Melissa K McCoy

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    J Neuroinflammation 5:45. 2008
  2. pmc Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response
    Jae Kyung Lee
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    J Neurosci 28:8517-28. 2008
  3. pmc Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Ther 16:1572-9. 2008
  4. ncbi request reprint Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Front Biosci 13:709-17. 2008
  5. pmc Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Exp Neurol 210:14-29. 2008
  6. pmc The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Neuroinflammation 5:14. 2008
  7. pmc Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Exp Neurol 208:1-25. 2007
  8. pmc Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:9365-75. 2006

Detail Information

Publications8

  1. pmc TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
    J Neuroinflammation 5:45. 2008
    ....
  2. pmc Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response
    Jae Kyung Lee
    Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
    J Neurosci 28:8517-28. 2008
    ..RGS10 emerges as a novel drug target for prevention of nigrostriatal pathway degeneration, the neuropathological hallmark of PD...
  3. pmc Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Ther 16:1572-9. 2008
    ..This strategy holds the potential for therapeutic application in the treatment of PD...
  4. ncbi request reprint Neuroinflammation in Parkinson's disease: is there sufficient evidence for mechanism-based interventional therapy?
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9040, USA
    Front Biosci 13:709-17. 2008
    ..The rationale for current and future use of anti-inflammatory approaches to protect vulnerable neuronal populations in PD is also reviewed...
  5. pmc Autologous transplants of Adipose-Derived Adult Stromal (ADAS) cells afford dopaminergic neuroprotection in a model of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Exp Neurol 210:14-29. 2008
    ..ADAS cells may be ideal for ex vivo gene transfer therapies in Parkinson's disease treatment...
  6. pmc The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
    Thi A Tran
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Neuroinflammation 5:14. 2008
    ..Therefore, the aims of our study were to identify specific microglial activities modulated by CDDO-Me in vitro, and to determine the extent to which this modulation affords neuroprotection against inflammatory stimuli...
  7. pmc Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Exp Neurol 208:1-25. 2007
    ....
  8. pmc Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease
    Melissa K McCoy
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:9365-75. 2006
    ....