Daniel C Masison

Summary

Affiliation: National Institutes of Health
Country: USA

Publications

  1. pmc Function of SSA subfamily of Hsp70 within and across species varies widely in complementing Saccharomyces cerevisiae cell growth and prion propagation
    Deepak Sharma
    Laboratory of Biochemistry and Genetics, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e6644. 2009
  2. pmc Influence of Hsp70s and their regulators on yeast prion propagation
    Daniel C Masison
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0830, USA
    Prion 3:65-73. 2009
  3. pmc Sti1 regulation of Hsp70 and Hsp90 is critical for curing of Saccharomyces cerevisiae [PSI+] prions by Hsp104
    Michael Reidy
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 30:3542-52. 2010
  4. pmc Curing of yeast [PSI+] prion by guanidine inactivation of Hsp104 does not require cell division
    Yue Xuan Wu
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8017, USA
    Proc Natl Acad Sci U S A 102:12789-94. 2005
  5. pmc Prokaryotic chaperones support yeast prions and thermotolerance and define disaggregation machinery interactions
    Michael Reidy
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 192:185-93. 2012
  6. pmc Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities
    Patrick G Needham
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Building 8, Room 407, LBG NIDDK, Bethesda, MD 20892 0851, USA
    Arch Biochem Biophys 478:167-74. 2008
  7. pmc Application of GFP-labeling to study prions in yeast
    Lois E Greene
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD 20892 0301, USA
    Protein Pept Lett 16:635-41. 2009
  8. pmc Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity
    P Aaron Kirkland
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Genetics 188:565-77. 2011
  9. pmc Application of photobleaching for measuring diffusion of prion proteins in cytosol of yeast cells
    Yue Xuan Wu
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD 20892 0301, USA
    Methods 39:43-9. 2006
  10. pmc Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast
    Olivier Genest
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 49:464-73. 2013

Collaborators

Detail Information

Publications30

  1. pmc Function of SSA subfamily of Hsp70 within and across species varies widely in complementing Saccharomyces cerevisiae cell growth and prion propagation
    Deepak Sharma
    Laboratory of Biochemistry and Genetics, National Institutes of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e6644. 2009
    ..However, while several reports suggest that specialized functions of Hsp70 orthologs were selected through evolution, few studies addressed systematically this issue...
  2. pmc Influence of Hsp70s and their regulators on yeast prion propagation
    Daniel C Masison
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0830, USA
    Prion 3:65-73. 2009
    ..We discuss the variety of effects Hsp70 and its regulators have on different prions and how the effects might be due to the many ways chaperones interact with each other and with amyloid...
  3. pmc Sti1 regulation of Hsp70 and Hsp90 is critical for curing of Saccharomyces cerevisiae [PSI+] prions by Hsp104
    Michael Reidy
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 30:3542-52. 2010
    ....
  4. pmc Curing of yeast [PSI+] prion by guanidine inactivation of Hsp104 does not require cell division
    Yue Xuan Wu
    Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 8017, USA
    Proc Natl Acad Sci U S A 102:12789-94. 2005
    ..Rather, curing apparently occurs because Sup35-GFP polymers slowly depolymerize in the absence of Hsp104 activity. Hsp104 then counteracts this curing possibly by catalyzing formation of new polymers...
  5. pmc Prokaryotic chaperones support yeast prions and thermotolerance and define disaggregation machinery interactions
    Michael Reidy
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genetics 192:185-93. 2012
    ..Our results define cooperative interactions among these components that are specific or interchangeable across life kingdoms and imply Hsp100 family disaggregases possess intrinsic amyloid remodeling activity...
  6. pmc Prion-impairing mutations in Hsp70 chaperone Ssa1: effects on ATPase and chaperone activities
    Patrick G Needham
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Building 8, Room 407, LBG NIDDK, Bethesda, MD 20892 0851, USA
    Arch Biochem Biophys 478:167-74. 2008
    ..Our data suggest that prion-impairing mutations of Ssa1 can increase or decrease substrate interactions, alter the Hsp70 reaction cycle at different points and impair normal NBD-SBD cooperation...
  7. pmc Application of GFP-labeling to study prions in yeast
    Lois E Greene
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD 20892 0301, USA
    Protein Pept Lett 16:635-41. 2009
    ....
  8. pmc Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity
    P Aaron Kirkland
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Genetics 188:565-77. 2011
    ..This work also uncovered a growth inhibition caused by [PSI(+)] when certain functions of Sis1p were absent, suggesting that Sis1p protects cells from cytotoxicity caused by [PSI(+)] prions...
  9. pmc Application of photobleaching for measuring diffusion of prion proteins in cytosol of yeast cells
    Yue Xuan Wu
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, MD 20892 0301, USA
    Methods 39:43-9. 2006
    ..A detailed description of the FRAP technique is given, including its application to measuring the mobility of GFP-tagged Sup35p in [psi(-)] and [PSI(+)] cells...
  10. pmc Uncovering a region of heat shock protein 90 important for client binding in E. coli and chaperone function in yeast
    Olivier Genest
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 49:464-73. 2013
    ..coli mutant proteins. Our results identify a region in Hsp90 important for client binding in E. coli Hsp90 and suggest an evolutionary divergence in the mechanism of client interaction by bacterial and yeast Hsp90...
  11. pmc Curing of yeast [URE3] prion by the Hsp40 cochaperone Ydj1p is mediated by Hsp70
    Deepak Sharma
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 181:129-37. 2009
    ..Our data imply that curing of [URE3] by overproduced Ydj1p does not involve direct interaction of Ydj1p with Ure2p but rather works through regulation of Hsp70 through a specific J-protein/Hsp70 interaction...
  12. pmc N-terminal domain of yeast Hsp104 chaperone is dispensable for thermotolerance and prion propagation but necessary for curing prions by Hsp104 overexpression
    Guo Chiuan Hung
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 173:611-20. 2006
    ....
  13. pmc Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding
    Gary Jones
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Mol Cell Biol 24:3928-37. 2004
    ..Although Cpr7p and Sti1p are Hsp90 cochaperones, we provide evidence that Hsp90 is not involved in [PSI(+)] propagation, suggesting that Sti1p and Cpr7p functionally interact with Hsp70 independently of Hsp90...
  14. pmc Single methyl group determines prion propagation and protein degradation activities of yeast heat shock protein (Hsp)-70 chaperones Ssa1p and Ssa2p
    Deepak Sharma
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:13665-70. 2011
    ..Our data suggest a rationale for maintaining multiple Hsp70s and suggest that subtle differences among Hsp70s evolved to provide functional specificity without affecting overall enzymatic activity...
  15. pmc Functionally redundant isoforms of a yeast Hsp70 chaperone subfamily have different antiprion effects
    Deepak Sharma
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 179:1301-11. 2008
    ....
  16. pmc Primate chaperones Hsc70 (constitutive) and Hsp70 (induced) differ functionally in supporting growth and prion propagation in Saccharomyces cerevisiae
    Yusuf Tutar
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 172:851-61. 2006
    ..Our data support a view that intrinsic activities of Hsp70 isoforms are comparable, and functional differences in vivo lie mainly in complex interactions of Hsp70 with cochaperones...
  17. pmc Role for Hsp70 chaperone in Saccharomyces cerevisiae prion seed replication
    Youtao Song
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Eukaryot Cell 4:289-97. 2005
    ..Our data suggest that Ssa1-21p interferes with disruption of large Sup35p aggregates, which lack or have limited capacity to function as seed, into polymers that function more efficiently as [PSI+] seeds...
  18. pmc Saccharomyces cerevisiae Hsp70 mutations affect [PSI+] prion propagation and cell growth differently and implicate Hsp40 and tetratricopeptide repeat cochaperones in impairment of [PSI+]
    Gary W Jones
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Genetics 163:495-506. 2003
    ..Other suppressing mutations are in residues important for interactions with Hsp40 or TPR-containing cochaperones, suggesting that such interactions are necessary for the impairment of [PSI(+)] propagation caused by mutant Ssa1p...
  19. pmc Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation
    Marika Miot
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:6915-20. 2011
    ....
  20. pmc Hsp70 structure, function, regulation and influence on yeast prions
    Deepak Sharma
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0851, USA
    Protein Pept Lett 16:571-81. 2009
    ..Various co-chaperones specify Hsp70 function and broaden its substrate range. We discuss Hsp70 structure and function, regulation by co-factors and influence on propagation of yeast prions...
  21. pmc Ure2p function is enhanced by its prion domain in Saccharomyces cerevisiae
    Frank Shewmaker
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0830, USA
    Genetics 176:1557-65. 2007
    ..Finally, we demonstrate that the prion domain may affect the interaction of Ure2p with other components of the nitrogen regulation system, specifically the negative regulator of nitrogen catabolic genes, Gzf3p...
  22. doi request reprint Hsp104 Overexpression Cures Saccharomyces cerevisiae [PSI+] by Causing Dissolution of the Prion Seeds
    Yang Nim Park
    Laboratory of Cell Biology, NHLBI, NIH, Bethesda, Maryland, USA
    Eukaryot Cell 13:635-47. 2014
    ..First, trimming of the prion seeds by Hsp104 reduces their size, and second, their amyloid core is eliminated, most likely by proteolysis. ..
  23. pmc Schizosaccharomyces pombe disaggregation machinery chaperones support Saccharomyces cerevisiae growth and prion propagation
    Michael Reidy
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Eukaryot Cell 12:739-45. 2013
    ..These results are consistent with a view that mechanisms underlying prion replication and elimination are distinct...
  24. pmc Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1)
    Youtao Song
    Laboratory of Biochemistry and Genetics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    J Biol Chem 280:34178-85. 2005
    ..We further demonstrate that client folding depended upon bridging of Hsp70 and Hsp90 by Sti1p and find conservation of the independent regulation of Hsp70 and Hsp90 by human Hop1...
  25. pmc Amino acid residue 184 of yeast Hsp104 chaperone is critical for prion-curing by guanidine, prion propagation, and thermotolerance
    Giman Jung
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Building 8, Room 407, Bethesda, MD 20892 0851, USA
    Proc Natl Acad Sci U S A 99:9936-41. 2002
    ..Our data suggest that Hsp104 activity can be reduced substantially without affecting [PSI(+)] stability, and that Hsp104 interacts differently with prion aggregates than with aggregates of thermally denatured protein...
  26. pmc Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p
    Christine Schwimmer
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0851, USA
    Mol Cell Biol 22:3590-8. 2002
    ..Our data also suggest that differences in how [PSI(+)] and [URE3] interact with Hsp104 and Hsp70 may contribute to their antagonistic interactions...
  27. doi request reprint Modulation and elimination of yeast prions by protein chaperones and co-chaperones
    Michael Reidy
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
    Prion 5:245-9. 2011
    ..In spite of a considerable amount of information, a clear understanding of the molecular mechanisms underlying these effects remains wanting...
  28. pmc Yeast ornithine decarboxylase and antizyme form a 1:1 complex in vitro: purification and characterization of the inhibitory complex
    Manas K Chattopadhyay
    Laboratory of Biochemistry and Genetics, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, Bldg 8, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 406:177-82. 2011
    ..Comparison of the circular dichroism (CD) spectra of the two individual proteins and of the ODC:AZ complex shows a change in the secondary structure in the complex...
  29. pmc Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis
    Satish K Madala
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Proteins 79:282-93. 2011
    ..Thus, high-density peptide arrays combined with molecular docking studies provide a novel, rapid, and reliable method to map cytokine-receptor interactions that may be used to generate signaling and decoy receptor-specific antagonists...
  30. ncbi request reprint Protein synthesis assayed by electroporation of mRNA in Saccharomyces cerevisiae
    Anjanette M Searfoss
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
    Methods Enzymol 351:631-9. 2002