Research Topics
Genomes and GenesSpecies | Francis J McMahonSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohortSilvia Paddock
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD, USA
Am J Psychiatry 164:1181-8. 2007..The purpose of the present study was to utilize a second wave of genotype results, for a more powerful analysis, in the complete cohort of patients with available deoxyribonucleic acid (DNA) samples...
Pharmacogenomics and personalized medicine in neuropsychiatryFrancis J McMahon
National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
Neuron 74:773-6. 2012..Here we discuss the promise of personalized medicine in developing more efficacious and individualized pharmacotherapies that take into account genetic variation and target groups of patients who share biology, not just symptoms...- Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1Francis J McMahon
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
Nat Genet 42:128-31. 2010..83-0.92), with supportive evidence for association observed in two out of three independent replication cohorts. These results provide an example of a shared genetic susceptibility locus for bipolar disorder and MDD... - Genetic markers of suicidal ideation emerging during citalopram treatment of major depressionGonzalo Laje
Genetic Basis of Mood and Anxiety Disorders, NIMH, 35 Convent Dr, Rm 1A207, Bethesda, MD 20892 3719, USA
Am J Psychiatry 164:1530-8. 2007..Genetic markers may shed light on the causes of treatment-emergent suicidal ideation and help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, or specialty care... - Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatientsGonzalo Laje
Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Pharmacogenet Genomics 19:666-74. 2009.... 
Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASBGonzalo Laje
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
Int J Neuropsychopharmacol 13:715-24. 2010....- Family-based association study of Neuregulin 1 with psychotic bipolar disorderFernando S Goes
Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 150:693-702. 2009.... - Sequence variation in DOCK9 and heterogeneity in bipolar disorderSevilla D Detera-Wadleigh
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health U S DHHS, 35 Convent Drive, Bethesda, MD 20892, USA
Psychiatr Genet 17:274-86. 2007..Subsequent reports have shown that variations in the DAOA (G72) locus on 13q33 display association with bipolar disorder but these may not account for all of the linkage evidence in the region... - Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depressionXian Zhang Hu
Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
Arch Gen Psychiatry 64:783-92. 2007.... - Pharmacogenetics studies in STAR*D: strengths, limitations, and resultsGonzalo Laje
Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, Bethesda, MD 20892, USA
Psychiatr Serv 60:1446-57. 2009..Replication of these findings in independent samples could lead to the development of new treatments and to optimization of available treatments... - A genome-wide association study of amygdala activation in youths with and without bipolar disorderXinmin Liu
National Institute of Mental Health, Bethesda, MD 20892, USA
J Am Acad Child Adolesc Psychiatry 49:33-41. 2010..We undertook a genome-wide association study to explore the genetic architecture of this neuroimaging phenotype... - Gene expression and genetic variation data implicate PCLO in bipolar disorderKwang H Choi
Stanley Laboratory of Brain Research, Rockville, Maryland, USA
Biol Psychiatry 69:353-9. 2011..We then tested these SNPs for association with bipolar disorder in large case-control samples... - Common genetic variation in the indoleamine-2,3-dioxygenase genes and antidepressant treatment outcome in major depressive disorderJessica A Cutler
Genetic Basis of Mood and Anxiety Disorders Unit, National Institute of Mental Health, Bethesda, MD 20892 3719, USA
J Psychopharmacol 26:360-7. 2012..We conclude that common genetic variation in IDO1 and IDO2 may play a role in antidepressant treatment outcome. These results are modest in a genome-wide context and need to be replicated in an independent sample... - Convergent genome wide association results for bipolar disorder and substance dependenceCatherine Johnson
Molecular Neurobiology Branch, NIDA IRP, NIH, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 150:182-90. 2009..Variants in these "addiction/bipolar" genes are candidates to influence the brain in ways that manifest as enhanced vulnerabilites to both substance dependence and bipolar disorder... - The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populationsJohannes Schumacher
Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
Hum Mol Genet 18:2719-27. 2009..Furthermore, our phenotype-genotype results--including the consideration of sex-specific effects--highlight the value of homogenous samples in mapping risk genes for schizophrenia in general, and at the DISC locus in particular... - Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulationMelissa A Brotman
Emotion and Development Branch and the Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Disorders Program, NIMH, NIH, Department of Health and Human Services, Bethesda, MD 20892, USA
Am J Psychiatry 164:1238-41. 2007..The authors compared axis I diagnoses in parents of children with narrow phenotype bipolar disorder and parents of youth with severe mood dysregulation... - Familiality of polarity at illness onset in bipolar affective disorderLayla Kassem
Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, 35 Convent Dr, Rm 1A202 MSC 3616, Bethesda, MD 20809 3616, USA
Am J Psychiatry 163:1754-9. 2006..The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder... - Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attemptsVictor A Lopez
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
Biol Psychiatry 61:181-6. 2007..No studies have examined TPH2 in large samples of subjects with BPAD and suicide attempts (SA). We tested for a relationship between genetic variation in TPH2 and risk for BPAD and SA in a large family sample... - Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sampleMichael Cabanero
Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 3719, USA
Pharmacogenet Genomics 19:235-8. 2009..We conclude that PDE11A, PDE9A, and PDE1A are unlikely to play an important role in antidepressant outcome in this sample... - Genome-wide association studies of antidepressant outcome: a brief reviewGonzalo Laje
Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, NIH, US DHHS, Bethesda, MD, United States
Prog Neuropsychopharmacol Biol Psychiatry 35:1553-7. 2011..This review discusses the published GWAS studies, their strengths, limitations, and possible future directions... - The pharmacogenetics of major depression: past, present, and futureGonzalo Laje
Genetic Basis of Mood and Anxiety Disorders Unit, Mood and Anxiety Program, National Institute of Mental Health, Bethesda, MD 20892, USA
Biol Psychiatry 62:1205-7. 2007 - The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorderRodrigo Machado-Vieira
Laboratory of Molecular Pathophysiology and Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 69:344-52. 2011..Here, we examined the effects of the Bcl-2 gene single nucleotide polymorphism (SNP) rs956572 on intracellular Ca(2+) dynamics in patients with BPD... - A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammationWilliam C Kreisl
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 1026, USA
J Cereb Blood Flow Metab 33:53-8. 2013..011). Our results show that TSPO genotype influences PBR28 binding in vitro and in vivo. Correcting for this genotype increased statistical power in our postmortem study and is recommended for in vivo positron emission tomography studies... - Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humansGiacomo Salvadore
Mood and Anxiety Disorders Program, National Institute of Mental Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Biol Psychiatry 66:804-7. 2009..We tested the hypothesis that this SNP would modulate gray matter (GM) volume in the limbic-cortical-striatal-pallidal-thalamic circuitry that plays major roles in mood regulation... - The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatmentThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 3719, USA
Neuropsychobiology 62:72-8. 2010..A stringent phenotype definition of response is one of the hallmarks of this collaboration. ConLiGen invites all lithium researchers to join its efforts... - A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sampleSilvia Buervenich
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
Arch Neurol 62:74-8. 2005..In a previous study, significant association of an ADH class IV allele with Parkinson disease (PD) was found in a Swedish sample... - Identity-by-descent filtering as a tool for the identification of disease alleles in exome sequence data from distant relativesNirmala Akula
Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA
BMC Proc 5:S76. 2011..IBD filtering may be a useful strategy for narrowing down the list of candidate variants in exome data, but the optimal degree of relatedness of affected pairs will depend on the genetic architecture of the disease under study... - Association study of serotonin pathway genes in attempted suicideJennifer T Judy
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 159:112-9. 2012..Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior... - G72/G30 in schizophrenia and bipolar disorder: review and meta-analysisSevilla D Detera-Wadleigh
National Institute of Mental Health Intramural Research Program, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
Biol Psychiatry 60:106-14. 2006..The association findings in the G72/G30 region, among the most compelling in psychiatry, may expose an important molecular pathway involved in susceptibility to schizophrenia and bipolar disorder... - Genetic association studies in mood disorders: issues and promiseSevilla D Detera-Wadleigh
Mood and Anxiety Disorders Program, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 3719, USA
Int Rev Psychiatry 16:301-10. 2004..Relating associated variants to the phenotype represents the next critical step toward establishing the pathogenic role of gene variants in mood disorders... - Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigreesThomas G Schulze
Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
Biol Psychiatry 56:18-23. 2004.... - Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatmentFrancis J McMahon
Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health NIMH, National Institutes of Health, Bethesda, MD 20892 3719, USA
Am J Hum Genet 78:804-14. 2006..Taken together with prior neurobiological findings, these new genetic data make a compelling case for a key role of HTR2A in the mechanism of antidepressant action... - Genome-wide scan and conditional analysis in bipolar disorder: evidence for genomic interaction in the National Institute of Mental Health genetics initiative bipolar pedigreesMelvin G McInnis
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287-7463, USA
Biol Psychiatry 54:1265-73. 2003..Application of conditional analyses is potentially useful in larger sample collections to identify susceptibility genes of modest influence that may not be identified in a genome-wide scan aimed to identify single gene effects... - Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigreesJames B Potash
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Med Genet B Neuropsychiatr Genet 116:90-7. 2003..Families with this subtype should be used to search for susceptibility genes common to bipolar disorder and schizophrenia, and for biological markers that may be shared with schizophrenia... - A network-based approach to prioritize results from genome-wide association studiesNirmala Akula
Mood and Anxiety Section, Human Genetics Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
PLoS ONE 6:e24220. 2011..NIMMI is a simple, user-friendly, open-source software tool that efficiently combines genetic association data with biological networks, translating GWAS findings into biological hypotheses...