Research Topics
| J A MatochikSummaryAffiliation: National Institutes of Health Country: USA Publications
| Collaborators
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Detail Information
Publications
Age-related decline in striatal volume in rhesus monkeys: assessment of long-term calorie restrictionJohn A Matochik
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
Neurobiol Aging 25:193-200. 2004..Further study, involving sequential imaging, is warranted in order to clarify the possible effects of CR on age-related changes in striatal volume...- Age-related decline in striatal volume in monkeys as measured by magnetic resonance imagingJ A Matochik
Brain Imaging Center, Neuroimaging Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Neurobiol Aging 21:591-8. 2000..The current results provide normative data to assess potential interventions (e.g. caloric restriction) in the aging process... - Altered brain tissue composition in heavy marijuana usersJohn A Matochik
Intramural Research Program, Neuroimaging Research Branch, National Institute on Drug Abuse, NIH DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
Drug Alcohol Depend 77:23-30. 2005..045). Our preliminary results suggest evidence of possible structural differences in the brain of heavy marijuana users, and localize regions for further investigation of the effects of marijuana in the brain... - Frontal cortical tissue composition in abstinent cocaine abusers: a magnetic resonance imaging studyJohn A Matochik
Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Neuroimage 19:1095-102. 2003..These results extend our previous findings of defective frontal cortical activation (indexed by cerebral blood flow) in cocaine abusers to include abnormalities in gray matter tissue density in the same frontal cortical regions... - Sex-related differences in a gambling task and its neurological correlatesK I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Cereb Cortex 14:1226-32. 2004..These results also provide further evidence of sexual dimorphism in neurocognitive performance and brain function... 
Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380Alane S Kimes
Neuroimaging Research Branch, NIDA IRP NIH DHHS, Baltimore, MD 21224, USA
Neuroimage 39:717-27. 2008..The results of repeated PET studies with 2FA showed a high reproducibility of V(T) measurements. We conclude that B/I methodology will be useful for clinical and research studies of brain nAChRs...- Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making taskK I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Neuroimage 19:1085-94. 2003..Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence... - High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorderM Ernst
Laboratory of Cerebral Metabolism, NIMH, Bethesda, MD, USA
Am J Psychiatry 156:1209-15. 1999..Converging evidence, however, suggests a primary role of the dopaminergic system... - Neural substrates of decision making in adults with attention deficit hyperactivity disorderMonique Ernst
Intramural Research Program, NIMH, Natioanl Institute on Drug Abuse, Baltimore, MD, USA
Am J Psychiatry 160:1061-70. 2003..The study examined reward responsivity in ADHD by comparing the neural correlates of decision making in adults with childhood-onset ADHD and in healthy adults... - 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humansAlane S Kimes
NIDA Intramural Research Program Baltimore, Maryland 21224, USA
FASEB J 17:1331-3. 2003..180 +/- 30 mSv/MBq or 0.7 rem/mCi with a 2.4 h void interval) suggests that multiple studies could be performed in a single subject. The results predict that quantitative PET imaging of nAChRs in human brain with 2-[18F]FA is feasible... - Decision-making in a risk-taking task: a PET studyMonique Ernst
Intramural Research Program of the National Institute on Drug Abuse, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
Neuropsychopharmacology 26:682-91. 2002..The findings provide a framework for future investigations of decision-making in maladaptive behaviors... - Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusersDiana H Fishbein
Transdisciplinary Behavioral Science Program, RTI International, 6801 Eastern Avenue, Suite 203, Baltimore, MD 21224, USA
Brain Res Cogn Brain Res 23:119-36. 2005..Attenuated activation of the pregenual ACC in the drug abusers relative to the controls during performance on the RDMT may underlie the abusers' tendency to choose risky outcomes... - Effect of nicotine on brain activation during performance of a working memory taskM Ernst
Brain Imaging Center and Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 98:4728-33. 2001..Furthermore, the lack of enhancement of activation after nicotine administration in smokers likely reflects tolerance... - Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380Alexey G Mukhin
National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA
J Nucl Med 49:1628-35. 2008..Quantitative PET imaging of nAChRs in humans has recently been reported using the alpha4beta2* subtype-specific radioligand 2-(18)F-FA-85380 (2FA)... - Abnormal brain activity in prefrontal brain regions in abstinent marijuana usersDana A Eldreth
Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Neuroimage 23:914-20. 2004..These differences in brain activity may be a common denominator in the evolution of maladaptive behaviors such as substance abuse and other neuropsychiatric disorders... - Neural substrates of faulty decision-making in abstinent marijuana usersKaren I Bolla
Department of Neurology, Johns Hopkins University School of Medicine, Bayview Medical Center, Baltimore, MD 21224, USA
Neuroimage 26:480-92. 2005..Finally, it is unclear if these neurologic findings will become progressively worse with continued heavy MJ use or if they will resolve with abstinence from MJ use... - Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusersEdythe D London
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California Los Angeles, 760 Westwood Plaza, PO Box 175919, Los Angeles, CA 90024 1759, USA
Arch Gen Psychiatry 61:73-84. 2004..Mood disturbances in methamphetamine (MA) abusers likely influence drug use, but the neurobiological bases for these problems are poorly understood... - Education-associated cortical glucose metabolism during sustained attentionDaniel P Eisenberg
Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA
Neuroreport 16:1473-6. 2005..Previously, these structures have shown early impairment in dementia. Further investigation should explore whether metabolic changes in these regions contribute to the possible protective effect of education on cognition...