Stuart Maudsley

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Functional signaling biases in G protein-coupled receptors: Game Theory and receptor dynamics
    S Maudsley
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mini Rev Med Chem 12:831-40. 2012
  2. doi request reprint Bioinformatic approaches to metabolic pathways analysis
    Stuart Maudsley
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Biol 756:99-130. 2011
  3. pmc Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy
    Bronwen Martin
    Metabolism Unit, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 287:31766-82. 2012
  4. pmc Altered hypothalamic protein expression in a rat model of Huntington's disease
    Wei Na Cong
    Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e47240. 2012
  5. pmc Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression
    Bronwen Martin
    National Institutes of Health, National Institute on Aging, Baltimore, Maryland, USA
    Diabetes 59:1143-52. 2010
  6. pmc VennPlex--a novel Venn diagram program for comparing and visualizing datasets with differentially regulated datapoints
    Huan Cai
    Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e53388. 2013
  7. pmc Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides
    Byung Joon Kim
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 334:682-92. 2010
  8. pmc Cortical gene transcription response patterns to water maze training in aged mice
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    BMC Neurosci 12:63. 2011
  9. pmc Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses
    Wayne Chadwick
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e14352. 2010
  10. pmc Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD)
    Wells W Wu
    Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Proteomics 75:2480-7. 2012

Detail Information

Publications70

  1. ncbi request reprint Functional signaling biases in G protein-coupled receptors: Game Theory and receptor dynamics
    S Maudsley
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mini Rev Med Chem 12:831-40. 2012
    ....
  2. doi request reprint Bioinformatic approaches to metabolic pathways analysis
    Stuart Maudsley
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
    Methods Mol Biol 756:99-130. 2011
    ..In this overview, we shall attempt to assist the navigation into this new field of cell signaling and highlight several methodologies and technologies to appreciate this exciting new age of signal transduction...
  3. pmc Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy
    Bronwen Martin
    Metabolism Unit, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 287:31766-82. 2012
    ..Euglycemic agents targeting hypothalamic and energy regulation dysfunction in HD could potentially alter disease progression and improve quality of life in HD...
  4. pmc Altered hypothalamic protein expression in a rat model of Huntington's disease
    Wei Na Cong
    Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e47240. 2012
    ..Gaining a greater understanding of the hypothalamic and metabolic alterations that occur in HD, could lead to the development of novel therapeutics for early interventional treatment of HD...
  5. pmc Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression
    Bronwen Martin
    National Institutes of Health, National Institute on Aging, Baltimore, Maryland, USA
    Diabetes 59:1143-52. 2010
    ..We used VIP knockout mice to investigate VIP's specific role in taste perception and connection to energy regulation...
  6. pmc VennPlex--a novel Venn diagram program for comparing and visualizing datasets with differentially regulated datapoints
    Huan Cai
    Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e53388. 2013
    ....
  7. pmc Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides
    Byung Joon Kim
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 334:682-92. 2010
    ..EX-4-Tf proved to be as effective as EX-4 but had longer lived effects on blood glucose and food intake. This novel transferrin fusion technology could improve the pharmacology of various peptides...
  8. pmc Cortical gene transcription response patterns to water maze training in aged mice
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    BMC Neurosci 12:63. 2011
    ..We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training...
  9. pmc Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses
    Wayne Chadwick
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 5:e14352. 2010
    ..Our paradigm indicates how cellular physiology can subtly change in different contexts and potentially aid the appreciation of stress response adaptations...
  10. pmc Discovery- and target-based protein quantification using iTRAQ and pulsed Q collision induced dissociation (PQD)
    Wells W Wu
    Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Proteomics 75:2480-7. 2012
    ..Our findings should aid LTQ users who desire to explore iTRAQ quantitative proteomics but have limited access to the more costly Orbitrap or other instruments...
  11. pmc Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice
    Alexis M Stranahan
    Cellular and Molecular Neuroscience Section, Laboratory of Neurosciences, National Institute on Aging, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224 6825, United States
    Neurobiol Aging 31:1937-49. 2010
    ..These results suggest that the enhancement of cognitive function by lifelong exercise is associated with an altered transcriptional profile following learning...
  12. pmc Age-related changes in mouse taste bud morphology, hormone expression, and taste responsivity
    Yu Kyong Shin
    Laboratory of Clinical Investigation, Diabetes Section, National Institute on Aging, Baltimore, MD 21224, USA
    J Gerontol A Biol Sci Med Sci 67:336-44. 2012
    ..Concordant with taste cell alterations, the 18-month-old animals demonstrated reduced sweet taste responsivity compared with the younger animals and the other major taste modalities (salty, sour, and bitter) remained intact...
  13. pmc Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responses
    Bronwen Martin
    Laboratory of Neurosciences, Research Resources Branch, NIA, Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 284:2493-511. 2009
    ....
  14. pmc GIT2 acts as a potential keystone protein in functional hypothalamic networks associated with age-related phenotypic changes in rats
    Wayne Chadwick
    Receptor Pharmacology Unit, Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore, Maryland, United States of America
    PLoS ONE 7:e36975. 2012
    ....
  15. ncbi request reprint Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders
    Huan Cai
    Metabolism Unit, National Institute on Aging, Baltimore, MD 21224, USA
    Curr Alzheimer Res 9:5-17. 2012
    ..It is likely that in the near future, therapeutics with combinatorial neuroprotective and 'eumetabolic' activities may possess superior efficacies compared to less pluripotent remedies...
  16. doi request reprint Precursor ion exclusion for enhanced identification of plasma biomarkers
    Wells W Wu
    Metabolism Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Proteomics Clin Appl 6:304-8. 2012
    ..Our study aims to establish a plasma biomarker analysis workflow, with fewer fractionation steps, for enhanced identification of plasma biomarkers by precursor ion exclusion (PIE)...
  17. pmc Effective correction of experimental errors in quantitative proteomics using stable isotope labeling by amino acids in cell culture (SILAC)
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States
    J Proteomics 75:3720-32. 2012
    ..Based on our results, we suggest that SILAC experiments should be designed to incorporate label-swap replications for enhanced reliability in expression ratios...
  18. pmc Gonadotropin-releasing hormone receptor system: modulatory role in aging and neurodegeneration
    Liyun Wang
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Biomedical Research Center, Baltimore MD 21224, USA
    CNS Neurol Disord Drug Targets 9:651-60. 2010
    ..We have therefore summarized the evidence supporting a central direct role of GnRH ligands and receptors in controlling central nervous physiology and pathophysiology...
  19. pmc Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity
    Wayne Chadwick
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e21660. 2011
    ..These results indicate that amitriptyline has significant beneficial actions in aged and damaged AD brains and that it shows promise as a tolerable novel therapeutic for the treatment of AD...
  20. pmc Caloric restriction: impact upon pituitary function and reproduction
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ageing Res Rev 7:209-24. 2008
    ....
  21. pmc Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells
    Wook Kim
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Diabetes 60:1198-209. 2011
    ..We undertook the current study to investigate if intraislet endogenous cannabinoids (ECs) regulate β-cell proliferation and if they influence insulin action...
  22. pmc VENNTURE--a novel Venn diagram investigational tool for multiple pharmacological dataset analysis
    Bronwen Martin
    Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 7:e36911. 2012
    ..This study highlights the potential for such a program in fields such as pharmacology, genomics, and bioinformatics...
  23. ncbi request reprint Therapeutic targeting of the endoplasmic reticulum in Alzheimer's disease
    Wayne Chadwick
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    Curr Alzheimer Res 9:110-9. 2012
    ..While not a classical drug target, even with minimal levels of beneficial modulation, its multifactorial efficacy may amplify small effects resulting in significant therapeutic efficacy...
  24. pmc The mammalian tachykinin ligand-receptor system: an emerging target for central neurological disorders
    Nick Pantaleo
    Receptor Pharmacology Unit, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 9:627-35. 2010
    ..The development of our understanding of the role of the tachykinin receptor-ligand system in higher order central functions is likely to allow the creation of more specific and selective tachykinin-related neurotherapeutics...
  25. pmc Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms
    Wayne Chadwick
    Receptor Pharmacology Unit, Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Signal Transduct 2011:636951. 2011
    ..Our data indicates that components of peroxide-induced ERK1/2 cascades are differentially affected by repeated exposures, indicating that oxidative signaling may be contextually variable...
  26. pmc Modulation of taste sensitivity by GLP-1 signaling in taste buds
    Bronwen Martin
    National Institute on Aging NIH, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1170:98-101. 2009
    ..Together, these findings suggest a novel paracrine mechanism for the hormonal modulation of taste function in mammals...
  27. pmc Chemical modification of class II G protein-coupled receptor ligands: frontiers in the development of peptide analogs as neuroendocrine pharmacological therapies
    Megan C Chapter
    Receptor Pharmacology Unit, Laboratory of Neuroscience, National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd, Baltimore MD 21224, USA
    Pharmacol Ther 125:39-54. 2010
    ..Currently, Class II-based drugs include synthesized analogs of vasoactive intestinal peptide for type 2 diabetes or parathyroid hormone for osteoporosis...
  28. pmc Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Diabetes 58:318-28. 2009
    ..Similarly to Huntington's disease patients, mice expressing the mutated human huntingtin protein also exhibit neurodegenerative changes, motor dysfunction, perturbed energy metabolism, and elevated blood glucose levels...
  29. pmc Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders
    Liyun Wang
    Receptor Pharmacology Unit, and Metabolism Unit, The National Institutes of Health, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Pharmacol Exp Ther 331:340-8. 2009
    ....
  30. pmc Gonadal transcriptome alterations in response to dietary energy intake: sensing the reproductive environment
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4146. 2009
    ....
  31. pmc Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults
    Ira Driscoll
    Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 7:e35217. 2012
    ..Together, our findings contribute to furthering the understanding of the relationships between plasma BDNF, structural brain integrity and cognition. Potential mechanisms mediating these relationships merit further investigation...
  32. pmc Ghrelin receptor signaling: a promising therapeutic target for metabolic syndrome and cognitive dysfunction
    Wei Na Cong
    Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 9:557-63. 2010
    ..We will also discuss the potential pharmacotherapeutic role of GSH-R1a-mediated ghrelin signaling for the treatment of complex neuroendocrine disorders...
  33. pmc Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body
    Bronwen Martin
    National Institute on Aging, NIH, Gerontology Research Center, Baltimore, MD 21224, USA
    Histol Histopathol 23:237-50. 2008
    ..Therefore treatment of both the peripheral and central pathophysiologies of HD could form the basis of a more effective HD therapeutic strategy...
  34. pmc Rapid and enhanced proteolytic digestion using electric-field-oriented enzyme reactor
    Yu Zhou
    Receptor Pharmacology Unit, Laboratory of Neuroscience, National Institute on Aging, Biomedical Research Center, Baltimore, MD, USA
    J Proteomics 74:1030-5. 2011
    ....
  35. pmc Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes
    Wayne Chadwick
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 6:e21638. 2011
    ..The functional interaction of these transcriptional 'programs' may serve to regulate the dynamic vascular responsivity of the central nervous system during periods of stress or heightened activity...
  36. pmc Long-Term Artificial Sweetener Acesulfame Potassium Treatment Alters Neurometabolic Functions in C57BL/6J Mice
    Wei Na Cong
    Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, Maryland, United States of America
    PLoS ONE 8:e70257. 2013
    ..Our data suggest that chronic use of ACK could affect cognitive functions, potentially via altering neuro-metabolic functions in male C57BL/6J mice. ..
  37. pmc Textrous!: extracting semantic textual meaning from gene sets
    Hongyu Chen
    Receptor Pharmacology Unit, Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
    PLoS ONE 8:e62665. 2013
    ..Textrous!, therefore, is able to facilitate the output of quantitatively significant and easily appreciable semantic words and phrases linked to both individual gene and batch genomic data...
  38. pmc Pancreas++: automated quantification of pancreatic islet cells in microscopy images
    Hongyu Chen
    Receptor Pharmacology Unit, Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health Baltimore, MD, USA
    Front Physiol 3:482. 2012
    ..Our Pancreas++ analysis was significantly faster than other methods, while still retaining low error rates and a high degree of result correlation with the manually generated reference standard...
  39. pmc "Control" laboratory rodents are metabolically morbid: why it matters
    Bronwen Martin
    Metabolism Unit, Laboratory of Clinical Investigation, Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 107:6127-33. 2010
    ....
  40. ncbi request reprint Anti-inflammatory effects of physical activity in relationship to improved cognitive status in humans and mouse models of Alzheimer's disease
    Alexis M Stranahan
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
    Curr Alzheimer Res 9:86-92. 2012
    ..In this respect, physical activity may promote neuronal resilience by reducing inflammation...
  41. pmc Identification of proteins and phosphoproteins using pulsed Q collision induced dissociation (PQD)
    Wells W Wu
    Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Am Soc Mass Spectrom 22:1753-62. 2011
    ..g., phosphopeptides). The higher energy fragmentation pathway of PQD on peptide fragmentation was further compared to those of CID and the quadrupole-type activation in parallel experiments...
  42. pmc Growth inhibition by miR-519 via multiple p21-inducing pathways
    Kotb Abdelmohsen
    Laboratory of Molecular Biology and Immunology, Research Resources Branch, National Institute on Aging, NIH, Baltimore, Maryland, USA
    Mol Cell Biol 32:2530-48. 2012
    ..Our results indicate that miR-519 promotes DNA damage, alters Ca(2+) homeostasis, and enhances energy production; together, these processes elevate the expression level of p21, promoting growth inhibition and cell survival...
  43. pmc Live longer sans the AT1A receptor
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Cell Metab 9:403-5. 2009
    ..AT(1A)R-deficient mice live longer and have lower levels of oxidative stress than wild-type mice (Benigni et al., 2009), suggesting a role for AT(1A)R signaling in the aging process...
  44. pmc BRET Biosensor Analysis of Receptor Tyrosine Kinase Functionality
    Sana Siddiqui
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health Baltimore, MD, USA
    Front Endocrinol (Lausanne) 4:46. 2013
    ..It is clear even from the relatively sparse experimental RTK BRET evidence that there is tremendous potential for this technological application for the functional investigation of RTK biology...
  45. doi request reprint Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
    Mali Jiang
    Division of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 18:153-8. 2012
    ..These findings show a neuroprotective role for Sirt1 in mammalian Huntington's disease models and open new avenues for the development of neuroprotective strategies in Huntington's disease...
  46. pmc Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders
    Caitlin M White
    Metabolism Unit, Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA
    CNS Neurol Disord Drug Targets 9:661-6. 2010
    ....
  47. ncbi request reprint BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Trends Neurosci 27:589-94. 2004
    ..Behavioral and pharmacological manipulations that enhance 5-HT and BDNF signaling could help promote healthy brain aging...
  48. pmc The origins of diversity and specificity in g protein-coupled receptor signaling
    Stuart Maudsley
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, 5600 Nathan Shock Drive, Johns Hopkins Medical Center, Baltimore, MD, USA
    J Pharmacol Exp Ther 314:485-94. 2005
    ..As a more comprehensive understanding of the complexity of GPCR signaling is developed, the rational design of ligands possessing increased specific efficacy and attenuated side effects may become the standard mode of drug development...
  49. pmc Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2398. 2008
    ....
  50. ncbi request reprint A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin
    Mark P Mattson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Ageing Res Rev 3:445-64. 2004
    ....
  51. doi request reprint Neonatal estrogenic effects upon the male rat pituitary: early gonadotrophin attenuation precedes long-term recovery
    Bronwen Martin
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, Queen s Medical Research Institute, Edinburgh, UK
    Neuromolecular Med 11:76-86. 2009
    ..Therefore, despite acute and selective ablation of FSH expression the gonadotrophs were able to recover in adulthood, suggesting that perinatal estrogenic exposure was only temporarily deleterious...
  52. pmc Effective use of latent semantic indexing and computational linguistics in biological and biomedical applications
    Hongyu Chen
    Laboratory of Neuroscience, Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health Baltimore, MD, USA
    Front Physiol 4:8. 2013
    ..LSI has been used successfully to formulate new hypotheses, generate novel connections from existing data, and validate empirical data...
  53. ncbi request reprint G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeutics
    Stuart Maudsley
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Gerontology Research Center, Johns Hopkins Medical Center, Baltimore, MD 21224, USA
    Curr Alzheimer Res 4:3-19. 2007
    ..As a more comprehensive understanding of the complexity of GPCR signaling is developed, the rational design of ligands possessing increased specific efficacy and attenuated side effects may become the standard mode of drug development...
  54. pmc Caloric restriction and intermittent fasting: two potential diets for successful brain aging
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Ageing Res Rev 5:332-53. 2006
    ..A better understanding of the impact of CR and IF on the aging nervous system will likely lead to novel approaches for preventing and treating neurodegenerative disorders...
  55. pmc Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    Endocrinology 148:4318-33. 2007
    ....
  56. pmc Regulation of Caenorhabditis elegans vitellogenesis by DAF-2/IIS through separable transcriptional and posttranscriptional mechanisms
    Ana S Depina
    Laboratory of Neurosciences, NIA Intramural Research Program, NIH, Baltimore, MD 21224, USA
    BMC Physiol 11:11. 2011
    ..However, little is known about the pathways regulating vitellogenesis in response to prolongevity cues...
  57. pmc Modulation of taste sensitivity by GLP-1 signaling
    Yu Kyong Shin
    National Institute on Aging NIH, Baltimore, Maryland 21224, USA
    J Neurochem 106:455-63. 2008
    ..A modest increase in citric acid taste sensitivity in these knockout mice suggests GLP-1 signaling may modulate sour taste, as well. Together, these findings suggest a novel paracrine mechanism for the regulation of taste function...
  58. pmc Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease
    Wayne Chadwick
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    Int J Alzheimers Dis 2010:604792. 2010
    ..Our results show that there are significant alterations in numerous receptor/cell signaling proteins in cortical lipid rafts isolated from 3xTgAD mice...
  59. pmc Hormones in the naso-oropharynx: endocrine modulation of taste and smell
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Trends Endocrinol Metab 20:163-70. 2009
    ..Gaining a greater appreciation of how flavor perception is linked to peripheral metabolism could lead to novel therapeutic strategies for obesity and lifestyle-related diseases...
  60. pmc Central role of the EGF receptor in neurometabolic aging
    Sana Siddiqui
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, MD 21224, USA
    Int J Endocrinol 2012:739428. 2012
    ..Understanding the positioning of the EGFR within the neurometabolic domain will enhance our appreciation of the ability of this receptor system to underpin highly complex physiological paradigms such as aging and neurodegeneration...
  61. pmc Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women
    Olga Carlson
    Diabetes Section, Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Metabolism 56:1729-34. 2007
    ..The impaired glucose tolerance was reversible and was not associated with alterations in the levels of adipokines or BDNF...
  62. doi request reprint Systems analysis of arrestin pathway functions
    Stuart Maudsley
    Receptor Pharmacology Unit, National Institute on Aging, Baltimore, Maryland, USA
    Prog Mol Biol Transl Sci 118:431-67. 2013
    ....
  63. pmc Aging and bone health in individuals with developmental disabilities
    Joan Jasien
    Metabolism Unit, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224, USA
    Int J Endocrinol 2012:469235. 2012
    ..Gaining a greater understanding of how bone health is affected in individuals with D/ID could lead to better customized treatments for these specific populations...
  64. pmc Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells
    Catherine M Schwartz
    National Institute on Aging Intramural Research Program, National Institutes of Health, Laboratory of Neurosciences, Baltimore, MD 21224, USA
    J Neurosci Res 90:1367-81. 2012
    ..These results indicate that SDF1α, sFRP1, and VEGFD are major components of SDIA and suggest the potential use of these defined factors to elicit DA differentiation of pluripotent human stem cells for therapeutic intervention in PD...
  65. pmc Diminished iron concentrations increase adenosine A(2A) receptor levels in mouse striatum and cultured human neuroblastoma cells
    Seema Gulyani
    Neurology Department, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Exp Neurol 215:236-42. 2009
    ..In conclusion, the A(2A)R is increased across different iron-insufficient conditions. The relation between A(2A)R and cellular iron status may be an important pathway by which adenosine may alter the function of the dopaminergic system...
  66. pmc Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice
    Rhonda L Nelson
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA
    Exp Neurol 205:166-76. 2007
    ....
  67. pmc Class II G protein-coupled receptors and their ligands in neuronal function and protection
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Ageing Intramural Research Program, Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuromolecular Med 7:3-36. 2005
    ..A better understanding of the cellular and molecular mechanisms by which class II GPCRs signaling modulates neuronal survival and plasticity will likely lead to novel therapeutic interventions for neurodegenerative disorders...
  68. pmc iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease
    Bronwen Martin
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Biomedical Research Center, Baltimore, Maryland, United States of America
    PLoS ONE 3:e2750. 2008
    ..Our findings have elucidated some of the complex proteome changes that occur in a mouse model of AD, which could potentially illuminate novel therapeutic avenues for the treatment of AD and other neurodegenerative disorders...
  69. pmc Discontinuous pH gradient-mediated separation of TiO2-enriched phosphopeptides
    Sung Soo Park
    Receptor Pharmacology Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Anal Biochem 409:81-8. 2011
    ....
  70. pmc Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets
    Jie Zhou
    Diabetes Section, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Am J Physiol Endocrinol Metab 293:E538-47. 2007
    ..These results suggest that the GIP-R is ubiquitated, resulting in downregulation of the actions of GIP...