Research Topics
| S M MbulaiteyeSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Burkitt lymphoma risk in U.S. solid organ transplant recipientsSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Am J Hematol 88:245-50. 2013..In conclusion, BL risk is markedly elevated in transplant recipients, and it is associated with certain demographic and clinical features. EBV was positive in most but not all BL cases with results...- Pediatric, elderly, and emerging adult-onset peaks in Burkitt's lymphoma incidence diagnosed in four continents, excluding AfricaSam M Mbulaiteye
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, Rockville, MD 20892, USA
Am J Hematol 87:573-8. 2012..Our findings, based on the international BL cases, support our hypothesis that BL is multimodal and that BL peaks at different ages may be clues to differences in the etiology and/or biology of BL at those ages... - A case-control study of Burkitt lymphoma in East Africa: are local health facilities an appropriate source of representative controls?Sonya Baik
Infections and Immunoepidemiology Branch, National Cancer Institute, Bethesda, MD, USA
Infect Agent Cancer 7:5. 2012..abstract:.. - Cancer risk in persons with HIV/AIDS in India: a review and future directions for researchRobert J Biggar
Dept, of Research, LV Prasad Eye Hospital, Hyderabad, India
Infect Agent Cancer 4:4. 2009..With the population's geographic and social diversity, India presents unique research opportunities that can be embedded in programs targeting HIV/AIDS and other public health priorities... - HLA polymorphisms and detection of kaposi sarcoma-associated herpesvirus DNA in saliva and peripheral blood among children and their mothers in the uganda sickle cell anemia KSHV StudyMercy Guech-Ongey
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, Bethesda, Maryland, USA
Infect Agent Cancer 5:21. 2010..Larger population-based studies are needed to estimate the magnitude and direction of association of HLA with KSHV shedding and viral control... - Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30Colleen Pelser
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
Infect Agent Cancer 5:18. 2010..To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV)... - Sporadic childhood Burkitt lymphoma incidence in the United States during 1992-2005Sam M Mbulaiteye
Infections and Immunoepidemiology Branch, DCEG, National Cancer Institute, Bethesda, Maryland, USA
Pediatr Blood Cancer 53:366-70. 2009..The risk factors and co-factors for sporadic childhood BL are unknown. We investigated demographic and age-specific characteristics of childhood BL (0-14 years) in the U.S... 
Water, socioeconomic factors, and human herpesvirus 8 infection in Ugandan children and their mothersSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA
J Acquir Immune Defic Syndr 38:474-9. 2005..Human herpesvirus 8 (HHV-8) infection is common in sub-Saharan Africa, but its distribution is uneven. Transmission occurs during childhood within families by unclear routes...- Spectrum of cancers among HIV-infected persons in Africa: the Uganda AIDS-Cancer Registry Match StudySam M Mbulaiteye
Division Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Int J Cancer 118:985-90. 2006..We confirm the increased risks of AIDS-defining cancers and report increased risks of a few non-AIDS-defining cancers... - High levels of Epstein-Barr virus DNA in saliva and peripheral blood from Ugandan mother-child pairsSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
J Infect Dis 193:422-6. 2006..Our results indicate that EBV infection persists, with virus readily detectable in saliva and buffy coats from persons without apparent symptoms in Africa... - Risk factors for human herpesvirus 8 seropositivity in the AIDS Cancer Cohort StudySam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH DHHS, 6120 Executive Blvd, Executive Plaza South Rm 8006, Mail Stop Center 7248, Rockville, MD 20852, USA
J Clin Virol 35:442-9. 2006..Cigarette smoking has been associated with a decreased risk for AIDS-related and classical KS, but whether it is associated with decreased risk of human herpesvirus 8 (HHV-8) infection is unknown... - Kaposi's sarcoma risk among transplant recipients in the United States (1993-2003)Sam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Int J Cancer 119:2685-91. 2006..The high KS risk immediately posttransplant and in persons with HLA-B mismatch highlights the role of immunosuppression and/or immune stimulation in KS pathogenesis... - Helicobacter Pylori associated global gastric cancer burdenSam M Mbulaiteye
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Front Biosci 14:1490-504. 2009..These discoveries invite strategies to prevent infection to be the logical primary goals in a multi-pronged effort to curtail suffering and death from H. pylori infection-associated cancers... - Absence of Y-chromosome sequences in tumors from African women with AIDS-related Kaposi sarcomaSam M Mbulaiteye
Viral Epidemiology Branch, DCEG, National Cancer Institute, Executive Plaza South Rm 7080, Rockville, MD 20852, USA
Cancer Lett 248:229-33. 2007..Among 25 unique tumors tested, none was positive for SRY sequence. While our results do not exclude sexual cellular transmission of whole KS cells, they suggest that if it occurs, it is rare... - Incidence of visual loss in rural southwest UgandaS M Mbulaiteye
Medical Research Council Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda
Br J Ophthalmol 87:829-33. 2003..Surveys have been conducted to measure prevalence of eye disease in Africa, but not of incidence, which is needed to forecast trends. The incidence of visual loss is reported in southwest Uganda... - Detection of kaposi sarcoma-associated herpesvirus DNA in saliva and buffy-coat samples from children with sickle cell disease in UgandaSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, Maryland, USA
J Infect Dis 190:1382-6. 2004..Detection was associated with K8.1 seropositivity, younger age, and high household density, indicating the importance of in-household person-to-person transmission, likely via saliva... - Pleural and peritoneal lymphoma among people with AIDS in the United StatesSam M Mbulaiteye
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA
J Acquir Immune Defic Syndr 29:418-21. 2002..To describe the occurrence and characteristics of pleural and peritoneal lymphoma in a large cohort of persons with AIDS in 11 regions in the United States... - Trimodal age-specific incidence patterns for Burkitt lymphoma in the United States, 1973-2005Sam M Mbulaiteye
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, Bethesda, MD 20852, USA
Int J Cancer 126:1732-9. 2010..To our knowledge, tri/bimodal incidence patterns have not previously been reported for BL. Trimodal/bimodal BL suggests heterogeneity in etiology or biology of BL diagnosed at different ages in males and females... - Evaluation of E-optotypes as a screening test and the prevalence and causes of visual loss in a rural population in SW UgandaS M Mbulaiteye
Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
Ophthalmic Epidemiol 9:251-62. 2002..In the present paper, we describe the prevalence of visual loss in rural Uganda and the screening accuracy of E-optotypes when used by non-medical staff... - Immune deficiency and risk for malignancy among persons with AIDSSam M Mbulaiteye
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, Bethesda, MD 20852, USA
J Acquir Immune Defic Syndr 32:527-33. 2003..People with AIDS have an elevated risk for cancer. We studied the relationship between cancer risk and AIDS-related immunosuppression as measured by CD4 count at AIDS onset... - Human herpesvirus 8 infection within families in rural TanzaniaSam M Mbulaiteye
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
J Infect Dis 187:1780-5. 2003..2; 95% CI, 1.9-9.4). Our data are consistent with the occurrence of HHV-8 transmission within families, from mothers and other relatives to children via nonsexual routes and between spouses via sexual routes... - HIV and cancer in Africa: mutual collaboration between HIV and cancer programs may provide timely research and public health dataSam M Mbulaiteye
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Infect Agent Cancer 6:16. 2011..In this paper, we review current literature and explore merits for integrating cancer research in established HIV programs to obtain timely data about the incidence and burden of cancer in HIV-infected persons in Africa... - Epidemiology of AIDS-related malignancies an international perspectiveSam M Mbulaiteye
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Hematol Oncol Clin North Am 17:673-96, v. 2003..Further therapeutic advances that extend survival with HIV infection with varying reconstitution of immune competence may lead to additional alterations in cancer risk... - Human herpesvirus 8 infection and transfusion history in children with sickle-cell disease in UgandaSam M Mbulaiteye
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 95:1330-5. 2003..We studied the association between HHV-8 seropositivity and transfusion history among children with sickle-cell disease in Uganda, where HHV-8 infection is common in blood donors... - Seroprevalence and risk factors for human herpesvirus 8 infection, rural EgyptSam M Mbulaiteye
National Cancer Institute, Bethesda, MD, USA
Emerg Infect Dis 14:586-91. 2008..1, 95% CI 0.3-16.4), but marginal for women (OR 1.5, 95% CI 1.0-2.5). Our findings suggest salivary and possible nosocomial HHV-8 transmission in rural Egypt... - HIV-1 epidemic trends in rural south-west Uganda over a 10-year periodJ A G Whitworth
Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
Trop Med Int Health 7:1047-52. 2002..This was an observational cohort exposed to national health education messages, giving hope that similar campaigns elsewhere in Africa could be used effectively in efforts to control the HIV epidemic... - Generalizability of population-based studies on AIDS: a comparison of newly and continuously surveyed villages in rural southwest UgandaS M Mbulaiteye
Medical Research Council Programme on AIDS Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda
Int J Epidemiol 31:961-7. 2002..However, longitudinal studies are susceptible to bias from added attention caused by study activities. We compare HIV-1 prevalence in previously and newly surveyed villages in rural southwest Uganda... - Alcohol and HIV: a study among sexually active adults in rural southwest UgandaS M Mbulaiteye
Medical Research Council Programme on AIDS, Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda
Int J Epidemiol 29:911-5. 2000..To investigate the association between alcohol consumption and HIV sero-positivity in a rural Ugandan population... - Declining HIV-1 incidence and associated prevalence over 10 years in a rural population in south-west Uganda: a cohort studyS M Mbulaiteye
Medical Research Council Programme on AIDS in Uganda, Uganda Virus Research Institute, PO Box 49, Entebbe, Uganda
Lancet 360:41-6. 2002..001, chi(2) for trend). INTERPRETATION: Our findings of a significant drop in adult HIV-1 incidence in rural Ugandans give hope to AIDS control programmes elsewhere in sub-Saharan Africa where rates of HIV-1 infection remain high... - Trends in Kaposi's sarcoma and non-Hodgkin's lymphoma incidence in the United States from 1973 through 1998Mohamed A Eltom
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Natl Cancer Inst 94:1204-10. 2002..Notably, non-AIDS-associated NHL incidence has continued to increase steadily through 1998... - Sex and geographic patterns of human herpesvirus 8 infection in a nationally representative population‐based sample in UgandaBenon Biryahwaho
Uganda Virus Research Institute, Entebbe, Uganda
J Infect Dis 202:1347-53. 2010..Variation in HHV8 seropositivity across small-area regions within countries in Africa is unknown. We investigated this issue in Uganda, where Kaposi sarcoma distribution is uneven and well described... - Risk factors for Kaposi's sarcoma among HHV-8 seropositive homosexual men with AIDSEric Nawar
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Int J Cancer 115:296-300. 2005..Alternatively, our findings may reflect factors protective against KS in individuals infected with HHV-8. Future research should focus on identifying practical measures for countering KS that do not increase the risk of other diseases... - African Burkitt lymphoma: age-specific risk and correlations with malaria biomarkersBenjamin Emmanuel
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Bethesda, MD 20852, USA
Am J Trop Med Hyg 84:397-401. 2011..Our findings suggest that concurrent infection with multiple malaria genotypes may be related to onset of African Burkitt lymphoma... 
Geographic heterogeneity of prevalence of the human herpesvirus 8 in sub-Saharan Africa: clues about etiologyRuth M Pfeiffer
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
Ann Epidemiol 20:958-63. 2010..We assessed HHV-8 seropositivity in several African countries with heterogeneous environments and varying KS incidence using a unified approach...- Transmission of human herpesvirus 8 by sexual activity among adults in Lagos, NigeriaMohamed A Eltom
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics DCEG, National Cancer Institute, 6120 Executive Boulevard, EPS Room 8014, Rockville, MD 20852 MSC 7248, USA
AIDS 16:2473-8. 2002..Studies in Europe and America suggest spread through homosexual contact, but evidence of heterosexual spread is inconsistent. We examined the association between HHV-8 and markers of risky sexual activity in Nigeria... - Kaposi sarcoma-associated herpesvirus in non-Hodgkin lymphoma and reactive lymphadenopathy in UgandaEric A Engels
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Hum Pathol 38:308-14. 2007..We describe the first case of a KSHV-positive NHL from this region; this case is also the first reported pediatric lymphoma associated with KSHV infection... - AIDS-related Burkitt lymphoma in the United States: what do age and CD4 lymphocyte patterns tell us about etiology and/or biology?Mercy Guech-Ongey
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
Blood 116:5600-4. 2010..2-0.6]). The bimodal peaks for BL, in contrast to non-BL NHL, suggest effects of noncumulative risk factors at different ages. Underascertainment or biological reasons may account for BL deficit at low CD4 lymphocyte counts... - The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns: a need for reappraisalCindy M Chang
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7074, Rockville, MD 20892, USA
Virus Res 143:209-21. 2009.... - Hepatitis C virus genotype 4 in Ugandan children and their mothersRobert J Biggar
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20852, USA
Emerg Infect Dis 12:1440-3. 2006..However, only approximately 10% of positive results were confirmed by reverse transcription-PCR, which suggests frequent false-positive results or viral clearance. All sequenced types were genotype 4... - Underestimation of relative risks by standardized incidence ratios for AIDS-related cancersAnil K Chaturvedi
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
Ann Epidemiol 18:230-4. 2008..We quantified the extent of this underestimation for 3 AIDS-related cancers: Kaposi sarcoma (KS), central nervous system non-Hodgkin lymphoma (CNS NHL) and cervical cancer... - Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United StatesMercy Guech-Ongey
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA
Int J Cancer 122:2590-3. 2008..We show significantly increased incidence of SCCC among persons with HIV/AIDS in the U.S. The associations with age and geography are in accord with etiological role for ultraviolet radiation in SCCC... - Intestinal parasites in Kaposi sarcoma patients in Uganda: indication of shared risk factors or etiologic associationCynthia J Lin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Am J Trop Med Hyg 78:409-12. 2008..While our findings may be due to confounding, they are compatible with shared risk factors or etiological association between parasites and KS, and warrant well-designed follow up studies... - Child survival in relation to mother's HIV infection and survival: evidence from a Ugandan cohort studyJessica S Nakiyingi
Medical Research Council Programme on AIDS in Uganda, Uganda Virus Research Institute PO Box 49, Entebbe, Uganda
AIDS 17:1827-34. 2003..To analyse the contribution of maternal survival and HIV status to child (under-5 years) mortality in a rural population cohort in South-west Uganda... - Transmission of Kaposi sarcoma-associated herpesvirus in sub-Saharan AfricaSam M Mbulaiteye
AIDS 22:535-7. 2008 - Human herpesvirus 8 load and progression of AIDS-related Kaposi sarcoma lesionsMartin M Nsubuga
Makerere University Medical School, Kampala, Uganda
Cancer Lett 263:182-8. 2008..We investigated these relationships in persons with AIDS... - Incidence and geographic distribution of endemic Burkitt lymphoma in northern Uganda revisitedMartin D Ogwang
Department of Surgery, St Mary s Hospital, Lacor, Gulu, Uganda
Int J Cancer 123:2658-63. 2008..Jaw tumors were characterized by young age and male gender, but presentation has shifted away from facial to mostly abdominal...