Mark L Mayer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, United States
    Curr Opin Neurobiol 21:283-90. 2011
  2. pmc The N-terminal domain of GluR6-subtype glutamate receptor ion channels
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Struct Mol Biol 16:631-8. 2009
  3. ncbi request reprint Glutamate receptors at atomic resolution
    Mark L Mayer
    Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Nature 440:456-62. 2006
  4. pmc Emerging models of glutamate receptor ion channel structure and function
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Structure 19:1370-80. 2011
  5. ncbi request reprint Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 26:2852-61. 2006
  6. ncbi request reprint Glutamate receptor ion channels
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, Building 35 Room 3B 1002 MSC 3712, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
    Curr Opin Neurobiol 15:282-8. 2005
  7. pmc Structure and assembly mechanism for heteromeric kainate receptors
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Neuron 71:319-31. 2011
  8. ncbi request reprint Regulation of AMPA receptor gating by ligand binding core dimers
    Michelle S Horning
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 41:379-88. 2004
  9. pmc AMPA receptor ligand binding domain mobility revealed by functional cross linking
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Neurosci 29:11912-23. 2009
  10. ncbi request reprint Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Neuron 45:539-52. 2005

Collaborators

Detail Information

Publications36

  1. pmc Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, United States
    Curr Opin Neurobiol 21:283-90. 2011
    ....
  2. pmc The N-terminal domain of GluR6-subtype glutamate receptor ion channels
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Struct Mol Biol 16:631-8. 2009
    ....
  3. ncbi request reprint Glutamate receptors at atomic resolution
    Mark L Mayer
    Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Nature 440:456-62. 2006
    ....
  4. pmc Emerging models of glutamate receptor ion channel structure and function
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Structure 19:1370-80. 2011
    ....
  5. ncbi request reprint Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 26:2852-61. 2006
    ....
  6. ncbi request reprint Glutamate receptor ion channels
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, Building 35 Room 3B 1002 MSC 3712, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
    Curr Opin Neurobiol 15:282-8. 2005
    ..Functional studies suggest that glutamate receptor gating is distinct from that of structurally related voltage-gated ion channels...
  7. pmc Structure and assembly mechanism for heteromeric kainate receptors
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Neuron 71:319-31. 2011
    ..Using these structures as a guide, we perform a mutant cycle analysis to probe the energetics of assembly and show that high-affinity ATD interactions are required for biosynthesis of functional heteromeric receptors...
  8. ncbi request reprint Regulation of AMPA receptor gating by ligand binding core dimers
    Michelle S Horning
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 41:379-88. 2004
    ....
  9. pmc AMPA receptor ligand binding domain mobility revealed by functional cross linking
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Neurosci 29:11912-23. 2009
    ..These data show that the glutamate binding domains are surprisingly mobile in the absence of ligand, which could influence receptor activity in the brain...
  10. ncbi request reprint Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Neuron 45:539-52. 2005
    ..This, together with extensive interdomain contacts between domains 1 and 2 of GluR5 and GluR6, absent from AMPA receptors, likely contributes to the high stability of GluR5 and GluR6 kainate complexes...
  11. pmc Molecular basis of kainate receptor modulation by sodium
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Neuron 58:720-35. 2008
    ....
  12. pmc Domain organization and function in GluK2 subtype kainate receptors
    Utpal Das
    Laboratory of Cellular and Molecular Neurophysiology, Department of Health and Human Services, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:8463-8. 2010
    ..These results establish that kainate and AMPA receptors have a conserved extracellular architecture and provide insight into the role of individual dimer assemblies in activation of ion channel gating...
  13. pmc Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions
    Charu Chaudhry
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:12329-34. 2009
    ....
  14. ncbi request reprint Structure and mechanism of kainate receptor modulation by anions
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 53:829-41. 2007
    ..In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously...
  15. pmc Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
    Yongneng Yao
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
    EMBO J 27:2158-70. 2008
    ..MD simulations revealed numerous interdomain contacts, which stabilize the agonist-bound closed-cleft conformation, and a novel twisting motion for the loop 1 helix that is unique in NR3 subunits...
  16. doi request reprint Anions mediate ligand binding in Adineta vaga glutamate receptor ion channels
    Suvendu Lomash
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development NIH DHHS, Bethesda, MD 20892, USA
    Structure 21:414-25. 2013
    ....
  17. pmc Analysis of high-affinity assembly for AMPA receptor amino-terminal domains
    Huaying Zhao
    Laboratory of Cellular Imaging and Macromolecular Biophysics, Bioengineering and Physical Science Shared Resource, Section on Biophotonics, The National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Gen Physiol 139:371-88. 2012
    ..Thus, for unknown reasons, the concentration dependence of sedimentation coefficients obtained with fluorescence detection SV may be unreliable, limiting the usefulness of this technique for quantitative analysis...
  18. pmc Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization
    Charu Chaudhry
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
    EMBO J 28:1518-30. 2009
    ..Our results show how neurotransmitter receptors with similar structures and gating mechanisms can exhibit strikingly different functional properties...
  19. pmc Conformational analysis of NMDA receptor GluN1, GluN2, and GluN3 ligand-binding domains reveals subtype-specific characteristics
    Yongneng Yao
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, Department of Health and Human Services, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 21:1788-99. 2013
    ..This variation highlights the structural complexity of signaling by glutamate receptor ion channels...
  20. ncbi request reprint Structure and function of glutamate receptor ion channels
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Building 36, Room 2B28, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
    Annu Rev Physiol 66:161-81. 2004
    ..In the space of months we have gone from cartoons of postulated mechanisms to hard fact. It is anticipated that this level of understanding will emerge for other synaptic proteins in the coming decade...
  21. pmc Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain
    David M Schauder
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:5921-6. 2013
    ..From fits of the amino terminal domain and LBD domains into the density map of the desensitized state we have derived a structural model for differences in quaternary conformation between the resting and desensitized states...
  22. pmc Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domains
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 404:680-96. 2010
    ..Our results provide the first insights into the structure and function of GluK4-GluK5, the least understood family of iGluRs...
  23. pmc Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Building 35, Room 3B 1002, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
    Neuropharmacology 56:114-20. 2009
    ..Hence, the apparent insensitivity of the M739D mutant to monovalent cations is due to the adventitious allosteric effects of divalent ions at physiological concentrations and below...
  24. doi request reprint Accounting for solvent signal offsets in the analysis of interferometric sedimentation velocity data
    Huaying Zhao
    Dynamics of Macromolecular Assembly, Laboratory of Bioengineering and Physical Science, NIBIB, National Institutes of Health, Bethesda, Maryland, USA
    Macromol Biosci 10:736-45. 2010
    ..We demonstrate how this can restore the SV analysis to yield a high quality fit of the data and to provide correct macromolecular sedimentation parameters...
  25. pmc Analysis of high affinity self-association by fluorescence optical sedimentation velocity analytical ultracentrifugation of labeled proteins: opportunities and limitations
    Huaying Zhao
    Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, Bethesda, Maryland, United States of America
    PLoS ONE 8:e83439. 2013
    ....
  26. doi request reprint Functional insights from glutamate receptor ion channel structures
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
    Annu Rev Physiol 75:313-37. 2013
    ..The structural basis for ion permeation and ion channel block also remain areas of uncertainty, and despite substantial progress, molecular dynamics simulations have yet to reveal how glutamate binding opens the ion channel pore...
  27. pmc Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists
    Gregory M Alushin
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Neuropharmacology 60:126-34. 2011
    ....
  28. ncbi request reprint Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A
    Yongneng Yao
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 26:4559-66. 2006
    ....
  29. pmc Analysis of protein interactions with picomolar binding affinity by fluorescence-detected sedimentation velocity
    Huaying Zhao
    Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
    Anal Chem 86:3181-7. 2014
    ....
  30. ncbi request reprint GRIK4 and the kainate receptor
    Mark L Mayer
    Bethesda, MD, USA
    Am J Psychiatry 164:1148. 2007
  31. ncbi request reprint Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists
    Nigel P Dolman
    Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Med Chem 50:1558-70. 2007
    ....
  32. ncbi request reprint Conformational restriction blocks glutamate receptor desensitization
    Matthew C Weston
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Mol Biol 13:1120-7. 2006
    ....
  33. ncbi request reprint Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate
    Matthew C Weston
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:7650-8. 2006
    ..We conclude that interdomain interactions have evolved as a distinct mechanism that contributes to the unique kinetic properties of AMPA and kainate receptors...
  34. ncbi request reprint Some assembly required
    Mark L Mayer
    Nat Struct Mol Biol 12:208-9. 2005
  35. ncbi request reprint Structural basis for partial agonist action at ionotropic glutamate receptors
    Rongsheng Jin
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168 Street, New York, New York 10032, USA
    Nat Neurosci 6:803-10. 2003
    ..Our findings thus provide a structure-based model of partial agonism...
  36. ncbi request reprint Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate
    Rongsheng Jin
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Biochemistry 41:15635-43. 2002
    ..The hydrophobic pocket, which is predicted to vary in chemical character between receptor subtypes, probably plays an important role in determining receptor subtype specificity...