Dorian B McGavern

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Microglia development and function
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 email
    Annu Rev Immunol 32:367-402. 2014
  2. pmc A little 'help' from IL-21 during persistent viral infection
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Cell Biol 2:8-10. 2010
  3. doi request reprint Illuminating viral infections in the nervous system
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 11:318-29. 2011
  4. pmc Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20882, USA
    J Virol 83:8905-15. 2009
  5. pmc PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
    Bernd H Zinselmeyer
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 210:757-74. 2013
  6. pmc Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    PLoS Pathog 9:e1003395. 2013
  7. doi request reprint Inflammation on the mind: visualizing immunity in the central nervous system
    Silvia S Kang
    National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Top Microbiol Immunol 334:227-63. 2009
  8. pmc Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:7060-71. 2012
  9. pmc Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection
    Silvia S Kang
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:747-59. 2011
  10. doi request reprint Transcranial amelioration of inflammation and cell death after brain injury
    Theodore L Roth
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 505:223-8. 2014

Collaborators

  • Alan P Koretsky
  • Lawrence L Latour
  • Simon J Davis
  • David G Brooks
  • Jiyun V Kim
  • Debasis Nayak
  • Silvia S Kang
  • Sara Heydari
  • Lucile Garidou
  • Theodore L Roth
  • Bernd H Zinselmeyer
  • Jasmin Herz
  • Phi Truong
  • Dhammika H M L P Navarathna
  • Michael L Dustin
  • Tatjana Atanasijevic
  • Martin J Lizak
  • Kory R Johnson
  • Xiaoxiao Cheng
  • Catarina Sacristán
  • Jeeva Munasinghe
  • Michael Cammer
  • David D Roberts
  • Selamawit Gossa
  • Phillip Stewart-Hutchinson

Detail Information

Publications14

  1. doi request reprint Microglia development and function
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 email
    Annu Rev Immunol 32:367-402. 2014
    ..We also delve into the world of microglial dynamics recently uncovered using real-time imaging techniques. ..
  2. pmc A little 'help' from IL-21 during persistent viral infection
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Cell Biol 2:8-10. 2010
    ..Three recent studies suggest that CD4(+) T cells accomplish this in part through the release of IL-21...
  3. doi request reprint Illuminating viral infections in the nervous system
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 11:318-29. 2011
    ..A special emphasis is placed on immune surveillance of persistent and latent viral infections and on recent insights gained from imaging both protective and pathogenic antiviral immune responses...
  4. pmc Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20882, USA
    J Virol 83:8905-15. 2009
    ....
  5. pmc PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
    Bernd H Zinselmeyer
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 210:757-74. 2013
    ....
  6. pmc Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    PLoS Pathog 9:e1003395. 2013
    ..This Achilles' heel could explain why so many neurotropic viruses have acquired strategies to suppress IFN-I...
  7. doi request reprint Inflammation on the mind: visualizing immunity in the central nervous system
    Silvia S Kang
    National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Top Microbiol Immunol 334:227-63. 2009
    ..This review will focus on how imaging techniques have elevated our understanding of CNS inflammation as well as the exciting prospects that lie ahead as we begin to pursue investigation of the inflamed CNS in real time...
  8. pmc Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:7060-71. 2012
    ..These data suggest that therapeutic neutralization of TGF-β is not an efficacious means to promote clearance of a persistent viral infection...
  9. pmc Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection
    Silvia S Kang
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:747-59. 2011
    ..These results demonstrate that CTLs are poised to divide in transit and that their numbers can be influenced locally at the site of infection through interactions with cells displaying cognate antigen...
  10. doi request reprint Transcranial amelioration of inflammation and cell death after brain injury
    Theodore L Roth
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 505:223-8. 2014
    ..Our results shed light on the acute cellular response to TBI and provide a means to locally deliver therapeutic compounds to the site of injury. ..
  11. doi request reprint Microbial induction of vascular pathology in the CNS
    Silvia S Kang
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Neuroimmune Pharmacol 5:370-86. 2010
    ..Emphasis is placed on CNS diseases that result from a pathogenic interplay between host immune defenses and the invading microbe...
  12. pmc MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis
    Dhammika H M L P Navarathna
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    NMR Biomed 26:1125-34. 2013
    ..albicans infections, to define the roles of Candida virulence genes in kidney versus brain infection and to assess new therapeutic measures for drug development...
  13. pmc Two-photon imaging of microbial immunity in living tissues
    Jasmin Herz
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    Microsc Microanal 18:730-41. 2012
    ..This review focuses on how two-photon microscopy can be used to study tissue-specific immune responses in vivo, and how this approach has advanced our understanding of host-immune interactions following infection...
  14. doi request reprint Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons
    Phi Truong
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:3895-905. 2009
    ....