Seth L Masters

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)
    Seth L Masters
    The National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 27:621-68. 2009
  2. ncbi request reprint Recent advances in the molecular pathogenesis of hereditary recurrent fevers
    Seth L Masters
    The National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda 20892, Maryland, USA
    Curr Opin Allergy Clin Immunol 6:428-33. 2006
  3. pmc The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
    Jae Jin Chae
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892 1820, USA
    Blood 112:1794-803. 2008
  4. pmc Familial Mediterranean fever with a single MEFV mutation: where is the second hit?
    Matthew G Booty
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 60:1851-61. 2009
  5. pmc An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    N Engl J Med 360:2426-37. 2009
  6. pmc The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production
    Jae Jin Chae
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9982-7. 2006
  7. pmc STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    N Engl J Med 357:977-86. 2007
  8. pmc Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia
    Protein Sci 15:2761-72. 2006
  9. ncbi request reprint The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Victoria, Australia
    Nat Struct Mol Biol 13:77-84. 2006
  10. ncbi request reprint Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)
    Shenggen Yao
    J Biomol NMR 31:69-70. 2005

Detail Information

Publications10

  1. pmc Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)
    Seth L Masters
    The National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Immunol 27:621-68. 2009
    ..A system based on molecular pathophysiology will bring greater clarity to our discourse while catalyzing new hypotheses both at the bench and at the bedside...
  2. ncbi request reprint Recent advances in the molecular pathogenesis of hereditary recurrent fevers
    Seth L Masters
    The National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda 20892, Maryland, USA
    Curr Opin Allergy Clin Immunol 6:428-33. 2006
    ....
  3. pmc The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment
    Jae Jin Chae
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892 1820, USA
    Blood 112:1794-803. 2008
    ..Our data support a new pyrin/caspase-1 pathway for NF-kappaB activation...
  4. pmc Familial Mediterranean fever with a single MEFV mutation: where is the second hit?
    Matthew G Booty
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 60:1851-61. 2009
    ..The purpose of this study was to perform an extensive search for a second MEFV mutation in 46 patients diagnosed clinically as having FMF and carrying only 1 high-penetrance FMF mutation...
  5. pmc An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
    Ivona Aksentijevich
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892, USA
    N Engl J Med 360:2426-37. 2009
    ..We report a disorder caused by mutations of IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement of skin and bone...
  6. pmc The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production
    Jae Jin Chae
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9982-7. 2006
    ..Our data support a direct, ASC-independent effect of pyrin on IL-1beta activation and suggest heightened IL-1 responsiveness as one factor selecting for pyrin mutations...
  7. pmc STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
    Elaine F Remmers
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA
    N Engl J Med 357:977-86. 2007
    ..Rheumatoid arthritis is a chronic inflammatory disease with a substantial genetic component. Susceptibility to disease has been linked with a region on chromosome 2q...
  8. pmc Dynamics of the SPRY domain-containing SOCS box protein 2: flexibility of key functional loops
    Shenggen Yao
    The Walter and Eliza Hall Institute of Medical Research, Parkville 3050, Victoria, Australia
    Protein Sci 15:2761-72. 2006
    ..The underlying flexibility of certain regions of the B30.2/SPRY domain-containing proteins may also contribute to some apparent structural differences observed between GUSTAVUS or PRYSPRY and SSB-2...
  9. ncbi request reprint The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues
    Seth L Masters
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050, Victoria, Australia
    Nat Struct Mol Biol 13:77-84. 2006
    ..Our findings provide a template for SPRY-domain structure and an insight into the mechanism of SPRY-protein interaction...
  10. ncbi request reprint Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)
    Shenggen Yao
    J Biomol NMR 31:69-70. 2005