Mary J Mattapallil

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Common genetic determinants of uveitis shared with other autoimmune disorders
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA
    J Immunol 180:6751-9. 2008
  2. pmc Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:1977-85. 2011
  3. pmc Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice
    Lizette M Cortes
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1946-56. 2008
  4. pmc Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1957-70. 2008
  5. pmc Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells
    Lizette M Cortes
    Laboratory of Immunoregulation, National Eye Institute, National Institute of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20893 1857, USA
    J Leukoc Biol 84:577-85. 2008
  6. pmc The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition
    Ru Zhou
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    J Immunol 188:1742-50. 2012
  7. pmc Mouse models of experimental autoimmune uveitis
    Rachel R Caspi
    Laboratory of Immunology, NEI, NIH, Bethesda, MD 20892 1857, USA
    Ophthalmic Res 40:169-74. 2008
  8. pmc A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
    Giuseppina Pennesi
    Laboratory of Immunology, National Eye Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Invest 111:1171-80. 2003
  9. pmc An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms
    Dody Avichezer
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1665-76. 2003
  10. pmc Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen
    Reiko Horai
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA Electronic address
    J Autoimmun 44:21-33. 2013

Collaborators

Detail Information

Publications13

  1. pmc Common genetic determinants of uveitis shared with other autoimmune disorders
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, NIH, Bethesda, MD 20892, USA
    J Immunol 180:6751-9. 2008
    ..Our results suggest that uveitis shares some of the pathogenic mechanisms associated with other autoimmune diseases, and lends support to the "common gene, common pathway" hypothesis for autoimmune disorders...
  2. pmc Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 187:1977-85. 2011
    ....
  3. pmc Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice
    Lizette M Cortes
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1946-56. 2008
    ..The purpose of this study was to identify and characterize additional uveitogenic epitopes in B10.RIII and C57BL/6 mice and to compare epitope recognition in wild-type versus IRBP-deficient mice on both backgrounds...
  4. pmc Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Invest Ophthalmol Vis Sci 49:1957-70. 2008
    ..The primary objective of this study was to identify the non-MHC genes involved in the pathogenesis of EAU, to identify potential drug targets and possibly to target their protein products for immunotherapy...
  5. pmc Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinal autoimmunity by inducing type 2 and regulatory T cells
    Lizette M Cortes
    Laboratory of Immunoregulation, National Eye Institute, National Institute of Health, 10 Center Drive, 10 10N222, Bethesda, MD 20893 1857, USA
    J Leukoc Biol 84:577-85. 2008
    ..Thus, IPA pretreatment prevents induction of EAU by skewing the response to a subsequent uveitogenic challenge with the native peptide to a nonpathogenic phenotype, as well as by eliciting transferable regulatory cells...
  6. pmc The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition
    Ru Zhou
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    J Immunol 188:1742-50. 2012
    ..These findings shed new light on the phenomenon of immune privilege and on its role, as well as its limitations, in actively controlling immune responses in the tissue...
  7. pmc Mouse models of experimental autoimmune uveitis
    Rachel R Caspi
    Laboratory of Immunology, NEI, NIH, Bethesda, MD 20892 1857, USA
    Ophthalmic Res 40:169-74. 2008
    ..The current overview will summarize the salient features of the experimental autoimmune uveitis model and discuss its mechanisms...
  8. pmc A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
    Giuseppina Pennesi
    Laboratory of Immunology, National Eye Institute NIH, 10 Center Drive, Bethesda, MD 20892, USA
    J Clin Invest 111:1171-80. 2003
    ..Thus, EAU in HLA TG mice offers a new model of uveitis that should represent human disease more faithfully than currently existing models...
  9. pmc An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms
    Dody Avichezer
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1665-76. 2003
    ..Thus, uveitis-susceptible individuals display a detectable and functionally significant tolerance to their target antigen, in which central mechanisms play a prominent role...
  10. pmc Breakdown of immune privilege and spontaneous autoimmunity in mice expressing a transgenic T cell receptor specific for a retinal autoantigen
    Reiko Horai
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA Electronic address
    J Autoimmun 44:21-33. 2013
    ....
  11. pmc Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection
    Matthew D Eberly
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 182:1439-48. 2009
    ..Our results demonstrate that IL-15 contributes to the increased susceptibility of memory CD4 T cells to SIV during the early phase of acute SIV infection...
  12. pmc A new look at immune privilege of the eye: dual role for the vision-related molecule retinoic acid
    Ru Zhou
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 1857, USA
    J Immunol 187:4170-7. 2011
    ..Nevertheless, primed effector T cells are relatively insensitive to AH, helping to explain their ability to induce uveitis despite an inhibitory ocular microenvironment...
  13. pmc The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes
    Mary J Mattapallil
    Laboratory of Immunology, National Eye Institute, Bethesda, Maryland, USA
    Invest Ophthalmol Vis Sci 53:2921-7. 2012
    ..We set out to examine the prevalence of this mutation in induced mutant mouse lines, vendor C57BL/6 mice and in widely used embryonic stem cells...