Research Topics
Genomes and GenesSpecies | Polly MatzingerSummaryAffiliation: National Institutes of Health Country: USA Publications
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Publications
Friendly and dangerous signals: is the tissue in control?Polly Matzinger
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 8:11-3. 2007..In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. T(H)1-T(H)2 and T(reg) is far too simple a representation of the breathtaking variety of the resulting responses...
Antigen-specific T-T interactions regulate CD4 T-cell expansionJulie Helft
Laboratoire d Immunologie Clinique, INSERM U653, Institut Curie, Paris
Blood 112:1249-58. 2008..In this way, CD4 T-cell proliferation is regulated in a functional relationship to the amount of Ag, while allowing naive T cells to generate repertoire variety...- An innate sense of dangerPolly Matzinger
National Institute of Allergy and Infectious Diseases/NIH, Building4 Room 111, Bethesda, MD 20894, USA
Ann N Y Acad Sci 961:341-2. 2002 - Unexpected regeneration in middle-aged miceBrandon Reines
Ghost Lab, T cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology, Twinbrook III, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Rejuvenation Res 12:45-52. 2009..The data suggest that the age at which various inbred mouse strains become capable of epimorphic regeneration may be correlated with adult body weight... 
The evolution of the danger theory. Interview by Lauren Constable, Commissioning EditorPolly Matzinger
Ghost Laboratory, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases NIH, Bethesda, MD 20894, USA
Expert Rev Clin Immunol 8:311-7. 2012b>Polly Matzinger, now Chief of the Ghost Laboratory and the section on T-cell Tolerance and Memory at the NIH, has previously worked as a bartender, carpenter, jazz musician, Playboy bunny and dog trainer...- Tissue-based class control: the other side of tolerancePolly Matzinger
Laboratory of Cellular and Molecular Immunology, T cell Tolerance and Memory Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Rev Immunol 11:221-30. 2011.... - The danger model: a renewed sense of selfPolly Matzinger
Ghost Lab, Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Science 296:301-5. 2002..This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign... - Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?Kaveh Abdi
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 188:5981-9. 2012..These data suggest that LPS activation does not exhaust DCs but rather primes them for subsequent signals from T cells... - CD4 cells can be more efficient at tumor rejection than CD8 cellsAinhoa Perez-Diez
Ghost Lab, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Blood 109:5346-54. 2007..These findings suggest that CD4 T cells can be powerful antitumor effector cells that can, in some cases, outperform CD8 T cells, which are the current "gold standard" effector cell in tumor immunotherapy... - Resident peritoneal NK cellsRosemary Gonzaga
Ghost Laboratory, T Cell Memory and Tolerance Section, Laboratory of Cellular and Molecular Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 187:6235-42. 2011..These data suggest that the peritoneum is not only home to a new subset of tissue-resident NK cells, but that it differentially regulates the migration and homeostatic proliferation of immature versus mature NK cells... - Immunological concerns with bioengineering approachesDavid M Harlan
National Institute of Diabetes, Digestive and Kidney Diseases/NIH, Building 10, Room 11S210, 10 Center Drive, Bethesda, MD 20892, USA
Ann N Y Acad Sci 961:323-30. 2002 - Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responsesSeung-Yong Seong
Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Insstitute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Nat Rev Immunol 4:469-78. 2004 - Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cellsMartin Guimond
Pediatric Oncology Branch, National Cancer Institute, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 10:149-57. 2009..Our results indicate that IL-7Ralpha(+) DCs are regulators of the peripheral CD4(+) T cell niche and that IL-7 signals in DCs prevent uncontrolled CD4(+) T cell population expansion in vivo... - Thymic cortical epithelium induces self toleranceKissinger P Goldman
Ghost Lab, LCMI, NIAID, NIH, Bethesda, MD, USA
Eur J Immunol 35:709-17. 2005..These results establish the ability of cortical epithelium to induce central tolerance, and impinge on several of the models concerning positive selection of newly developing T cells... - The JAM Test and its daughter P-JAM: simple tests of DNA fragmentation to measure cell death and stasisDavid Usharauli
Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 111, Bethesda, Maryland 20892, USA
Nat Protoc 1:672-82. 2006..The P-JAM, also discussed, additionally allows for assessment of death in cells that don't fragment their DNA, and allows for assays of agents that induce cell stasis rather than death... - 'Educated' dendritic cells act as messengers from memory to naive T helper cellsOral Alpan
Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 5:615-22. 2004..The orally immunized T cells use IL-4 and IL-10 (but not CD40 ligand) to 'educate' dendritic cells, which in turn induce naive T cells to produce the same cytokines as those produced by the orally immunized memory T cells... - Immune response to engineered tissues and cells: breakout session summaryDavid M Harlan
National Institute of Diabetes, Digestive and Kidney Diseases/NIH, Building 10, Room 11S210, 10 Center Drive, Bethesda, MD 20892, USA
Ann N Y Acad Sci 961:350-1. 2002 - Intensity of the vaccine-elicited immune response determines tumor clearanceAinhoa Perez-Diez
Surgery Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
J Immunol 168:338-47. 2002..The results from this mouse model have major implications for the implementation of tumor vaccines in humans... - Are major histocompatibility complex molecules involved in the survival of naive CD4+ T cells?Isabelle Grandjean
Laboratoire d Immunologie, Institut Curie, 26 Rue d Ulm, 75005 Paris, France
J Exp Med 198:1089-102. 2003.... - Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathwayAnna Valujskikh
Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Nat Immunol 3:844-51. 2002..The findings suggest an alternate indirect effector pathway that requires processing and presentation of the donor H-Y antigen by recipient endothelium and have implications for both transplantation and autoimmune disease... - Molecular profiling improves diagnoses of rejection and infection in transplanted organsAndrey Morgun
Immunogenetics Division, Pediatrics Department, Federal University of Sao Paulo, Brazil
Circ Res 98:e74-83. 2006....