Olga A Maximova

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Assurance of neuroattenuation of a live vaccine against West Nile virus: a comprehensive study of neuropathogenesis after infection with chimeric WN/DEN4Δ30 vaccine in comparison to two parental viruses and a surrogate flavivirus reference vaccine
    Olga A Maximova
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States Electronic address
    Vaccine 32:3187-97. 2014
  2. pmc Cellular inflammatory response to flaviviruses in the central nervous system of a primate host
    Olga A Maximova
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 3203, USA
    J Histochem Cytochem 57:973-89. 2009
  3. pmc High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence
    Olga A Maximova
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Vaccine 28:8315-26. 2010
  4. pmc MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype
    Brian L Heiss
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:5647-59. 2012
  5. pmc Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype
    Brian L Heiss
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 85:1464-72. 2011
  6. pmc The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome
    Amber R Engel
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 405:243-52. 2010
  7. ncbi request reprint The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation
    Yuko Yoshida
    Program in Genomics of Differentiation, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 40:187-98. 2014
  8. ncbi request reprint Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions
    Natalya L Teterina
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    Virology 456:247-58. 2014
  9. doi request reprint Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss
    Sergei Gaidamakov
    Intramural Research Programs of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 34:123-31. 2014
  10. pmc Visceral and neural larva migrans in rhesus macaques
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Assoc Lab Anim Sci 47:64-7. 2008

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Assurance of neuroattenuation of a live vaccine against West Nile virus: a comprehensive study of neuropathogenesis after infection with chimeric WN/DEN4Δ30 vaccine in comparison to two parental viruses and a surrogate flavivirus reference vaccine
    Olga A Maximova
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States Electronic address
    Vaccine 32:3187-97. 2014
    ..These results support the use of this NHP model for translational studies of WNV neuropathogenesis and/or testing the effectiveness of vaccines and therapeutic approaches. ..
  2. pmc Cellular inflammatory response to flaviviruses in the central nervous system of a primate host
    Olga A Maximova
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892 3203, USA
    J Histochem Cytochem 57:973-89. 2009
    ....
  3. pmc High-throughput automated image analysis of neuroinflammation and neurodegeneration enables quantitative assessment of virus neurovirulence
    Olga A Maximova
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Vaccine 28:8315-26. 2010
    ..The implementation of this high-throughput AIA will markedly advance many fields of research including virology, neuroinflammation, neuroscience, and vaccinology...
  4. pmc MicroRNA targeting of neurotropic flavivirus: effective control of virus escape and reversion to neurovirulent phenotype
    Brian L Heiss
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:5647-59. 2012
    ....
  5. pmc Insertion of microRNA targets into the flavivirus genome alters its highly neurovirulent phenotype
    Brian L Heiss
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 85:1464-72. 2011
    ..This work suggests that microRNA targeting to control flavivirus tissue tropism and pathogenesis might represent a rational approach for virus attenuation and vaccine development...
  6. pmc The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome
    Amber R Engel
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Virology 405:243-52. 2010
    ..The high level of safety in the central nervous system indicates that vDelta30/E(315)/NS5(654,655) should be further evaluated as a TBEV vaccine...
  7. ncbi request reprint The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation
    Yuko Yoshida
    Program in Genomics of Differentiation, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 40:187-98. 2014
    ..Finally, IRF8 activated microglia and exacerbated neuroinflammation. Together, this work provides mechanistic bases by which IRF8 contributes to the pathogenesis of MS...
  8. ncbi request reprint Silencing of neurotropic flavivirus replication in the central nervous system by combining multiple microRNA target insertions in two distinct viral genome regions
    Natalya L Teterina
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States
    Virology 456:247-58. 2014
    ..This miRNA co-targeting approach can be adapted for other viruses in order to minimize their replication in a cell- or tissue-type specific manner, but most importantly, to prevent virus escape from miRNA-mediated silencing. ..
  9. doi request reprint Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss
    Sergei Gaidamakov
    Intramural Research Programs of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Mol Cell Biol 34:123-31. 2014
    ..The data indicate that La is required not only in proliferating cells but also in nondividing postmitotic cells. Thus, La is essential in different cell types and required for normal development of various tissue types. ..
  10. pmc Visceral and neural larva migrans in rhesus macaques
    Alfonso S Gozalo
    Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    J Am Assoc Lab Anim Sci 47:64-7. 2008
    ..These cases are similar to the low-level or covert cases of Baylisascaris infection described to occur in humans and provide further evidence of the existence of this parasite in the southeastern United States...