M L Mayer

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Neuron 45:539-52. 2005
  2. ncbi request reprint Structure and function of glutamate receptor ion channels
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Building 36, Room 2B28, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
    Annu Rev Physiol 66:161-81. 2004
  3. ncbi request reprint Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state
    M L Mayer
    Laboratory of Cellular and MolecularNeurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A78, 49 Convent Drive MSC 4495, Bethesda, MD 20892, USA
    J Mol Biol 311:815-36. 2001
  4. ncbi request reprint Regulation of AMPA receptor gating by ligand binding core dimers
    Michelle S Horning
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 41:379-88. 2004
  5. pmc Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis
    V A Panchenko
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Gen Physiol 117:345-60. 2001
  6. pmc AMPA receptor ligand binding domain mobility revealed by functional cross linking
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Neurosci 29:11912-23. 2009
  7. pmc Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction
    M Benveniste
    Section of Neurophysiology and Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland 20892
    Br J Pharmacol 104:207-21. 1991
  8. pmc Domain organization and function in GluK2 subtype kainate receptors
    Utpal Das
    Laboratory of Cellular and Molecular Neurophysiology, Department of Health and Human Services, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:8463-8. 2010
  9. pmc Molecular basis of kainate receptor modulation by sodium
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Neuron 58:720-35. 2008
  10. ncbi request reprint Structure and mechanism of kainate receptor modulation by anions
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 53:829-41. 2007

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Neuron 45:539-52. 2005
    ..This, together with extensive interdomain contacts between domains 1 and 2 of GluR5 and GluR6, absent from AMPA receptors, likely contributes to the high stability of GluR5 and GluR6 kainate complexes...
  2. ncbi request reprint Structure and function of glutamate receptor ion channels
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Building 36, Room 2B28, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
    Annu Rev Physiol 66:161-81. 2004
    ..In the space of months we have gone from cartoons of postulated mechanisms to hard fact. It is anticipated that this level of understanding will emerge for other synaptic proteins in the coming decade...
  3. ncbi request reprint Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state
    M L Mayer
    Laboratory of Cellular and MolecularNeurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A78, 49 Convent Drive MSC 4495, Bethesda, MD 20892, USA
    J Mol Biol 311:815-36. 2001
    ..We propose that ligand-induced conformational changes cause the ion channel to open as a result of an increase in domain 2 separation relative to the dimer interface...
  4. ncbi request reprint Regulation of AMPA receptor gating by ligand binding core dimers
    Michelle S Horning
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 41:379-88. 2004
    ....
  5. pmc Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis
    V A Panchenko
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Gen Physiol 117:345-60. 2001
    ....
  6. pmc AMPA receptor ligand binding domain mobility revealed by functional cross linking
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Neurosci 29:11912-23. 2009
    ..These data show that the glutamate binding domains are surprisingly mobile in the absence of ligand, which could influence receptor activity in the brain...
  7. pmc Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restriction
    M Benveniste
    Section of Neurophysiology and Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland 20892
    Br J Pharmacol 104:207-21. 1991
    ....
  8. pmc Domain organization and function in GluK2 subtype kainate receptors
    Utpal Das
    Laboratory of Cellular and Molecular Neurophysiology, Department of Health and Human Services, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:8463-8. 2010
    ..These results establish that kainate and AMPA receptors have a conserved extracellular architecture and provide insight into the role of individual dimer assemblies in activation of ion channel gating...
  9. pmc Molecular basis of kainate receptor modulation by sodium
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
    Neuron 58:720-35. 2008
    ....
  10. ncbi request reprint Structure and mechanism of kainate receptor modulation by anions
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Neuron 53:829-41. 2007
    ..In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously...
  11. pmc Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions
    Charu Chaudhry
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:12329-34. 2009
    ....
  12. ncbi request reprint Exploiting the complete yeast genome sequence
    D E Bassett
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Curr Opin Genet Dev 6:763-6. 1996
    ....
  13. ncbi request reprint Glutamate receptor ion channels
    Mark L Mayer
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, Building 35 Room 3B 1002 MSC 3712, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
    Curr Opin Neurobiol 15:282-8. 2005
    ..Functional studies suggest that glutamate receptor gating is distinct from that of structurally related voltage-gated ion channels...
  14. doi request reprint Accounting for solvent signal offsets in the analysis of interferometric sedimentation velocity data
    Huaying Zhao
    Dynamics of Macromolecular Assembly, Laboratory of Bioengineering and Physical Science, NIBIB, National Institutes of Health, Bethesda, Maryland, USA
    Macromol Biosci 10:736-45. 2010
    ..We demonstrate how this can restore the SV analysis to yield a high quality fit of the data and to provide correct macromolecular sedimentation parameters...
  15. ncbi request reprint Glutamate receptors at atomic resolution
    Mark L Mayer
    Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
    Nature 440:456-62. 2006
    ....
  16. ncbi request reprint Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists
    Mark L Mayer
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 26:2852-61. 2006
    ....
  17. ncbi request reprint Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo III
    M L Mayer
    Laboratory of Developmental Neurobiology, NICHD, Bethesda, Maryland 20892
    J Neurosci 7:3230-44. 1987
    ..The Ca2+ flux gated by NMDA-receptor-specific agonists may play a role in synaptic plasticity, in regulating excitability, and in the excitotoxic response to excitatory amino acids...
  18. pmc The N-terminal domain of GluR6-subtype glutamate receptor ion channels
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
    Nat Struct Mol Biol 16:631-8. 2009
    ....
  19. pmc Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization
    Charu Chaudhry
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
    EMBO J 28:1518-30. 2009
    ..Our results show how neurotransmitter receptors with similar structures and gating mechanisms can exhibit strikingly different functional properties...
  20. pmc Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
    Yongneng Yao
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
    EMBO J 27:2158-70. 2008
    ..MD simulations revealed numerous interdomain contacts, which stabilize the agonist-bound closed-cleft conformation, and a novel twisting motion for the loop 1 helix that is unique in NR3 subunits...
  21. pmc Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domains
    Janesh Kumar
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Mol Biol 404:680-96. 2010
    ..Our results provide the first insights into the structure and function of GluK4-GluK5, the least understood family of iGluRs...
  22. ncbi request reprint GRIK4 and the kainate receptor
    Mark L Mayer
    Bethesda, MD, USA
    Am J Psychiatry 164:1148. 2007
  23. ncbi request reprint Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A
    Yongneng Yao
    Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    J Neurosci 26:4559-66. 2006
    ....
  24. ncbi request reprint N-methyl-D-aspartic acid receptor structure and function
    C J McBain
    Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
    Physiol Rev 74:723-60. 1994
  25. pmc Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors
    Andrew J R Plested
    Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Building 35, Room 3B 1002, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
    Neuropharmacology 56:114-20. 2009
    ..Hence, the apparent insensitivity of the M739D mutant to monovalent cations is due to the adventitious allosteric effects of divalent ions at physiological concentrations and below...
  26. ncbi request reprint Conformational restriction blocks glutamate receptor desensitization
    Matthew C Weston
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Struct Mol Biol 13:1120-7. 2006
    ....
  27. ncbi request reprint Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate
    Matthew C Weston
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:7650-8. 2006
    ..We conclude that interdomain interactions have evolved as a distinct mechanism that contributes to the unique kinetic properties of AMPA and kainate receptors...
  28. ncbi request reprint Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists
    Nigel P Dolman
    Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Med Chem 50:1558-70. 2007
    ....
  29. ncbi request reprint Some assembly required
    Mark L Mayer
    Nat Struct Mol Biol 12:208-9. 2005
  30. ncbi request reprint Structural basis for partial agonist action at ionotropic glutamate receptors
    Rongsheng Jin
    Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168 Street, New York, New York 10032, USA
    Nat Neurosci 6:803-10. 2003
    ..Our findings thus provide a structure-based model of partial agonism...
  31. ncbi request reprint Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate
    Rongsheng Jin
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Biochemistry 41:15635-43. 2002
    ..The hydrophobic pocket, which is predicted to vary in chemical character between receptor subtypes, probably plays an important role in determining receptor subtype specificity...