K A McGlynn

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Adolescent and adult risk factors for testicular cancer
    Katherine A McGlynn
    Division of Hormonal and Reproductive Epidemiology, National Cancer Institute, Suite 550 6120 Executive Boulevard, Rockville, MD 20852, USA
    Nat Rev Urol 9:339-49. 2012
  2. pmc Intrauterine environments and breast cancer risk: meta-analysis and systematic review
    Sue Kyung Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Yeongeon Dong, Jongro Gu, Seoul 110 799, Seoul, Republic of Korea
    Breast Cancer Res 10:R8. 2008
  3. ncbi request reprint Hemochromatosis gene mutations and distal adenomatous colorectal polyps
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:158-63. 2005
  4. ncbi request reprint Maternal smoking and testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 15:1820-4. 2006
  5. pmc Polychlorinated biphenyls and risk of testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Res 69:1901-9. 2009
  6. ncbi request reprint Epidemiology and natural history of hepatocellular carcinoma
    Katherine A McGlynn
    HREB DCEG, National Cancer Institute, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Best Pract Res Clin Gastroenterol 19:3-23. 2005
  7. pmc Etiologic factors in testicular germ-cell tumors
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852 7234, USA
    Future Oncol 5:1389-402. 2009
  8. ncbi request reprint Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7060, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 98:1005-10. 2006
  9. ncbi request reprint Maternal hormone levels and risk of cryptorchism among populations at high and low risk of testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7060, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:1732-7. 2005
  10. pmc Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    Environ Health Perspect 117:1472-6. 2009

Detail Information

Publications83

  1. doi request reprint Adolescent and adult risk factors for testicular cancer
    Katherine A McGlynn
    Division of Hormonal and Reproductive Epidemiology, National Cancer Institute, Suite 550 6120 Executive Boulevard, Rockville, MD 20852, USA
    Nat Rev Urol 9:339-49. 2012
    ....
  2. pmc Intrauterine environments and breast cancer risk: meta-analysis and systematic review
    Sue Kyung Park
    Department of Preventive Medicine, Seoul National University College of Medicine, Yeongeon Dong, Jongro Gu, Seoul 110 799, Seoul, Republic of Korea
    Breast Cancer Res 10:R8. 2008
    ..Despite ample biologic plausibility, epidemiologic studies to date have yielded conflicting results. We investigated the associations between perinatal factors and subsequent breast cancer risk through meta-analyses...
  3. ncbi request reprint Hemochromatosis gene mutations and distal adenomatous colorectal polyps
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:158-63. 2005
    ..These results do not support a relationship between HFE heterozygosity and risk of advanced distal adenoma...
  4. ncbi request reprint Maternal smoking and testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA
    Cancer Epidemiol Biomarkers Prev 15:1820-4. 2006
    ..Other early life exposures, however, may explain the familial clustering of lung cancer in mothers and TGCT in sons...
  5. pmc Polychlorinated biphenyls and risk of testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
    Cancer Res 69:1901-9. 2009
    ..006), nonseminoma (P(trend) = 0.007), and seminoma (P(trend) = 0.05). Overall, these data do not support the hypothesis that PCB exposure increases the risk of TGCT...
  6. ncbi request reprint Epidemiology and natural history of hepatocellular carcinoma
    Katherine A McGlynn
    HREB DCEG, National Cancer Institute, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20892, USA
    Best Pract Res Clin Gastroenterol 19:3-23. 2005
    ..Vaccination programs against hepatitis B virus will likely decrease the HCC rate even further in decades to come...
  7. pmc Etiologic factors in testicular germ-cell tumors
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852 7234, USA
    Future Oncol 5:1389-402. 2009
    ..However, an accumulating body of evidence suggests that testicular cancer arises in fetal life. Perinatal factors, including exposure to endocrine-disrupting chemicals, have been suggested to be related to risk...
  8. ncbi request reprint Serum concentrations of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and risk of primary liver cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, EPS 7060, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 98:1005-10. 2006
    ..Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear...
  9. ncbi request reprint Maternal hormone levels and risk of cryptorchism among populations at high and low risk of testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7060, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 14:1732-7. 2005
    ..05). These results do not support either the estrogen or the androgen hypothesis. Rather, lower estrogens in case mothers may indicate that a placental defect increases the risk of cryptorchism and, possibly, testicular cancer...
  10. pmc Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852 7234, USA
    Environ Health Perspect 117:1472-6. 2009
    ..It has been suggested, however, that in utero hormone levels may be related to risk. Endocrine-disrupting chemicals, including polychlorinated biphenyl (PCB) compounds, may alter hormone levels and thereby affect the fetus...
  11. ncbi request reprint Increasing incidence of testicular germ cell tumors among black men in the United States
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd, Rm 7060, Rockville, MD 20852 7234, USA
    J Clin Oncol 23:5757-61. 2005
    ..However, a recent examination of ethnic-specific rates suggested that the incidence among black men may have begun to change in the 1990s...
  12. pmc Risk factors for cryptorchism among populations at differing risks of testicular cancer
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
    Int J Epidemiol 35:787-95. 2006
    ..However, while TGCT incidence varies greatly between white and black men, little variability has been reported between the two groups in cryptorchism prevalence. This may suggest that cryptorchism risk factors differ by ethnicity...
  13. ncbi request reprint Body size, dairy consumption, puberty, and risk of testicular germ cell tumors
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
    Am J Epidemiol 165:355-63. 2007
    ..As adult height is largely determined in the first 2 years of life, increased attention to events in this interval may help elucidate the etiology of TGCTs...
  14. ncbi request reprint A comparison of trends in the incidence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the United States
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7060, 6120 Executive Boulevard, Rockville, MD 20854 7234, USA
    Cancer Epidemiol Biomarkers Prev 15:1198-203. 2006
    ..In conclusion, the rates of HCC and ICC approximately doubled between 1976 and 2000. Trends by age, gender, ethnicity, and birth cohort suggest that heterogeneity exists in the factors influencing these rates...
  15. doi request reprint Persistent organochlorine pesticides and risk of testicular germ cell tumors
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7234, USA
    J Natl Cancer Inst 100:663-71. 2008
    ..Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs)...
  16. ncbi request reprint Risks of cancer among a cohort of 23,935 men and women with osteoporosis
    Katherine A McGlynn
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Int J Cancer 122:1879-84. 2008
    ..Conversely, factors associated with later onset osteoporosis may be related to a decreased risk of cancer...
  17. doi request reprint The global epidemiology of hepatocellular carcinoma: present and future
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5020, 6120 Executive Boulevard, Rockville, MD 20852 7234, USA
    Clin Liver Dis 15:223-43, vii-x. 2011
    ..Alcohol may be less of a factor in HCC in coming years. However, obesity and diabetes may become even more important risk factors for HCC...
  18. ncbi request reprint A phylogenetic analysis identifies heterogeneity among hepatocellular carcinomas
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Hepatology 36:1341-8. 2002
    ..In conclusion, it appears that in HCC, allele loss is not random, but clusters into definable groups that are characterized by distinctive rates of loss...
  19. ncbi request reprint Trends in the incidence of testicular germ cell tumors in the United States
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 7060, Bethesda, MD 20892 7234, USA
    Cancer 97:63-70. 2003
    ..This study was conducted to examine whether rates among white men in the United States have begun to stabilize and whether rates among black men in the United States have remained low...
  20. pmc Endogenous DNA damage and testicular germ cell tumors
    M B Cook
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 7234, USA
    Int J Androl 32:599-606. 2009
    ..This may partly explain the more aggressive biology and younger age-of-onset of this histologic subgroup compared with the relatively less aggressive, later-onset seminoma...
  21. pmc Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes
    V M Chia
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892 7234, USA
    Int J Androl 33:588-96. 2010
    ..With false discovery rate values >0.2, however, caution is advisable when interpreting the findings of this study...
  22. doi request reprint Trends in sex hormone concentrations in US males: 1988-1991 to 1999-2004
    S J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Androl 35:456-66. 2012
    ..These changes may be related to the increasing prevalence of reproductive disorders in young men...
  23. pmc Childhood infections, orchitis and testicular germ cell tumours: a report from the STEED study and a meta-analysis of existing data
    B Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852 7234, USA
    Br J Cancer 106:1331-4. 2012
    ....
  24. pmc Risk of testicular germ-cell tumours in relation to childhood physical activity
    M B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Br J Cancer 98:174-8. 2008
    ..Future studies should seek to validate responses further using recorded information sources such as school records...
  25. pmc Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 5:1221-8. 2007
    ..Because the etiology of both tumors is poorly understood, a population-based case-control study was conducted to examine the association of ECC and ICC with preexisting medical conditions...
  26. pmc Risk of liver cancer among US male veterans with cirrhosis, 1969-1996
    E C Persson
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852 7234 USA
    Br J Cancer 107:195-200. 2012
    ..Regardless of aetiology, cirrhosis is a strong risk factor for liver cancer. As mortality from cirrhosis has been declining in recent decades, it is possible that the risk of liver cancer among persons with cirrhosis has been affected...
  27. pmc Baldness, acne and testicular germ cell tumours
    B Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852 7234, USA
    Int J Androl 34:e59-67. 2011
    ..Additional studies of endogenous hormone levels during puberty and early adult life are warranted, especially studies evaluating the role of androgen synthesis, metabolism and uptake...
  28. pmc Maternal hormone levels among populations at high and low risk of testicular germ cell cancer
    Y Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS 7060, Rockville, MD 20852, USA
    Br J Cancer 92:1787-93. 2005
    ....
  29. ncbi request reprint International trends and patterns of primary liver cancer
    K A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. mcglynnkmail.nih.gov
    Int J Cancer 94:290-6. 2001
    ..Further progress against PLC may be seen in the developing world once the HBV-vaccinated segment of the population reaches adulthood. Published 2001 Wiley-Liss, Inc...
  30. ncbi request reprint Blood folate levels and risk of liver damage and hepatocellular carcinoma in a prospective high-risk cohort
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, EPS, Bethesda, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 16:1279-82. 2007
    ..To examine this association in humans, folate levels in blood and risk for subsequent liver damage and hepatocellular carcinoma (HCC) were assessed in a population at high risk of liver cancer in China...
  31. ncbi request reprint Association of genetic variants in the calcium-sensing receptor with risk of colorectal adenoma
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA
    Cancer Epidemiol Biomarkers Prev 13:2181-6. 2004
    ..We assessed the associations between CASR gene variants and risk for colorectal adenoma, a cancer precursor. We further investigated gene-diet interactions between the CASR variants and calcium intake on adenoma risk...
  32. pmc Gonadal and extragonadal germ cell tumours in the United States, 1973-2007
    A Stang
    Institut für Klinische Epidemiologie, Medizinische Fakultat, Martin Luther Universitat Halle Wittenberg, Halle, Germany
    Int J Androl 35:616-25. 2012
    ..The different incidence trends of GGCTs and EGCTs and distinct age-specific incidence patterns by anatomical site of EGCTs suggest that GGCTs and EGCTs may have different aetiologies...
  33. ncbi request reprint Vitamin D receptor gene polymorphisms, insulin-like growth factors, and prostate cancer risk: a population-based case-control study in China
    A P Chokkalingam
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD 21201, USA
    Cancer Res 61:4333-6. 2001
    ..Our findings in a low-risk population suggest that the IGF and vitamin D regulatory systems may interact to affect prostate cancer risk. Larger studies are needed to confirm these findings and clarify the underlying mechanisms...
  34. pmc Genetic variation in the inhibin pathway and risk of testicular germ cell tumors
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA
    Cancer Res 68:3043-8. 2008
    ..89-2.99; TT: OR, 4.54; 95% CI 2.00-10.3; P(trend) = 0.0008). We found no evidence of association with variants in the other investigated genes. These findings suggest that genetic variation in the INHA locus influences TGCT development...
  35. doi request reprint Insulin-like growth factor 1, insulin-like growth factor-binding protein 3, and testicular germ-cell tumor risk
    Victoria M Chia
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Suite 550, 6120 Executive Boulevard, Rockville, MD 20892 7234, USA
    Am J Epidemiol 167:1438-45. 2008
    ..40, 1.09). Although there were no overall associations with insulin-like growth factor, contrary to expectation, there was a suggestion that IGF-1 concentrations may be inversely associated with risk of seminoma...
  36. doi request reprint Risk of testicular germ cell tumors and polymorphisms in the insulin-like growth factor genes
    Victoria M Chia
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 17:721-6. 2008
    ..There was a suggestion, however, that adult height may modify the relationship between an IGF-1 haplotype and TGCT risk. These results suggest that, in aggregate, genetic variation in IGF loci is not associated with TGCT risk...
  37. doi request reprint Perinatal factors and the risk of testicular germ cell tumors
    Michael B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892 7234, USA
    Int J Cancer 122:2600-6. 2008
    ..00-3.30) were risk factors. Nonseminoma was associated with breech birth (OR = 2.44, 95%CI: 1.25-4.78) and Cesarean section (OR = 2.10, 95%CI: 1.25-3.54). These results support the hypothesis that TGCT may originate in very early life...
  38. doi request reprint Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors
    Jonine D Figueroa
    Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 19:917-29. 2008
    ..02. Caution in interpretation is warranted until findings are replicated in other studies; however, the results suggest that genetic variation in CYP1A1 may be associated with nonseminoma...
  39. pmc Placental characteristics as a proxy measure of serum hormone and protein levels during pregnancy with a male fetus
    Britton Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852 7234, USA
    Cancer Causes Control 22:689-95. 2011
    ..Associations with birth weight were also examined...
  40. pmc Sex disparities in cancer incidence by period and age
    Michael B Cook
    National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 18:1174-82. 2009
    ..Cancer epidemiology articles often point out that cancer rates tend to be higher among males than females yet rarely is this theme the subject of investigation...
  41. pmc A systematic review and meta-analysis of perinatal variables in relation to the risk of testicular cancer--experiences of the mother
    Michael B Cook
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Int J Epidemiol 38:1532-42. 2009
    ..We undertook a systematic review and meta-analysis of perinatal variables in relation to testicular cancer risk, with a specific focus upon characteristics of the mother...
  42. pmc Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    Sean F Altekruse
    Division of Cancer Control and Population Sciences, and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 8316, USA
    J Clin Oncol 27:1485-91. 2009
    ..Incidence rates are increasing in the United States. Monitoring incidence, survival, and mortality rates within at-risk populations can facilitate control efforts...
  43. pmc Prediagnostic serum concentrations of organochlorine compounds and risk of testicular germ cell tumors
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Environ Health Perspect 117:1514-9. 2009
    ..Recent findings suggest that exposure to organochlorine (OC) compounds, chlordanes and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in particular, may increase the risk of developing testicular germ cell tumors (TGCTs)...
  44. pmc Sex disparities in colorectal cancer incidence by anatomic subsite, race and age
    Gwen Murphy
    Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Int J Cancer 128:1668-75. 2011
    ..These findings may partially reflect differences in screening experiences and access to medical care but also suggest that etiologic factors may be playing a role...
  45. pmc Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls
    Victoria M Chia
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Int J Cancer 124:952-7. 2009
    ..69, 95% CI: 0.51-0.94). Thus, this study suggests that there may be aggregation of cancer among families of men diagnosed with TGCT...
  46. pmc Association of meat and fat intake with liver disease and hepatocellular carcinoma in the NIH-AARP cohort
    Neal D Freedman
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, Rockville, MD 20852, USA
    J Natl Cancer Inst 102:1354-65. 2010
    ..Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations...
  47. pmc Marijuana use and testicular germ cell tumors
    Britton Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer 117:848-53. 2011
    ..The purpose of this study was to evaluate the relation between marijuana use and TGCTs in a hospital-based case-control study...
  48. pmc Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992-2004
    Graca M Dores
    Department of Veterans Affairs Medical Center, Medical Service, Oklahoma City, OK 73104, USA
    Br J Haematol 144:86-94. 2009
    ..Five-year relative survival for P-bone, P-extramedullary, and MM varied significantly by age (<60/60+ years), supporting age-related differences in disease burden at presentation, disease biology, and/or treatment approaches...
  49. ncbi request reprint Circulating vitamin D metabolites, polymorphism in vitamin D receptor, and colorectal adenoma risk
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, EPS 3024, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 13:546-52. 2004
    ..We investigated the association of circulating vitamin D metabolites and a genetic variant of the VDR gene with advanced colorectal adenoma, a precursor lesion of colorectal cancer...
  50. ncbi request reprint Toenail selenium and risk of hepatocellular carcinoma mortality in Haimen City, China
    Lori C Sakoda
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, Department of Health and Human Services, Rockville, MD 20852, USA
    Int J Cancer 115:618-24. 2005
    ....
  51. ncbi request reprint Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 7084, MSC 7234 6120 Executive Blvd, Bethesda, MD 20892, USA
    J Natl Cancer Inst 98:873-5. 2006
    ..001)...
  52. ncbi request reprint Intrauterine environment and breast cancer risk in a population-based case-control study in Poland
    Sue Kyung Park
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Int J Cancer 119:2136-41. 2006
    ..Our results add support to the growing evidence that some perinatal exposures may relate to breast cancer risk. Additional studies are needed to confirm associations and clarify the biologic mechanisms underlying these associations...
  53. pmc Maternal hormone levels and perinatal characteristics: implications for testicular cancer
    Yawei Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Ann Epidemiol 17:85-92. 2007
    ..To examine the hypothesis, some studies used perinatal factors as surrogates for hormone levels. To determine the validity of this assumption, hormone-perinatal factor relationships were examined in the Collaborative Perinatal Project...
  54. doi request reprint Genetic variants in the 8q24 locus and risk of testicular germ cell tumors
    Michael B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7234, USA
    Hum Genet 123:409-18. 2008
    ..In conclusion, this study has found little evidence for an association between the reported 8q24 SNPs and TGCTs, although the findings for nonseminoma may be worth further investigation...
  55. ncbi request reprint Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case-control study
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7234, USA
    Int J Cancer 120:638-41. 2007
    ..02, 95% CI = 1.05-8.69). Obesity was unrelated to risk. These results confirm that prior bile duct diseases increase risk of ICC and suggest that alcoholic liver disease and diabetes may also increase risk...
  56. ncbi request reprint A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 8009, 6120 Executive Boulevard, Rockville, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 16:77-83. 2007
    ..In conclusion, our findings suggest that polymorphisms in TGFB1 and LTA/TNF, and possibly other immune function genes, may influence susceptibility to TGCT...
  57. ncbi request reprint Biliary tract cancer and stones in relation to chronic liver conditions: A population-based study in Shanghai, China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Int J Cancer 120:1981-5. 2007
    ..Given that chronic infection with hepatitis B virus (HBV) is the most common cause of liver disease in China, serologic markers of HBV need to be measured in future studies to examine the link between HBV and bile duct cancer...
  58. ncbi request reprint International patterns and trends in testis cancer incidence
    Mark P Purdue
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7240, USA
    Int J Cancer 115:822-7. 2005
    ..Rates appear to be leveling off in some populations. The increases in testis cancer remain unexplained, although changes in the prevalence of important risk factors for this disease may be responsible...
  59. ncbi request reprint Hepatitis B and C virus infection and the risk of biliary tract cancer: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd, Bethesda, MD 20852 7234, USA
    Int J Cancer 122:1849-53. 2008
    ..In Shanghai, an HBV endemic area, chronic HBV infection was associated with a 2.4-fold risk of extrahepatic bile duct cancer. These results should be confirmed in other populations with varying risks of HBV and HCV infection...
  60. pmc Etiologic factors for male breast cancer in the U.S. Veterans Affairs medical care system database
    Louise A Brinton
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Room 5018, Rockville, MD 20852, USA
    Breast Cancer Res Treat 119:185-92. 2010
    ..21-8.03), obesity (1.91, 1.50-2.44), and orchitis/epididymitis (1.80, 1.08-3.01). These results support previous speculations that male breast cancer is influenced not only by tissue at risk, but also by hormonal and inflammatory factors...
  61. ncbi request reprint Risk of germ cell tumors among men with HIV/acquired immunodeficiency syndrome
    James J Goedert
    Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA
    Cancer Epidemiol Biomarkers Prev 16:1266-9. 2007
    ..Men with HIV/acquired immunodeficiency syndrome (AIDS) are reported to be at increased risk for germ cell tumors (GCT), particularly testicular seminoma. We investigated correlates of this association to improve understanding of GCTs...
  62. pmc Organochlorine compounds and testicular dysgenesis syndrome: human data
    M B Cook
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20852 7234, USA
    Int J Androl 34:e68-84; discussion e84-5. 2011
    ....
  63. pmc Impact of classification of mixed germ-cell tumours on incidence trends of non-seminoma
    B Trabert
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852 7234, USA
    Int J Androl 34:e274-7. 2011
    ..These results suggest that analysis of trends in specific histological types of non-seminoma should be interpreted cautiously...
  64. ncbi request reprint Genetic susceptibility and dietary patterns in lung cancer
    Ya Yu Tsai
    Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
    Lung Cancer 41:269-81. 2003
    ..Adjustments using dietary pattern may be useful in elucidating the effects of polymorphisms in genes responsible for carcinogen metabolism...
  65. ncbi request reprint Calcium intake and colorectal adenoma in a US colorectal cancer early detection program
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
    Am J Clin Nutr 80:1358-65. 2004
    ..Calcium can reduce the risk of colorectal tumors by binding secondary bile and fatty acids, which leads to antiproliferative effects in the bowel, or by acting directly on the colonic epithelium, which affects differentiation and apoptosis...
  66. ncbi request reprint Susceptibility to aflatoxin B1-related primary hepatocellular carcinoma in mice and humans
    Katherine A McGlynn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Boulevard, Bethesda, MD 20892, USA
    Cancer Res 63:4594-601. 2003
    ..These results indicate that the comparison of results from human studies and the AFB(1)-susceptible mouse model may provide new insights into hepatocarcinogenesis...
  67. pmc International trends in the incidence of testicular cancer, 1973-2002
    Victoria M Chia
    Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS Suite 550, 6120 Executive Boulevard, Rockville, MD 20892 7234, USA
    Cancer Epidemiol Biomarkers Prev 19:1151-9. 2010
    ..In a prior report, global testicular cancer incidence rates and trends for the years 1973 to 1997 were summarized. The current report extends these analyses with an additional 5 years of data from Cancer Incidence in Five Continents...
  68. pmc The association of coffee intake with liver cancer incidence and chronic liver disease mortality in male smokers
    G Y Lai
    1 Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, 9609 Medical Center Drive, Room 2W136 MSC 9712, Bethesda, MD 20892, USA 2 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Room 1E326, MSC 9704, Bethesda, MD 20892, USA
    Br J Cancer 109:1344-51. 2013
    ..We observed similar associations for those drinking boiled or filtered coffee.Conclusion:These findings suggest that drinking coffee may have benefits for the liver, irrespective of whether coffee was boiled or filtered. ..
  69. ncbi request reprint Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas
    U Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Epidemiol Biomarkers Prev 10:1267-74. 2001
    ..The VDR FokI polymorphism was not significantly associated with colorectal adenoma and did not modify the effect of vitamin D or calcium. In conclusion, the study results suggested a protective effect for vitamin D on colorectal adenoma...
  70. ncbi request reprint Risk factors of intrahepatic cholangiocarcinoma in the United States: a case-control study
    Yasser H Shaib
    Section of Health Services Research, Michael E DeBakey Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Gastroenterology 128:620-6. 2005
    ..In this case-control study, we used the Surveillance, Epidemiology, and End Results-Medicare database to evaluate the prevalence of known risk factors for intrahepatic cholangiocarcinoma and explore other potential risk factors...
  71. ncbi request reprint Calcium, vitamin D, and risk for colorectal adenoma: dependency on vitamin D receptor BsmI polymorphism and nonsteroidal anti-inflammatory drug use?
    Sonia M Boyapati
    Center for Health Services Research, Vanderbilt University, Nashville, Tennessee, USA
    Cancer Epidemiol Biomarkers Prev 12:631-7. 2003
    ....
  72. ncbi request reprint Endoscopic and surgical therapy for intrahepatic cholangiocarcinoma in the united states: a population-based study
    Yasser H Shaib
    Sections of Health Services, Houston, TX, USA
    J Clin Gastroenterol 41:911-7. 2007
    ..Intrahepatic cholangiocarcinoma (ICC) is a highly fatal disease with limited therapeutic options. The determinants, trends, and outcomes of different therapies for ICC are largely unknown in the United States...
  73. ncbi request reprint Interpreting the international trends in testicular seminoma and nonseminoma incidence
    Freddie Bray
    Cancer Registry of Norway, Institute of Population Based Cancer Research, Montebello, N 0310 Oslo, Norway
    Nat Clin Pract Urol 3:532-43. 2006
    ..The findings presented are related to current theories and evidence regarding the determinants of testicular germ cell cancer...
  74. ncbi request reprint The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update
    Hashem B El-Serag
    The Houston Center for Quality of Care and Utilization Studies, Sections of Gastroenterology and Health Services Research at The Houston Veterans Affairs Medical Center, and Baylor College of Medicine, Houston, Texas 77030, USA
    Ann Intern Med 139:817-23. 2003
    ..The incidence of hepatocellular carcinoma was reported to be increasing in the United States. However, alternate explanations were diagnostic or reclassification bias and changes in the demographic features of the general population...
  75. pmc Re: Nguyen MM, Ellison LM: Testicular cancer patterns in Asian-American males: an opportunity for public health education to impact outcomes (Urology 66: 606-609, 2005) and Gajendran VK, Nguyen M, Ellison LM: Testicular cancer patterns in African-American
    Katherine A McGlynn
    Urology 71:356-7. 2008
  76. ncbi request reprint Folate intake, MTHFR C677T polymorphism, alcohol consumption, and risk for sporadic colorectal adenoma (United States)
    Sonia M Boyapati
    Division of General Internal Medicine, Department of Medicine, Center for Health Services Research, Vanderbilt University School of Medicine, Nashville, TN, USA
    Cancer Causes Control 15:493-501. 2004
    ....
  77. ncbi request reprint Trends in testicular germ cell tumours by ethnic group in the United States
    Mona N Shah
    United States Military Cancer Institute, Walter Reed Army Medical Center, Washington, DC, USA
    Int J Androl 30:206-13; discussion 213-4. 2007
    ..These data suggest that rates are increasing among Hispanic white men and black men, but are stabilizing among white men and API/AIAN men. The peak of the TGCT epidemic may have been reached in these latter groups...
  78. ncbi request reprint Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study
    Jessica A Davila
    Section of Health Services Research, Houston Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Gastroenterology 127:1372-80. 2004
    ..A significant increase in the incidence of hepatocellular carcinoma (HCC) has been reported in the United States. The risk factors underlying this increase remain unclear...
  79. ncbi request reprint Treatment and outcomes of treating of hepatocellular carcinoma among Medicare recipients in the United States: a population-based study
    Hashem B El-Serag
    Section of Health Services Research, Houston Veterans Affairs Medical Center, Baylor College of Medicine, 2002 Holcombe Boulevard 152, Houston, TX 77030, USA
    J Hepatol 44:158-66. 2006
    ..Yet, neither the extent to which potentially curative or palliative therapy is used to treat HCC, nor the determinants of using such therapies are known. Further, it is unclear how effective different modalities are for treating HCC...
  80. ncbi request reprint Risk of contralateral testicular cancer: a population-based study of 29,515 U.S. men
    Sophie D Fossa
    Department of Clinical Cancer Research, The Norwegian Radium Hospital, University of Oslo, Norway
    J Natl Cancer Inst 97:1056-66. 2005
    ..We evaluated the risk of contralateral testicular cancer and survival in a large population-based cohort of men diagnosed with testicular cancer before age 55 years...
  81. ncbi request reprint Noncancer causes of death in survivors of testicular cancer
    Sophie D Fossa
    Department of Clinical Cancer Research, Rikshospitalet Radiumhospitalet Trust, Oslo, Norway
    J Natl Cancer Inst 99:533-44. 2007
    ..We conducted a population-based study to quantify the long-term risks of mortality from noncancer causes among men with testicular cancer...
  82. ncbi request reprint Colonic epithelial cell proliferation decreases with increasing levels of serum 25-hydroxy vitamin D
    Peter R Holt
    Gastrointestinal Division, St Luke s Roosevelt Hospital Center, New York, NY 10025, USA
    Cancer Epidemiol Biomarkers Prev 11:113-9. 2002
    ....
  83. ncbi request reprint Birth weight and risk of testicular cancer
    Michael B Cook
    Int J Cancer 122:957; author reply 958-9. 2008