David H McDermott

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study
    David H McDermott
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    Circulation 112:1113-20. 2005
  2. pmc Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:2793-802. 2010
  3. pmc AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Cell Mol Med 15:2071-81. 2011
  4. pmc CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection but not for viral transmission
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 201:178-85. 2010
  5. pmc Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome
    Hyun Sik Jun
    Section on Cellular Differentiation, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 116:2783-92. 2010
  6. pmc WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4
    Qian Liu
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:181-9. 2012
  7. pmc The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 118:4957-62. 2011
  8. pmc Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000321. 2009
  9. doi request reprint Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 197:262-5. 2008
  10. ncbi request reprint CCR5: no longer a "good for nothing" gene--chemokine control of West Nile virus infection
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 27:308-12. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study
    David H McDermott
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1886, USA
    Circulation 112:1113-20. 2005
    ..Monocyte chemoattractant protein-1 (MCP-1) is a chemokine strongly implicated in promoting atherosclerosis in animal models, but human genetic evidence is contradictory...
  2. pmc Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 116:2793-802. 2010
    ..Thus, myelokathexis associated with abnormally high neutrophil CXCR4 expression may contribute to neutropenia in G6PC3 deficiency and responds well to granulocyte colony-stimulating factor...
  3. pmc AMD3100 is a potent antagonist at CXCR4(R334X) , a hyperfunctional mutant chemokine receptor and cause of WHIM syndrome
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Cell Mol Med 15:2071-81. 2011
    ..Together, our data provide further evidence that CXCR4(R334X) is a gain-of-function mutation, and support clinical evaluation of AMD3100 as mechanism-based treatment in patients with WHIM syndrome...
  4. pmc CCR5 deficiency is a risk factor for early clinical manifestations of West Nile virus infection but not for viral transmission
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, Laboratory of Cellular and Molecular Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 201:178-85. 2010
    ....
  5. pmc Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome
    Hyun Sik Jun
    Section on Cellular Differentiation, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD, USA
    Blood 116:2783-92. 2010
    ..The results establish that in nonapoptotic neutrophils, G6Pase-β is essential for normal energy homeostasis. A G6Pase-β deficiency prevents recycling of ER glucose to the cytoplasm, leading to neutrophil dysfunction...
  6. pmc WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4
    Qian Liu
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 120:181-9. 2012
    ..Therefore, in addition to truncating mutations in the C-terminal domain of CXCR4, WHIM syndrome may be caused by a single charge-changing amino acid substitution in this domain, E343K, that results in increased receptor signaling...
  7. pmc The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome
    David H McDermott
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 118:4957-62. 2011
    ..This study is registered at http://www.clinicaltrials.gov as NCT00967785...
  8. pmc Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA
    PLoS Pathog 5:e1000321. 2009
    ..0001). Together, these data identify OAS1 SNP rs10774671 as a host genetic risk factor for initial infection with WNV in humans...
  9. doi request reprint Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 197:262-5. 2008
    ..1 [95% CI, 0.9-11.2] [P= .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P= .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States...
  10. ncbi request reprint CCR5: no longer a "good for nothing" gene--chemokine control of West Nile virus infection
    Jean K Lim
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Trends Immunol 27:308-12. 2006
    ..Although CCR5 might be a logical target for new drug development in HIV/AIDS, the benefits of blocking CCR5 could carry the cost of an increased risk of WNV disease in co-infected patients...
  11. pmc CCR5 deficiency increases risk of symptomatic West Nile virus infection
    William G Glass
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:35-40. 2006
    ..03). We conclude that CCR5 mediates resistance to symptomatic WNV infection. Because CCR5 is also the major HIV coreceptor, these findings have important implications for the safety of CCR5-blocking agents under development for HIV/AIDS...
  12. ncbi request reprint Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms
    Jana Barlic
    Molecular Signaling Section, Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:48520-34. 2004
    ..We propose that expression of CX3CR1 and possibly other immunoregulatory genes may be determined in part by the balance of NFAT1 and NFAT2 activity in leukocytes...
  13. pmc Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans
    David H McDermott
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases NIH, Building 10, 9000 Rockville Pike, Bethesda, MD 20892 1886, USA
    J Clin Invest 111:1241-50. 2003
    ..Moreover, they suggest that CX3CR1-M280 is a genetic risk factor for CVD...
  14. pmc Complete genome sequence of a tenth human polyomavirus
    Christopher B Buck
    NCI, Bethesda, Maryland, USA
    J Virol 86:10887. 2012
    ....
  15. pmc Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation
    David H McDermott
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 115:2311-8. 2010
    ..This finding suggests that donor and/or recipient CCR5 genotypes may be associated with HSCT outcome and suggests new diagnostic and therapeutic strategies for optimizing therapy...
  16. pmc Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice
    Wuzhou Wan
    Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Circ Res 109:374-81. 2011
    ..Recent evidence suggests that both CCR6 and its ligand CCL20 are also present in human atheroma; however, their functional roles in atherogenesis remain undefined...
  17. ncbi request reprint Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C
    Kittichai Promrat
    The Liver Diseases Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Gastroenterology 124:352-60. 2003
    ..The roles of other disease-associated chemokine system polymorphisms have not been evaluated in hepatitis C virus infection...
  18. pmc Role for CCR5Delta32 protein in resistance to R5, R5X4, and X4 human immunodeficiency virus type 1 in primary CD4+ cells
    Lokesh Agrawal
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Virol 78:2277-87. 2004
    ....
  19. ncbi request reprint Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, Boston, Massachesetts, USA
    J Am Soc Nephrol 13:754-8. 2002
    ..20; P = 0.032) and homozygosity for the 59029-A allele (OR, 0.26; P = 0.027). It was concluded that the risk of acute rejection in renal transplantation is associated with genetic variation in the chemokine receptors CCR2 and CCR5...
  20. ncbi request reprint Role of beta3 integrin in acute renal allograft rejection in humans
    Arun Chandrakantan
    Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin J Am Soc Nephrol 2:1268-73. 2007
    ..Beta3 Integrin may play a role in the process of acute rejection by increasing leukocyte adhesion to the endothelium, cytotoxic T lymphocyte activation, and platelet aggregation...
  21. ncbi request reprint Assessment of cumulative evidence on genetic associations: interim guidelines
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 37:120-32. 2008
    ..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...