    ....
  30. pmc Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
    Jiajun Shi
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1047-55. 2008
    ..00000172). It remains significant after correcting for multiple testing using the False Discovery Rate method. Our results indicate an interaction between three circadian genes in susceptibility to bipolar disorder...
  31. ncbi request reprint A success at the end of an era, and a glimpse of things to come
    Francis J McMahon
    Am J Psychiatry 164:999-1001. 2007
  32. ncbi request reprint Can long-range microsatellite data be used to predict short-range linkage disequilibrium?
    Thomas G Schulze
    Department of Psychiatry, The University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 11:1363-72. 2002
    ....
  33. ncbi request reprint Frequency Finder: a multi-source web application for collection of public allele frequencies of SNP markers
    Tu H Nguyen
    Department of Psychiatry, University of Chicago, IL 60616, USA
    Bioinformatics 20:439-43. 2004
    ..While limited to public databases that provide web-based access to allele frequencies, Frequency Finder provides a single, user-friendly interface for retrieving allele frequencies for large batches of SNPs from multiple data sources...
  34. ncbi request reprint Defining haplotype blocks and tag single-nucleotide polymorphisms in the human genome
    Thomas G Schulze
    Dicvision of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health ZI, 68159 Mannheim, Germany
    Hum Mol Genet 13:335-42. 2004
    ..More information is needed to guide the choice of method, marker allele frequencies, and parameters in the development of a haplotype map...
  35. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  36. ncbi request reprint Genetic linkage and association studies in bipolar affective disorder: a time for optimism
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Am J Med Genet C Semin Med Genet 123:36-47. 2003
    ..Once these genes are identified, genetic mapping methods will yield to the other methods of 21st-century molecular biology as we begin to elucidate the pathophysiology of BPAD...
  37. ncbi request reprint Genome scan of a second wave of NIMH genetics initiative bipolar pedigrees: chromosomes 2, 11, 13, 14, and X
    Peter P Zandi
    Department of Mental Hygiene, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, Maryland 21204, USA
    Am J Med Genet B Neuropsychiatr Genet 119:69-76. 2003
    ..Large samples such as that being collected by the NIMH Initiative will be necessary to examine the heterogeneity and identify these susceptibility genes...
  38. ncbi request reprint Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, USA
    Am J Psychiatry 160:680-6. 2003
    ....
  39. ncbi request reprint Additional, physically ordered markers increase linkage signal for bipolar disorder on chromosome 18q22
    Thomas G Schulze
    Department of Psychiatry, The University of Chicago, Chicago, Illinois, USA
    Biol Psychiatry 53:239-43. 2003
    ..Here, we test for linkage in the same sample with a denser set of markers, now physically ordered according to the draft sequence of the human genome...
  40. ncbi request reprint Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003
    ..Families with this subtype should be used to search for susceptibility genes common to bipolar disorder and schizophrenia, and for biological markers that may be shared with schizophrenia...
  41. ncbi request reprint Diagnostic reliability of bipolar II disorder
    Sylvia G Simpson
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 59:736-40. 2002
    ....
  42. ncbi request reprint Lack of support for a genetic association of the XBP1 promoter polymorphism with bipolar disorder in probands of European origin
    Sven Cichon
    Nat Genet 36:783-4; author reply 784-5. 2004
  43. ncbi request reprint Neither single-marker nor haplotype analyses support an association between genetic variation near NOTCH4 and bipolar disorder
    Sridhar Prathikanti
    Department of Psychiatry, University of Chicago, Chicago, Illinois 60615, USA
    Am J Med Genet B Neuropsychiatr Genet 131:10-5. 2004
    ..These results do not support an association between genetic variation near NOTCH4 and BPAD in this sample...
  44. ncbi request reprint Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33
    Fernando S Goes
    Johns Hopkins Hospital, 600 North Wolfe St, Meyer 4 119, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:236-47. 2007
    ..This study attempts to characterize clinical correlates, familial aggregation, and genetic linkage in subjects with these features...
  45. ncbi request reprint Defining the phenotype in human genetic studies: forward genetics and reverse phenotyping
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Hum Hered 58:131-8. 2004
    ..The stakes are high, since the success of gene mapping in genetically complex disorders hinges on the ability to delineate the target phenotype with accuracy and precision...
  46. ncbi request reprint Familial variation in episode frequency in bipolar affective disorder
    Maria E Fisfalen
    Department of Psychiatry, Mount Sinai Medical Center, Rosalind Franklin University of Medicine and Science, California at 15th Street, Chicago, IL 60608, USA
    Am J Psychiatry 162:1266-72. 2005
    ..The authors analyzed the recurrence frequency of affective episodes (episode frequency), along with associated clinical and demographic variables, in families with at least three members with a major affective disorder...
  47. ncbi request reprint What is familial about familial bipolar disorder? Resemblance among relatives across a broad spectrum of phenotypic characteristics
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, 15, 68159 Mannheim, Germany
    Arch Gen Psychiatry 63:1368-76. 2006
    ..Familial features of bipolar disorder should help define more homogeneous subtypes, but there are few data indicating which clinical features of bipolar disorder are the most familial...
  48. ncbi request reprint The bipolar disorder phenome database: a resource for genetic studies
    James B Potash
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287 7419, USA
    Am J Psychiatry 164:1229-37. 2007
    ..The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies...
  49. ncbi request reprint Attempted suicide in bipolar disorder pedigrees: evidence for linkage to 2p12
    Virginia L Willour
    Department of Psychiatry and Behaviorial Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 61:725-7. 2007
    ..We are interested in identifying susceptibility genes that predispose subjects to attempted suicide...
  50. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
    ....
  51. ncbi request reprint Rapid mood switching and suicidality in familial bipolar disorder
    Dean F MacKinnon
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Bipolar Disord 7:441-8. 2005
    ....
  52. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  53. pmc Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative
    Danielle M Dick
    Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
    Am J Hum Genet 73:107-14. 2003
    ..10), on chromosomes 2p, 3q, and 8q. This study, which is based on the largest linkage sample for bipolar disorder analyzed to date, indicates that several genes contribute to bipolar disorder...
  54. ncbi request reprint Genome scan of the fifty-six bipolar pedigrees from the NIMH genetics initiative replication sample: chromosomes 4, 7, 9, 18, 19, 20, and 21
    Virginia L Willour
    The Johns Hopkins University, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 121:21-7. 2003
    ..38, which exceeds standard criteria for suggestive linkage, and a corresponding parametric HLOD score of 2.98. The combined analysis did not provide further support for linkage to 4q32 and 4q35...
  55. pmc Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q
    Matthew B McQueen
    Harvard School of Public Health, Department of Epidemiology, Boston, MA 02115, USA
    Am J Hum Genet 77:582-95. 2005
    ..Our results establish genomewide significant linkage to BP on chromosomes 6q and 8q, which provides solid information to guide future gene-finding efforts that rely on fine-mapping and association approaches...
  56. ncbi request reprint Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines
    Thomas G Schulze
    Department of Psychiatry, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet 114:1-11. 2002
    ..We present an overview of the development of genetic association tests, with practical guidelines on which test might be the most suitable for a given study...
  57. ncbi request reprint Using duplicate genotyped data in genetic analyses: testing association and estimating error rates
    Nathan L Tintle
    Hope College, USA
    Stat Appl Genet Mol Biol 6:Article4. 2007
    ..Power increases ranged from 0.776% to 4.652% for 80% powered tests and 0.292% to 2.028% for 95% powered tests. Researchers now can compute the value of the duplicate genotyped data as part of the design of the study...

Research Grants2

  1. GENETIC LINKAGE STUDIES IN BIPOLAR DISORDERS
    Francis McMahon; Fiscal Year: 2000
    ..The enlargement, continued maintenance, and analysis of this unique family resource is important to the field and will form the basis for many future studies. ..
  2. GENETIC LINKAGE STUDIES IN BIPOLAR DISORDERS
    Francis McMahon; Fiscal Year: 2001
    ..The enlargement, continued maintenance, and analysis of this unique family resource is important to the field and will form the basis for many future studies. ..