Francis J McMahon

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort
    Silvia Paddock
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Am J Psychiatry 164:1181-8. 2007
  2. pmc Pharmacogenomics and personalized medicine in neuropsychiatry
    Francis J McMahon
    National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuron 74:773-6. 2012
  3. pmc Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
    Francis J McMahon
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 42:128-31. 2010
  4. ncbi request reprint Genetic markers of suicidal ideation emerging during citalopram treatment of major depression
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders, NIMH, 35 Convent Dr, Rm 1A207, Bethesda, MD 20892 3719, USA
    Am J Psychiatry 164:1530-8. 2007
  5. pmc Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB
    Gonzalo Laje
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
    Int J Neuropsychopharmacol 13:715-24. 2010
  6. pmc Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Pharmacogenet Genomics 19:666-74. 2009
  7. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
  8. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
  9. ncbi request reprint Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression
    Xian Zhang Hu
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:783-92. 2007
  10. pmc In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Brain 136:2228-38. 2013

Detail Information

Publications44

  1. ncbi request reprint Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort
    Silvia Paddock
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Am J Psychiatry 164:1181-8. 2007
    ..The purpose of the present study was to utilize a second wave of genotype results, for a more powerful analysis, in the complete cohort of patients with available deoxyribonucleic acid (DNA) samples...
  2. pmc Pharmacogenomics and personalized medicine in neuropsychiatry
    Francis J McMahon
    National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuron 74:773-6. 2012
    ..Here we discuss the promise of personalized medicine in developing more efficacious and individualized pharmacotherapies that take into account genetic variation and target groups of patients who share biology, not just symptoms...
  3. pmc Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1
    Francis J McMahon
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Nat Genet 42:128-31. 2010
    ..83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD...
  4. ncbi request reprint Genetic markers of suicidal ideation emerging during citalopram treatment of major depression
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders, NIMH, 35 Convent Dr, Rm 1A207, Bethesda, MD 20892 3719, USA
    Am J Psychiatry 164:1530-8. 2007
    ..Genetic markers may shed light on the causes of treatment-emergent suicidal ideation and help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, or specialty care...
  5. pmc Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB
    Gonzalo Laje
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
    Int J Neuropsychopharmacol 13:715-24. 2010
    ....
  6. pmc Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Pharmacogenet Genomics 19:666-74. 2009
    ....
  7. ncbi request reprint Sequence variation in DOCK9 and heterogeneity in bipolar disorder
    Sevilla D Detera-Wadleigh
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
    Psychiatr Genet 17:274-86. 2007
    ..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region...
  8. pmc Family-based association study of Neuregulin 1 with psychotic bipolar disorder
    Fernando S Goes
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009
    ....
  9. ncbi request reprint Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression
    Xian Zhang Hu
    Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:783-92. 2007
    ....
  10. pmc In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, USA
    Brain 136:2228-38. 2013
    ..11)C-PBR28 may be useful in longitudinal studies to mark the conversion from mild cognitive impairment or to assess response to experimental treatments of Alzheimer's disease. ..
  11. pmc Race, genetic ancestry and response to antidepressant treatment for major depression
    Eleanor Murphy
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    Neuropsychopharmacology 38:2598-606. 2013
    ..Larger samples would be needed to identify the specific genetic mechanisms that may be involved, but these findings underscore the importance of including more African-American patients in drug trials...
  12. pmc Pharmacogenetics studies in STAR*D: strengths, limitations, and results
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, Bethesda, MD 20892, USA
    Psychiatr Serv 60:1446-57. 2009
    ..Replication of these findings in independent samples could lead to the development of new treatments and to optimization of available treatments...
  13. pmc A genome-wide association study of amygdala activation in youths with and without bipolar disorder
    Xinmin Liu
    National Institute of Mental Health, Bethesda, MD 20892, USA
    J Am Acad Child Adolesc Psychiatry 49:33-41. 2010
    ..We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype...
  14. pmc Gene expression and genetic variation data implicate PCLO in bipolar disorder
    Kwang H Choi
    Stanley Laboratory of Brain Research, Rockville, Maryland, USA
    Biol Psychiatry 69:353-9. 2011
    ..We then tested these SNPs for association with bipolar disorder in large case-control samples...
  15. pmc Retention and attrition among African Americans in the STAR*D study: what causes research volunteers to stay or stray?
    Eleanor J Murphy
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, NIH, USDHHS, Bethesda, MD
    Depress Anxiety 30:1137-44. 2013
    ..Here, in addition to comparing patterns of attrition between African Americans and Whites, we identify predictors of overall and early attrition among African Americans...
  16. doi request reprint Common genetic variation in the indoleamine-2,3-dioxygenase genes and antidepressant treatment outcome in major depressive disorder
    Jessica A Cutler
    Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
    J Psychopharmacol 26:360-7. 2012
    ..We conclude that common genetic variation in IDO1 and IDO2 may play a role in antidepressant treatment outcome. These results are modest in a genome-wide context and need to be replicated in an independent sample...
  17. pmc Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder
    Pablo R Moya
    National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA
    Mov Disord 28:1263-70. 2013
    ..Thus, altered SERT activity represents a potential contributor to serotonergic abnormalities in TD. The present results call for replication in a similarly intensively evaluated sample. © 2013 Movement Disorder Society. ..
  18. pmc Amish revisited: next-generation sequencing studies of psychiatric disorders among the Plain people
    Liping Hou
    Human Genetics Branch, National Institute of Mental Health NIMH Intramural Research Program, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, MD, USA
    Trends Genet 29:412-8. 2013
    ..We discuss the new opportunities for NGS in these populations, with particular emphasis on investigating psychiatric disorders. We also address some of the challenges facing NGS-based studies of complex phenotypes in founder populations...
  19. pmc Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample
    Michael Cabanero
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
    Pharmacogenet Genomics 19:235-8. 2009
    ..We conclude that PDE11A, PDE9A, and PDE1A are unlikely to play an important role in antidepressant outcome in this sample...
  20. ncbi request reprint Convergent genome wide association results for bipolar disorder and substance dependence
    Catherine Johnson
    Molecular Neurobiology Branch, NIDA IRP, NIH, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 150:182-90. 2009
    ..Variants in these "addiction/bipolar" genes are candidates to influence the brain in ways that manifest as enhanced vulnerabilites to both substance dependence and bipolar disorder...
  21. ncbi request reprint Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts
    Victor A Lopez
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 61:181-6. 2007
    ..No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample...
  22. ncbi request reprint Familiality of polarity at illness onset in bipolar affective disorder
    Layla Kassem
    Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
    Am J Psychiatry 163:1754-9. 2006
    ..The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder...
  23. pmc The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations
    Johannes Schumacher
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Hum Mol Genet 18:2719-27. 2009
    ..Furthermore, our phenotype-genotype results--including the consideration of sex-specific effects--highlight the value of homogenous samples in mapping risk genes for schizophrenia in general, and at the DISC locus in particular...
  24. ncbi request reprint Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation
    Melissa A Brotman
    Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
    Am J Psychiatry 164:1238-41. 2007
    ..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation...
  25. ncbi request reprint Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
    D T Chen
    Human Genetics Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA
    Mol Psychiatry 18:195-205. 2013
    ..Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD...
  26. pmc Genome-wide association studies of antidepressant outcome: a brief review
    Gonzalo Laje
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, NIH, US DHHS, Bethesda, MD, United States
    Prog Neuropsychopharmacol Biol Psychiatry 35:1553-7. 2011
    ..This review discusses the published GWAS studies, their strengths, limitations, and possible future directions...
  27. ncbi request reprint The pharmacogenetics of major depression: past, present, and future
    Gonzalo Laje
    Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD 20892, USA
    Biol Psychiatry 62:1205-7. 2007
  28. pmc The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder
    Rodrigo Machado-Vieira
    Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:344-52. 2011
    ..Here, we examined the effects of the Bcl-2 gene single nucleotide polymorphism (SNP) rs956572 on intracellular Ca(2+) dynamics in patients with BPD...
  29. pmc A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation
    William C Kreisl
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 1026, USA
    J Cereb Blood Flow Metab 33:53-8. 2013
    ..011). Our results show that TSPO genotype influences PBR28 binding in vitro and in vivo. Correcting for this genotype increased statistical power in our postmortem study and is recommended for in vivo positron emission tomography studies...
  30. pmc The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Neuropsychobiology 62:72-8. 2010
    ..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts...
  31. pmc Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Biol Psychiatry 66:804-7. 2009
    ..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation...
  32. ncbi request reprint A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample
    Silvia Buervenich
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Arch Neurol 62:74-8. 2005
    ..In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample...
  33. ncbi request reprint Pharmacogenetics of antidepressants, mood stabilizers, and antipsychotics in diverse human populations
    Eleanor Murphy
    Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Discov Med 16:113-22. 2013
    ..The vision of more personalized psychopharmacology may critically depend on larger studies in more diverse human populations. ..
  34. pmc Identity-by-descent filtering as a tool for the identification of disease alleles in exome sequence data from distant relatives
    Nirmala Akula
    Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
    BMC Proc 5:S76. 2011
    ..IBD filtering may be a useful strategy for narrowing down the list of candidate variants in exome data, but the optimal degree of relatedness of affected pairs will depend on the genetic architecture of the disease under study...
  35. pmc Association study of serotonin pathway genes in attempted suicide
    Jennifer T Judy
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012
    ..Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior...
  36. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  37. ncbi request reprint Genetic association studies in mood disorders: issues and promise
    Sevilla D Detera-Wadleigh
    Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
    Int Rev Psychiatry 16:301-10. 2004
    ..Relating associated variants to the phenotype represents the next critical step toward establishing the pathogenic role of gene variants in mood disorders...
  38. ncbi request reprint G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis
    Sevilla D Detera-Wadleigh
    National Institute of Mental Health Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
    Biol Psychiatry 60:106-14. 2006
    ..The association findings in the G72/G30 region, among the most compelling in psychiatry, may expose an important molecular pathway involved in susceptibility to schizophrenia and bipolar disorder...
  39. pmc Do participants in genome sequencing studies of psychiatric disorders wish to be informed of their results? A survey study
    Elise T Bui
    Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e101111. 2014
    ..This study provides information on psychiatric research volunteers' attitudes, beliefs, and concerns with respect to participation in DNA sequencing studies and reporting of individual results...
  40. pmc Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment
    Francis J McMahon
    Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health, Bethesda, MD 20892 3719, USA
    Am J Hum Genet 78:804-14. 2006
    ..Taken together with prior neurobiological findings, these new genetic data make a compelling case for a key role of HTR2A in the mechanism of antidepressant action...
  41. ncbi request reprint Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees
    James B Potash
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003
    ..Families with this subtype should be used to search for susceptibility genes common to bipolar disorder and schizophrenia, and for biological markers that may be shared with schizophrenia...
  42. ncbi request reprint Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigrees
    Melvin G McInnis
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287 7463, USA
    Biol Psychiatry 54:1265-73. 2003
    ..The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied...
  43. pmc Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions
    Girma Woldehawariat
    Genetic Basis of Mood and Anxiety Disorders Section, Human Genetics Branch, National Institute of Mental Health, NIH, DHHS, Bethesda, Maryland, United States of America
    PLoS ONE 9:e99980. 2014
    ..Genetic factors play an important role in corpus callosum size among individuals. Distinct genetic factors seem to be involved in caudal and rostral regions, consistent with the divergent functional specialization of these brain areas. ..
  44. pmc A network-based approach to prioritize results from genome-wide association studies
    Nirmala Akula
    Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
    PLoS ONE 6:e24220. 2011
    ..NIMMI is a simple, user-friendly, open-source software tool that efficiently combines genetic association data with biological networks, translating GWAS findings into biological hypotheses...