Polly Matzinger

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. ncbi request reprint Friendly and dangerous signals: is the tissue in control?
    Polly Matzinger
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:11-3. 2007
  2. pmc Antigen-specific T-T interactions regulate CD4 T-cell expansion
    Julie Helft
    Laboratoire d Immunologie Clinique, INSERM U653, Institut Curie, Paris
    Blood 112:1249-58. 2008
  3. ncbi request reprint An innate sense of danger
    Polly Matzinger
    National Institute of Allergy and Infectious Diseases NIH, Building4 Room 111, Bethesda, MD 20894, USA
    Ann N Y Acad Sci 961:341-2. 2002
  4. pmc Unexpected regeneration in middle-aged mice
    Brandon Reines
    Ghost Lab, T cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology, Twinbrook III, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Rejuvenation Res 12:45-52. 2009
  5. doi request reprint The evolution of the danger theory. Interview by Lauren Constable, Commissioning Editor
    Polly Matzinger
    Ghost Laboratory, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20894, USA
    Expert Rev Clin Immunol 8:311-7. 2012
  6. doi request reprint Tissue-based class control: the other side of tolerance
    Polly Matzinger
    Laboratory of Cellular and Molecular Immunology, T cell Tolerance and Memory Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 11:221-30. 2011
  7. ncbi request reprint The danger model: a renewed sense of self
    Polly Matzinger
    Ghost Lab, Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 296:301-5. 2002
  8. pmc Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
    Kaveh Abdi
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:5981-9. 2012
  9. pmc CD4 cells can be more efficient at tumor rejection than CD8 cells
    Ainhoa Perez-Diez
    Ghost Lab, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 109:5346-54. 2007
  10. pmc Resident peritoneal NK cells
    Rosemary Gonzaga
    Ghost Laboratory, T Cell Memory and Tolerance Section, Laboratory of Cellular and Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:6235-42. 2011

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Friendly and dangerous signals: is the tissue in control?
    Polly Matzinger
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:11-3. 2007
    ..In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. T(H)1-T(H)2 and T(reg) is far too simple a representation of the breathtaking variety of the resulting responses...
  2. pmc Antigen-specific T-T interactions regulate CD4 T-cell expansion
    Julie Helft
    Laboratoire d Immunologie Clinique, INSERM U653, Institut Curie, Paris
    Blood 112:1249-58. 2008
    ..In this way, CD4 T-cell proliferation is regulated in a functional relationship to the amount of Ag, while allowing naive T cells to generate repertoire variety...
  3. ncbi request reprint An innate sense of danger
    Polly Matzinger
    National Institute of Allergy and Infectious Diseases NIH, Building4 Room 111, Bethesda, MD 20894, USA
    Ann N Y Acad Sci 961:341-2. 2002
  4. pmc Unexpected regeneration in middle-aged mice
    Brandon Reines
    Ghost Lab, T cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology, Twinbrook III, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Rejuvenation Res 12:45-52. 2009
    ..The data suggest that the age at which various inbred mouse strains become capable of epimorphic regeneration may be correlated with adult body weight...
  5. doi request reprint The evolution of the danger theory. Interview by Lauren Constable, Commissioning Editor
    Polly Matzinger
    Ghost Laboratory, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20894, USA
    Expert Rev Clin Immunol 8:311-7. 2012
    b>Polly Matzinger, now Chief of the Ghost Laboratory and the section on T-cell Tolerance and Memory at the NIH, has previously worked as a bartender, carpenter, jazz musician, Playboy bunny and dog trainer...
  6. doi request reprint Tissue-based class control: the other side of tolerance
    Polly Matzinger
    Laboratory of Cellular and Molecular Immunology, T cell Tolerance and Memory Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 11:221-30. 2011
    ....
  7. ncbi request reprint The danger model: a renewed sense of self
    Polly Matzinger
    Ghost Lab, Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 296:301-5. 2002
    ..This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign...
  8. pmc Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?
    Kaveh Abdi
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 188:5981-9. 2012
    ..These data suggest that LPS activation does not exhaust DCs but rather primes them for subsequent signals from T cells...
  9. pmc CD4 cells can be more efficient at tumor rejection than CD8 cells
    Ainhoa Perez-Diez
    Ghost Lab, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 109:5346-54. 2007
    ..These findings suggest that CD4 T cells can be powerful antitumor effector cells that can, in some cases, outperform CD8 T cells, which are the current "gold standard" effector cell in tumor immunotherapy...
  10. pmc Resident peritoneal NK cells
    Rosemary Gonzaga
    Ghost Laboratory, T Cell Memory and Tolerance Section, Laboratory of Cellular and Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:6235-42. 2011
    ..These data suggest that the peritoneum is not only home to a new subset of tissue-resident NK cells, but that it differentially regulates the migration and homeostatic proliferation of immature versus mature NK cells...
  11. ncbi request reprint Immunological concerns with bioengineering approaches
    David M Harlan
    National Institute of Diabetes, Digestive and Kidney Diseases NIH, Building 10, Room 11S210, 10 Center Drive, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 961:323-30. 2002
  12. ncbi request reprint Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
    Seung Yong Seong
    Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Insstitute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Rev Immunol 4:469-78. 2004
  13. pmc Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells
    Martin Guimond
    Pediatric Oncology Branch, National Cancer Institute, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 10:149-57. 2009
    ..Our results indicate that IL-7Ralpha(+) DCs are regulators of the peripheral CD4(+) T cell niche and that IL-7 signals in DCs prevent uncontrolled CD4(+) T cell population expansion in vivo...
  14. ncbi request reprint Thymic cortical epithelium induces self tolerance
    Kissinger P Goldman
    Ghost Lab, LCMI, NIAID, NIH, Bethesda, MD, USA
    Eur J Immunol 35:709-17. 2005
    ..These results establish the ability of cortical epithelium to induce central tolerance, and impinge on several of the models concerning positive selection of newly developing T cells...
  15. ncbi request reprint The JAM Test and its daughter P-JAM: simple tests of DNA fragmentation to measure cell death and stasis
    David Usharauli
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, Bethesda, Maryland 20892, USA
    Nat Protoc 1:672-82. 2006
    ..The P-JAM, also discussed, additionally allows for assessment of death in cells that don't fragment their DNA, and allows for assays of agents that induce cell stasis rather than death...
  16. ncbi request reprint 'Educated' dendritic cells act as messengers from memory to naive T helper cells
    Oral Alpan
    Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 5:615-22. 2004
    ..The orally immunized T cells use IL-4 and IL-10 (but not CD40 ligand) to 'educate' dendritic cells, which in turn induce naive T cells to produce the same cytokines as those produced by the orally immunized memory T cells...
  17. ncbi request reprint Immune response to engineered tissues and cells: breakout session summary
    David M Harlan
    National Institute of Diabetes, Digestive and Kidney Diseases NIH, Building 10, Room 11S210, 10 Center Drive, Bethesda, MD 20892, USA
    Ann N Y Acad Sci 961:350-1. 2002
  18. pmc Intensity of the vaccine-elicited immune response determines tumor clearance
    Ainhoa Perez-Diez
    Surgery Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 168:338-47. 2002
    ..The results from this mouse model have major implications for the implementation of tumor vaccines in humans...
  19. pmc Are major histocompatibility complex molecules involved in the survival of naive CD4+ T cells?
    Isabelle Grandjean
    Laboratoire d Immunologie, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
    J Exp Med 198:1089-102. 2003
    ....
  20. ncbi request reprint Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathway
    Anna Valujskikh
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Nat Immunol 3:844-51. 2002
    ..The findings suggest an alternate indirect effector pathway that requires processing and presentation of the donor H-Y antigen by recipient endothelium and have implications for both transplantation and autoimmune disease...
  21. ncbi request reprint Molecular profiling improves diagnoses of rejection and infection in transplanted organs
    Andrey Morgun
    Immunogenetics Division, Pediatrics Department, Federal University of Sao Paulo, Brazil
    Circ Res 98:e74-83. 2006
    ....