Julie A McCarron

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Synthesis and initial evaluation of [11C](R)-RWAY in monkey-a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET
    Julie A McCarron
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, B3 C346A, 10 Center Drive, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 34:1670-82. 2007
  2. ncbi request reprint Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements
    Xiang Yang Zhang
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:469-77. 2007
  3. ncbi request reprint Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 60:510-20. 2006
  4. ncbi request reprint Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY
    Jeih San Liow
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:96-105. 2007
  5. ncbi request reprint Two C-methyl derivatives of [11C]WAY-100635--effects of an amido alpha-methyl group on metabolism and brain 5-HT1A receptor radioligand behavior in monkey
    Julie A McCarron
    MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London, W12 0NN, UK
    Mol Imaging Biol 7:209-19. 2005
  6. ncbi request reprint The pyridinyl-6 position of WAY-100635 as a site for radiofluorination--effect on 5-HT1A receptor radioligand behavior in vivo
    Julie A McCarron
    PET Radiopharmaceutical Sciences Section, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Mol Imaging Biol 6:17-26. 2004
  7. ncbi request reprint Synthesis of a [6-pyridinyl-18F]-labelled fluoro derivative of WAY-100635 as a candidate radioligand for brain 5-HT1A receptor imaging with PET
    Mylène Karramkam
    Service Hospitalier Frederic Joliot, Departement de Recherche Medicale, CEA, 4 Place du General Leclerc, F 91401 Orsay, France
    Bioorg Med Chem 11:2769-82. 2003

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Synthesis and initial evaluation of [11C](R)-RWAY in monkey-a new, simply labeled antagonist radioligand for imaging brain 5-HT1A receptors with PET
    Julie A McCarron
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, B3 C346A, 10 Center Drive, Bethesda, MD 20892, USA
    Eur J Nucl Med Mol Imaging 34:1670-82. 2007
    ..We aimed to fulfill a need for a radioligand that may be simply labeled with carbon-11 for effective positron emission tomography (PET) imaging of brain 5-HT(1A) receptors...
  2. ncbi request reprint Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements
    Xiang Yang Zhang
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:469-77. 2007
    ..Although prior studies in rodents and nonhuman primates showed [(11)C](R)-(-)-RWAY to be a promising radiotracer, we suspect that a species difference in metabolism caused this serious deficiency in humans...
  3. ncbi request reprint Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 60:510-20. 2006
    ....
  4. ncbi request reprint Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY
    Jeih San Liow
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892 0135, USA
    Synapse 61:96-105. 2007
    ..The effects of CsA in rats are mediated by both P-gp blockade and displacement of the radiotracer from plasma proteins. Studies with wild type and knockout mice showed that CsA affected only P-gp in this species...
  5. ncbi request reprint Two C-methyl derivatives of [11C]WAY-100635--effects of an amido alpha-methyl group on metabolism and brain 5-HT1A receptor radioligand behavior in monkey
    Julie A McCarron
    MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, London, W12 0NN, UK
    Mol Imaging Biol 7:209-19. 2005
    ..Here, in a search for a radioligand that overcomes these limitations, we investigated the effects of introducing a single methyl group at either of the carbon atoms alpha to the amide bond in [11C]WAY-100635...
  6. ncbi request reprint The pyridinyl-6 position of WAY-100635 as a site for radiofluorination--effect on 5-HT1A receptor radioligand behavior in vivo
    Julie A McCarron
    PET Radiopharmaceutical Sciences Section, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Mol Imaging Biol 6:17-26. 2004
    ....
  7. ncbi request reprint Synthesis of a [6-pyridinyl-18F]-labelled fluoro derivative of WAY-100635 as a candidate radioligand for brain 5-HT1A receptor imaging with PET
    Mylène Karramkam
    Service Hospitalier Frederic Joliot, Departement de Recherche Medicale, CEA, 4 Place du General Leclerc, F 91401 Orsay, France
    Bioorg Med Chem 11:2769-82. 2003
    ..7 GBq) aliquot of a batch of cyclotron-produced [(18)F]fluoride. This (18)F-labelled radioligand is now being evaluated in PET studies...