Dorian B McGavern

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. doi request reprint Microglia development and function
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 email
    Annu Rev Immunol 32:367-402. 2014
  2. pmc A little 'help' from IL-21 during persistent viral infection
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Cell Biol 2:8-10. 2010
  3. doi request reprint Illuminating viral infections in the nervous system
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 11:318-29. 2011
  4. pmc Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20882, USA
    J Virol 83:8905-15. 2009
  5. pmc PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
    Bernd H Zinselmeyer
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 210:757-74. 2013
  6. pmc Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    PLoS Pathog 9:e1003395. 2013
  7. doi request reprint Inflammation on the mind: visualizing immunity in the central nervous system
    Silvia S Kang
    National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Top Microbiol Immunol 334:227-63. 2009
  8. pmc Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:7060-71. 2012
  9. pmc Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging
    Selamawit Gossa
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Sci Rep 4:6664. 2014
  10. pmc Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection
    Silvia S Kang
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:747-59. 2011

Collaborators

  • Rosanne Spolski
  • Joshua D Milner
  • Elizabeth P Sampaio
  • David G Brooks
  • Alan P Koretsky
  • Lawrence L Latour
  • Simon J Davis
  • Jiyun V Kim
  • Debasis Nayak
  • Jasmin Herz
  • Theodore L Roth
  • Silvia S Kang
  • Bernd H Zinselmeyer
  • Sara Heydari
  • Lucile Garidou
  • Selamawit Gossa
  • Phi Truong
  • Chi Keung Wan
  • Kara N Corps
  • Kory R Johnson
  • Dhammika H M L P Navarathna
  • E Ashley Moseman
  • Michael L Dustin
  • Steven M Holland
  • Allison B Andraski
  • Alexandra F Freeman
  • Majid Kazemian
  • Jangsuk Oh
  • Peng Li
  • Phillip A Swanson
  • Leigh Samsel
  • Warren J Leonard
  • Tatjana Atanasijevic
  • David D Roberts
  • Xiaoxiao Cheng
  • Michael Cammer
  • Martin J Lizak
  • Jeeva Munasinghe
  • Catarina Sacristán
  • Phillip Stewart-Hutchinson

Detail Information

Publications19

  1. doi request reprint Microglia development and function
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 email
    Annu Rev Immunol 32:367-402. 2014
    ..We also delve into the world of microglial dynamics recently uncovered using real-time imaging techniques. ..
  2. pmc A little 'help' from IL-21 during persistent viral infection
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Cell Biol 2:8-10. 2010
    ..Three recent studies suggest that CD4(+) T cells accomplish this in part through the release of IL-21...
  3. doi request reprint Illuminating viral infections in the nervous system
    Dorian B McGavern
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 11:318-29. 2011
    ..A special emphasis is placed on immune surveillance of persistent and latent viral infections and on recent insights gained from imaging both protective and pathogenic antiviral immune responses...
  4. pmc Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20882, USA
    J Virol 83:8905-15. 2009
    ....
  5. pmc PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
    Bernd H Zinselmeyer
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 210:757-74. 2013
    ....
  6. pmc Type I interferon programs innate myeloid dynamics and gene expression in the virally infected nervous system
    Debasis Nayak
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    PLoS Pathog 9:e1003395. 2013
    ..This Achilles' heel could explain why so many neurotropic viruses have acquired strategies to suppress IFN-I...
  7. doi request reprint Inflammation on the mind: visualizing immunity in the central nervous system
    Silvia S Kang
    National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Curr Top Microbiol Immunol 334:227-63. 2009
    ..This review will focus on how imaging techniques have elevated our understanding of CNS inflammation as well as the exciting prospects that lie ahead as we begin to pursue investigation of the inflamed CNS in real time...
  8. pmc Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection
    Lucile Garidou
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:7060-71. 2012
    ..These data suggest that therapeutic neutralization of TGF-β is not an efficacious means to promote clearance of a persistent viral infection...
  9. pmc Development of an immunologically tolerated combination of fluorescent proteins for in vivo two-photon imaging
    Selamawit Gossa
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Sci Rep 4:6664. 2014
    ..Here we evaluate the immunologic visibility of several commonly used FPs by the murine immune system and identify a spectrally compatible, immunologically tolerated combination of FPs well suited for in vivo two-photon imaging. ..
  10. pmc Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection
    Silvia S Kang
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 208:747-59. 2011
    ..These results demonstrate that CTLs are poised to divide in transit and that their numbers can be influenced locally at the site of infection through interactions with cells displaying cognate antigen...
  11. pmc Transcranial amelioration of inflammation and cell death after brain injury
    Theodore L Roth
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 505:223-8. 2014
    ..Our results shed light on the acute cellular response to TBI and provide a means to locally deliver therapeutic compounds to the site of injury. ..
  12. doi request reprint Microbial induction of vascular pathology in the CNS
    Silvia S Kang
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Neuroimmune Pharmacol 5:370-86. 2010
    ..Emphasis is placed on CNS diseases that result from a pathogenic interplay between host immune defenses and the invading microbe...
  13. pmc Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells
    Jasmin Herz
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    J Exp Med 212:1153-69. 2015
    ..We propose that noncytopathic CNS viral clearance can be achieved by therapeutic antiviral T cells reliant on restricted chemoattractant production and interactions with apoptosis-resistant microglia. ..
  14. pmc The great balancing act: regulation and fate of antiviral T-cell interactions
    E Ashley Moseman
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Immunol Rev 255:110-24. 2013
    ....
  15. doi request reprint Persistent viral infection elevates central nervous system MHC class I through chronic production of interferons
    Phi Truong
    National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:3895-905. 2009
    ....
  16. pmc Two-photon imaging of microbial immunity in living tissues
    Jasmin Herz
    National Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, MD 20892, USA
    Microsc Microanal 18:730-41. 2012
    ..This review focuses on how two-photon microscopy can be used to study tissue-specific immune responses in vivo, and how this approach has advanced our understanding of host-immune interactions following infection...
  17. doi request reprint Inflammation and neuroprotection in traumatic brain injury
    Kara N Corps
    Viral Immunology and Intravital Imaging Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland
    JAMA Neurol 72:355-62. 2015
    ....
  18. pmc Opposing roles of STAT1 and STAT3 in IL-21 function in CD4+ T cells
    Chi Keung Wan
    Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674
    Proc Natl Acad Sci U S A 112:9394-9. 2015
    ..These data indicate an interplay between STAT1 and STAT3 in fine-tuning IL-21 actions. ..
  19. pmc MRI confirms loss of blood-brain barrier integrity in a mouse model of disseminated candidiasis
    Dhammika H M L P Navarathna
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1500, USA
    NMR Biomed 26:1125-34. 2013
    ..albicans infections, to define the roles of Candida virulence genes in kidney versus brain infection and to assess new therapeutic measures for drug development...