Research Topics
| Donna O McCarthySummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Rethinking nutritional support for persons with cancer cachexiaDonna O McCarthy
National Institute of Nursing Research, 31 Center Drive, Room 5B 13, Bethesda, MD 20892 2178, USA
Biol Res Nurs 5:3-17. 2003..These factors and foods are sometimes called nutraceuticals, and research is needed to evaluate their efficacy in combating cancer cachexia...
Inhibitors of COX activity preserve muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanomaErin Graves
Laboratory of Symptom Management, National Institute of Nursing Research, Bethesda, MD, USA
Res Nurs Health 29:87-97. 2006..Further study is needed to understand the relationship between COX and SMW, and whether patients with cancer cachexia might benefit from COX inhibitors...
Indomethacin preserves muscle mass and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius muscle of tumor-bearing miceAndrew Hitt
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
Res Nurs Health 28:56-66. 2005..These data also demonstrate that E3 ligases, which are involved in disuse atrophy, also are associated with tumor-induced skeletal muscle wasting...
Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinomaErin Graves
National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
Res Nurs Health 28:48-55. 2005..CLA preserved gastrocnemius muscle mass and reduced TNF receptors in muscle of tumor-bearing mice. These data suggest that CLA may preserve muscle mass by reducing the catabolic effects of TNF on skeletal muscle...
Conjugated linoleic acid preserves muscle mass in mice bearing the Lewis lung carcinoma, but not the B16 melanomaDonna O McCarthy
Laboratory of Symptom Management, National Institute of Nursing Research, NIH, Bethesda, MD, USA
Res Nurs Health 29:98-104. 2006..5% CLA reduced SMW, but had no effect on muscle levels of TNFR1. We conclude that that tumor-induced SMW can occur independent of muscle levels of TNFR1. Further study is needed before CLA can be tested in persons with cancer cachexia...
Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinomaDonna O McCarthy
National Institute of Nursing Research, National Institutes of Health, 31 Center Drive, Rm. 5B13, Bethesda, MD 20892, USA
Res Nurs Health 27:174-84. 2004..The data suggest that ibuprofen may have beneficial effects in the treatment of cancer cachexia...
Altered expression of skeletal muscle myosin isoforms in cancer cachexiaGary M Diffee
Biodynamics Laboratory, University of Wisconsin, Madison, Wisconsin 53706, USA
Am J Physiol Cell Physiol 283:C1376-82. 2002..MHC isoform content was not significantly different from control in plantaris and gastrocnemius muscles. These data are the first to show a change in myosin isoform expression accompanying muscle atrophy during cancer cachexia...
