Research Topics
| Mark L MayerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Detail Information
Publications
Structure and mechanism of glutamate receptor ion channel assembly, activation and modulationMark L Mayer
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, United States
Curr Opin Neurobiol 21:283-90. 2011....
Glutamate receptors at atomic resolutionMark L Mayer
Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
Nature 440:456-62. 2006....- Emerging models of glutamate receptor ion channel structure and functionMark L Mayer
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
Structure 19:1370-80. 2011.... - Glutamate receptor ion channelsMark L Mayer
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, Building 35 Room 3B 1002 MSC 3712, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
Curr Opin Neurobiol 15:282-8. 2005..Functional studies suggest that glutamate receptor gating is distinct from that of structurally related voltage-gated ion channels... - Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonistsMark L Mayer
Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 26:2852-61. 2006.... - Structure and assembly mechanism for heteromeric kainate receptorsJanesh Kumar
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
Neuron 71:319-31. 2011..Using these structures as a guide, we perform a mutant cycle analysis to probe the energetics of assembly and show that high-affinity ATD interactions are required for biosynthesis of functional heteromeric receptors... - AMPA receptor ligand binding domain mobility revealed by functional cross linkingAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Neurosci 29:11912-23. 2009..These data show that the glutamate binding domains are surprisingly mobile in the absence of ligand, which could influence receptor activity in the brain... - Molecular basis of kainate receptor modulation by sodiumAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
Neuron 58:720-35. 2008.... - Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivityMark L Mayer
Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Neuron 45:539-52. 2005..This, together with extensive interdomain contacts between domains 1 and 2 of GluR5 and GluR6, absent from AMPA receptors, likely contributes to the high stability of GluR5 and GluR6 kainate complexes... - Domain organization and function in GluK2 subtype kainate receptorsUtpal Das
Laboratory of Cellular and Molecular Neurophysiology, Department of Health and Human Services, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:8463-8. 2010..These results establish that kainate and AMPA receptors have a conserved extracellular architecture and provide insight into the role of individual dimer assemblies in activation of ion channel gating... - Regulation of AMPA receptor gating by ligand binding core dimersMichelle S Horning
Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuron 41:379-88. 2004.... - Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ionsCharu Chaudhry
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:12329-34. 2009.... - Structure and mechanism of kainate receptor modulation by anionsAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuron 53:829-41. 2007..In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously... - Molecular mechanism of ligand recognition by NR3 subtype glutamate receptorsYongneng Yao
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
EMBO J 27:2158-70. 2008..MD simulations revealed numerous interdomain contacts, which stabilize the agonist-bound closed-cleft conformation, and a novel twisting motion for the loop 1 helix that is unique in NR3 subunits... - Analysis of high-affinity assembly for AMPA receptor amino-terminal domainsHuaying Zhao
Laboratory of Cellular Imaging and Macromolecular Biophysics, Bioengineering and Physical Science Shared Resource, Section on Biophotonics, The National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Gen Physiol 139:371-88. 2012..Thus, for unknown reasons, the concentration dependence of sedimentation coefficients obtained with fluorescence detection SV may be unreliable, limiting the usefulness of this technique for quantitative analysis... - Stability of ligand-binding domain dimer assembly controls kainate receptor desensitizationCharu Chaudhry
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
EMBO J 28:1518-30. 2009..Our results show how neurotransmitter receptors with similar structures and gating mechanisms can exhibit strikingly different functional properties... - The N-terminal domain of GluR6-subtype glutamate receptor ion channelsJanesh Kumar
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Nat Struct Mol Biol 16:631-8. 2009.... - Engineering a high-affinity allosteric binding site for divalent cations in kainate receptorsAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Building 35, Room 3B 1002, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
Neuropharmacology 56:114-20. 2009..Hence, the apparent insensitivity of the M739D mutant to monovalent cations is due to the adventitious allosteric effects of divalent ions at physiological concentrations and below... - Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domainsJanesh Kumar
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Biol 404:680-96. 2010..Our results provide the first insights into the structure and function of GluK4-GluK5, the least understood family of iGluRs... - Structure and function of glutamate receptor ion channelsMark L Mayer
Laboratory of Cellular and Molecular Neurophysiology, Building 36, Room 2B28, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
Annu Rev Physiol 66:161-81. 2004..In the space of months we have gone from cartoons of postulated mechanisms to hard fact. It is anticipated that this level of understanding will emerge for other synaptic proteins in the coming decade... 
Accounting for solvent signal offsets in the analysis of interferometric sedimentation velocity dataHuaying Zhao
Dynamics of Macromolecular Assembly, Laboratory of Bioengineering and Physical Science, NIBIB, National Institutes of Health, Bethesda, Maryland, USA
Macromol Biosci 10:736-45. 2010..We demonstrate how this can restore the SV analysis to yield a high quality fit of the data and to provide correct macromolecular sedimentation parameters...- Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonistsGregory M Alushin
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
Neuropharmacology 60:126-34. 2011.... - Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3AYongneng Yao
Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 26:4559-66. 2006.... - GRIK4 and the kainate receptorMark L Mayer
Bethesda, MD, USA
Am J Psychiatry 164:1148. 2007 - Functional insights from glutamate receptor ion channel structuresJanesh Kumar
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
Annu Rev Physiol 75:313-37. 2013..The structural basis for ion permeation and ion channel block also remain areas of uncertainty, and despite substantial progress, molecular dynamics simulations have yet to reveal how glutamate binding opens the ion channel pore... - Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonistsNigel P Dolman
Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
J Med Chem 50:1558-70. 2007.... - Conformational restriction blocks glutamate receptor desensitizationMatthew C Weston
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Struct Mol Biol 13:1120-7. 2006.... - Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamateMatthew C Weston
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 26:7650-8. 2006..We conclude that interdomain interactions have evolved as a distinct mechanism that contributes to the unique kinetic properties of AMPA and kainate receptors... - Some assembly requiredMark L Mayer
Nat Struct Mol Biol 12:208-9. 2005 - Structural basis for partial agonist action at ionotropic glutamate receptorsRongsheng Jin
Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168 Street, New York, New York 10032, USA
Nat Neurosci 6:803-10. 2003..Our findings thus provide a structure-based model of partial agonism... - Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualateRongsheng Jin
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Biochemistry 41:15635-43. 2002..The hydrophobic pocket, which is predicted to vary in chemical character between receptor subtypes, probably plays an important role in determining receptor subtype specificity...