Thomas F McCutchan

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Use of malaria rapid diagnostic test to identify Plasmodium knowlesi infection
    Thomas F McCutchan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Pkwy, Rockville, MD 20892, USA
    Emerg Infect Dis 14:1750-2. 2008
  2. pmc Compensatory evolution in the human malaria parasite Plasmodium ovale
    Thomas F McCutchan
    Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Genetics 166:637-40. 2004
  3. pmc Measuring the effects of an ever-changing environment on malaria control
    Thomas F McCutchan
    Laboratory of Parasitic Diseases, Section of Growth and Development, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Infect Immun 72:2248-53. 2004
  4. pmc Radiation-induced cellular and molecular alterations in asexual intraerythrocytic Plasmodium falciparum
    Miranda S Oakley
    Division of Bacterial, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, USA
    J Infect Dis 207:164-74. 2013
  5. pmc Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites
    Miranda S M Oakley
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIH, Rockville, MD 20892, USA
    Infect Immun 75:2012-25. 2007
  6. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
  7. ncbi request reprint Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:40905-10. 2003
  8. pmc Molecular correlates of experimental cerebral malaria detectable in whole blood
    Miranda S Oakley
    Division of Bacterial, Parasitic, and Allergenic Products Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA
    Infect Immun 79:1244-53. 2011
  9. doi request reprint Clinical and molecular aspects of malaria fever
    Miranda S Oakley
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA
    Trends Parasitol 27:442-9. 2011
  10. ncbi request reprint Ambient glucose concentration and gene expression in Plasmodium falciparum
    Jun Fang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 133:125-9. 2004

Collaborators

Detail Information

Publications27

  1. pmc Use of malaria rapid diagnostic test to identify Plasmodium knowlesi infection
    Thomas F McCutchan
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Pkwy, Rockville, MD 20892, USA
    Emerg Infect Dis 14:1750-2. 2008
    ..We report the use of a rapid test to supplement microscopic analysis in distinguishing the 5 malaria species that infect humans...
  2. pmc Compensatory evolution in the human malaria parasite Plasmodium ovale
    Thomas F McCutchan
    Growth and Development Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Genetics 166:637-40. 2004
    ..The appearance of compensatory mutations and intermediate states in P. ovale raises interesting questions about population structure that could have considerable impact on the control of the associated disease...
  3. pmc Measuring the effects of an ever-changing environment on malaria control
    Thomas F McCutchan
    Laboratory of Parasitic Diseases, Section of Growth and Development, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Infect Immun 72:2248-53. 2004
    ..These results indicate that dominant environmental parameters associated with malaria deaths can be addressed before their application to a less malleable human system...
  4. pmc Radiation-induced cellular and molecular alterations in asexual intraerythrocytic Plasmodium falciparum
    Miranda S Oakley
    Division of Bacterial, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, USA
    J Infect Dis 207:164-74. 2013
    ..irradiation is commonly used to create attenuation in Plasmodium parasites. However, there are no systematic studies on the survival, reversion of virulence, and molecular basis for γ-radiation-induced cell death in malaria parasites...
  5. pmc Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites
    Miranda S M Oakley
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases NIH, Rockville, MD 20892, USA
    Infect Immun 75:2012-25. 2007
    ..These studies enhance the possibility of designing vaccines and drugs on the basis of disruption in molecules and pathways of parasite survival and virulence activated in response to febrile temperatures...
  6. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
    ..We find that OX40, a marker of both T cell activation and memory, is selectively upregulated in the brain during ECM and its distribution among CD4(+) and CD8(+) T cells accumulated in the brain vasculature is approximately equal...
  7. ncbi request reprint Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:40905-10. 2003
    ..falciparum CSP (PfCSP). We suggest that a difference in the binding affinity for the liver cell receptor is a mechanism involved in maintaining the host specificity by the malaria parasite...
  8. pmc Molecular correlates of experimental cerebral malaria detectable in whole blood
    Miranda S Oakley
    Division of Bacterial, Parasitic, and Allergenic Products Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, USA
    Infect Immun 79:1244-53. 2011
    ..A subset of these mediators of ECM warrant validation in P. falciparum-infected young African children as diagnostic markers of CM...
  9. doi request reprint Clinical and molecular aspects of malaria fever
    Miranda S Oakley
    Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA
    Trends Parasitol 27:442-9. 2011
    ..The potential molecular mechanisms that could be responsible for the induction and regulation of cyclical malaria fevers caused by different species of Plasmodium are also discussed...
  10. ncbi request reprint Ambient glucose concentration and gene expression in Plasmodium falciparum
    Jun Fang
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biochem Parasitol 133:125-9. 2004
  11. ncbi request reprint The effects of glucose concentration on the reciprocal regulation of rRNA promoters in Plasmodium falciparum
    Jun Fang
    Section of Molecular Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    J Biol Chem 279:720-5. 2004
    ..These putative promoter structures are considerably different from one another and contain structures remarkably similar to rRNA control elements in other organisms...
  12. pmc Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice
    Miranda S Oakley
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Infect Immun 76:4518-29. 2008
    ..Our studies greatly enhance the repertoire of host molecules for use as diagnostics and novel therapeutics in CM...
  13. ncbi request reprint Construction of a gene library with mung bean nuclease-treated genomic DNA
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Med 72:253-63. 2002
  14. ncbi request reprint Thermoregulation in a parasite's life cycle
    Jun Fang
    Growth and Development Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0425, USA
    Nature 418:742. 2002
    ..falciparum from human to mosquito. Our findings offer new insight into how the malaria parasite senses and reacts to its environment...
  15. pmc Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione
    Dipak Kumar Raj
    Laboratory of Malaria and Vector Research, Research Technologies Branch, and Biostatistical Research Branch, NIAID, National Institutes of Health, Bethesda, Maryland 20892 8132, USA
    J Biol Chem 284:7687-96. 2009
    ..The results suggest that PfMRP plays a role in the efflux of glutathione, CQ, and QN and contributes to parasite responses to multiple antimalarial drugs, possibly by pumping drugs outside the parasite...
  16. pmc Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1245-52. 2008
    ....
  17. ncbi request reprint Construction of genomic libraries from the DNA of Plasmodium species
    Leda M Cummings
    Institute for Genome Research, Rockville, MD, USA
    Methods Mol Med 72:241-51. 2002
  18. ncbi request reprint Binding and invasion of liver cells by Plasmodium falciparum sporozoites. Essential involvement of the amino terminus of circumsporozoite protein
    Dharmendar Rathore
    Growth and Development Section, Laboratory of Malaria and Vector Research, NIAID National Institutes of Health, 4 Center Drive MSC 0425, Bethesda, MD 20892 0425, USA
    J Biol Chem 277:7092-8. 2002
    ..This indicates that both assays are measuring interrelated phenomenon and points to the essential involvement for the amino-terminal portion of the CS protein in these processes...
  19. ncbi request reprint Molecular phylogenetic analysis of the avian malarial parasite Plasmodium (Novyella) juxtanucleare
    Jessica C Kissinger
    Centro de Pesquisas René Rachou FIOCRUZ Avenida Augusto de Lima 1715, Barro Preto, Belo Horizonte, Minas Gerais 30190 002, Brazil
    J Parasitol 88:769-73. 2002
    ....
  20. doi request reprint Beyond bed nets
    Thomas F McCutchan
    Science 319:33. 2008
  21. ncbi request reprint Construction of Plasmodium falciparum lambda cDNA libraries
    David A Fidock
    Department of Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, The Bronx, NY, USA
    Methods Mol Med 72:265-75. 2002
  22. ncbi request reprint Plasmodium Juxtanucleare associated with mortality in black-footed penguins (Spheniscus demersus) admitted to a rehabilitation center
    K Christiana Grim
    Medical Department, The Baltimore Zoo, Baltimore, Maryland 21217, USA
    J Zoo Wildl Med 34:250-5. 2003
    ..A species-specific variable region of this gene was compared with the same region on genes from other known avian malarial organisms, establishing that Plasmodium juxtanucleare was involved...
  23. ncbi request reprint An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    J Biol Chem 280:20524-9. 2005
    ....
  24. pmc Malaria control in Africa: a mirage à trois
    Thomas F McCutchan
    Future Microbiol 3:479-83. 2008
  25. pmc Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method
    Jian Li
    Laboratory of Parasitology Research, School of Life Science, Xiamen University, Xiamen, Fujian 361005, The People s Republic of China
    Mol Biochem Parasitol 155:94-102. 2007
    ..yoelii. There is a good possibility that this method can be applied to type MS from other malaria parasites including important human pathogens Plasmodium falciparum and Plasmodium vivax...
  26. ncbi request reprint Is a monkey malaria from Borneo an emerging human disease?
    Thomas F McCutchan
    Future Microbiol 3:115-8. 2008
  27. ncbi request reprint Antimalarial drugs: current status and new developments
    Dharmendar Rathore
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Washington Street, Blacksburg, VA 24061, USA
    Expert Opin Investig Drugs 14:871-83. 2005
    ....