Research Topics
Genomes and Genes | M L MayerSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
|
Detail Information
Publications
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivityMark L Mayer
Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Neuron 45:539-52. 2005..This, together with extensive interdomain contacts between domains 1 and 2 of GluR5 and GluR6, absent from AMPA receptors, likely contributes to the high stability of GluR5 and GluR6 kainate complexes...- Structure and function of glutamate receptor ion channelsMark L Mayer
Laboratory of Cellular and Molecular Neurophysiology, Building 36, Room 2B28, NICHD, NIH, DHHS, Bethesda, Maryland 20892, USA
Annu Rev Physiol 66:161-81. 2004..In the space of months we have gone from cartoons of postulated mechanisms to hard fact. It is anticipated that this level of understanding will emerge for other synaptic proteins in the coming decade... - Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo stateM L Mayer
Laboratory of Cellular and MolecularNeurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 49, Room 5A78, 49 Convent Drive MSC 4495, Bethesda, MD 20892, USA
J Mol Biol 311:815-36. 2001..We propose that ligand-induced conformational changes cause the ion channel to open as a result of an increase in domain 2 separation relative to the dimer interface... - Regulation of AMPA receptor gating by ligand binding core dimersMichelle S Horning
Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuron 41:379-88. 2004.... 
Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesisV A Panchenko
Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Gen Physiol 117:345-60. 2001....- AMPA receptor ligand binding domain mobility revealed by functional cross linkingAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
J Neurosci 29:11912-23. 2009..These data show that the glutamate binding domains are surprisingly mobile in the absence of ligand, which could influence receptor activity in the brain... - Structure-activity analysis of binding kinetics for NMDA receptor competitive antagonists: the influence of conformational restrictionM Benveniste
Section of Neurophysiology and Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland 20892
Br J Pharmacol 104:207-21. 1991.... - Domain organization and function in GluK2 subtype kainate receptorsUtpal Das
Laboratory of Cellular and Molecular Neurophysiology, Department of Health and Human Services, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:8463-8. 2010..These results establish that kainate and AMPA receptors have a conserved extracellular architecture and provide insight into the role of individual dimer assemblies in activation of ion channel gating... - Molecular basis of kainate receptor modulation by sodiumAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD 20892, USA
Neuron 58:720-35. 2008.... - Structure and mechanism of kainate receptor modulation by anionsAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuron 53:829-41. 2007..In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously... - Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ionsCharu Chaudhry
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:12329-34. 2009.... - Exploiting the complete yeast genome sequenceD E Bassett
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
Curr Opin Genet Dev 6:763-6. 1996.... - Glutamate receptor ion channelsMark L Mayer
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, Building 35 Room 3B 1002 MSC 3712, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
Curr Opin Neurobiol 15:282-8. 2005..Functional studies suggest that glutamate receptor gating is distinct from that of structurally related voltage-gated ion channels... 
Accounting for solvent signal offsets in the analysis of interferometric sedimentation velocity dataHuaying Zhao
Dynamics of Macromolecular Assembly, Laboratory of Bioengineering and Physical Science, NIBIB, National Institutes of Health, Bethesda, Maryland, USA
Macromol Biosci 10:736-45. 2010..We demonstrate how this can restore the SV analysis to yield a high quality fit of the data and to provide correct macromolecular sedimentation parameters...- Glutamate receptors at atomic resolutionMark L Mayer
Building 35, Room 3B1002, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892, USA
Nature 440:456-62. 2006.... - Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonistsMark L Mayer
Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 26:2852-61. 2006.... - Agonist- and voltage-gated calcium entry in cultured mouse spinal cord neurons under voltage clamp measured using arsenazo IIIM L Mayer
Laboratory of Developmental Neurobiology, NICHD, Bethesda, Maryland 20892
J Neurosci 7:3230-44. 1987..The Ca2+ flux gated by NMDA-receptor-specific agonists may play a role in synaptic plasticity, in regulating excitability, and in the excitotoxic response to excitatory amino acids... - The N-terminal domain of GluR6-subtype glutamate receptor ion channelsJanesh Kumar
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, Bethesda, Maryland, USA
Nat Struct Mol Biol 16:631-8. 2009.... - Stability of ligand-binding domain dimer assembly controls kainate receptor desensitizationCharu Chaudhry
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
EMBO J 28:1518-30. 2009..Our results show how neurotransmitter receptors with similar structures and gating mechanisms can exhibit strikingly different functional properties... - Molecular mechanism of ligand recognition by NR3 subtype glutamate receptorsYongneng Yao
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Bethesda, MD, USA
EMBO J 27:2158-70. 2008..MD simulations revealed numerous interdomain contacts, which stabilize the agonist-bound closed-cleft conformation, and a novel twisting motion for the loop 1 helix that is unique in NR3 subunits... - Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domainsJanesh Kumar
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Mol Biol 404:680-96. 2010..Our results provide the first insights into the structure and function of GluK4-GluK5, the least understood family of iGluRs... - GRIK4 and the kainate receptorMark L Mayer
Bethesda, MD, USA
Am J Psychiatry 164:1148. 2007 - Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3AYongneng Yao
Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
J Neurosci 26:4559-66. 2006.... - N-methyl-D-aspartic acid receptor structure and functionC J McBain
Laboratory of Cellular and Molecular Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland
Physiol Rev 74:723-60. 1994 - Engineering a high-affinity allosteric binding site for divalent cations in kainate receptorsAndrew J R Plested
Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, NICHD, NIH, DHHS, Building 35, Room 3B 1002, 35 Lincoln Drive, Bethesda, MD 20892 3712, USA
Neuropharmacology 56:114-20. 2009..Hence, the apparent insensitivity of the M739D mutant to monovalent cations is due to the adventitious allosteric effects of divalent ions at physiological concentrations and below... - Conformational restriction blocks glutamate receptor desensitizationMatthew C Weston
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
Nat Struct Mol Biol 13:1120-7. 2006.... - Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamateMatthew C Weston
Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 26:7650-8. 2006..We conclude that interdomain interactions have evolved as a distinct mechanism that contributes to the unique kinetic properties of AMPA and kainate receptors... - Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonistsNigel P Dolman
Department of Pharmacology, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
J Med Chem 50:1558-70. 2007.... - Some assembly requiredMark L Mayer
Nat Struct Mol Biol 12:208-9. 2005 - Structural basis for partial agonist action at ionotropic glutamate receptorsRongsheng Jin
Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168 Street, New York, New York 10032, USA
Nat Neurosci 6:803-10. 2003..Our findings thus provide a structure-based model of partial agonism... - Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualateRongsheng Jin
Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
Biochemistry 41:15635-43. 2002..The hydrophobic pocket, which is predicted to vary in chemical character between receptor subtypes, probably plays an important role in determining receptor subtype specificity...